Exosomal miR-494 from Bone Marrow Mesenchymal Stem Cells Attenuates Ferroptosis and Enhances Spinal Cord Injury Repair by Modulating the SIRT1/HO-1 Pathway.

Spinal cord injury (SCI) is a severe traumatic disorder of the central nervous system, often resulting in partial or complete loss of sensory and motor functions. Ferroptosis, a lipid peroxidation-driven apoptotic process triggered by iron overload, has emerged as a novel form of programmed cell death and a focal point in post-SCI cell death research. Exosomes (Exo), as delivery vehicles, exhibit multiple advantages, including superior encapsulation capacity, high targeting efficiency, and enhanced blood-brain barrier penetration to reach the central nervous system.

Outcomes of patients treated with venetoclax plus azacitidine versus azacitidine alone stratified by advanced age and acute myeloid leukemia composite model.

Venetoclax plus azacitidine is recognized as standard of care for patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy (IC). However, some patients may still not be treated with venetoclax combinations due to frailty concerns. We evaluated efficacy and safety of venetoclax plus azacitidine vs.

Interpretable machine learning model predicts 1-year inguinal hernia risk after robot-assisted radical prostatectomy.

Inguinal hernia represents a clinically significant yet underreported complication of robot-assisted radical prostatectomy (RARP) for localized prostate cancer, with a notably high incidence within the first postoperative year. Despite its adverse impact on quality of life and potential for severe sequelae, predictive tools for this outcome remain limited. To develop and validate the first machine learning (ML)-based clinical prediction model for inguinal hernia within 1 year after RARP, leveraging explainable artificial intelligence (AI) techniques for clinical interpretability.

Divergent structural and functional brain alterations in HIV-infected patients: a multimodal meta-analysis.

Neuroimaging studies have identified brain structural and functional alterations in HIV-infected patients; however, the results are inconsistent. This study aimed to characterize the effects of HIV infection on regional gray matter volume (GMV) and resting-state brain activity, and to further investigate the relations between abnormalities in these two modalities. We conducted voxel-wise meta-analysis of voxel-based morphometry (VBM) and functional studies, respectively, to identify regional GMV and brain activity alterations in HIV-infected patients.

The relationship between social support and employment anxiety in preschool teacher trainees in China: the mediating role of psychological capital and the moderating role of professional identity.

Introduction: Against the backdrop of a continuously declining birth rate in China, pre-school teacher trainees are facing severe employment challenges and have experienced problems such as employment anxiety. Effective social support, positive psychological capital, and a high level of professional identity can act as a buffer against employment anxiety, alleviating the negative impact of the tense job market on employment anxiety.

Methods: This study recruited 1195 students majoring in preschool education from Years 1 to 4 at four applied-oriented undergraduate institutions in Shanghai, China.

Study design and rationale of the TXL-CAP trial: a randomized, double-blind, placebo-controlled, multicenter clinical trial assessing the effect of Tongxinluo capsules on the stability of coronary atherosclerotic plaques.

Recent clinical trials have demonstrated a protective effect in using traditional Chinese medicine Tongxinluo (TXL) capsule to treat atherosclerosis. However, clinical evidence of the effects of TXL treatment on coronary plaque vulnerability is unavailable. In response, we developed this study to investigate the hypothesis that on the basis of statin therapy, treatment with TXL capsule may stabilize coronary lesions in patients with acute coronary syndrome (ACS).

Association between homocysteine levels and cognition in late-life depression.

Background: Cognitive impairment frequently occurs in patients with late-life depression (LLD) and could be associated with variations in homocysteine (Hcy) levels. This study aimed to evaluate the relationship between Hcy levels and cognitive function, with particular attention on how baseline cognitive status may impact this relationship.

Methods: This cross-sectional study included 60 patients with LLD meeting Diagnostic and Statistical Manual of Mental Disorders, V Edition (DSM-5) diagnostic criteria and 46 age-matched healthy controls (HCs).

Cholesterol metabolism modulation facilitates CAR-T induced killing of ovarian cancer.

Unlabelled: Ovarian cancer is one of the most lethal gynecological cancers worldwide and has one of the highest recurrence rates. Recently developed Chimeric Antigen Receptor T (CAR-T) cell therapy has shown potent clinical efficacy against hematological malignancies. However, solid tumors, including ovarian cancer, possess several mechanisms that hinder T cell activity, and metabolic alteration of cancer cells has been shown to contribute to resistance to immune cell attack against solid tumors.

Identification of proteomic markers of chronic prostatitis/chronic pelvic pain syndrome treated with melatonin using a tandem mass tag approach.

Background: Chronic prostatitis (CP)/chronic pelvic pain syndrome is the most common urological disorder in young and middle-aged men. A previous study showed that melatonin attenuates prostate inflammation through Sirt1-dependent suppression of the nonobese diabetic-like receptor thermal protein domain-associated protein 3 inflammasome in mouse models of experimental autoimmune prostatitis (EAP). However, the main differentially expressed proteins (DEPs) in melatonin-treated mice with EAP have not yet been fully identified.

Early-stage diagnosis of HIV-associated neurocognitive disorders via multiple learning models based on resting-state functional magnetic resonance imaging.

Background: People living with human immunodeficiency virus (PLWH) are at risk of human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND). The mildest disease stage of HAND is asymptomatic neurocognitive impairment (ANI), and the accurate diagnosis of this stage can facilitate timely clinical interventions. The aim of this study was to mine features related to the diagnosis of ANI based on resting-state functional magnetic resonance imaging (rs-fMRI) and to establish classification models.

PANoptosis-mediated mechanisms underlying AST elevation in Talaromyces marneffei infection.

Background: Talaromyces marneffei (T. marneffei), a life-threatening opportunistic fungal pathogen, is endemic to Southeast Asia. Although elevated aspartate aminotransferase (AST) levels are commonly observed in infected individuals, the origin and mechanism of this phenomenon remain unclear.

Assessing difficulties in regulating negative and positive emotions: The Difficulties in Emotion Regulation Scale-Expanded (DERS-X).

Negative and positive emotion regulation are important to psychological well-being. However, most individual-difference measures of emotion regulation focus primarily or exclusively on negative emotion regulation. In the present research, we sought to expand the widely used Difficulties in Emotion Regulation Scale (DERS) by including items assessing positive as well as negative emotion regulation.

Genetic variants of LncRNA associated with splicing regulation and their impact on ovarian cancer development.

Ovarian cancer (OC) is a highly lethal gynecologic malignancy that lacks reliable early biomarkers. Numerous long non-coding RNAs (lncRNAs) have been found to play critical regulatory roles in OC, yet the mechanisms underlying most of them remain unclear. Recently, lncRNAs have emerged as key regulators of RNA splicing, while splicing dysregulation is widespread and plays critical roles in cancer.

Prognostic Effect of Left Atrial Function by Three-Dimensional Speckle-Tracking Echocardiography on Adverse Pregnancy Outcomes in Patients With Hypertensive Disorders of Pregnancy: A Preliminary Study.

Objective: To evaluate the left atrial function in pregnant women with hypertension versus those with normotension using three-dimensional speckle tracking echocardiography (3D-STE) and investigate the association between left atrial dysfunction and adverse pregnancy outcomes.

Methods: A total of 94 pregnant women registered at the Tiantan Hospital between August 2023 and October 2024 who underwent comprehensive prenatal exams were enrolled. They were divided into three groups according to their blood pressure: gestational hypertension (GH), preeclampsia (PE), and normotensive control groups.

Development and Validation of a Machine Learning-Based Risk Prediction Model for Delirium in Older Inpatients: A Prospective Cohort Study.

Aims: To develop and validate a machine learning-based risk prediction model for delirium in older inpatients.

Design: A prospective cohort study.

Methods: A prospective cohort study was conducted.

Metal/non-metal doped graphene quantum dots as dual fluorescent probes for detection of pesticide residues and heavy metal ions.

Heavy metals (Fe) and pesticides (diquat) pose serious threats to the environment and human health, necessitating the development of efficient detection technologies. In this study, metal/non-metal doped graphene quantum dots (GQDs) were developed. Given excellent sensitivity, stability and selectivity, it was used as a fluorescent probe with multiple functions for simultaneous detection of two pollutants.

Comparative Effectiveness of Exercise Modalities for Fibromyalgia: A Systematic Review and Bayesian Network Meta-Analysis.

Objective: To synthesise existing evidence assessing the impact of exercise-based therapies on pain in patients with fibromyalgia syndrome (FM), determine the efficacy of various exercise modalities, and establish the optimal exercise dosage for pain management.

Design: Systematic review and network meta-analysis.

Data Sources: MEDLINE, Embase, Web of Science, Cochrane Library, Scopus and SPORT Discus were searched from inception to July 2024.

A Modality Alignment and Fusion-Based Method for Around-the-Clock Remote Sensing Object Detection.

Cross-modal remote sensing object detection holds significant potential for around-the-clock applications. However, the modality differences between cross-modal data and the degradation of feature quality under adverse weather conditions limit detection performance. To address these challenges, this paper presents a novel cross-modal remote sensing object detection framework designed to overcome two critical challenges in around-the-clock applications: (1) significant modality disparities between visible light, infrared, and synthetic aperture radar data, and (2) severe feature degradation under adverse weather conditions including fog, and nighttime scenarios.

The Non-Traditional Cardiovascular Culprits in Chronic Kidney Disease: Mineral Imbalance and Uremic Toxin Accumulation.

Chronic kidney disease (CKD) is associated with a significantly elevated mortality rate, primarily due to cardiovascular disease (CVD), highlighting a complex bidirectional relationship between the two conditions. Life-threatening cardiovascular events occur despite control of the traditional risk factors, emphasizing the underlying role of non-traditional risk factors. CKD, causing mineral imbalance and the accumulation of uremic toxins due to a compromised ability to excrete waste products, imposes extra pressure on the cardiovascular system.

Differential Impact of Methamphetamine Dependence and Social Media Overuse on Cognitive Control: Based on the Dual Mechanisms of Control Theory.

Cognitive control impairments contribute to the onset and maintenance of both substance and behavioral addictions. Guided by the Dual Mechanisms of Control framework, this study examined cognitive control deficits in methamphetamine-dependent individuals and those who overuse social media, each compared to a matched control group. Across two experiments, participants completed an operational working memory span task (Experiment 1) to assess their cognitive control resources, and a modified AX-Continuous Performance Test (AX-CPT, Experiment 2) to evaluate their inhibition-based proactive and reactive control.

The application of the metaverse in surgical clinical teaching: transforming medical education through immersive approaches.

With the rapid development of immersive technologies such as virtual reality (VR) and augmented reality (AR), the Metaverse is emerging as a transformative platform in medical education. This study examines the integration of the Metaverse into surgical clinical teaching, highlighting its potential to enhance educational outcomes, overcome traditional limitations, and foster global collaboration in medical training. Core features of the Metaverse offer medical students a safe virtual setting for practicing complex surgical procedures and honing clinical decision-making skills.

Postoperative massive hemorrhage in oral cancer surgery nursing interventions and outcomes: A case report.

Background: Post-operative massive hemorrhage is a critical concern in oral cancer surgery, associated with severe complications and heightened morbidity and mortality rates.

Case Summary: A 46-year-old male with advanced poorly differentiated squamous cell carcinoma (ypT4aN3bN0M0) of the oral floor underwent extensive surgery, including total glossectomy, partial mandibulectomy, and free flap reconstruction. Postoperatively, he developed life-threatening hemorrhage on day 3 due to wound dehiscence.

Decoding the healing secrets of Gegenqinlian decoction: A promising approach to radiation-induced intestinal injury.

Ethnopharmacological Relevance: Gegenqinlian Decoction (GQD), a Traditional Chinese Medicine formula comprising Pueraria lobata(Willd.)Ohwi, Scutellaria baicalensis Georgi, Coptis teeta Wall. and Glycyrrhiza uralensis Fisch.

A Rare Case of Coinfection of and in an Immunocompetent Human Host.

Background: and are aerobic, gram-positive bacteria distributed extensively in the sediment of various environments globally. They usually manifest as opportunistic infections in immunocompromised hosts. Here, we report a coinfection case of and in a patient with normal immune system.

Deubiquitinase Genes as Prognostic Biomarkers in Osteosarcoma: Insights From Single-Cell Sequencing and Machine Learning-Based Prognostic Modeling.

Osteosarcoma (OS) is a highly aggressive bone tumor characterized by poor prognosis and frequent metastasis. Despite advances in treatment, the survival rate remains low. This study investigates the role of deubiquitinase (DUB) genes in OS to identify novel prognostic biomarkers and therapeutic targets.