Influence of sulfur/chlorine-containing pesticides on the aging and heavy metal dynamics of PBAT and LDPE microplastics in soil.

Microplastics (MPs) pollution in soil has emerged as a significant environmental concern, particularly regarding the interactions between MPs and chemical contaminants such as pesticides. This study focused on the aging of biodegradable poly(butylene adipate--terephthalate) (PBAT) and low-density polyethylene (LDPE) films in the presence of five sulfur/chlorine (S/Cl)-containing pesticides (prothioconazole, myclobutanil, isazophos, harmony, and flumetsulam), selected for their common use in agricultural practices and potential environmental persistence. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and inductively coupled plasma mass spectrometry (ICP-MS) were employed to investigate the dynamics of heavy metal adsorption and release (specifically Ni, Cu, and Sn) during MPs aging, as indicated by changes in surface morphology and polymer functional groups.

WEE1 inhibitor exerts synergistic effect with KRAS G12C inhibitor via MYBL2-RRM2 axis in KRAS-mutant lung cancer.

The clinical effect of KRAS G12C inhibitors (G12Ci) as monotherapy is poor, prompting the development of combination treatment strategies. Here, we demonstrate that the WEE1 kinase inhibitor (WEE1i), Adavosertib, can sensitize the effect of G12Ci through the MYBL2-RRM2 axis, which is associated with poor prognosis in lung cancer. Overexpressing the MYBL2-RRM2 axis or supplementing the products of the RRM2 enzyme, dNTPs/dNs, can partially reverse this synergistic inhibitory effect.

Quanzhenyiqitang and its polysaccharides alleviate chronic obstructive pulmonary disease inflammatory injury through TLR4/MyD88/MAPK signaling pathway.

Ethnopharmacological Relevance: Quanzhenyiqitang (QZYQT) is a classic decoction used for treating chronic obstructive pulmonary disease (COPD), with Quanzhenyiqitang polysaccharides (QZYQTP) identified as the active component. Both have demonstrated effectiveness in treating COPD in clinical and experimental studies. However, the active components and potential mechanisms in treating COPD remain incompletely understood.

One-Step Electrospun WO/CuO p-n Heterojunction Nanocomposites for Ultrasensitive and Rapid HS Detection.

Hydrogen sulfide (HS), a critical industrial gas, exhibits high toxicity, flammability, and strong corrosiveness, posing severe health risks at elevated concentrations. Consequently, developing highly sensitive and rapid-response detection methods is imperative. In this study, WO/CuO nanocomposites were synthesized via a one-step electrospinning technique, enabling the fabrication of high-performance HS gas sensors.

All-optical remotely controllable 1 × 8 silicon thermo-optic switch based on Mach-Zehnder interferometers.

We have proposed an all-optical switch based on a thermo-optic (TO) phase shifter with pump lights to control the on/off state of signal lights. In this study, we experimentally demonstrate the 1 × 8 Mach-Zehnder interferometer (MZI)-based silicon TO switch that performed broadband switching with the worst crosstalk of 15.2 dB in the C-band wavelength range and minimum insertion loss of 5.

Cerebrospinal fluid quantitative proteomic reveals potential mechanisms and biomarker candidates of children with bacterial meningitis complicated by neurological complications.

Background: Bacterial meningitis complicated by neurological complications (BMN) is a major cause of poor outcomes and mortality among children with bacterial meningitis. So far, the host-related mechanisms and diagnostic biomarkers of BMN and bacterial meningitis without neurological complications (BM) remain poorly understood and limited.

Methods: We implemented a two-stage cerebrospinal fluid (CSF) quantitative proteomics study involving three groups: children with BMN, BM, and diseases not involving the central nervous system(Ctrl).

A smart CO-releasing MnSiO-based hydrogel enhances diabetic wound healing through NIR-triggered antibacterial, anti-inflammatory, and pro-regenerative mechanisms.

Diabetes is a growing global health concern often associated with chronic wounds characterized by persistent infection, excessive inflammation, and impaired angiogenesis. To address these challenges, we developed a multifunctional hydrogel MnSiO-Fe(CO)/ICG@PF127 (MF/ICG@PF127) that combines photothermal and photodynamic antibacterial effects, controlled carbon monoxide (CO) release, and immunomodulatory activity to promote diabetic wound healing. This hydrogel was constructed by encapsulating Fe(CO) within MnSiO nanoparticles (MF) and co-assembling with indocyanine green (ICG) into a thermosensitive Pluronic F127 matrix ), forming a near-infrared (NIR)-responsive platform.

Combination of resveratrol and epirubicin to overcome chemoresistance in lung adenocarcinoma organoids: synergistic effects and translational implications.

Lung adenocarcinoma (LAC) is the main histological type of non-small cell lung cancer (NSCLC). Adjuvant therapy is required in LAC management but usually encounters drug resistance. Resveratrol (RES) enhances the anti-NSCLC effects of chemotherapeutic agents , while the efficacy for LAC individuals remains unclear.

Metabolomics-guided analysis combined with network pharmacology and molecular simulations reveals the mechanism of JHT in treating septic intestinal dysfunction.

Ethnopharmacological Relevance: Jinhong Tang (JHT), recorded in Surgery of Traditional Chinese Medicine, is a famous modern prescription for acute abdomen. Our previous study demonstrated that JHT can improved the immune function and organ function of patients with sepsis, achieving favorable clinical outcomes. However, the basis of these effects and the underlying mechanisms remain unclear.

Proteomic profiling of cerebrospinal fluid reveals pathophysiology changes and diversity of treatment response in pediatric meningitis.

Background: meningitis (SPM) is a critical pediatric infection with a high mortality rate. This study aimed to investigate changes in the cerebrospinal fluid (CSF) proteome in SPM patients and identify biomarkers for SPM diagnosis and treatment monitoring.

Research Design And Methods: Here, we retrospectively collected and evaluated CSF proteomes of 47 SPM and 116 non-CNS-infected patients (Control), including longitudinal samples from 11 SPM patients.

Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma.

Esophageal squamous-cell carcinoma (ESCC) is one of the most common gastrointestinal cancers in China, characterized by high malignancy and poor prognosis. Nowadays, the therapeutic options for this cancer are very limited. Notch-signaling is often overactivated in ESCC, but its role remains to be fully elucidated.

Integrative radiomics of intra- and peri-tumoral features for enhanced risk prediction in thymic tumors: a multimodal analysis of tumor microenvironment contributions.

Objectives: This study aims to explore the role of intra- and peri-tumoral radiomics features in tumor risk prediction, with a particular focus on the impact of peri-tumoral characteristics on the tumor microenvironment.

Methods: A total of 133 patients, including 128 with thymomas and 5 with thymic carcinomas, were ultimately enrolled in this study. Based on the high- and low-risk classification, the cohort was divided into a training set (n = 93) and a testing set (n = 40) for subsequent analysis.

Elevation from Binary to Ternary Resistive Switching Behaviors by Graphitizing Transformation from Nanodiamond to Onion-like Carbon in Their Chitosan Composites.

The development of green high-density memristors is urgent for the coming big-data era. In this work, the graphitization degree of the nanodiamond (ND) was modulated by thermal annealing at different temperatures. Consequently, the graphitizing transformation from the ND structure to partial onion-like carbon (OLC-1) and complete OLC-2 was achieved, which has been validated by increased sp/sp ratios and carbonyl contents.

Therapeutic Potential of Ginsenosides in the Treatment of Endocrine Diseases: Roles and Mechanisms.

Endocrine diseases continue to surge as a global health concern, posing a serious threat to human health and placing a tremendous burden on society. The pathophysiology of endocrine diseases is intricate and multifactorial, often associated with dysregulation in feedback mechanisms or malfunctions within the endocrine system. Numerous studies have been conducted to develop pharmacological agents that prevent or alleviate endocrine disorders.

When "Aging" meets "Intelligence": smart health cognition and intentions of older adults in rural Western China.

Background: Population aging is occurring at an unprecedented pace, rendering "healthy aging" a critical issue of global importance. China is at the forefront of this demographic transformation and faces substantial challenges, especially in its western rural regions. In this context, smart health technology, propelled by advancements in medical care and information technology, emerges as a vital strategy to address the challenges associated with aging.

Integration of partial nitrification, endogenous denitrification and anaerobic ammonia oxidation in low dissolved oxygen anaerobic/oxic/anoxic-aerobic granular sludge reactor treating low carbon to nitrogen ratios wastewater.

The anaerobic/aerobic/anoxic-aerobic granular sludge (AOA-AGS) process effectively removes nitrogen while tolerating limited oxygen and carbon. However, integrating anaerobic ammonia oxidation (Anammox), which thrives under low organic carbon and oxygen conditions, with AOA-AGS remains challenging. This study investigated nitrogen removal performance and community changes in an AOA-AGS sequencing batch reactor with low carbon to nitrogen ratios (C/N) wastewater and reduced dissolved oxygen (DO) from 5-7 mg/L to 0.

2'-O-methylation and N6-methyladenosine enhance the oral delivery of small RNAs in mice.

Studies have demonstrated that small RNAs originating from plants can be taken up by the human digestive system and play a role in regulating gene expression. However, the impact of naturally occurring RNA modifications in these small RNAs on their absorption has been underexplored. Here, we show that 2'-O-methylation (2'-O-Me), N6-methyladenosine (mA), and 5-methylcytidine (mC) exhibit high abundance in small RNAs (18-30 nt) derived from herbal decoction.

Patient perceptions of primary care rapid respiratory microbiological point-of-care testing: a qualitative study.

Objectives: Rapid microbiological point-of-care tests (RM-POCTs) have the potential to reduce antimicrobial overuse for respiratory tract infections (RTIs). However, patient perspectives regarding RM-POCTs remain unclear. Therefore, this study aimed to explore patients' and parents' experiences using RM-POCTs for RTIs and their views on how RM-POCTs influence treatment decisions, symptom management and future consulting.

Impact of Molecular Structure on Secondary Organic Aerosol Formation from Aliphatic Carbonyls.

Aliphatic carbonyls widely exist in source emissions and the atmosphere, serving as secondary organic aerosol (SOA) precursors. Molecular structure including carbon number and functional groups influences SOA formation. However, limited research was conducted on the vastly different SOA yields among aliphatic carbonyls, and the impact of the molecular structure remains unclear and controversial.

Characterizing volatile organic compounds from personal protective equipment users: Implications to cleanroom air quality and occupational health.

Human-related contaminants are the primary pollution source in cleanrooms. This study employed time-of-flight mass spectrometry (PTR-ToF-MS) to characterize volatile organic compound (VOC) emissions from breath and skin under different activity levels and personal protective equipment (PPE) conditions in a climatic chamber. The results show that, without PPE, breath and skin emission rates were 968.

ELD1 mediates photoperiodic flowering via OsCCA1 alternative splicing and interacts with phytochrome signaling in rice.

Photoperiodic flowering in plants is orchestrated by the dynamic interaction between light signals and the endogenous circadian clock, but how light signals integrate into the clock remains to be fully elucidated. Here, we identify ELD1, a CCHC-type zinc finger protein that is essential for rice embryo survival. Notably, partial loss of ELD1 function results in early flowering under long-day conditions.

Human congenital cataract mutation in alters F-actin organization and cell functions.

Aim: To explore the role of a previously-found tail domain mutation (p.E1384Q) in the pathogenesis of congenital cataract.

Methods: The cell experiments were conducted .

Atmospheric emerging pollutants of cyclic volatile methyl siloxanes across the Yangtze River Delta region revealed by mobile measurements.

Cyclic volatile methyl siloxanes (cVMS) are a large class of high-production-volume chemicals that have garnered increasing scrutiny due to their potential adverse effects on air quality and human health. Among cVMS, octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) dominate global production, with China playing a pivotal role in their manufacture and consumption. Despite their widespread use, the atmospheric occurrence and sources of these compounds in China, even in the Yangtze River Delta (YRD)-the nation's most densely populated and economically developed region-remain largely unknown.

Effects of work cessation on cognitive functioning in rural older adults in China: a cross-sectional study based on CHARLS.

Objectives: This study investigated the effects of work cessation on cognitive function among older adults in rural China. Given that cognitive disorders affect 6.04% of individuals aged 60 and above-with higher prevalence in rural areas-understanding this relationship is critical.