Network dysfunction precedes neurodegeneration in a dox-regulatable TDP-43 mouse model of ALS-FTD.

Neuronal hyperexcitability is a hallmark of amyotrophic lateral sclerosis (ALS) but its relationship with the TDP-43 aggregates that comprise the predominant pathology in over 90% of ALS cases remains unclear. Emerging evidence indicates that TDP-43 pathology induces neuronal hyperexcitability, which may contribute to excitotoxic neuronal death. To characterize TDP-43 mediated network excitability changes in a disease-relevant model, we performed in vivo continuous electroencephalography monitoring and ex vivo acute hippocampal slice electrophysiology in rNLS8 mice (males and females), which express human TDP-43 with a defective nuclear localization signal (hTDP-43ΔNLS).

Effect of semaglutide on arrhythmic, major cardiovascular, and renal outcomes in patients with overweight or obesity: a systematic review and meta-analysis.

Background: Semaglutide has demonstrated potential in controlling hyperglycemia and lowering cardiovascular (CV) risk. However, its impact on arrhythmic, major CV, and renal outcomes is not well-defined. This systematic review and meta-analysis aimed to assess these effects in patients with overweight or obesity.

Rare earth doping: a strategy to enhance the catalytic activity of ZnFeO in activating peroxymonosulfate for acetaminophen degradation.

In this paper, ZnFeO was doped by two rare earth metals (La and Pr), and the as-prepared ZnLaFeO and ZnPrFeO were applied to activate PMS for acetaminophen degradation. ZnLaFeO with the largest oxygen vacancy (O) content showed the highest acetaminophen degradation efficacy. About 89.

Genistein ameliorates thoracic aortic dissection by inhibiting CB1 receptor hyperactivation and modulating its-mediated cAMP-PKA signaling.

Background: Thoracic aortic dissection (TAD) is a fatal cardiovascular disease characterized by vascular smooth muscle cell (VSMC) phenotypic remodeling and inflammation. Cannabinoid 1 (CB1/Cnr1) receptor has been implicated in cardiovascular diseases, but its role in TAD and its downstream signaling remains unclear. Genistein (Gen), an isoflavone abundant in legumes, has demonstrated promising therapeutic potential in cardiovascular diseases such as vascular calcification, hypertension, and atherosclerosis due to its anti-inflammatory, antioxidant, and metabolic regulatory properties.

Highly efficient peroxymonosulfate catalyst prepared from electrolytic manganese residues coupled with Camellia oleifera shell biochar for ethylparaben degradation.

Pharmaceuticals and personal care products (PPCPs) contamination can be effectively remediated using sulfate radical-based advanced oxidation processes (SR-AOPs). In this work, a novel composite catalyst (EMR-BC) was successfully prepared using Camellia oleifera shell (COS) biochar (BC) coupled with electrolytic manganese residue (EMR), and the as-obtained catalyst was used to activate peroxymonosulfate (PMS) for the degradation of ethylparaben (EtP). EMR-BC showed superior catalytic performance comparing to EMR and BC, with an EtP remove rate of 97.

Embedding Fe/FeO Heterojunctions in Nitrogen-Doped Carbon Nanotubes for Efficient Removal of Organic Pollutants via Heterogeneous Electro-Fenton Catalysis.

The electro-Fenton process is considered one of the most reliable techniques for eliminating organic pollutants from water. However, its performance is still not up to par with its potential due to the lack of cathodic catalysts with the essential cycling catalytic functionality required for sustained Fenton reactions. Herein, Fe and FeO heterojunctions embedded in N-doped carbon nanotubes stitched on porous nitrogen-doped carbon (denoted Fe/FeO@PNC) are fabricated and employed as a bifunctional cathode catalyst for the highly efficient degradation of organic pollutants.

Novel heterogeneous Fenton catalysts prepared using electrolytic manganese residue for efficient degradation of acetaminophen.

Electrolytic manganese residue (EMR) was used as a support to prepare novel EMR-supported catalysts for the heterogeneous Fenton degradation of acetaminophen. Among the five supported catalysts, Co/EMR showed the highest catalytic activity. Several important factors influencing the decay of acetaminophen, including Co loading content, catalyst dosage, HO concentration and initial solution pH, were investigated.

Hyperforin-induced gut microbiota metabolite carbocysteine protects against depressive-like behaviors in mice by modulating the colonic mucus barrier.

Objective: Depression affects millions, and current treatments have limitations, necessitating new approaches. Earlier research confirms Hyperforin's ability to reduce anhedonic behaviors in mice and modulate gut microbiota. This study aims to identify specific metabolic changes induced by Hyperforin that could illuminate its impact on gut microbiome metabolism, possibly uncovering novel metabolites for developing antidepressant therapies.

Selective Trapping of In(III) Ions under σ-π* Bond Synergistic Effects by Modulating Lewis Basicity of Capture Sites on Nanofibers.

Effectively selective recovery and separation of indium from alternative resources are of great environmental and economic significance. Although adsorption plays a critical role in this process, the design of highly selective capture sites remains a great challenge. Inspired by molecular orbital theory and hard and soft acids and bases theory (HSAB), we recognize that the nonequivalent orbital hybridization of In(III) ions renders them susceptible to deformation, exhibiting softer Lewis acidity.

Establishing a universal IVRP method for quadrivalent HPV vaccines to replace in vivo potency tests.

Several human papillomavirus (HPV) L1-based virus-like particle (VLP) vaccines are in development to meet future global vaccination needs. Type-specific monoclonal antibodies with good reactivity to all types of vaccines are urgently needed to evaluate vaccine potency. In this study, binding activity, neutralizing activity, conformational sensitivity, immunodominance in human serum, and versatility were compared among antibodies.

A phase 3 clinical trial on the immunogenicity and safety of booster vaccination after Zagreb or Essen regimens.

The Zagreb and Essen regimens are comparable in terms of immunogenicity; however, how these regimens impact the immunogenicity of booster vaccination remains unknown. We conducted a clinical trial to assess the immunogenicity of booster vaccination with a purified Vero cell rabies vaccine after primary vaccination with the Zagreb or Essen regimens. This randomized, open-label, controlled, phase 3 trial, conducted in Shangyu City and Shengzhou City, Zhejiang Province, China, was divided into the primary and booster vaccination phases.

Boosting Acetylene Packing Density within an Isoreticular Metal-Organic Framework for Efficient CH/CO Separation.

Porous solid adsorbents for CH/CO separation are generally confronted with poor stability, high cost, or high regeneration energy, which largely inhibit their industrial implementation. A desired adsorbent material for practical implementation should exhibit a good balance between low cost, high stability, scale-up production feasibility, and good separation performance. An effective strategy is herein explored based on reticular chemistry through embedding methyl groups in a prototype microporous metal-organic framework (MOF) featuring low cost and high stability to effectively separate an CH/CO mixture.

N-doped carbon nanotubes encapsulated NiZnC nanoparticles catalyst for peroxymonosulfate activation: Heterojunction structure and N-doping enhance electron transfer capability.

In this paper, a type of N-doped carbon nanotube-coated NiZnC metal nanoparticle heterostructure catalyst (NZC-C-700) was prepared by two-step roasting method and applied to depredate bisphenol A (BPA) with peroxymonosulfate (PMS) activation. Characterizations and first principles calculation (DFT) reveal that the heterostructure formed by the graphite carbon layer and NiZnC metal nanoparticles, coupled with various N doping, can effectively modulate surface charge distribution, which could improve charge transfer capability between the catalyst and PMS. Meanwhile, the results of quenching experiments, electron paramagnetic resonance (EPR) and chronoamperometry proposed that the system is a typical singlet oxygen (O) -dominated non-radical pathway.

High-Efficiency Catalytic Ozonation Degradation of Ni Complex Wastewater Using Mn-N Codoped Active Carbon Catalyst.

With the rapid development of electroless nickel (Ni) plating industry, a large amount of Ni complex wastewater is inevitably produced, which is a serious threat to the ecological environment. Herein, a novel Mn-N codoped active carbon (Mn-N@AC) catalyst with high catalytic ozonation ability was synthesized by the impregnation precipitation method and was characterized by BET, XRD, Raman, SEM, FTIR, and TPR. Meanwhile, Mn-N@AC showed excellent catalytic ozonation ability, stability, and applicability.

A roadmap of isolating and investigating bacteriophage infecting human gut anaerobes.

Bacteriophages, viruses that infect bacteria, play a crucial role in manipulating the gut microbiome, with implications for human health and disease. Despite the vast amount of data available on the human gut virome, the number of cultured phages that infect human gut bacteria-particularly obligate anaerobes-remains strikingly limited. Here, we summarize the resources and basic characteristics of phages that infect the human gut obligate anaerobe.

Safety, immunogenicity and immune-persistence of a lyophilized human rabies vaccine (Vero cells) under Zagreb and Essen regimens: a randomized, open-label, controlled phase III clinical trial in healthy participants aged 10-60 years in China.

Background: Rabies continues to be a significant global public health concern, particularly in the Asia region where it is associated with high mortality rate. The administration of effective vaccination is essential in preventing this potentially fatal viral infection. The objective of this study was to evaluate the immunogenicity and safety of two rabies vaccination schedules: the Zagreb (2-1-1) and Essen (1-1-1-1-1) regimens, in a cohort of healthy Chinese individuals aged 10-60 years.

Hyperexcitability precedes CA3 hippocampal neurodegeneration in a dox-regulatable TDP-43 mouse model of ALS-FTD.

Unlabelled: Neuronal hyperexcitability is a hallmark of amyotrophic lateral sclerosis (ALS) but its relationship with the TDP-43 aggregates that comprise the predominant pathology in over 90% of ALS cases remains unclear. Emerging evidence in tissue and slice culture models indicate that TDP-43 pathology induces neuronal hyperexcitability suggesting it may be responsible for the excitotoxicity long believed to be a major driver of ALS neuron death. Here, we characterized hyperexcitability and neurodegeneration in the hippocampus of doxycycline-regulatable rNLS8 mice (NEFH-tTA x tetO-hTDP-43ΔNLS), followed by treatment with AAV encoded DREADDs and anti-seizure medications to measure the effect on behavioral function and neurodegeneration.

Early inhibition of the ATM/p53 pathway reduces the susceptibility to atrial fibrillation and atrial remodeling following acute myocardial infarction.

Atrial fibrillation (AF) emerges as a critical complication following acute myocardial infarction (AMI) and is associated with a significant increased risk of heart failure, stroke and mortality. Ataxia telangiectasia mutated (ATM), a key player in DNA damage repair (DDR), has been implicated in multiple cardiovascular conditions, however, its involvement in the development of AF following AMI remains unexplored. This study seeks to clarify the contribution of the ATM/p53 pathway in the onset of AF post-AMI and to investigate the underlying mechanisms.

Fabrication of Microgel-Modified Hydrogel Flexible Strain Sensors Using Electrohydrodynamic Direct Printing Method.

Hydrogel flexible strain sensors, renowned for their high stretchability, flexibility, and wearable comfort, have been employed in various applications in the field of human motion monitoring. However, the predominant method for fabricating hydrogels is the template method, which is particularly inefficient and costly for hydrogels with complex structural requirements, thereby limiting the development of flexible hydrogel electronic devices. Herein, we propose a novel method that involves using microgels to modify a hydrogel solution, printing the hydrogel ink using an electrohydrodynamic printing device, and subsequently forming the hydrogel under UV illumination.

Flexible tactile sensors with interlocking serrated structures based on stretchable multiwalled carbon nanotube/silver nanowire/silicone rubber composites.

Flexible tactile sensors have attracted significant interest because of their application scope in the fields of biomedicine, motion detection, and human-computer interaction. However, the development of tactile sensors with high sensitivity and flexibility remains a critical challenge. This study develops a patterned, stretchable, and fully elastomeric multiwalled carbon nanotube (MWCNT)/silver nanowire (Ag NW)/silicone rubber (SR) composite.

A microporous bismuth-based MOF for efficient separation of acetylene from carbon dioxide.

The separation of acetylene from carbon dioxide is challenging due to their almost identical molecular sizes and volatilities. Metal-organic frameworks (MOFs) in general are strong candidates for the separation of gas mixtures owing to the presence of functional pore surfaces that can selectively capture specific target molecules. Herein, we report a stable and easily synthesized bismuth-based MOF, Bi-BTC, which can achieve the separation of acetylene and carbon dioxide.

Conductivity enhancement of Ag nanowire ink by decoratingformed Ag particles under low-temperature sintering.

Silver nanowires (AgNWs) have attractive applications in the fabrication of flexible electronics because of their adequate electrical conductivity, mechanical properties, and oxidation resistance. However, the film produced by AgNW ink needs to be sintered at temperatures above 200 °C to obtain high electrical conductivity, which is incompatible with commonly used flexible substrates such as paper or polymer materials. In this study, the AgNW network was decorated byreduced Ag particles (AgPs) to improve the structural integrity and conductivity of the film.

Reversible synaptic adaptations in a subpopulation of murine hippocampal neurons following early-life seizures.

Early-life seizures (ELSs) can cause permanent cognitive deficits and network hyperexcitability, but it is unclear whether ELSs induce persistent changes in specific neuronal populations and whether these changes can be targeted to mitigate network dysfunction. We used the targeted recombination of activated populations (TRAP) approach to genetically label neurons activated by kainate-induced ELSs in immature mice. The ELS-TRAPed neurons were mainly found in hippocampal CA1, remained uniquely susceptible to reactivation by later-life seizures, and displayed sustained enhancement in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated (AMPAR-mediated) excitatory synaptic transmission and inward rectification.