Dynamic changes of the S wave in lead V6: A novel visual indicator for left bundle branch capture.

Background: During the electrode screwing process in left bundle branch pacing (LBBP), the significance of the S wave in lead V6 remains elusive. Our study analyzes the change of the S wave in lead V6 under different patterns of capture and explores its mechanisms.

Methods: This study included 243 cases with criterion of selective LBBP (SLBBP), we performed continuous pacing technique and classified the electrophysiological characteristics observed during the screwing process into four patterns: left ventricular septal pacing (LVSP), non-selective LBBP (NSLBBP) in low output and in the lower output, selective LBBP.

CCR7 dendritic cells expressing both IL-23A and IL-12B potentially contribute to psoriasis relapse.

Interleukin (IL)-23 is the master pathogenic cytokine in psoriasis and neutralization of IL-23 alleviates psoriasis. Psoriasis relapses after the withdrawal of anti-IL-23 antibodies, and the persistence of IL-23-producing cells potentially contributes to such recurrence, but the cellular source of IL-23 is unclear. Here we show that IL4I1CD200CCR7 dendritic cells (CCR7 DC) are the main producer of IL-23 by concomitantly expressing the IL-23A and IL-12B subunits in human psoriatic skin.

Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8 T cell responses in vitiligo.

Vitiligo is an autoimmune disease characterized by depigmented patches of skin. Autoreactive CD8 T cells kill melanocytes in vitiligo, but the immunopathogenesis remains elusive and ideal drug targets are lacking. Through single-cell and spatial transcriptomic analysis of vitiligo lesional skin, we found that conventional type 1 dendritic cells (cDC1s) primed CD8 T cells and highly expressed the neuropeptide calcitonin gene-related peptide (CGRP) receptor.

Brassinosteroid promotes leaf wrinkling in Brassica campestris by regulating a key transcription factor and its downstream genes.

Chinese cabbage (Brassica campestris syn. B. rapa) is an important leafy vegetable featuring a variety of cultivars with diverse leaf morphologies.

Heterogeneous effects of obesity on all-cause mortality: A causal forest analysis of hospitalized patients in China.

Aims: To confirm the 'obesity paradox' in hospitalized populations and examine the heterogeneous effects of obesity on all-cause mortality risk.

Materials And Methods: We included 5967 hospitalized patients from the Real-world Data of Cardiometabolic Protection (RED-CARPET) study (ChiCTR2000039901) in China. After 1:1 k-nearest neighbours matching, a causal forest model classified the population into four subgroups.

Skeletal Muscle Mass and Mortality in Heart Failure: Mediation Role of Systemic Immune-Inflammatory Index.

Background: Heart failure (HF)-related skeletal muscle wasting inversely affects the prognosis of HF, in which systemic inflammation may be involved. The relationships among skeletal muscle mass (SMM), systemic inflammation, and cardiovascular outcomes have not been clarified.

Objectives: This study evaluated the associations of SMM with cardiovascular outcomes, systemic immune-inflammatory index (SII) with cardiovascular outcomes, and the mediation role of SII in the relationship between SMM and outcomes.

Equations for Predicting the 10-Year Risk of Atherosclerotic Cardiovascular Disease in Population With Obesity.

Background: Atherosclerotic cardiovascular disease (ASCVD) is a significant public health issue; however, current risk prediction models have limitations in populations with obesity.

Objectives: The aim of this study was to develop risk models for predicting ASCVD risk in patients with obesity.

Methods: Gender-specific equations to predict ASCVD were developed and validated using a cohort of 3,058 participants with obesity (body mass index ≥30 kg/m) in the ARIC (Atherosclerosis Risk In Communities) study and 1,953 participants in MESA (Multi-Ethnic Study of Atherosclerosis).

Single-Cell RNA Sequencing Identifies WARS1+ Mesenchymal Stem Cells with Enhanced Immunomodulatory Capacity and Improved Therapeutic Efficacy.

Psoriasis is a common inflammatory skin disorder with no cure. Mesenchymal stem cells (MSCs) have immunomodulatory properties for psoriasis, but the therapeutic efficacies varied, and the molecular mechanisms were unknown. In this study, we improved the efficacy by enhancing the immunomodulatory effects of umbilical cord-derived MSCs (UC-MSCs).

Molecular mechanism of wedelolactone inhibits high glucose-induced human retinal vascular endothelial cells injury through regulating miR-190 expression.

To investigate the effects and molecular mechanisms of wedelolactone (WEL) on high glucose-induced injury of human retinal vascular endothelial cells (HRECs). The cell injury model was established by incubating HRECs with 30 mmol/L glucose for 24 hour. HRECs were divided into control (Con) group, high glucose (HG) group, HG + WEL-low dose (L) group, HG + WEL-medium dose (M), HG + WEL-high dose (H) group, HG + miR-NC group, HG + miR-190 group, HG + WEL + antimiR-NC group, HG + WEL + antimiR-190 group.

Sex-based differences in brain morphometry under chronic stress: A pilot MRI study.

Background: Sex-based differences are known to be a significant feature of chronic stress; however, the morphological mechanisms of the brain underlying these differences remain unclear. The present study aimed to use magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) to investigate the effects of sex on gray matter volume (GMV) changes under conditions of chronic stress.

Methods: A total of 32 subjects were included for analysis in the present study: 16 participants experiencing chronic stress and 16 healthy controls.

A lncRNA Dleu2-encoded peptide relieves autoimmunity by facilitating Smad3-mediated Treg induction.

Micropeptides encoded by short open reading frames (sORFs) within long noncoding RNAs (lncRNAs) are beginning to be discovered and characterized as regulators of biological and pathological processes. Here, we find that lncRNA Dleu2 encodes a 17-amino-acid micropeptide, which we name Dleu2-17aa, that is abundantly expressed in T cells. Dleu2-17aa promotes inducible regulatory T (iTreg) cell generation by interacting with SMAD Family Member 3 (Smad3) and enhancing its binding to the Foxp3 conserved non-coding DNA sequence 1 (CNS1) region.

Association between Coronary Heart Disease, Heart Failure, and Risk of Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Background: Cardiovascular diseases such as coronary heart disease (CHD), heart failure (HF), and stroke have been linked to the development of Alzheimer's disease (AD). However, previous studies have reported inconsistent results. The study aimed to investigate the association between CHD, HF, and the risk of AD using a meta-analysis.

Cardiovascular effects of weight loss in old adults with overweight/obesity according to change in skeletal muscle mass.

Background: Patients with overweight/obesity and type 2 diabetes are encouraged to lose weight, but not all losing weight gain better cardiovascular health, especially old adults. The change in skeletal muscle mass (SMM) could be the key that explains the heterogenous cardiovascular effects of weight loss. This study aims to assess whether the cardiovascular effects of weight loss vary for those gaining skeletal muscle along with weight loss.

Serum Klotho Modifies the Associations of 25-Hydroxy Vitamin D With All-Cause and Cardiovascular Mortality.

Background: The association between 25-hydroxyvitamin D and mortality remains controversial. Klotho, a biomarker of vitamin D activation and metabolism, may play a key role in this association. However, it is unclear whether the association between vitamin D deficiency and mortality risk is modified by klotho levels.

CKBA suppresses mast cell activation via ERK signaling pathway in murine atopic dermatitis.

Atopic dermatitis (AD) is a common inflammatory skin disorder. Mast cells play an important role in AD because they regulate allergic reactions and inflammatory responses. However, whether and how the modulation of mast cell activity affects AD has not been determined.

The Expression and Prognostic Value of Co-stimulatory Molecules in Clear Cell Renal Cell Carcinoma (CcRcc).

Background: Renal cell carcinoma (RCC) was one of the most common malignant cancers in the urinary system. Clear cell carcinoma (ccRCC) is the most common pathological type, accounting for approximately 80% of RCC. The lack of accurate and effective prognosis prediction methods has been a weak link in ccRCC treatment.

Tenascin C papillary fibroblasts facilitate neuro-immune interaction in a mouse model of psoriasis.

Dermal fibroblasts and cutaneous nerves are important players in skin diseases, while their reciprocal roles during skin inflammation have not been characterized. Here we identify an inflammation-induced subset of papillary fibroblasts that promotes aberrant neurite outgrowth and psoriasiform skin inflammation by secreting the extracellular matrix protein tenascin-C (TNC). Single-cell analysis of fibroblast lineages reveals a Tnc papillary fibroblast subset with pro-axonogenesis and neuro-regulation transcriptomic hallmarks.

Association of metabolically healthy obesity in young adulthood with myocardial structure and function.

Background: Obesity is major cause of cardiovascular diseases. Metabolically healthy obesity (MHO) may increase heart failure risk early in life, and may be reflected in impaired cardiac structure and function. Therefore, we aimed to examine the relationship between MHO in young adulthood and cardiac structure and function.

Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis.

Protein Phosphatase 6 down-regulation in keratinocytes is a pivotal event that amplifies the inflammatory circuits in psoriasis, indicating that restoration of protein phosphatase 6 can be a rational strategy for psoriasis treatment. Through the phenotypic screen, we here identify L-menthol that ameliorates psoriasis-like skin inflammation by increasing protein phosphatase 6 in keratinocytes. Target identification approaches reveal an indispensable role for the transcription factor hairy and enhancer of split 1 in governing the protein phosphatase 6-upregulating function of L-menthol in keratinocytes.

A Continuous Pacing and Recording Technique for Differentiating Left Bundle Branch Pacing From Left Ventricular Septal Pacing: Electrophysiologic Evidence From an Intrapatient-Controlled Study.

Background: Left bundle branch pacing (LBBP) is a promising approach for achieving near-physiologic pacing. However, differentiating LBBP from left ventricular septal endocardial pacing (LVS(e)P) remains a challenge. This study aimed to establish a simple and effective method for differentiating LBBP from LVS(e)P and to evaluate their electrophysiologic characteristics.

The left bundle branch has been captured but shows the left ventricular septal pacing:What is the mechanism?

It was shown that V6 R-wave peak time (V6 RWPT) prolongs with transition form non-selective left bundle branch pacing (ns-LBBP) to left ventricular septal pacing (LVSP) but remains constant or slightly prolongs with transition to selective left bundle branch pacing (sel-LBBP) [1,2]. Here, we report on a patient who was observed with a LBB potential, isoelectric interval, where the V6 RWPT substantially prolonged with transition from ns-LBBP to sel-LBBP at near threshold output.

Characteristics of intracardiac electrogram of the interventricular septum in the left bundle branch pacing.

Background: Left bundle branch pacing (LBBP) has become a hot topic in the field of physiological pacing. However, only a few studies have described the characteristics of the intrinsic intracardiac electrogram (EGM) while placing the left bundle branch (LBB) lead.

Case Presentation: Herein, we reported a case with atrial premature contractions to the ventricle during the LBBP procedure.

PTSD Among Shidu Parents in China: The Roles of Personality Types and Social Support.

: The psychological problems of Shidu Parents (SDP) under the China's One-Child Policy have been documented. The purpose of this study was to investigate the relationships among personality types, social support, and post-traumatic stress disorder (PTSD) in SDP. : The PTSD Checklist-Civilian Version (PCL-C), The Big Five Personality Traits (NEO), and Social Support Revalued Scale (SSRS) were administered to the sample of 149 SDP who were over 50 years old and had lost their only child more than one year ago.