Co-existence of mcr-1 and bla from porcine-derived Escherichia coli isolated in China and selection of mcr-1 under cephalosporins pressure.

Objectives: The usage of cephalosporins (CEFs) and co-existence of extended-spectrum β-lactamase (ESBL) gene bla in the same host may promote the prevalence of colistin (CST) resistance gene mcr-1. This study aims to investigate the underlying mechanisms how the mcr-1 and bla demonstrate significant co-occurrence in Escherichia coli (E. coli).

Pharmacological Targeting of DHHC9-Mediated STRN4 Palmitoylation to Suppress YAP-Driven Cancer Metastasis.

Protein S-palmitoylation, a dynamic and reversible post-translational modification involving the attachment of palmitate to cysteine residues, is a key regulator of protein functionality and cellular signalling. Dysregulation of this modification has emerged as a critical driver of cancer progression. Among the 23 DHHC palmitoyl transferases responsible for catalysing S-palmitoylation, aberrant expression of specific members is linked to tumorigenesis and development, underscoring their potential as promising therapeutic targets.

Platelet-specific TGFβ deficiency aggravates atherosclerosis, vascular inflammation and hypercholesterolemia in mice.

Background Atherosclerosis involves inflammatory and thrombotic mechanisms, to which platelets, CD4+ T effector cells, and transforming growth factor β (TGFβ) all contribute importantly. Platelets are the principal source of circulating TGFβ, which profoundly regulates CD4+ T effector cell responses. The impact of platelet-derived TGFβ on atherosclerosis is, however, unknown.

Spatial heterogeneity reveals an evolutionary signature predicting therapeutic response and clinical outcomes in hepatocellular carcinoma.

Introduction: Intra-tumoral heterogeneity is a prominent characteristic of hepatocellular carcinoma (HCC). However, it remains unexplored whether intra-tumoral transcriptomic differences can capture crucial information regarding HCC evolution and be utilized to derive a predictive signature for patient's clinical trajectories.

Methods: We quantified transcriptomic heterogeneity using four multiregional HCC cohorts comprising 172 samples from 37 patients, and validated transcriptomic heterogeneity and spatial dynamics using multiregional single-cell transcriptomic profiling of 110,817 cells from 34 liver specimens.

Exploring the determinants of unhealthy dietary behaviors among pregnant women in China using the Theory of Planned Behavior-a cross-sectional study.

Background: Pregnant women in China are at risk of malnutrition due to an interplay of physiological, psychosocial, and environmental factors. Understanding the factors influencing dietary behaviors in pregnant women is vital for promoting maternal and infant health. This study explores the determinants of dietary behaviors among pregnant women in China based on the Theory of Planned Behavior (TPB).

Excessive reassurance-seeking and anxiety among Chinese new urban older adults: the role of attention to negative information and resilience.

Background: Policy-driven relocation of older adults from rural to urban areas in China is a significant stressor that often exacerbates anxiety. The mechanisms through which excessive reassurance seeking (ERS) heightens anxiety in this population remain poorly understood.

Methods: A cross-sectional survey was conducted with 301 relocated older adults (aged 60-89 years; 52.

A20's linear ubiquitin-binding motif restrains pathogenic activation of Th17 cells and IL-22-driven enteritis.

A20, encoded by the TNFAIP3 gene, is a protein linked to Crohn's disease and celiac disease in humans. We now find that mice expressing point mutations in A20's M1-ubiquitin-binding zinc finger 7 (ZF7) motif spontaneously develop proximal enteritis that requires both luminal microbes and T cells. Cellular and transcriptomic profiling reveals expansion of Th17 cells and exuberant expression of IL-17A and IL-22 in intestinal lamina propria of A20ZF7 mice.

Difference Analysis of Brain Functional Activity Between Patients with Residual Dizziness Caused by Benign Paroxysmal Positional Vertigo and Persistent Postural-Perceptual Dizziness: A Resting-State Functional Magnetic Resonance Imaging Study.

To explore brain function differences between patients with residual dizziness (RD) caused by benign paroxysmal positional vertigo (BPPV) and persistent postural-perceptual dizziness (PPPD) with resting-state functional magnetic resonance imaging. Using the Data Processing and Analysis for Brain Imaging software to analyze differences in the amplitude of low-frequency fluctuations (ALFF) and functional connectivity (FC) among RD, PPPD, and healthy controls groups. Then constructed a brain network and compared FC within the network.

High-efficiency chemiluminescent POCT assay for anti-Müllerian hormone: innovative development and application in polycystic ovary syndrome diagnosis.

In recent years, the decline in ovarian reserve function has become a major cause of reduced female fertility. Early identification, evaluation, and management of ovarian reserve dysfunction are essential for improving female fertility and reproductive health. Currently, the main diagnostic method is assessing ovarian function through measuring AMH serum concentration and follicle count.

Erythrabyssin ll is identified as a late-stage autophagy inhibitor reversing chemoresistance and promoting apoptosis in ovarian cancer.

A growing body of research suggests that inhibition of autophagy may be a novel means of treating cancer and suppressing drug resistance. Therefore, a series of drugs derived from the Linn were screened in this study. Among them, the pterocarpan erythrabyssin II (EL-19) is a potent late-stage autophagy inhibitor, which could effectively block the fusion of autophagosome and lysosome, leading to the accumulation of autophagic substrates in both ovarian cancer A2780 and A2780/DDP cells.

Photocatalyzed Decarboxylative B-C Couplings for the Synthesis of Carboranyl Amino Acids and Peptides.

Boron neutron capture therapy (BNCT) is a promising and selective strategy for treating aggressive and refractory tumors, but its clinical success depends on the development of effective boron delivery agents. These agents must offer high tumor selectivity, structural stability, and sufficient boron content─criteria that current clinical options fail to fully satisfy. Herein, we report a visible-light-driven decarboxylative B-C cross-coupling between boron-functionalized carborane carboxylic acids and dehydroalanine (Dha)-containing peptides, enabling the first synthesis of boron-vertex-substituted carboranyl peptides under mild conditions.

Converting Li-Rich Layered Oxide Cathode into Non-Shrinking Sacrificial Prelithiation Agent.

To improve the energy density of Li-ion batteries, conventional sacrificial prelithiation agents (LiFeO, LiO and LiCO, etc.) are introduced to compensate for active lithium loss, but they undergo serious volumetric shrinkage during decomposition, generating voids that compromise electrode architecture integrity and deteriorate electrochemical performance. Herein, the typical Li-rich layered oxide cathode is converted into Li-rich disordered rocksalt oxide (LRDO) prelithiation agent, achieving 330 mAh g charge capacity and retaining 130 mAh g reversible capacity (contributing 200 mAh g irreversible prelithiation capacity).

Decoding the healing secrets of Gegenqinlian decoction: A promising approach to radiation-induced intestinal injury.

Ethnopharmacological Relevance: Gegenqinlian Decoction (GQD), a Traditional Chinese Medicine formula comprising Pueraria lobata(Willd.)Ohwi, Scutellaria baicalensis Georgi, Coptis teeta Wall. and Glycyrrhiza uralensis Fisch.

Synergistic Dual-Pinning Engineering Enables Stable Mn-Based Layered Oxide Cathodes for High-Performance Sodium-Ion Batteries.

Mn-based oxide cathodes for sodium-ion batteries (SIBs) often suffer from structural degradation caused by Jahn-Teller distortion and irreversible phase transitions. Here, we propose a dual-site stabilization strategy by Mo/Mg codoping, which not only drives the transformation of the tunnel-type NaMnO into a P2-layered structure (NaMnMoMgO, denoted as MoMg-12) by modulating the total energy to enhance capacity but also employs Mo and Mg ions substituting Mn sites to implement synergistic dual-pinning engineering to stabilize the structure. This dual-pinning mechanism concurrently suppresses Jahn-Teller distortion by stabilizing Mn redox activity and improves air stability by reducing Na/H exchange while promoting a hydrophobic surface.

Ellagic Acid Mediates the Delay of Dermal Fibroblast Senescence via CSNK2A1.

Objective: This research seeks to explore the impact of Ellagic Acid (EA) on the aging process of human dermal fibroblasts Hs68 cells and to uncover the mechanisms involved.

Methods: Senescence was induced in Hs68 cells with HO, followed by treatment with EA and CSNK2A1 inhibitor (Silmitasertib). Bioinformatics identified EA's downstream targets.

KLK1 as an Epithelial-Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R-Mediated Fibroblast Phenotypic Transition.

Inflammatory bowel disease (IBD) is increasing worldwide, and the persistence of chronic inflammation may lead to colitis-associated colorectal cancer (CAC). KLK1 expression is reduced in colitis, and its potential role in the intestinal mucosal barrier is still unclear. Here, KLK1 is investigated whether a supplement can reduce colitis and colorectal carcinogenesis.

EXPRESS: Application of XGBoost in the prediction of acute postoperative pain after major noncardiac surgery in older patients.

Background: Acute postoperative pain (APP) are key factors in the recovery of surgical patients after surgery. This study used the machine learning eXtreme Gradient Boosting (XGBoost) algorithm for the prediction of acute postoperative pain after major noncardiac surgery in older patients.

Methods: This was a secondary analysis of data from a randomized controlled trial containing 1720 older patients undergoing general anesthesia.

Recombinant human collagen type III microgel: an advanced injectable dermal filler for rejuvenating aging skin.

Skin aging, characterized by reduced collagen regeneration, chronic inflammation and heightened skin cancer risk, poses a significant challenge. Collagen-based materials, employed as dermal fillers to smooth wrinkles, have attained extensive utilization. Nevertheless, traditional animal-derived collagen protein primarily presents concerns pertaining to disease risks, potential immunological reactions, and batch instability.

LiPO-enriched solid electrolyte interphase on Si-based anode for enhanced Li transport and interfacial stability in lithium batteries.

The structure and composition of the solid electrolyte interphase (SEI) exerts a significant influence on the fast-charging capability and stability of lithium-ion batteries (LIBs). However, elucidating the design principles governing anode interfacial structures and revealing the kinetics and mechanisms of Li transport remain challenging. SEI layer.

Hybrid biomaterials-based radiosensitizers: Preparations and their applications in enhancing tumor radiotherapy.

Radiotherapy is a critical modality in cancer treatment, yet its efficacy can be substantially hindered by the tumor microenvironment. Nanotechnology has empowered nanomaterials to assume multifunctional roles. These roles encompass drug delivery, radiosensitization, imaging, inducing DNA damage, and decreasing glutathione (GSH) levels to impede the neutralization of reactive oxygen species (ROS), thus enhancing therapeutic efficacy.

AI-driven reclassification of multiple sclerosis progression.

Multiple sclerosis (MS) affects 2.9 million people. Traditional classification of MS into distinct subtypes poorly reflects its pathobiology and has limited value for prognosticating disease evolution and treatment response, thereby hampering drug discovery.

My new home: study protocol for a prospective cohort study on the long-term personality development and short-term processes during transitions into nursing homes.

Background: Personality is a crucial predictor of many life outcomes, including successful ageing. The proportion of nursing home residents is increasing annually among older populations. Relocations to nursing homes affect multiple aspects of older people's lives, including their living environment, social interactions, and daily arrangements, which may indirectly affect their personality development.

Urinary Bladder Matrix as a Guide Bone Regeneration Barrier Membrane for Inhibiting Cell Invasion and Promoting Bone Formation.

Natural resorbable collagen membranes are widely used in guided bone regeneration (GBR) in oral implantology and prosthodontics. However, the rapid degradation and inadequate mechanical properties raise concerns about potentially compromising the ultimate bone regeneration efficacy. In this study, we developed a novel GBR membrane by coating a urinary bladder matrix (UBM) onto small intestinal submucosa (SIS), a commonly used acellular material, to improve the cell-barrier and bone-regeneration performances.