Effects of children exposure to pyrethroid pesticides during infancy and toddlerhood on their ADHD symptoms at preschool age: A prospective study in Southwestern China.

Background: Wide exposure to pyrethroid pesticides (PYRs) during infancy and toddlerhood may be associated with ADHD symptoms at preschool age.

Methods: A total of 292 mother-child pairs participated in our study, we collected urine samples from children's aged 1, 2, and 3 and measured the concentrations of PYRs metabolites, including 3-phenoxybenzoic acid(3PBA), 4-fluro-3-phenoxybenzoic acid (4F3PBA), and 3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylic acid (DBCA). Children ADHD symptoms were assessed using the Conners Parents Symptom Questionnaire (PSQ) at preschool age.

Cryo-EM structures of amino acid sensors bound to the human GATOR2 complex.

Mammalian cells regulate growth by integrating environmental cues through the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway. The human GATOR2 complex, comprising WDR59, WDR24, Mios, Sec13, and Seh1l, is key to mTORC1 regulation. Under amino acid deprivation, GATOR2 is inhibited through interactions with cytosolic leucine sensor Sestrin2 and arginine sensor cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1).

Application of the moving epidemic method for influenza surveillance in Kunming.

Objective: The Moving Epidemic Method (MEM) has been widely used to assess seasonal influenza epidemics in temperate and subtropical regions. This is the first study to validate the use of MEM in a subtropical plateau environment.

Methods: This study applied the Moving Epidemic Method (MEM) to establish influenza epidemic thresholds in Kunming, China, using virological surveillance data from 2011-2012 to 2023-2024.

Environmental tobacco smoke exposure in pregnant women and thyroid hormone levels in newborn cord blood: A birth cohort in China.

The impact of environmental tobacco smoke (ETS) exposure during pregnancy on neonatal thyroid hormones remains limited and inconclusive. This study aimed to evaluate the effects of ETS exposure on thyroid hormone levels in neonatal cord blood, using data from 591 mother-infant pairs. Maternal urinary cotinine (UC) concentrations, measured during the first, second, and third trimesters, served as biomarkers of ETS exposure.

Normotensive primary aldosteronism in a patient with myasthenia gravis: a localization diagnostic conundrum unraveled by Ga-pentixafor PET/CT - a case report with review of literature.

Purpose: While primary aldosteronism (PA) is typically screened in hypertensive patients, normotensive PA remains underrecognized, especially in complex cases where standard diagnostic approaches fail. We present a challenging case of normotensive PA complicated by myasthenia gravis (MG) requiring chronic glucocorticoids, which interfere with conventional cortisol-based adrenal venous sampling (AVS) interpretation. This case highlights the pivotal role of Ga-pentixafor PET/CT as an innovative alternative for subtype differentiation in such complex scenarios.

Linker-free PROTACs efficiently induce the degradation of oncoproteins.

Proteolysis-targeting chimeras (PROTACs) present a potentially effective strategy against various diseases via selective proteolysis. How to increase the efficacy of PROTACs remains challenging. Here, we explore the necessity of the linker, which has been deemed as an integral part of heterobifunctional PROTACs.

Evolution of Core Symptoms of Depression Disorders Among Chinese Adolescents Across Different Grades.

Adolescence is a high-risk period for depression, especially after the COVID-19 pandemic, when adolescent depression has become increasingly severe. This study employs network analysis to identify core symptoms at various stages. It explores the differences in depression symptom characteristics among Chinese adolescents of different genders during elementary, middle, and high school periods.

Molecularly Imprinted Titanium Dioxide: Synthesis Strategies and Applications in Photocatalytic Degradation of Antibiotics from Marine Wastewater: A Review.

Antibiotic residues in the marine environment pose a serious threat to ecosystems and human health, and there is an urgent need to develop efficient and selective pollution control technologies. Molecular imprinting technology (MIT) provides a new idea for antibiotic pollution control with its specific recognition and targeted removal ability. However, traditional titanium dioxide (TiO) photocatalysts have limited degradation efficiency and lack of selectivity for low concentrations of antibiotics.

MicroRNA-34a Mediates the Aldosterone-Induced Acceleration of Endothelial Senescence.

Inappropriate aldosterone production relative to sodium status is known to induce arterial hypertension and cause detrimental effects on endothelium and vascular remodeling. This study investigated whether microRNAs (miRs) serve as key mediators of aldosterone's effects on endothelial dysfunction. Using human umbilical vein endothelial cells (HUVECs) as a model system, we demonstrated that aldosterone treatment suppressed cellular proliferation and migration while promoting senescence.

Effects of daily exposure to pyrethroid pesticides during infancy on children neurodevelopment at age four: A prospective study in rural Yunnan, China.

Introduction: Exposure to pyrethroid pesticides (PYRs) of children in infancy at ages 1 and 2 may affect their neurodevelopmental outcomes at age 4.

Objectives: The study aimed to explore the longitudinal association of infancy PYRs exposure with neurodevelopment at age 4.

Methods: This study based on Xuanwei birth cohort study that started from January 2016 in rural Yunnan, China.

Mechanism exploration of intestinal mucus penetration of nano-Se: regulated by polysaccharides with different functional groups and molecular weights.

Selenium deficiency associated with a high risk of many diseases remains a global challenge. Owing to the narrow margin between "nutrition-toxicity" doses of selenium, it is imperative to achieve accurate selenium supplement. Nano‑selenium (SeNPs) is a novel form of selenium supplement with low toxicity, but it could be trapped and removed by intestinal mucus, thus limiting its oral delivery.

Integrative bioinformatics approach identifies novel drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidate.

Primary aldosteronism (PA), characterized by autonomous aldosterone overproduction, is a major cause of secondary hypertension with significant cardiovascular complications. Current treatments mainly focus on symptom management rather than addressing underlying mechanisms. This study aims to discover novel therapeutic targets for PA using integrated bioinformatics and experimental validation approaches.

LncRNA SERPINB9P1 Mitigates Cerebral Injury Induced by Oxygen‒Glucose Deprivation/Reoxygenation by Interacting with HSPA2.

Dysregulation of long non-coding RNAs (lncRNAs) is implicated in the pathophysiology of ischemic stroke (IS). However, the molecular mechanism of the lncRNA SERPINB9P1 in IS remains unclear. Our study aimed to explore the role and molecular mechanism of the lncRNA SERPINB9P1 in IS.

Annealing Effect on Linear and Ultrafast Nonlinear Optical Properties of BiTe Thin Films.

In recent years, the fabrication of materials with large nonlinear optical coefficients and the investigation of methods to enhance nonlinear optical performance have been in the spotlight. Herein, the bismuth telluride (BiTe) thin films were prepared by radio-frequency magnetron sputtering and annealed in vacuum at various temperatures. The structural and optical properties were characterized and analyzed using X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, spectroscopic ellipsometry, and UV/VIS/NIR spectrophotometry.

Diagnosis of Primary Aldosteronism without Discontinuation of Interfering Antihypertensive Medications.

Purpose Of Review: One of the challenges in the diagnosis and management of primary aldosteronism (PA), the most common type of secondary hypertension with curative potential, is the modification of antihypertensive medications. We seek to explore whether these medications can be continued during the diagnostic process of PA to minimize the duration and risks associated with medication adjustments.

Recent Findings: We searched PubMed for eligible original literature between 1990 and 2024 using the following keywords: (screening) AND (primary aldosteronism); (confirmatory) AND (primary aldosteronism); (adrenal vein sampling) AND primary aldosteronism).

Association of maternal pyrethroid pesticides exposure during the whole pregnancy with neonate lipid metabolism: A prospective birth cohort, Yunnan, China.

Dyslipidemias may emerge during the fetal period. However, the association between prenatal pyrethroid pesticides (PYRs) exposure and neonatal lipid metabolism remains uncertain. To explore the association of prenatal PYRs exposure and neonates' lipid metabolism, pregnant women were recruited in rural Yunnan, China, and their urine samples in the first, second, and third trimester and their neonates' cord blood samples were collected to obtain urinary PYRs metabolites (3PBA, 4F3PBA, and DBCA), cord blood TC, TG, HDL-C, LDL-C, and Non-HDL-C, AIP, CRI-I, CRI-II, AC, and LCI.

Atroposelective synthesis of axially chiral indolizinylpyrroles by catalytic asymmetric Paal-Knorr reaction.

We present herein a highly efficient atroposelective synthesis of five/five-membered -indolizinylpyrrole through the chiral phosphoric acid (CPA) catalyzed Paal-Knorr reaction of 3-aminoindolizines and 1,4-diketones. The reaction features mild reaction conditions, broad substrate scope and excellent enantioselectivity. Moreover, this method provides a facile approach to a novel axially chiral indolizine-pyrrole framework.

Association between particulate matter exposure and acute ischemic stroke admissions in less-polluted areas: a time-series study using a distributed lag nonlinear model.

Purpose: China has experienced a heavy public health burden due to the increasing incidence of ischemic stroke (IS). Few studies have evaluated the relationship between particulate matter (PM) exposure and acute ischemic stroke (AIS) in relatively less-polluted areas, and the results have been inconsistent. As a result, this study aimed to investigate and evaluate the association between PM exposure and hospitalizations for AIS in an area with less air pollution.

Self-assembled near-infrared-photothermal antibacterial Hericium erinaceus β-glucan/tannic acid/Fe (III) hydrogel for accelerating infected wound healing.

Bacterial infection severely hinders skin wound healing, highlighting the critical application value of developing antibacterial and anti-inflammatory hydrogel dressings. In this work, we focused on β-glucan from Hericium erinaceus (HEBG) as the research object, and proposed a solvent-induced combined temperature manipulation technique to trigger multilevel self-assembly of β-glucan. Furthermore, we incorporated green synthesized near-infrared photosensitizer tannic acid (TA)/iron (III) complex into the system.

Dietary Polysaccharide Improves Growth Performance and Meat Quality Associated with Alterations of Gut Microbiota in Arbor Acre Broilers.

Adding edible fungal polysaccharides to animal diets improves growth performance, meat quality, intestinal health, and immunity without adverse effects. This study aimed to evaluate the impact of polysaccharide (PCP, including PCP250, PCP500, PCP750, and PCP1000 mg/kg) on the growth performance, meat quality, and microbial composition of Arbor Acre (AA) broilers (total 180) by metabolomics and high-throughput sequencing. The results showed that adding PCP enhanced chicken meat tenderness, redness (*), and water retention and raised essential amino acids and flavor amino acids (such as umami and sweet amino acids) content.

New-generation tetracyclines for severe macrolide-resistant Mycoplasma pneumoniae pneumonia in children: a retrospective analysis.

Background: Macrolide-resistant Mycoplasma pneumoniae (MRMP) strains are increasingly prevalent, leading to a rise in severe Mycoplasma pneumoniae pneumonia incidence annually, which poses a significant threat to children's health. This study aimed to compare the effectiveness and safety of oral minocycline and doxycycline for the treatment of severe MRMP pneumonia in children.

Methods: This retrospective analysis included children treated for severe MRMP pneumonia at the Pediatric Department of Tongji Hospital, Shanghai, China, between September 2023 and January 2024 using minocycline and doxycycline.