Interpretable machine learning model predicts 1-year inguinal hernia risk after robot-assisted radical prostatectomy.

Inguinal hernia represents a clinically significant yet underreported complication of robot-assisted radical prostatectomy (RARP) for localized prostate cancer, with a notably high incidence within the first postoperative year. Despite its adverse impact on quality of life and potential for severe sequelae, predictive tools for this outcome remain limited. To develop and validate the first machine learning (ML)-based clinical prediction model for inguinal hernia within 1 year after RARP, leveraging explainable artificial intelligence (AI) techniques for clinical interpretability.

PIM1 protects pancreatic ductal cancer cells from glucose deprivation-induced oxidative stress via OXR1 phosphorylation.

Limited nutrient availability in pancreatic ductal adenocarcinoma (PDAC), due to its dense extracellular matrix, presents a significant metabolic challenge that tumor cells must overcome to survive oxidative stress-induced cell death. Here, we found that PIM1, a serine/threonine kinase, is upregulated in PDAC tumors and serves as a poor prognostic indicator. Although PIM1 does not significantly affect PDAC cell proliferation, it is essential for protecting cells from glucose deprivation-induced cell death.

Philippine archipelago and South China Sea monsoon plus ocean cooling buffer Northwestern Pacific super typhoons.

In dramatic contrast to the continuous intensification of strong Atlantic hurricanes moving into the Gulf of Mexico, super typhoons (SuperTYs) originating from the Northwest Pacific significantly weaken after entering the South China Sea (SCS). Using an idealized cyclone intensity model, we show that this striking discrepancy results from the SCS's buffering effects, including persistent topographic blocking by the Philippine archipelago and seasonally shifting atmospheric-oceanic constraints. The archipelago accounts for ~54% of typhoon weakening throughout the season, while environmental factors explain the remaining ~46% with the significant seasonal dependence on strong SCS monsoon-induced vertical wind shear in summer (~30%) and ocean cooling in autumn (~37%).

Does the occlusive sign play a role in endovascular thrombectomy: a radiomics-based approach.

Background And Purpose: Large vessel occlusion (LVO) is a major cause of acute ischemic stroke (AIS). Identifying its underlying etiology, particularly intracranial atherosclerotic stenosis (ICAS), is crucial for optimizing endovascular thrombectomy (EVT). Intra-procedural occlusive signs can offer clues, but their interpretation is often subjective.

Polyoxometalate Catalysis under Alkaline Conditions: Self-Assembly of Lanthanum Ion-Doped Steady Polyoxophosphitemolybdates for Quinazoline Synthesis.

The convenient and effective catalytic synthesis of quinazolines holds considerable significance due to their high economic value, and designing a cluster-type alkali-resisting catalyst such as polyoxometalates (POMs) still poses a significant challenge. Herein, three lanthanum ion-doped steady polyoxophosphitemolybdates with the formulas of [CHNH]{La(HO)Na[MoO(OH)(HPO)]}·10HO (), [CHNH]{La(HO)[MoO(OH)(HPO)]}·8HO (), and [CHNH]{La(HO)Na[MoO(OH)(HPO) (PO)]}·16HO () were synthesized by using HPO as the template. Structural analysis revealed that forms a three-dimensional structure through the connection of La with an hourglass-shaped {Na[PMoO]} unit.

A General Numerical Error Compensation Method for NLFM Signal in SAR System Based on Non-Start-Stop Model.

Nonlinear frequency modulated (NLFM) signals can be used to enhance the resolution, anti-jamming capability, and imaging quality of synthetic aperture radar (SAR) systems through optimized design, demonstrating substantial application potential. However, in a SAR system using NLFM signals, the non-start-stop effect, caused by the continuous motion of the platform during pulse transmission and reception, introduces significant errors, resulting in target defocusing. To tackle this problem, this paper proposes a general numerical error compensation method dedicated to NLFM signals.

Dynamic evaluation of winter wheat's freezing resistance under different low-temperature periods and durations.

Winter extreme low temperature events have been occurring frequently both before and after the winter season. The freezing resistance temperature of wheat is far lower than the intensity of low temperatures during the mid-winter period. Therefore, it is necessary to further quantify and evaluate the impact of low-temperature periods and durations during the early winter and the green-up period on the freezing resistance of wheat, based on different evaluation indicators.

A bibliometric and visualization analysis of the role of traditional Chinese medicine in cancer immunotherapy.

Objective: Traditional Chinese medicine (TCM) is used as a complementary treatment for patients with cancer, especially in immunotherapy. Although extensive clinical and basic research has been conducted on TCM in cancer immunotherapy, a comprehensive bibliometric analysis of this field has not yet been performed. This study aimed to investigate the progress and status of TCM, and the research focused on cancer immunotherapy.

The global, regional burden of pancreatic cancer and its attributable risk factors from 1990 to 2021.

Background: Pancreatic cancer is the 12th most common type of cancer, and the sixth leading cause of cancer-related mortality, worldwide. Up-to-date statistics on pancreatic cancer would provide us with a better understanding of epidemiology and identify the causative risk factors for the prevention of this disease.

Methods: The degree and change patterns of exposure as well as the attributable cancer burden, including incidence, mortality, disability-adjusted life years (DALYs), and prevalence in global and regional, by sex, age, year, for pancreatic cancer, with the data extracted from the Global Burden of Diseases Study (GBD) 2021.

[Progress on chemical constituents and quality control of Bovis Calculus and its substitutes].

Bovis Calculus, a traditional medicine with the role of clearing away heat and detoxification, extinguishing wind to arrest convulsions, is often used for brain-cerebrovascular diseases. However, the quality control of Bovis Calculus and its substitutes has attracted much attention due to the scarcity of resources and limitations of use. Based on the evolution of the use of substitutes and the chemical composition as the entry point, this article reviews the quality control methods from the following three aspects.

Clinical features and endovascular treatment of ruptured peripheral cerebral aneurysms associated with moyamoya disease: an 8-year single-center experience.

Objective: Ruptured peripheral cerebral aneurysm (PPCA) associated with moyamoya disease (MMD) is rarely reported, and its optimal treatment remains controversial. This study aims to present the clinical characteristics, treatment strategies, and outcome predictors of this rare clinical entity.

Methods: A retrospective review of patients with hemorrhagic MMD from January 2013 to December 2020 was performed.

Burden of Common Respiratory Pathogens Among Cats in China.

Background: Feline respiratory disease complex (FRDC) is a set of illnesses which are primarily associated with different types of viruses and bacteria. There is scarcity of data on pathogens associated with FRDC in China.

Objectives: The primary objective of this study was to investigate the prevalence and dynamics of FRDC pathogens in China.

Integrative indexes reveal the tolerance of winter wheat to different overwinter freezing injury.

Winter wheat ( L.) is a crucial crop that guarantees food supply in the North China Plain (NCP). As the frequency of extreme cold events increases, it is necessary to explore the freezing resistance of different wheat varieties in order to clarify planting boundaries and help with risk assessment.

The Latest Developments in Spaceborne High-Resolution Wide-Swath SAR Systems and Imaging Methods.

Azimuth resolution and swath width are two crucial parameters in spaceborne synthetic aperture radar (SAR) systems. However, it is difficult for conventional spaceborne SAR to simultaneously achieve high-resolution wide-swath (HRWS) due to the minimum antenna area constraint. To mitigate this limitation, some representative HRWS SAR imaging techniques have been investigated, e.

Advancements in calixarene-protected titanium-oxo clusters: from structural assembly to catalytic functionality.

This review explores calixarenes, a prominent family of third-generation supramolecules celebrated for their distinct hollow, cavity-shaped structures. These macrocycles are intricately assembled by linking multiple phenolic units orthogonally through methylene (-CH-), sulfur (-S-), or sulfonyl (-SO-) bridges. This structural framework plays a pivotal role in the intricate assembly of nanoclusters, significantly advancing the field of cluster chemistry.

Boundary guidance network for medical image segmentation.

Accurate segmentation of the tumor area is crucial for the treatment and prognosis of patients with bladder cancer. Cystoscopy is the gold standard for diagnosing bladder tumors. However, The vast majority of current work uses deep learning to identify and segment tumors from CT and MRI findings, and rarely involves cystoscopy findings.

Low-intensity pulsed ultrasound improves myocardial ischaemia‒reperfusion injury via migrasome-mediated mitocytosis.

During myocardial ischaemia‒reperfusion injury (MIRI), the accumulation of damaged mitochondria could pose serious threats to the heart. The migrasomes, newly discovered mitocytosis-mediating organelles, selectively remove damaged mitochondria to provide mitochondrial quality control. Here, we utilised low-intensity pulsed ultrasound (LIPUS) on MIRI mice model and demonstrated that LIPUS reduced the infarcted area and improved cardiac dysfunction.

Review on Phase Synchronization Methods for Spaceborne Multistatic Synthetic Aperture Radar.

Multistatic synthetic aperture radar (SAR) is a special mode of SAR system. The radar transmitter and receiver are located on different satellites, which brings many advantages, such as flexible baseline configuration, diverse receiving modes, and more detailed ground object classification information. The multistatic SAR has been widely used in interferometry, moving target detection, three-dimensional imaging, and other fields.

Ag incorporation a Zr-anchored metalloligand: fine-tuning catalytic Ag sites in Zr/Ag bimetallic clusters for enhanced eCORR-to-CO activity.

Attaining meticulous dominion over the binding milieu of catalytic metal sites remains an indispensable pursuit to tailor product selectivity and elevate catalytic activity. By harnessing the distinctive attributes of a Zr-anchored thiacalix[4]arene (TC4A) metalloligand, we have pioneered a methodology for incorporating catalytic Ag sites, resulting in the first Zr-Ag bimetallic cluster, ZrAg, which unveils a dualistic configuration embodying twin {ZrAg(TC4A)} substructures linked by an {AgSal} moiety. This cluster unveils a trinity of discrete Ag sites: a pair ensconced within {ZrAg(TC4A)} subunits and one located between two units.

infection status and molecular diversity in the species of tribe Tagiadini Mabille, 1878 (Lepidoptera: Hesperiidae) collected in China.

, one of the most ubiquitous heritable symbionts in lepidopteran insects, can cause mitochondrial introgression in related host species. We recently found mito-nuclear discordance in the Lepidopteran tribe Tagiadini Mabille 1878 from which has not been reported. In this study, we found that 13 of the 46 species of Tagiadini species tested were positive for Overall, 14% (15/110) of Tagiadini specimens were infected with and nine new STs were found from 15 isolates.

Design, synthesis, and evaluation of the novel ozagrel-paeonol codrug with antiplatelet aggregation activities as a potent anti-stroke therapeutic agent.

Ischemic stroke is the second most common chronic disease worldwide and is associated with high morbidity and mortality. Thromboembolism and platelet aggregation are the most characteristic features of stroke. Other than aspirin, no standard, accepted, or effective treatment for acute ischemic stroke has been established.

Isoliquiritigenin reduces experimental autoimmune prostatitis by facilitating Nrf2 activation and suppressing the NLRP3 inflammasome pathway.

Background: Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) lead to severe irritation and impaired sperm quality in males. However, current therapeutic options often fail to achieve satisfactory effects. Consequently, the investigation of novel treatment strategies or remedies holds substantial clinical importance.