Effects of a mind-body exercise intervention on anxiety, depression and quality of life in elderly patients with chronic obstructive pulmonary disease: A systematic evaluation and META analysis.

Background: Elderly patients with Chronic Obstructive Pulmonary Disease (COPD) commonly suffer from anxiety, depression, and impaired health-related quality of life (HRQOL). This review evaluated the effects of mind-body exercises on these outcomes and exercise tolerance in COPD patients aged ≥ 60 years.

Methods: Following PRISMA guidelines, we systematically searched PubMed, Embase, PsycINFO, Cochrane Library, and Web of Science (inception-January 2025) for randomized controlled trials (RCTs) comparing mind-body exercise versus usual care.

Microbiota-gut-brain axis and anxiety or depression: A perspective from bibliometric and visual analysis.

Background: Anxiety and depression are mental disorders that are prevalent worldwide. Previous studies have shown that it is related to the gut microbiota. The microbiota-gut-brain axis (MGB axis) is a bidirectional signaling pathway that links the gut and central nervous systems.

Improvement of classical therapy in EGFR inhibitors-induced cutaneous adverse reaction by microneedle delivery and Astragalus polysaccharide.

EGFR (epidermal growth factor receptor) inhibitors, as the first-line drugs of targeted therapy, often cause additional distress for patients due to the induced cutaneous adverse reactions (EICAR), while classical therapies represented by topical minocycline and epidermal growth factor have limitations especially for exacerbating immune imbalance. Here, we used Astragalus polysaccharide (APS), which has modulatory effects on both the epidermis and the immune system, as an adjuvant drug to reduce EICAR and achieve immune balance. APS, combined with minocycline or epidermal growth factor, was delivered by dissolvable microneedles (MN), a novel drug delivery method that penetrates the stratum corneum to deliver the drug directly into the skin tissue.

Irisin inhibits neutrophil extracellular traps formation and protects against acute pancreatitis in mice.

Introduction: Irisin is a newly discovered myokine which links exercise to inflammation and inflammation-related diseases through macrophage regulation. However, the effect of irisin on the activity of inflammation related immune cells (such as neutrophils) has not been clearly described.

Objectives: The objective of our study was to explore the effect of irisin on the neutrophil extracellular traps (NETs) formation.

Swimming exercise ameliorates depressive-like behavior by anti-inflammation activity, rebalancing gut Escherichia coli and Lactobacilli.

Major depressive disorder (MDD) is a common mental disease with high morbidity, recurrence and mortality and is a serious global health problem.Aerobic exercise produces beneficial effects on depression and associated comorbidities.Swimming exercise with high motor complexity may be particularly beneficial for patients with depression.

Design and evaluation of puborectalis-like artificial anal sphincter that replicates rectal perception.

While fecal incontinence (FI) is not fatal, it can dramatically decrease the patient's quality of life. An artificial anal sphincter (AAS) is an implantable device that treats FI by replacing a diseased or damaged anal sphincter, thus allowing the patient's continence to be maintained. Here, we report a novel implantable puborectalis-like artificial anal sphincter (PAAS) that replicates rectal perception and has a low risk of ischemia necrosis.

Inhibition of hyperplasia during the implantation of the puborectalis-like artificial anal sphincter.

Objectives: This study aims to extend the implantation lifetime of the puborectalis-like artificial anal sphincter by inhibiting the occurrence of hyperplasia following the implantation process.

Method: A new transmission structure was designed inside the puborectalis-like artificial anal sphincter to generate an adequate torque to maintain the feces, even if hyperplasia developed around the prosthetic sphincter. An outer shell was added to the prosthetic sphincter to decelerate the occurrence of hyperplasia on the outer shell side.