Simplified Assessment of Acetylcholinesterase Inhibition by Environmental Organophosphorus Pesticides.

Environmental contaminants, such as pesticides, can inhibit the enzymatic activity of acetylcholinesterase (AChE), an enzyme necessary for neurotransmission. The inhibitory effects of structurally diverse pesticides on AChE may result from either reversible or covalent interactions. Therefore, assessing their potency typically requires different assay design to determine either dissociation constants or rate constants, respectively.

Analysis of Blood Pressure Status and Influencing Factors Among 7218 Emergency Department Nurses: An Observational Cross-Sectional Study.

As frontline healthcare workers, emergency department nurses face high levels of urgency in their work and are exposed to a high risk of contingencies. Their blood pressure status and influencing factors require close attention. This study employed a census method and conducted a cross-sectional survey in 11 cities in Hebei Province from November 2016 to July 2018, measuring blood pressure and collecting questionnaires on influencing factors.

CAR-exosomes derived from immune cells: an emerging nanoscale vanguard in overcoming tumor immunotherapy hurdles.

Chimeric Antigen Receptor (CAR)-engineered cell therapies excel against hematologic malignancies, however, their efficacy in solid tumors is hampered by toxicity, poor tumor infiltration, immunosuppressive microenvironments, limited persistence, and expansion difficulties. Recently, exosomes derived from CAR-immune cells (CAR-Exosomes) have emerged rapidly as an innovative therapeutic platform. CAR-Exosomes, utilizing nanoscale communication pathways, inherit their parental cells' tumor-targeting capabilities while offering distinct advantage.

Semi-LLIE: Semi-supervised contrastive learning with Mamba-based low-light enhancement.

Recent advances in low-light image enhancement (LLIE) have achieved impressive progress. However, the scarcity of paired data has emerged as a significant obstacle to further advancements. In this work, we propose Semi-LLIE, a novel semi-supervised framework that introduces unpaired low- and normal-light images into model training via the mean-teacher paradigm.

Comprehensive safety assessment of ribociclib: A real-world analysis using the FDA Adverse Event Reporting System (FAERS) database.

Aims: Ribociclib is a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor that was approved by the US Food and Drug Administration (FDA) in 2017 for the treatment of advanced hormone receptor-positive (HR+) breast cancer. The presented study aimed to evaluate the ribociclib-associated adverse events (AEs) through data mining of the US Food and Drug Administration Adverse Event Reporting System (FAERS).

Methods: Data were collected from the FAERS database covering the period from the first quarter of 2017 to the first quarter of 2023.

Toxicity of Biogenic Secondary Organic Aerosol toward Nerve Cells.

Secondary organic aerosol (SOA) accounts for a large fraction of fine particulate matter (PM) in the atmosphere. Epidemiological studies have shown that SOA has adverse effects on human health. However, the current knowledge of the SOA's effect on the nervous system remains poorly understood.

The Adverse Event of Interstitial Lung Disease in Patients Treated with Antibody-Drug Conjugates.

Objectives: There has been a yearly increase in the incidence of interstitial lung disease (ILD) adverse events associated with antibody-drug conjugates (ADCs), which is becoming a significant challenge for the clinical application of ADCs. We aim to conduct an exhaustive analysis of the clinical characteristics and outcomes of ADC-associated ILD in the real world.

Methods: We utilized the FDA Adverse Event Reporting System database spanning from January 2004 to September 2023 to evaluate the clinical characteristics, onset times, and outcomes of ADC-associated ILD adverse events in patients.

Mechanism of lidocaine-induced ROS generation triggering DNA double-strand breaks and promoting intervertebral disc cell senescence via the MYC-DUSP1-P53 axis.

Discogenic lower back pain (DLBP) is a prevalent lumbar disorder. Functional Anesthetic Discography (FAD) is the primary diagnostic method for DLBP, with a high positivity rate. However, the mechanism by which lidocaine, a local anesthetic commonly used in FAD, induces damage to intervertebral disc cells remains unclear.

Minimizing Photovoltage Loss for Efficient p-i-n Perovskite Solar Cells via a Dual-Site Anchoring Bridge.

Perovskite solar cells (PSCs) suffer from severe nonradiative recombination-induced photovoltage loss, limiting the device overall performance. To address this key issue, an efficient strategy via a dual-site anchoring bridge is developed to engineer the heterointerface between perovskite and PCBM electron transport layer. The resulting reinforced and homogeneous passivation by forming strong dual-site P─O─Pb covalent bonds, effectively decreases perovskite surface defect density.

Sustainable risk management of heavy metal contaminated agricultural soil: Current frameworks and future perspectives.

Heavy metal (HM) contamination in agricultural soils poses a growing threat to sustainable agriculture, food safety, and human health. Risk Management Frameworks (RMFs) have been widely adopted to regulate HM contamination, but their effectiveness and adaptability vary across countries due to differences in institutional design, technical guidance, and regulatory implementation. Moreover, the limited sustainability and structural shortcomings of the RMFs remain significant obstacles to achieving the United Nations Sustainable Development Goals.

Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors that Demonstrate Potent Cellular Efficacy and In Vivo Activity in a Mouse Solid Tumor Xenograft Model.

The B cell lymphoma 2 (Bcl-2) family of proteins are key regulators of intrinsic apoptosis. The antiapoptotic protein myeloid cell leukemia 1 (Mcl-1), which is associated with high tumor grade, poor survival, and resistance to treatment, has emerged as a promising candidate for treating hematological and solid cancers. Herein, we report the structure-guided design of small molecule macrocyclic Mcl-1 inhibitors based on the ()-methyl-dihydropyrazinoindolone scaffold our group has previously disclosed.

Targeting the ANXA8-SP1-PPA1 Axis to Modulate TCA Cycle and Matrix Deposition in Diffuse-Type Gastric Cancer.

Diffuse-type gastric cancer (DGC) is an aggressive tumor type characterized by a dense extracellular matrix (ECM). Metabolic reprogramming, a key oncogenic factor driving tumor progression, is closely linked to ECM deposition, although the regulatory mechanisms remain poorly understood. In this study, we integrated single-cell sequencing, proteomics, metabolomics, and large-scale clinical data to identify the metabolic signature of DGC.

Causal Relationship Between Cataracts and Gastrointestinal Diseases: A Two-Sample Mendelian Randomization Study.

Purpose: Cataracts, a leading cause of blindness, have been linked to systemic conditions. Previous studies showing associations between cataracts and gastrointestinal diseases have not determined causal relationships. We aimed to investigate the causal relationship between cataracts and 23 gastrointestinal diseases through Mendelian randomization (MR).

Pd Single-Atoms Doped CuP Quantum Dots with Moderately Optimized H* Sorption Behaviors for Actualizing the Multifunctional "Formaldehyde-Nitrate" Galvanic System.

Nitrate and formaldehyde, which are substantial wastes in industrial and agricultural effluents, pose significant hazards to the human health and ecosystem. Current purification technologies remain great challenges due to the unsatisfactory energy-intensive, time-consuming and noticeably costly reasons. Herein, a bifunctional electrocatalysts of Pd single-atoms doped CuP quantum dots (Pd-CuP SA-QDs) are reported to moderately optimize the H* sorption behaviors for accelerating the kinetics of nitrate reduction (NORR) and formaldehyde oxidation (FOR) reactions in a dual-directional way, thus realizing the high activity and selectivity for both cathodic ammonia (NH) synthesis and anodic H production concurrently.

Application of Wharton's Jelly Mesenchymal Stem Cells in Critical Limb Ischemia.

Peripheral artery disease (PAD) is a chronic vascular condition, and patients in the advanced stages typically do not respond favorably to interventional or surgical approaches. Recent advancements in Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) fundamental research have produced promising data in the context of PAD management. As recent pilot studies have suggested WJ-MSCs efficacy in patients with end-stage PAD who lack alternative treatment option, WJ-MSCs may offer a novel therapeutic strategy for managing end-stage PAD.

Corrigendum to "Pan-cancer analysis of mutation and its association with the efficacy of immune checkpoint blockade" [Genes & Dis 12 (2025) 101450].

[This corrects the article DOI: 10.1016/j.gendis.

Development and mathematical modelling of a dual-rotor machine for wind turbine power generation system.

Insufficient power grid support for wind turbines has become evident as wind energy use rises, particularly with bigger turbines. This paper introduces a modeling approach for a dual-rotor machine. Furthermore, it proposes a mechanism to integrate the gearbox and synchronous generator with the dual-rotor assembly to serve as a front-end speed control system.

A meta-analysis of the correlation between the duration of the second stage of labor and recent postpartum pelvic floor injury in primiparous.

Objective: This study aimed to explore the correlation between the duration of the second stage of labor and recent postpartum pelvic floor injury in primiparous women.

Methods: Randomized controlled trials (RCTs) were systematically evaluated by a comprehensive literature review and inclusion criteria. This study aimed to evaluate the correlation between the duration of the second stage of labor and recent postpartum pelvic floor dysfunction in primiparous women.

A mitochondria-targeted near-infrared fluorescent probe for detecting HS, Cys, and GSH simultaneously in tumors.

In this study, we developed a mitochondria-targeted near-infrared fluorescent probe HD-Br-D for simultaneous detection of HS, Cys, and GSH and . We anticipate that HD-Br-D will become a powerful tool for diagnosis of diseases, such as tumors, in the near future.

Bioelectrochemistry increases the risk of resistance genes proliferation and transfer with sulfamethoxazole pressure decreasing in constructed wetlands: An overlooked double-edged effect.

Microbial electrochemical system-enhanced constructed wetland (MES-CW) attracts more attention for antibiotic-contaminated wastewater treatment, but the effect of bioelectrochemistry on resistance genes is still unclear with the removal of antibiotic. In this study, the antibiotic resistance genes (ARGs) dynamics, driving factors and transmission mechanism in effluent and substrate samples were investigated under decreasing sulfamethoxazole (SMX) pressure. Bioelectrochemistry was suitable for reducing the risk of ARGs proliferation and transmission at concentration of 0.

Determination of intramolecular isotope effects in the Be+(2P3/2) + HD reaction.

Isotope effects in the Be+(2P3/2) + HD reaction were investigated using an integrated ion trap and high-resolution time-of-flight mass spectrometer at a collision energy of 285 K (Ecoll/kB). The total rate constant was measured to be (1.4 ± 0.

Adaptive Integrated Navigation Algorithm Based on Interactive Filter.

To address the diverse requirements of accuracy and robustness in integrated navigation for unmanned aerial vehicles, an interactive robust filter algorithm that integrates the interactive multiple model concept and leverages the complementary applicability of the strong tracking filter and the smooth variable structure filter is proposed. The algorithm operates as follows: the strong tracking filter, along with the smooth variable structure filter, operates side by side with distinct models. During the filter process, the likelihood function is utilized to update the filter probabilities and determine the weights for each one of the filters.