Association of body mass index and pressure injuries in persons with traumatic spinal cord injury.

Background: There are conflicting findings in the literature about the association of body mass index (BMI) and pressure injury (PI) development in the population with traumatic spinal cord injury (SCI). It is important to investigate the relationship between BMI and risk of PI in persons with SCI because chronic PIs are associated with decreased participation in daily and community activities as well as the greatest average decline in life expectancy compared to other secondary health conditions.

Objective: To determine the relationship between BMI (kg/m) and self-reported PI in the traumatic SCI population.

Lewis Acid-Catalyzed Ring-Opening Reaction of Bicyclobutanes (BCBs) for the Highly Selective Synthesis of 1,1,3-Trisubstituted Cyclobutanes.

Herein, the first Lewis acid-catalyzed ring-opening reaction of bicyclobutanes (BCBs) with acyclic thioamides for the concise, modular synthesis of 1,1,3-trisubstituted cyclobutanes is described. These products feature valuable iminothioether-substituted cyclopropane moieties and single-configuration tetrasubstituted carbon stereocenters. The reaction proceeds under mild conditions and accommodates diverse acyclic thioamides and substituted acyl-BCBs, exhibiting excellent nucleophilic selectivity (S-H/N-H > 99/1) and chemoselectivity (/ > 98/2).

A meta-analysis of the correlation between the duration of the second stage of labor and recent postpartum pelvic floor injury in primiparous.

Objective: This study aimed to explore the correlation between the duration of the second stage of labor and recent postpartum pelvic floor injury in primiparous women.

Methods: Randomized controlled trials (RCTs) were systematically evaluated by a comprehensive literature review and inclusion criteria. This study aimed to evaluate the correlation between the duration of the second stage of labor and recent postpartum pelvic floor dysfunction in primiparous women.

Optimizing core needle biopsy specimen collection techniques to enhance molecular testing adequacy in non-small cell lung cancer.

Background: Core needle biopsy (CNB) is commonly used for histological diagnosis and molecular testing in patients with non-small cell lung cancer (NSCLC). However, the adequacy of CNB specimens is often compromised by low tumor cell content or insufficient nucleic acid quantity, which can negatively impact the success of downstream analyses. Moreover, variations in specimen collection techniques may further contribute to inconsistency in sample quality.

Enhanced Reality in Assessing Antibiotic Risks in Water: Bacterial Resistance Insight from the Microflora-Microcosm-Modeling Framework.

In addition to direct ecological effects, antibiotic residuals in the environment contribute to the development of antibiotic resistance, which is not addressed by traditional ecological risk assessment frameworks such as the persistence, bioaccumulation, and toxicity (P-B-T) criteria. Here, we propose a novel 3M (microflora-microcosm-modeling) framework to assess the risk of antibiotics in promoting bacterial resistance within bacterial flora. Results reveal that aquatic microflora in water environments harbor unexpectedly high antibiotic resistance levels, comparable to clinical settings, despite ambient antibiotic concentrations being orders of magnitude lower, which underscores the rationale for using bacterial resistance as a key indicator in antibiotic risk assessments.

Glycogen metabolism in mouse embryonic Sertoli cells sustains the germ line through the lactate shuttle.

Metabolites are key regulators of cell fate decisions, epigenetic remodeling, and lineage commitment. While genetic pathways governing testis differentiation are well studied, the role of metabolism remains poorly understood. In this study, we investigated a transient, male-specific accumulation of glycogen in supporting (Sertoli) cells of embryonic testis in mice.

A predictive model using platelets and neutrophil-to-lymphocyte ratio for the number of lymph node metastases in papillary thyroid carcinoma: a retrospective analysis.

Background: Large number lymph node metastases (LNLNMs) in papillary thyroid carcinoma (PTC) significantly increase recurrence risk, yet preoperative prediction remains challenging. This study aimed to develop a predictive model integrating blood inflammatory markers and clinical features to identify patients with high-risk LNLNM.

Methods: A retrospective cohort of 731 patients with PTC who underwent thyroid surgery at Hangzhou First People's Hospital between September 2021 and October 2022 was included.

Norethindrone causes oxidative stress, intestinal injury, and disturbed gut microbiota composition in adult female western mosquitofish (Gambusia affinis).

Norethindrone (NET), a widely used synthetic progestin, has been consistently detected in diverse aquatic ecosystems, raising significant concerns about its potential ecological risks. In this study, adult female western mosquitofish (Gambusia affinis) were exposed to environmentally relevant concentrations of NET (5.0, 50.

Current Trends and Research Hot Spots in Traumatic Birth: A Bibliometric Analysis.

The identification of traumatic birth is becoming a major global health concern. Evaluating the existing research can help shape future directions for traumatic birth studies. This study aimed to provide a comprehensive and up-to-date summary of research articles on traumatic birth.

Clinical analysis of 18 cases of intraumbilical vascular thrombosis.

Objective: This study aimed to assess the clinical characteristics and perinatal outcomes of intraumbilical vascular thrombosis, with the objective of improving diagnostic accuracy and developing better management strategies to enhance perinatal outcomes.

Methods: A retrospective analysis was conducted on 18 cases of intraumbilical vascular thrombosis diagnosed at the Obstetrics Department of the First Affiliated Hospital of Southern University of Science and Technology (Shenzhen, China) between January 2017 and December 2022. Data collected included maternal demographics, details of delivery, pregnancy outcomes, and pathological findings from the placenta and umbilical cord.

Subchronic Chlorpyrifos Exposure Induces Thyroid Follicular Cell Pyroptosis to Exacerbate Thyroid Toxicity by Modulating Nrf2/Keap1/NF-κB Pathway in Male Mice.

Purpose: Chlorpyrifos (CPF), a widely used organophosphate pesticide in agriculture, particularly in China, has raised significant environmental and health concerns due to its persistence and bioaccumulation. While CPF-induced toxicity in multiple organ systems has been documented, its long-term impact on thyroid homeostasis and the underlying mechanisms remain poorly understood. This study aimed to investigate the subchronic effects of CPF on thyroid function and elucidate the underlying mechanisms of CPF-induced thyroid toxicity.

Long Non-Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R-AKT-mTOR Axis and Hepatocellular Carcinoma.

The incomplete understanding of the IGFR pathway activation mechanism limits its clinical application in hepatocellular carcinoma (HCC). Here, a transcriptome-wide screening is performed and a novel HCC-associated lncRNA, named IGFR-inducing lncRNA (IGFRIL) is identified. IGFRIL is frequently upregulated in HCC tissues and predicts poor clinical outcomes.

Sex-Related Differences in Functional and Neurological Outcomes of Spinal Cord Injury.

Background And Objectives: Traumatic spinal cord injury (SCI) tends to occur in different demographics and with differing etiology between males and females. Sex-related differences may influence recovery, but there remains a lack of evidence on this subject. Our objective was to quantify the influence of sex on functional and neurological outcomes of SCI.

EIF4A3 Promotes Muscle Atrophy and Aging by Inhibiting the FAK Pathway Through NEDD9 mRNA Destabilization.

Background: Muscle atrophy has a poor prognosis, caused by various factors. Identifying a shared treatment target could address an unmet clinical need. The exon junction complex (EJC), a protein complex assembly that binds to RNA, facilitates post-transcriptional regulation by participating in mRNA splicing, mRNA export, translation and nonsense-mediated mRNA decay.

Can mutation abundance assess the biological behavior of BRAF-positive papillary thyroid carcinoma?

Background: BRAF mutation is the most common genetic change in papillary thyroid carcinoma (PTC). Nevertheless, the association between BRAF mutation status and abundance and the biological behavior of PTC is unclear. Thus, this study investigated whether BRAF mutation status and abundance are related to PTC biological behavior and whether BRAF mutation abundance can be used to further stratify risk.

Aberrant static and dynamic functional connectivity of insular cortex in patients with trigeminal neuralgia.

The abnormal insular-related static and dynamic functional connectivity (sFC and dFC) in patients with trigeminal neuralgia (TN) is not well understood. Therefore, we aimed to explore alterations in the sFC and dFC of the insular cortex(IC) and the relationships between functional connectivity (FC) alterations and clinical measures in TN. The study included 40 patients with TN and 30 healthy controls (HCs) who underwent resting-state functional magnetic resonance imaging and completed the visual analog scale (VAS) and mood questionnaires.

Distinct genes and microbial communities involved in nitrogen cycling between monsoon- and westerlies-dominated Tibetan glaciers.

The Tibetan Plateau (TP) glaciers are influenced by monsoon and westerlies. They are highly sensitive to climate change, with atmospheric nitrogen deposition significantly impacting microbial communities and functions. However, key uncertainties persist regarding biogeography and drivers of genes and microbial communities involved in nitrogen cycling.

Association of PROP bitter taste sensitivity with anhedonia and emotional eating in the Chinese population.

A bitter taste in response to 6-n-propylthiouracil (PROP) and phenylthiourea (PTC) is a partially genetically determined trait. Anhedonia, characterized by a diminished capacity to experience pleasure, is linked to both the sensitivity to bitter tastes and emotional eating. However, the relationship between bitter tastes, anhedonia, and emotional eating is rarely simultaneously studied.

Mitochondrial mass and mitochondrial membrane potential of peripheral lymphocytes: promising biomarkers of systemic lupus erythematosus.

Background: Mitochondrial dysfunction is implicated in the pathogenesis of systemic lupus erythematosus (SLE). Single-cell mitochondrial mass (SCMM), low mitochondrial membrane potential (MMP-Low) in lymphocytes, and circulating mitochondrial DNA (mtDNA) can reflect mitochondrial impairment and may serve as potential novel biomarkers for SLE.

Purpose: We investigated the diagnostic utility of MMP-Low and SCMM in lymphocytes, as well as circulating mtDNA levels, in patients with SLE and examined their correlation with disease activity.

Association between dietary vitamin intake and all-cause mortality in ovarian cancer patients: a prospective cohort study.

Background: While various lifestyle factors have been implicated in cancer prognosis, the role of dietary vitamins in ovarian cancer survival is not well understood. This study aimed to investigate the association between dietary vitamin intake and all-cause mortality in ovarian cancer patients, presenting a potential modifiable avenue for improving outcomes.

Methods: Data were obtained from 7 consecutive National Health and Nutrition Examination Survey (NHANES) cycles between 2003 and 2016, including 108 ovarian cancer patients.

Ultra-sensitive detection of intracellular Mycobacterium tuberculosis with CRISPR/Cas12a.

() invades and survives inside macrophages, evading detection and resisting antibiotic treatment, which results in severe clinical consequences such as fatal respiratory failure and systemic inflammation. Rapid and specific detection of intracellular is crucial for accurate diagnosis and optimizing treatment strategies. In this study, we developed a one-step CRISPR/Cas12a assay targeting the gene for the specific and rapid detection of intracellular .

Protective effects of derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease.

Introduction: Inflammatory bowel disease (IBD), a chronic immune-mediated gastrointestinal disorder mainly covering Crohn's Disease and Ulcerative Colitis, has an unclear etiology. The exploration of novel intervention strategies remains a key scientific issue that is urgently needed for IBD treatment. The hygiene hypothesis has led researchers to notice that worm infections can regulate the immune system, which might help treat inflammatory diseases.