Glutathione-responsive and mitochondria targeting enhanced photodynamic therapy and cascade-triggered carbon monoxide release for all-in-one tumor therapy.

Carbon monoxide (CO) has demonstrated significant potential in tumor therapy. However, the uncontrolled release of CO and single-modality therapy often fail to achieve the desired therapeutic outcomes. To address the above deficiencies, mesoporous silica nanoparticles containing tetrasulfide bonds (TMSNs) were constructed as intelligent nanocarriers to co-deliver a mitochondria-targeting photosensitizer (Au-TPP) and a photodynamically activated CO-releasing molecule (FeCO), enabling the synergistic combination of photodynamic therapy (PDT) and CO therapy.

Complete genome sequences of strains Y and N, capable of conjugated diene biohydrogenation.

We report the complete genome sequences of two acetogenic strains, Y and N, isolated from river sediment. Under anaerobic acetogenic conditions, strain Y biohydrogenates isoprene, while strain N transforms 1,3-butadiene to 1-butene.

Impact of mild cortisol excess on osteoporosis and the mediating role of sarcopenia-related traits: A Mendelian randomization study.

Studies show excessive cortisol is linked to osteoporosis (OP). However, the impact of mild cortisol excess (MCE) on bone mineral density (BMD) remains unclear. Sarcopenia may play a key role in this, particularly in aging or stress contexts.

Construction effect of fertile cultivated layer in albic soil. Ⅱ. Effects of deep tillage with organic materials on nutrient contents and pH in tillage layer of albic soil.

White slurry layer of albic soil has low fertility and poor nutrient availability. Organic material return to fields is a primary agricultural management practice for enhancing soil fertility. We examined the variations of soil nitrogen, phosphorus and potassium nutrient contents and pH of the topsoil layer (0-15 cm) and subsoil (15-35 cm) layers of albic soil under different treatments, including deep tillage at 35 cm without organic materials (T), straw deep mixing at 35 cm (T+S), organic fertilizer deep mixing at 35 cm (T+M), combined straw and organic fertilizer deep mixing at 35 cm (T+M+S), and conventional tillage at 15 cm without organic materials as the control (CK).

Prevalence and risk factors for depression in somatic symptom disorder patients: a cross-sectional clinical study in China.

Introduction And Objectives: The comorbidity of somatic symptom disorder (SSD) and depressive symptoms is common; however, the demographic and clinical factors correlated with depression among SSD patients remain unclear. The purpose of this study was to explore the prevalence and associated factors of depressive symptoms in Chinese Han patients with SSD.

Methods: In this cross-sectional study, 899 outpatients diagnosed with SSD were included.

The disease burden of ILD at the global, regional, and national levels from 1990 to 2021, and projections until 2035: the 2021 Global Burden of Disease study.

Background: Interstitial lung disease (ILD) is an important component of the global disease burden and health challenges. This study aims to describe and analyze the global and regional disease burden of ILD, and predict future epidemiological trends.

Methods: The data from the 2021 Global Burden of Disease, Injury and Risk Factors (GBD) were used to conduct a secondary analysis on the incidence rate, mortality and disability adjusted life year (DALY) of ILD in 21 regions and 204 countries and regions from 1990 to 2021, stratified by time, space, gender, age and social demographic index (SDI).

Mpox containment strategies in China, 2022-2023: from preparedness to legal management.

WHO declared mpox a Public Health Emergency of International Concern on 23 July 2022. China experienced the first imported case in September 2022, the first local case in May 2023, indigenous clustered outbreaks in June to August 2023 and finally has achieved routine management since September 2023. We designed a conceptual framework through literature review and theoretical underpinnings according to the risk management theory and Chinese mpox control practice, with the strategy and measures evolution of the mpox control in China over time from the stages of risk preparedness, emergency response and management, to routine report and management.

Evolution of the roof caving and fracture zones during mining of close range coal seams.

This study employs an integrated methodology combining slip line field theory, FLAC3D numerical simulation, and hydraulic injection testing to systematically investigate the evolutionary characteristics of roof two zones under repeated mining conditions in close range coal seams No.9 and 10 (average interburden thickness is 10.2 m).

Effects of a mind-body exercise intervention on anxiety, depression and quality of life in elderly patients with chronic obstructive pulmonary disease: A systematic evaluation and META analysis.

Background: Elderly patients with Chronic Obstructive Pulmonary Disease (COPD) commonly suffer from anxiety, depression, and impaired health-related quality of life (HRQOL). This review evaluated the effects of mind-body exercises on these outcomes and exercise tolerance in COPD patients aged ≥ 60 years.

Methods: Following PRISMA guidelines, we systematically searched PubMed, Embase, PsycINFO, Cochrane Library, and Web of Science (inception-January 2025) for randomized controlled trials (RCTs) comparing mind-body exercise versus usual care.

The collaborative evolution of trust, information flow, and social cooperation: a study on network stability based on dynamic game models.

Human society is organized around individual actors. When making behavioral choices, individuals engage in rational deductions based on their environment and select the 'most appropriate' actions. This paper introduces a social relations network information system that enables behavior nodes and their environments to observe behaviors and assign scores accordingly.

Dual DNAzyme-MoS/GDY Catalytic Assembly Enables Smartphone-Based Multiplex Detection of Sugarcane Pokkah Boeng Pathogens at Sub-Femtomolar Levels.

Rapid on-site detection of sugarcane pokkah boeng disease caused by Fusarium pathogens remains challenging due to the lack of portable platforms combining high sensitivity and multiplexing capability. Here, we present a self-powered biosensor integrating a dual DNAzyme-driven catalytic system with a MoS/graphdiyne (GDY) nanohybrid-modified biofuel cell (EBFC) for simultaneous detection of and . The key innovation lies in the windmill-shaped dual DNAzyme structure that enables Mn/Mg-dependent target recycling, synergistically coupled with the hybridization chain reaction (HCR) and triplex catalytic hairpin assembly (TCHA) for exponential signal amplification.

Autoencoder-Transformed Transcriptome Improves Genotype-Phenotype Association Studies.

Transcriptome-wide association study (TWAS) is an emerging model leveraging gene expressions to direct genotype-phenotype association mapping. A key component in TWAS is the prediction of gene expressions; and many statistical approaches have been developed along this line. However, a problem is that many genes have low expression heritability, limiting the performance of any predictive model.

Complete genome sequence of strain NK, an acid-tolerant organohalide-respiring bacterium.

strain NK reductively dechlorinates tetrachloroethene to ethene at pH 5.5. The metagenome-assembled strain NK genome is 1.

Machine perfusion prevents early tumor recurrence in liver transplantation for hepatocellular carcinoma: a multicenter retrospective cohort study.

There is controversy regarding whether the machine perfusion (MP) prevents hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). This study aimed to explore the impact of MP on HCC recurrence. We included data from the United Network for Organ Sharing (UNOS) database on HCC patients spanning from April 2015 and January 2024.

Nomogram model of mortality risk in patients with chronic obstructive pulmonary disease in intensive care unit: based on MIMIC-IV database and external validation study.

Objective: Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high incidence and mortality rates. This study aims to identify independent risk factors affecting the mortality risk of COPD patients and construct and validate a nomogram model to provide treatment guidance for COPD patients.

Methods: Data from COPD patients in the intensive care unit (ICU) were obtained from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) and the eICU Collaborative Research Database (eICU-CRD).

Multimodal tumor microenvironment signature of colorectal cancer for prediction prognosis and chemotherapy benefit.

The current tumor‒node‒metastasis (TNM) staging system cannot provide sufficient information for prognosis and chemotherapy benefits in patients with colorectal cancer (CRC). The tumor microenvironment plays a critical role in disease progression and therapeutic response. Here, we developed and validated a multimodal tumor microenvironment signature of CRC (MTMS) using 1314 CRC patients to enhance prognosis and chemotherapy benefit predictions.

Precise rewiring of corticospinal axons and spinal interneurons via near-infrared optogenetics for spinal cord injury treatment.

To date, precise restoration of proper connections between posttrauma axons and neurons following spinal cord injury (SCI) remains a substantial challenge. Here, we developed glutamate-linked upconversion nanoparticles (Glu-UCNP) to facilitate optogenetic control of axonal sprouting in SCI mice. After being specifically uptaken by the postsynaptic interneurons innervated by corticospinal tract (CST) axons, Glu-UCNP not only serves as internal light transducers that convert near-infrared light to visible light but also acts as nanobeacons that guide axonal sprouting toward postsynaptic neurons of glutamatergic synapses.

Highly Tunable Valley Polarization of Potential-Trapped Moiré Excitons in WSe_{2}/WS_{2} Heterojunctions.

Moiré superlattices created by stacking atomic layers of transition metal dichalcogenide semiconductors have emerged as a class of fascinating artificial photonic and electronic materials. An appealing attribute of these structures is the inheritance of the valley degree of freedom from the constituent monolayers. Recent studies show evidence that the valley polarization of the moiré excitons is highly tunable.

Accounting for Earth's curvature and elevation in animal movement modeling.

Animals move in three dimensions, yet movement models do not capture the third dimension when data are collected as longitude and latitude coordinates (only) and models are developed in two dimensions. Here, we ask the question to what extent topography and the shape of the Earth-its ellipsoidal shape-affect the quantification of animal movement. To answer this question, we draw from the fields of ecology and geodesy: geodesy provides the mathematics to solve the problem on the curved surface of the Earth exactly, as opposed to using a map projection, because all map projections impart a scale distortion that systematically enlarges or shrinks the distances between points in space.

Genetic Diversity and Population Structure Analysis of Based on Genome-Wide Markers.

The is an outstanding local breed in China that has been placed under conservation due to the impact of specialized breeding and the widespread adoption of commercial varieties. As such, this study analyzed reproductive traits across three consecutive generations and utilized whole-genome resequencing data from 60 to assess conservation efficacy through genetic diversity, run of homozygosity (ROH) distribution, kinship, and population structure so as to better conserve the breed. The results show that, across generations, the body weight at first egg increased, the age at first egg was delayed, and the egg weight at first laying increased.

β-Lactoglobulin Amyloid Fibrils-Poly(vinyl alcohol)-AgNPs Hydrogel as a Surface-Enhanced Raman Substrate for All-in-One Rapid Separation, Enrichment, and Detection of Small Molecules in Food Samples.

A β-lactoglobulin amyloid fibrils-poly(vinyl alcohol)-Ag nanoparticles (β-LAFs-PVA-AgNPs) hydrogel was prepared as a surface-enhanced Raman scattering (SERS) substrate based on poly(vinyl alcohol) (PVA) with adsorbent β-lactoglobulin amyloid fibrils (β-LAFs) structured into the network structure of the hydrogel using the immersion reduction method. Due to the high swelling and contraction properties of the hydrogel in different states and the "sieving" nature of its network cavities, small molecular target analytes can more easily enter the space-confined hydrogel and rapidly bind with the amide bonds of the protein structure. During the contraction process of the hydrogel, the target analytes are enriched, and the Ag nanoparticles (AgNPs) come closer together to form Raman "hot spots", generating stronger SERS signals.

A novel organoid model retaining the glioma microenvironment for personalized drug screening and therapeutic evaluation.

Glioma is an aggressive brain tumor with a poor prognosis. Establishing an in vitro culture model that closely replicates the cellular composition and microenvironment of the original tumor has been challenging, limiting its clinical applications. Here, we present a novel approach to generate glioma organoids with a microenvironment (GlioME) from patient-derived glioma tissue.

Repair of tetralogy of Fallot in neonates: a single-center case series.

Background: The optimal timing for surgical intervention in the management of tetralogy remains a subject of ongoing debate. This investigation involved a retrospective analysis of neonatal patients who had received continuous treatment for tetralogy of Fallot (TOF) at our centre. The objective of this study was to examine the feasibility and necessity of treating TOF in the neonatal period.

Factors Influencing Cardiac Rehabilitation Compliance in Elderly Myocardial Infarction Patients and the Development of a Nomogram Prediction Model.

Objective: To explore the influencing factors of cardiac rehabilitation compliance in elderly patients with acute myocardial infarction (AMI) and to construct a nomogram prediction model.

Methods: A retrospective study was conducted on 239 elderly AMI patients admitted to our hospital from April 2022 to April 2024. The patients were randomly assigned into a modeling group (167 cases) and a validation group (72 cases) in a 7:3 ratio.

Deciphering the mechanism and substance basis of Dingxiang Shidi Decoction for the treatment of chemotherapy-induced nausea and vomiting by integrating mass spectrometry, network pharmacology and molecular docking.

BackgroundChemotherapy-induced nausea and vomiting (CINV) remains a prevalent and debilitating side effect of cancer treatment with limited therapeutic options. Dingxiang Shidi Decoction (DXSD), a classical Chinese herbal formula, has demonstrated clinical efficacy in CINV management. However, its active components and mechanism of action require systematic investigation.