Targeting Ferroptosis: Emerging Insights into Osteoporosis Mechanisms.

Ferroptosis, a distinct form of programmed cell death characterized by iron-dependent lipid peroxidation, has emerged as a critical factor in the pathogenesis of various diseases. Given the increasing prevalence of osteoporosis worldwide and the increasing incidence of osteoporosis, understanding the molecular mechanisms underlying bone loss is imperative for developing targeted therapies. Recent evidence suggests that ferroptosis plays a pivotal role in osteoporosis by influencing the balance between osteoblast and osteoclast activity.

Esophageal pericardial fistula following radiation therapy after placement of an esophageal stent: A case report and literature review.

Esophageal pericardial fistula is a rare complication of esophageal cancer. This article reports the first documented case of an esophageal pericardial fistula following radiotherapy in the presence of an esophageal stent. A 62-year-old man with advanced esophageal and cardiac cancer underwent radiotherapy after esophageal stent placement and subsequently developed an esophageal pericardial fistula.

Discursive construction of the 'scholar' identity: a critical genre analysis of chinese and english academic biographies.

Scholar biographies, though often overlooked, serve as a significant genre for the discursive construction of academic identity. This study adopts a Critical Genre Analysis (CGA) framework to examine how professional identities are constructed in Chinese and English scholar profiles within the field of linguistics. Combining textual analysis with interview data, the research identifies shared rhetorical structures and recurring identity types, alongside notable cross-cultural differences shaped by institutional, and socio-cultural factors.

Sepsis toxicity network reconstruction-Dynamic signaling and multi-organ injury: A review.

Sepsis is a complex systemic disease in which systemic toxicity-arising from inflammation-immune dysregulation, oxidative stress, programmed cell death (apoptosis, pyroptosis, ferroptosis), and metabolic reprogramming-drives multi-organ injury. The aim of this review was to synthesize how signaling pathways evolve within and between key organs (lungs, liver, kidneys, heart) and to evaluate whether multi-omics integration and network modeling can identify critical toxic nodes and predict disease progression. We conducted a narrative review of English-language mechanistic studies published between 2015 and 2025 in PubMed, Web of Science, and Scopus, supplemented by bibliography screening, while excluding case reports, conference abstracts, and non-mechanistic work.

Peptide codes for organ-selective mRNA delivery.

Organ-selective delivery of messenger RNA (mRNA) is critical for fulfilling the therapeutic potential of mRNA-based gene and protein replacement technologies. Despite clinical advances in the hepatic delivery of mRNA using lipid nanoparticles (LNPs), current strategies for extrahepatic-organ-selective mRNA delivery still have limitations. Here we report a peptide-encoded organ-selective targeting (POST) method for the delivery of mRNA to extrahepatic organs after systemic administration, which is based on the modular tuning of LNPs through surface engineering with specific amino acid sequences (POST codes).

Safety of laser double zona drilling for trophectoderm biopsy in preimplantation genetic testing.

Objective: This study evaluates whether laser double-zona drilling (DZD) during trophectoderm biopsy improves clinical outcomes in preimplantation genetic testing (PGT).

Methods: A total of 545 couples who underwent PGT-A using trophectoderm biopsy between December 2016 and May 2023 were included in the study. PGT cycles were categorized into two groups: DZD and single-zona drilling (SZD).

Iron Oxide Nanoparticles Activate Innate Immunity Through Toll-Like Receptors and Cooperate with CpG as a Potent Nano-Adjuvant.

Iron oxide nanoparticles (IONPs) have wide biomedical applications and are initially considered with minimal immunogenicity. Recent studies reveal that IONPs can activate the immune system through reactive oxygen species (ROS) or interferon regulatory factor (IRF) pathways. However, the exact mechanism remains unclear.

The impact of pt-NGS technology on antimicrobial use and outcomes in patients with lower respiratory tract infections: a hospital-based real-world study.

Objective: This study aimed to evaluate the impact of pathogen-targeted next-generation sequencing (pt-NGS) technology on antimicrobial use and clinical outcomes in hospitalized adults with lower respiratory tract infections (LRTIs).

Methods: In this retrospective cohort study, 340 adult LRTI patients were stratified into two groups: a pt-NGS-guided group ( = 140) and a conventional microbiological testing-guided group ( = 200). Outcomes included pathogen detection rates, antimicrobial therapy adjustments, clinical outcomes (mortality, length of stay LOS, ICU admission), and healthcare costs.

Global Research Trends and Collaborative Networks in Bioelectrical Impedance Analysis for Dialysis Patients: A Bibliometric Analysis from 1990 to 2024.

Introduction: Chronic Kidney Disease (CKD) is a global public health issue. Bioelectrical impedance analysis (BIA) is a non-invasive and cost-effective method used for nearly three decades to assess the nutritional and volume status of dialysis patients. Despite its clinical utility, the quality of research and emerging trends in this field are not well understood.

Distributed Fault Detection for Cyber-Physical Systems With Application to Power Network System.

In this article, we investigate the problem of distributed fault detection for a class of CPS whose physical layer consists of numerous subsystems, each modeled as a linear discrete-time system. Considering the influence of process noise and measurement noise, the state estimation of each subsystem is completed using a distributed Kalman filter (DKF), in which the one-step prediction is corrected not only by the local innovation but also by the measurement errors of the neighbors at the previous step. Leveraging the DKF, a local residual generator is designed for each subsystem.

The preparation of amphiphilic carbonaceous particle-derived membranes as a potent sterilant and anticoagulant.

: To synthesize and evaluate the function of antibacterial and anticoagulant properties of amphiphilic carbonaceous particle (ACP) derived polyurethane composite membranes TPU/ACPs-CS-PVS-Ag/ACPs-CS-Hep. : ACPs, ACPs-CS, ACPs-CS-PVS-Ag, ACPs-CS-Hep and ACPs-CS-PVS-Ag/ACPs-CS-Hep were prepared and mixed with a TPU matrix, to assess the dispersibility respectively. The blank TPU, TPU/ACPs, TPU/ACPs-CS, TPU/ACPs-CS-PVS-Ag, TPU/ACPs-CS-Hep and TPU/ACPs-CS-PVS-Ag/ACPs-CS-Hep membranes were prepared.

Correction: The composition and predictive function of the fecal microbiota in female donkeys across different reproductive cycles.

[This corrects the article DOI: 10.3389/fmicb.2025.

Spatio-temporal characteristics of the gastrointestinal resistome in a cow-to-calf model and its environmental dissemination in a dairy production system.

Microbiome and resistome transmission from mother to child, as well as from animal to environment, has been widely discussed in recent years. Dairy cows mainly provide milk and meat. However, in the dairy production system, the characteristics and transmission trends of resistome assembly and the microbiome in the gastrointestinal tract (GIT) remain unclear.

Thermodynamic Miscibility-Guided Engineering of Bismuth-Tin Janus Catalysts for Durable Electrocatalytic CO Reduction.

Interfaces in heterogeneous bimetallic catalysts play a pivotal role in providing rich active sites and accelerating charge transfer during reaction process. However, designing an interface-rich catalyst with sufficient exposed active sites is crucial yet challenging. Janus catalysts containing bifunctional surfaces segregated by interfaces can boost the performance of electrochemical CO reduction by optimizing electronic structure and reaction pathway.

Effects of dietary cinnamic acid supplementation on growth performance, meat quality, muscle development and antioxidant capacity of Yuedong black pigs.

Cinnamic acid (CA) is a natural bioactive substance with antimicrobial, anti-inflammatory and antioxidant properties, which has potential value as a novel feed additive. This study investigated the effects of CA supplementation on growth performance, carcass characteristics, meat quality, energy metabolism and antioxidant capacity in muscle of Yuedong black pigs. A total of 100 3-month-old Yuedong black pigs with an initial body weight of 35 kg were selected and randomly assigned to two treatment groups: the control group and the 0.

Surface-Engineered Molybdenum Oxide with Cucurbit[6]uril for Enhanced Nitrogen Reduction Electrocatalysis.

Electrocatalytic nitrogen reduction (NRR) offers a sustainable pathway for ammonia (NH) production but is challenged by the low solubility of N in aqueous electrolytes, the high energy barrier of N activation, and the competing hydrogen evolution reaction (HER). Herein, cucurbit[6]uril (CB[6]) is immobilized onto the surface of molybdenum oxide (CB[6]@MoO). The CB[6]@MoO catalyst exhibits a high NH production rate of 27.

Resveratrol Improves Idiopathic Pulmonary Fibrosis by Targeting IKZF3.

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited treatment options. This study investigates the therapeutic potential of resveratrol, a natural compound, in treating IPF by targeting IKZF3, a transcription factor upregulated in IPF patients. Using bioinformatics analysis of the GSE110147 dataset, we identified IKZF3 as a key molecule in IPF progression.

Toti: An integrated multi-omics database to decipher the epigenetic regulation of gene expression in totipotent stem cells.

Totipotent stem cells (TSCs), the origin of mammalian life and the foundation of early embryogenesis, possess the highest differentiation capacity and extensive developmental potential. However, none of the existing embryonic databases have provided epigenetic and transcriptomic resources on totipotency, greatly limiting our understanding of its establishment and exit mechanisms. Here, we present Toti, a pioneering multi-omics database developed to investigate transcriptional and epigenetic factors governing totipotency, encompassing in vivo, in vitro, and genome-edited human and mouse embryonic TSCs, TSC-like cells, pluripotent stem cells, and embryos spanning preimplantation stages, with a total of 8,284 samples.

Improved preoperative planning for endovascular therapy: High-resolution vessel wall magnetic resonance imaging shows promise in identifying proximal occlusion site and distal boundary of the occlusion of acute ischemic stroke.

Background And Purpose: Detecting the proximal occlusion site (POS) and distal boundary of the occlusion (DBO) of arterial occlusion is very important for the prognosis of endovascular treatment. Recent studies have shown that magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) are also beneficial for preoperative patient selection for endovascular therapy. High-resolution vessel wall MRI (HRVW-MRI) for intraluminal detection of arterial largevessel occlusions (LVOs) is receiving increasing attention.

Discovery of a novel mitophagy inducer attenuating postoperative cognitive dysfunction through structure-based virtual screening and biological validation.

Postoperative cognitive dysfunction (POCD), a prevalent complication following surgery and anesthesia, currently lacks effective therapeutics. Given the crucial regulatory role of the PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy in maintaining mitochondrial homeostasis and suppressing neuroinflammatory responses, we aimed to identify novel mitophagy inducers as potential therapeutic interventions for POCD. Employing structure-based virtual screening of a small-molecule library of compounds, we identified tamarixetin as a potent and selective PINK1 activator.

[Influence of hypertension and antihypertensive drugs on erectile dysfunction and the underlying mechanism: An update].

Hypertension is a most common chronic disease and a most important risk factor for cardiovascular and cerebrovascular diseases, and is also closely related to the development and progression of erectile dysfunction (ED). Existing evidence shows that hypertension is a risk factor for ED due to comorbidities. ED can also be regarded as the "message tree" of cardiovascular diseases.

Three-Dimensional Computed Tomography Angiography Fusion Imaging for Posterior Interosseous Artery Perforator Location of Forearm Flap: A Retrospective Study of 23 Patients.

BackgroundFlap surgery necessitates accurate identification of perforator locations for optimal outcomes. Color Doppler Sonography (CDS) has been a routine examination in preoperative planning, but its limitations in providing a comprehensive map of perforators relationships prompts exploration of alternative imaging modalities. This study introduces the application of a novel technique, three-dimensional computed tomography angiography fusion imaging (3D-CTA-FI), for precise interosseous artery perforator locating in forearm flap surgery.

Spatial-temporal cascaded network for dynamic [C]acetate cardiac PET parametric images generation based on one-tissue compartment model.

Background: One-tissue compartment model (1TCM) kinetic parameters calculated from dynamic [C]aceta te cardiac PET/CT imaging can assess cardiac function and assist clinical diagnosis. However, the long acquisition time of dynamic data hinders its clinical application.

Purpose: This study proposed a deep learning-based method for the generation of [C]acetate 1TCM kinetic parametric images with shortened dynamic PET data, aiming to explore the feasibility of reducing the time required for parametric analysis.

Tris(2-chloroethyl) phosphate alters gut microbiota and hepatic metabolism in freshwater turtles at environmentally relevant concentrations.

Tris(2-chloroethyl) phosphate (TCEP), a widely used organophosphate flame retardant continuously released into freshwater ecosystems, poses potential environmental risks due to its persistence and mobility. While TCEP toxicity has been studied in aquatic organisms, its effects on reptiles remain understudied. This study exposed 40 juvenile male Mauremys reevesii to environmentally relevant TCEP concentrations (0, 10, 100, and 1000 μg/L) for 60 days.

Differences in Habitat Quality Drive Behavioral Contrasts in Two Family Groups of the Critically Endangered Hainan Gibbon (Nomascus hainanus).

Understanding how spatiotemporal habitat variability shapes endangered species' behavior is crucial for effective conservation. This study examined the impact of fine-scale habitat variation on four behavioral patterns (feeding, resting, social, and traveling) of the critically endangered Hainan gibbon. Year-round behavior data were collected from two groups: GC inhabiting an area with abundant food resources, and GE in a secondary forest with sparse resources.