Diagnostic Performance of CT-Based Artificial Intelligence for Early Recurrence of Cholangiocarcinoma: A Systematic Review and Meta-Analysis.

Background: Despite AI models demonstrating high predictive accuracy for early cholangiocarcinoma(CCA) recurrence, their clinical application faces challenges such as reproducibility, generalizability, hidden biases, and uncertain performance across diverse datasets and populations, raising concerns about their practical applicability.

Objective: This meta-analysis aims to systematically assess the diagnostic performance of artificial intelligence (AI) models utilizing computed tomography (CT) imaging to predict early recurrence of CCA.

Methods: A systematic search was conducted in PubMed, Embase, and Web of Science for studies published up to May 2025.

Spatio-temporal characteristics of the gastrointestinal resistome in a cow-to-calf model and its environmental dissemination in a dairy production system.

Microbiome and resistome transmission from mother to child, as well as from animal to environment, has been widely discussed in recent years. Dairy cows mainly provide milk and meat. However, in the dairy production system, the characteristics and transmission trends of resistome assembly and the microbiome in the gastrointestinal tract (GIT) remain unclear.

Predicting knee osteoarthritis progression using neural network with longitudinal MRI radiomics, and biochemical biomarkers: A modeling study.

Background: Knee osteoarthritis (KOA) worsens both structurally and symptomatically, yet no model predicts KOA progression using Magnetic Resonance Image (MRI) radiomics and biomarkers. This study aimed to develop and test the longitudinal Load-Bearing Tissue Radiomic plus Biochemical biomarker and Clinical variable Model (LBTRBC-M) to predict KOA progression.

Methods And Findings: Data from the Foundation of the National Institutes of Health Osteoarthritis Biomarkers Consortium were used.

Reduced Antarctic Bottom Water overturning rate during the early last deglaciation inferred from radiocarbon records.

The rapid CO rise during the early deglaciation is often linked to enhanced ventilation by intensified Antarctic Bottom Water (AABW) overturning. The recorded radiocarbon ventilation seesaw during the early deglaciation, which describes improved Southern Ocean and reduced North Atlantic abyssal radiocarbon ventilation, has been interpreted as intensified AABW and reduced North Atlantic Deep Water convections. However, abyssal radiocarbon records also reflect changes in surface reservoir ages and interior water mass mixing.

MOF Glass Confined Black Phosphorus via Co─P Anchoring for Advanced Lithium-Ion Battery Anodes.

Although lithium-ion batteries (LIBs) dominate the commercial energy storage market, the prevailing graphite anode is approaching its theoretical capacity limit. Alloy-type anode materials like black phosphorus (BP) offer high theoretical capacity and intrinsic conductivity, but suffer from severe volume expansion and resultant structural instability. Here, an in situ vitrification strategy is reported to construct a composite anode material by integrating BP, Ketjenblack, and single wall carbon nanotube into a zeolitic imidazolate framework (ZIF) glass matrix.

Synthesis of Fluorinated 3-Pyrroline Aminals by a Pd(0)-Catalyzed Three-Component Hydroamidation/Heck/Tsuji-Trost Reactions.

Pyrrolidine aminal skeletons are found in many natural products and biologically active compounds. Therefore, the development of a new methodology for rapid access to this core is of high importance. Herein, we first reported results of a Pd(0)-catalyzed three-component hydroamidation/Heck/Tsuji-Trost reaction to afford fluorinated 3-pyrroline aminal derivatives based on β-CF-1,3-enynamides.

Global and regional temporal changes in cross-country inequalities of site-specific osteoarthritis burden, 1990-2021.

Objective: This study examined the global and regional temporal changes in cross-country inequalities of site-specific osteoarthritis (OA) burden from 1990 to 2021.

Methods: Age-standardized years lived with disability rate for site-specific OA across 204 countries/territories were obtained from the Global Burden of Diseases Study (GBD) 2021. The slope index of inequality (SII) and the concentration index (CCI) were calculated to quantify the absolute and relative cross-country inequalities.

Prognostic Value of 18Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography in Type A Aortic Intramural Haematoma.

Objectives: In this study, we aimed to assess 18fluorodeoxyglucose (18F-FDG) uptake in patients with type A aortic intramural haematoma (IMH) to establish its association with disease progression.

Methods: Patients with type A IMH receiving medical management were included. After the patient agreed to participate, 18F-FDG PET/CT was performed.

36 Mitigates Alcoholic-Associated Liver Disease Through Modulation of Microbiota and AMPK Signaling.

Background: Alcohol-associated liver disease (ALD) is characterized by gut-liver axis dysfunction and metabolic dysregulation, yet the therapeutic potential of probiotics remains underexplored. This study aimed to investigate the protective effects and mechanisms of 36 (LP36) against ethanol-induced ALD in mice.

Methods: Mice were pretreated with LP36 prior to ethanol exposure.

Intestinal microbiota changes in early life of very preterm infants with bronchopulmonary dysplasia: a nested case-control study.

Background And Aim: Bronchopulmonary dysplasia (BPD) is one of the most important complications of very preterm infants. This study was to investigate changes in the intestinal microbiota of very preterm infants with BPD.

Methods: We enrolled 50 very preterm infants at the gestational age of 24+-31+ weeks, categorizing them into the BPD group and control group, and fecal samples were collected on days 1, 7, 14, 21, and 28, respectively.

No apparent state-dependency of equilibrium climate sensitivity between the Pleistocene glacial and interglacial climate states.

Quantifying climate sensitivity is essential for future climate projections, yet it varies with major Earth system changes. We present a glacial CO₂ reconstruction using paleosols from the Chinese Loess Plateau, covering 2580 to 800 thousand years ago. A stepwise decline in glacial CO₂ levels from ~300 ppm to <200 ppm is observed.

Network pharmacology research and experimental verification of dietary flavonoid fisetin in treating myocardial hypertrophy.

In this study, network pharmacology was developed to study the mechanism of fisetin in the treatment of myocardial hypertrophy. A total of 41 common targets were obtained through multi-database screening, and the core targets were determined by PPI network analysis. KEGG enrichment suggested that the effects of fisetin were mainly related to PI3K-AKT and apoptotic pathways.

Microbial-mediated transformation shapes the molecular diversity of landfill leachate under anthropogenic and natural covariation.

Extensive landfill leachate from human activities is one of the most intractable liquid waste due to the presence of stubborn leachate dissolved organic matter (LDOM) and various pollutants. However, critical driving forces regarding LDOM complexity are still unclear. This study explores relationships between LDOM chemical composition, microbial community, anthropogenic factors and climate conditions based on national-scale landfill leachates in China.

AB-side growth strategy: a new approach to regulate the electrocatalytic performance of metal-organic framework composite materials.

In this work, we propose a new AB-side growth strategy for the first time to enhance the electrocatalytic activity and stability of pristine metal-organic framework (MOF) materials. This work provides a new perspective and synthetic strategy to construct high-performance and highly stable MOF composite materials.

Effects of different respiratory training methods on respiratory function in patients with spinal cord injury: a network meta-analysis of randomized controlled trials.

Objective: This network meta-analysis (NMA) compared the efficacy of various respiratory training methods in improving respiratory function in patients with spinal cord injury (SCI).

Methods: Randomized controlled trials (RCTs) on respiratory training interventions for SCI patients were searched in PubMed, Embase, Web of Science, and the Cochrane Library through September 1, 2024. The risk of bias in the included studies was assessed using the Cochrane tool.

Life-cycle assessment of concrete production with carbon capture and carbon upcycling process.

The main CO utilization methods for concrete production, aimed at reducing its carbon footprint, include several promising approaches. These methods include the carbonation of concrete, where CO reacts with calcium hydroxide to form calcium carbonate; CO-activated concrete, achieved by infusion of CO into concrete during the mixing or curing process; and carbonation of recycled concrete, which uses industrial byproducts like slag and fly ash to sequester CO. Another method is the use of biochar in concrete, where CO is sequestered from organic waste to enhance material properties.

Flexible multichannel muscle impedance sensors for collaborative human-machine interfaces.

The demand for advanced human-machine interfaces (HMIs) highlights the need for accurate measurement of muscle contraction states. Traditional methods, such as electromyography, cannot measure passive muscle contraction states, while optical and ultrasonic techniques suffer from motion artifacts due to their rigid transducers. To overcome these limitations, we developed a flexible multichannel electrical impedance sensor (FMEIS) for noninvasive detection of skeletal muscle contractions.

Maternal Electronic Cigarette Exposure Induces Dysregulation of Autophagy via Oxidative Stress/DNA Methylation in Pulmonary Hypertension Offspring.

Objective: Electronic cigarettes (ECs) differ from traditional tobacco smoke but may contribute to cardiopulmonary remodeling. Pulmonary hypertension (PH), characterized by pulmonary artery and right ventricle remodeling, poses a significant risk of mortality in infants, children, and adolescents. However, the impact of maternal EC exposure on PH development in offspring remains unclear.

Fabricated CoFePBA/NF-Derived Mixed Metal Sulfide as Multifunctional Catalysts for Enhanced Urea-Water Electrolysis.

This study demonstrates the successful fabrication of mixed-metal CoFePBA/NF with hierarchical 1D + 3D string-bead morphology through in situ conversion, followed by sulfidation to obtain highly active s-CoFePBA/NF. The optimized s-CoFePBA/NF (500 °C) demonstrates exceptional trifunctional electrocatalytic performance, achieving ultralow overpotentials of 226 mV (OER) and 127 mV (HER) at 10 mA cm, along with a remarkable UOR potential of 1.317 V.

Peroxiredoxin 6: A Regulatory Target in Cellular Senescence and Age-Related Diseases.

Oxidative stress is a key factor in inducing cellular senescence and age-related diseases. When the redox balance within the body is disrupted, sustained oxidative stress can lead to cellular senescence. The accumulation of senescent cells, in turn, triggers a variety of age-related diseases.

Mendelian Randomization Assessment of the Genetic Effects of Lipid-Lowering Drugs on Digestive System Cancers.

The relationship between lipid-lowering drugs and the risk of digestive system cancers remains unclear. This study aims to assess the risk association between lipid-lowering drugs and digestive system cancers through mendelian randomization (MR) analysis. We utilized genetic instruments to substitute for the exposure to lipid-lowering drugs, including expression quantitative trait loci (eQTL) for HMGCR, PCSK9, and NPC1L1, as well as genetic variants associated with low-density lipoprotein (LDL) from the Global Lipids Genetics Consortium's genome-wide association study (GWAS) data for target genes.

National Assessment of PFAS in Landfill Leachate in China: Non-Negligible Ultrashort-Chain Components and Socioeconomic Impacts.

The persistent leaching of per- and polyfluoroalkyl substances (PFAS) from landfills poses significant environmental risks, particularly to surrounding water systems. However, information regarding the occurrence and fate of PFAS in landfills across the country is limited. Here we investigated the distribution profiles and sources of 60 PFAS in landfill leachate across 31 provinces in mainland of China, showing the total levels of ∑PFAS from 3.