Dynamic changes of the S wave in lead V6: A novel visual indicator for left bundle branch capture.

Background: During the electrode screwing process in left bundle branch pacing (LBBP), the significance of the S wave in lead V6 remains elusive. Our study analyzes the change of the S wave in lead V6 under different patterns of capture and explores its mechanisms.

Methods: This study included 243 cases with criterion of selective LBBP (SLBBP), we performed continuous pacing technique and classified the electrophysiological characteristics observed during the screwing process into four patterns: left ventricular septal pacing (LVSP), non-selective LBBP (NSLBBP) in low output and in the lower output, selective LBBP.

Short- to Mid-Term Efficacy and Safety of Left Bundle Branch Pacing Guided by Continuous Uninterrupted Paced Intracardiac Electrogram Monitoring Targeting Transition to Selective Left Bundle Branch Capture.

Background: Uninterrupted left bundle branch pacing (LBBP) lead implantation with the endpoint of transition to selected (S)-left bundle (LB) capture is feasible and safe during the procedure; however, the relatively long-term outcomes remain unknown.

Objective: The present study aimed to evaluate the short- to mid-term performance and safety of uninterrupted LBBP lead implantation.

Methods: Patients who underwent successful LBBP and achieved the implantation endpoint, guided by continuous paced intracardiac electrogram monitoring, were enrolled.

Electrogram transition patterns in left bundle branch pacing: a case report.

Introduction: Left bundle branch (LBB) pacing (LBBP) demonstrates clinical potential but faces challenges in confirming selective capture via dynamic electrogram (EGM) criteria.

Case Report: A 69-year-old male with a complete atrioventricular block underwent LBBP implantation. Real-time EGM monitoring (high-pass/low-pass filters: 200/500 Hz) revealed an abrupt shortening of stimulus-to-V6 R-wave peak time (Sti-V6 RWPT) from 87 to 69 ms during lead deployment, indicating a transition from septal pacing to LBBP.

DNMT3A triggers tumorigenesis of non-small cell lung cancer through regulation of SLIT2 methylation and SLIT2-mediated macrophage M1/M2 polarization.

Background: Increased DNA methylation is prevalent in human cancers and is one of the important characteristics of tumors. This research aims to investigate the molecular mechanisms that involve DNMT3A and DNA methylation modification of SLIT2 in non-small cell lung cancer (NSCLC).

Methods: Gene expression was examined using Western blot assay, immunohistochemistry and RT-qPCR.

Comparison of electrophysiological left bundle branch pacing characteristics in different bilateral electrode pacing vector configurations.

Introduction: Left bundle branch pacing (LBBP) in bipolar pacing with anodal capture produces a more balanced ventricular activation than conventional unipolar pacing but need high pacing output. The present study aimed to compare the electrophysiological characteristics of LBBP in different bilateral electrode pacing vector configurations.

Methods: A total of 57 patients who met the criteria for left bundle branch (LBB) capture and underwent three bilateral electrode pacing vector configuration test were enrolled.

Left Bundle Branch Pacing in a Pediatric Patient With Tricuspid Valve Replacement for a Complex Ebstein Anomaly.

This paper presents a unique case of successful implementation of left bundle branch pacing (LBBP) in a pediatric patient with third-degree atrioventricular block following tricuspid valve replacement for a complex Ebstein anomaly. The procedure was performed under real-time recording technique, and resulted in the resolution of the patient's symptoms. This case underscores the feasibility and potential benefits of LBBP in pediatric patients, particularly in those with complex congenital heart conditions and following valve replacement surgery.

Electrophysiological characteristics of lead position-dependent electrogram uninterrupted transition during left bundle branch pacing.

Background: The interrupted technique of left bundle branch pacing (LBBP) limits the continuous monitoring of paced electrocardiogram and intracardiac electrogram (EGM) transitions, which may result in overlooked or misinterpreted subtle transitions.

Objectives: This study aimed to explore the electrophysiological characteristics of lead position-dependent EGM continuous transitions to evaluate lead depth and to investigate the clinical significance of transseptal pacing modalities.

Methods: A continuous pacing and recording technique enabled by a rotatable connector was used to allow the real-time monitoring of progressive changes in paced EGM and electrocardiographic morphology.

Six transition patterns and seven capture types in different left bundle branch bipolar pacing configurations.

Aims: This study aims to explore the different transition patterns and capture types during two bipolar pacing tests based on the selective left bundle branch (LBB) capture determined by the continuous pacing and recording technique.

Methods: In total, 67 patients completed two unipolar and two bipolar pacing tests based on selective LBB capture during screwing-in for left bundle branch pacing (LBBP) using the continuous pacing and recording technique. The electrophysiological characteristics and potential mechanisms of different pacing configurations were further evaluated in this study.

Left bundle branch pacing guide by uninterrupted recording of intrinsic filtered and unfiltered intracardiac electrograms.

Background: Currently, the interrupted recording technique is commonly used to perform left bundle branch (LBB) pacing (LBBP). However, this method requires repeated testing to confirm that the LBB is captured and perforations are avoided. An automated solution may make this repetitive work easier.

Corrigendum: Guidance on left bundle branch pacing using continuous pacing technique and changes in lead V1 characteristics under real-time monitoring.

[This corrects the article DOI: 10.3389/fcvm.2023.

Guidance on left bundle branch pacing using continuous pacing technique and changes in lead V1 characteristics under real-time monitoring.

Background: The changes in the morphology and characteristics of the V1 leads during left bundle branch capturing still need to be fully understood.

Objective: This study aims to provide some suggestions about the LBB capture process through the morphology and characteristics of the V1 lead.

Method: LBBP using the continuous pacing and morphology monitoring technique during screw-in using a revolving connector (John Jiang's connecting cable).

A shorter R wave peak time in left bundle branch pacing may not be a marker of more physiological ventricular activation: A case report.

Left bundle branch pacing (LBBp) is a promising alternative to conventional biventricular pacing cardiac resynchronization therapy. The left anterior fascicle (LAF) is adjacent to the left ventricular outflow tract, while the left posterior fascicle (LPF) dominates a broader area of the left ventricle. Whether LAF or LPF dominates ventricular activation has not been determined.

2:1 Intrahisian block with Wenckebach phenomenon during his bundle pacing.

Background: Intrahisian blocks with split His bundle (HB) potentials are occasionally observed in practice with intrahisian Wenckebach phenomenon being rare.

Case Presentation: We report a case of an 85c and third-degree atrioventricular block. Some electrophysiological phenomena were recorded which serve as evidence of second-degree block intrahisian within the HB.

Case report: Left bundle branch pacing guided by real-time monitoring of current of injury and electrocardiography.

Background: Left bundle branch (LBB) pacing (LBBP) has recently emerged as a physiological pacing mode. Current of injury (COI) can be used as the basis for electrode fixation position and detection of perforation. However, because the intermittent pacing method cannot monitor the changes in COI in real time, it cannot obtain information about the entire COI change process during implantation.

Interesting phenomena during threshold testing of conduction system pacing: What is the mechanism?

Background: Although the interest in conduction system pacing is increasing, the data on longitudinal dissociation in the literature is still limited. METHODS AND RESULTS: We performed left bundle branch (LBB) pacing on a patient with sick sinus syndrome and atrioventricular block. The transition of QRS morphology can be observed during the threshold testing.

A Continuous Pacing and Recording Technique for Differentiating Left Bundle Branch Pacing From Left Ventricular Septal Pacing: Electrophysiologic Evidence From an Intrapatient-Controlled Study.

Background: Left bundle branch pacing (LBBP) is a promising approach for achieving near-physiologic pacing. However, differentiating LBBP from left ventricular septal endocardial pacing (LVS(e)P) remains a challenge. This study aimed to establish a simple and effective method for differentiating LBBP from LVS(e)P and to evaluate their electrophysiologic characteristics.

The left bundle branch has been captured but shows the left ventricular septal pacing:What is the mechanism?

It was shown that V6 R-wave peak time (V6 RWPT) prolongs with transition form non-selective left bundle branch pacing (ns-LBBP) to left ventricular septal pacing (LVSP) but remains constant or slightly prolongs with transition to selective left bundle branch pacing (sel-LBBP) [1,2]. Here, we report on a patient who was observed with a LBB potential, isoelectric interval, where the V6 RWPT substantially prolonged with transition from ns-LBBP to sel-LBBP at near threshold output.

Interesting electrophysiological phenomenon during positioning of the lead deep inside the septum.

Left bundle branch pacing (LBBP) is a developing physiological pacing technique. Wu et al. proposed that direct LBB capture could be confirmed by recording retrograde His potential (Po ) and mapping of the left conduction system potential.

Electrophysiological characteristics and possible mechanism of bipolar pacing in left bundle branch pacing.

Background: Left bundle branch pacing is a physiological pacing modality with a low and stable threshold. The electrophysiological characteristics and mechanisms of bipolar pacing remain unclear.

Objectives: This study aimed to assess the electrophysiological characteristics of bipolar pacing of left bundle branch pacing and to infer the mechanisms underlying each electrocardiogram and electrogram waveform morphology.