Regioselective construction of two isomeric BN-fused aromatic frameworks enabling the synthesis of ultralong room-temperature phosphorescence materials.

BN-fused aromatic compounds have garnered significant attention due to their unique electronic structures and exceptional photophysical properties, positioning them as highly promising candidates for applications in organic optoelectronics. However, the regioselective synthesis of BN isomers remains a formidable challenge, primarily stemming from the difficulty in precisely controlling reaction sites, limiting structural diversity and property tunability. Herein, we propose a regioselective synthetic strategy that employs 2,1-BN-naphthalene derivatives, wherein selective activation of N-H and C-H bonds is achieved in conjunction with -halogenated phenylboronic acids.

Pulsatile sequential drug release system for cascade tumor deep penetration and differentiation therapy to enhance chemoimmunotherapy.

Cancer stem cells (CSCs) and myeloid-derived suppressor cells (MDSCs) contribute to chemoresistance and immunosuppression, constraining chemoimmunotherapy outcomes. Differentiation therapy, aiming to mature CSCs and MDSCs, shows great promise. However, its efficacy is hindered by limited accessibility in hypoxic deep tumor regions.

Development and interlaboratory validation of a linearized plasmid DNA certified reference material by single molecule direct counting and digital PCR.

Digital PCR (dPCR) technology is widely utilized for various applications, including the quantification of gene mutations and copy number variations. Certified reference materials (CRMs) play a critical role in improving the comparability of dPCR results, establishing SI-traceable copy number concentration values for dPCR calibration remains a key challenge due to the limited availability of CRMs value-assigned by higher-order, independent methods. To tackle this issue, a linearized plasmid DNA reference material (RM) was developed and rigorously characterized through an interlaboratory comparison involving three national measurement institutes (NMIs) from China (NIM), South Korea (KRISS), and Japan (NMIJ).

Porous Janus membrane for ultrasensitive detection and efficient degradation of sulfur mustard simulant.

The development of integrated systems for simultaneous chemical threat detection and decontamination is hindered by inherent sensitivity-efficiency trade-offs. We address this challenge through interfacial engineering of a Janus membrane combining D-A molecule functionalized MOFs with PDMS. A gas-liquid interfacial self-assembly strategy enables the creation of a microporous PDMS top layer for vapor preconcentration and vertically aligned MOF nanochannels (2.

Impact of Multidisciplinary Collaboration on Microbiological Specimen Submission and Appropriate Use of Carbapenems: A Pre-Post Cohort Study.

Purpose: This study assessed the impact of multidisciplinary collaborative management on microbiological specimen submission rates and the rational use of carbapenem antibiotics.

Patients And Methods: A pre- and post-intervention cohort design was employed. From February to November 2024, a multidisciplinary antimicrobial stewardship intervention was implemented for hospitalized patients receiving carbapenem antibiotics.

Association Between ABCB1 Gene Polymorphism with Hyperglycemia and MACE in Patients Undergoing Clopidogrel Treatment After PCI.

Purpose: To evaluate the effect of C3435T gene polymorphism with hyperglycemia on the risk of major adverse cardiovascular events (MACE) in patients treated with clopidogrel after percutaneous coronary intervention (PCI).

Patients And Methods: A total of 117 patients were studied, of which 52 developed MACE. We used fluorescence in situ hybridization to detect the genotype of the and C3435T loci.

Statistical Analysis Plan for a Randomized Controlled Trial of Intensive Blood Pressure Control on Cardiovascular risk Reduction in Patients with Atrial Fibrillation.

Introduction: Elevated blood pressure (BP) is a key modifiable risk factor for cardiovascular (CV) complications in patients with atrial fibrillation (AF). While current guidelines recommend modest BP targets, the optimal target in AF patients remains uncertain. The Cardiovascular Risk Reduction in Atrial Fibrillation Trial (CRAFT) is a multicenter, prospective, randomized, open-label, blinded-endpoint trial that evaluates whether intensive home systolic BP control (<120 mmHg) is superior to standard BP control (<135 mmHg) in reducing major CV events.

Analyses of the formation and characteristics of flavor and taste in a sesame meal-based soy sauce.

Background: Sesame meal, characterized by high moisture, viscosity and oxidative instability, presents utilization challenges and is frequently relegated to farmland fertilizer - a practice that underutilizes its rich protein content.

Methods: This study developed three types of soy sauce using sesame meal supplemented with soybeans. For the first time, a dual-strain co-fermentation system employing Aspergillus oryzae 3.

Research on Deep Learning-Based Multi-Level Cross-Domain Foreign Object Detection in Power Transmission Lines.

With the rapid advancement of deep learning technology, deep learning-based methods have become the mainstream approach for detecting potential safety hazards in transmission lines, playing a crucial role in power grid safety monitoring. However, existing models are often overly complex and struggle with detecting small or occluded targets, limiting their effectiveness in edge-device deployment and real-time detection scenarios enhanced the YOLOv11 model by integrating it with the ConvNeXt network, a multi-level cross-domain analysis detection model (ConvNeXt-You Only Look Once) is proposed. Additionally, Bayesian optimization was employed to fine-tune the model's hyperparameters and accelerate convergence.

The United States Preventive Services Task Force (USPSTF) Guidelines vs. Electronic Health Record (EHR)-Based Screening: A Comparative Accuracy Study in Prostate Cancer.

Background: The United States Preventive Services Task Force (USPSTF) provides age-based recommendations for prostate cancer screening. Such a single-criterion strategy can not only miss aggressive cancers that occur before the designated cut-off age, but also over-screen men whose cancers occur at a much older age. A multi-factorial model incorporating a wide spectrum of medical history may offer more accurate predictions.

The TyG Index Mediates Air-Pollution-Associated Chronic Kidney Disease Incidence in HIV/AIDS Patients: A 20-Year Cohort Study.

Ambient air pollutants (APs) are associated with increased chronic kidney disease (CKD) risk in general populations, but their renal impact on HIV/AIDS patients remains understudied. This dynamic cohort included 7981 HIV/AIDS patients without baseline kidney disease from Wuhan and Zhenjiang, followed every 6 months with fasting blood tests to assess the triglyceride-glucose (TyG) index and estimated glomerular filtration rate (eGFR). Monthly average exposures to six APs were estimated from geocoded residential addresses.

Development and validation of an explainable machine learning model for predicting the risk of sleep disorders in older adults with multimorbidity: a cross-sectional study.

Objective: To develop and validate an explainable machine learning model for predicting the risk of sleep disorders in older adults with multimorbidity.

Methods: A total of 471 older adults with multimorbidity were recruited between October and November 2024. We employed six machine learning (ML) methods, namely logistic regression (LR), neural network (NN), support vector machine (SVM), gradient boosting machine (GBM), K-Nearest Neighbors (KNN), and light gradient boosting machine (LightGBM), to predict the risk of sleep disorders based on their sociodemographic data, health behavior factors, mental health, and disease-related data.

The role of serological testing for vaccination with a focus on immunocompromised patients: a synthesis of current evidence.

Immunocompromised individuals are at high risk of vaccine-preventable diseases, but typically have impaired immune responses to vaccination and require altered vaccination schedules. Serological testing can inform vaccination decisions in this vulnerable population, but is frequently ordered inappropriately. Furthermore, misinterpretion of serological results can misguide clinical decisions.

Spinal segment-specific properties of neural stem cells contribute to the outcomes of spinal cord injury repair.

Neurons in distinct spinal cord segments serve specific functions, raising questions about whether human spinal cord-derived neural stem cells (hscNSCs) retain segment-specific properties crucial for spinal cord injury (SCI) repair. We established a culture system amplifying hscNSCs from cervical, thoracic, and lumbar segments, revealing segment-specific transcriptional profiles and differentiation potentials. Notably, thoracic hscNSCs exhibited elevated hepatocyte growth factor (HGF) expression inherited from the pre-ganglionic column, enhancing their differentiation into motor neurons.

Influence of hydrophilic polysaccharides as fat substitutes on the digestibility of myofibrillar protein gels.

Among all fat substitutes, hydrophilic polysaccharides can simultaneously meet the requirements of processing, sensory, and functional properties, thus have been widely used in meat products. However, there are few reports on the impact of the addition of hydrophilic polysaccharides on the digestibility of myofibrillar protein gels. This study focused on four hydrophilic polysaccharides including octenyl succinic anhydride (OSA) modified starch, sodium alginate (SA), konjac gum (KG) and xanthan gum (XG).

Predictive modeling of antioxidant synergies in fruits and vegetables: A multi-objective optimization approach for functional food design.

Complex interactions among phytochemicals in fruits and vegetables underpin their antioxidant benefits. Here, we introduce a multi-objective optimization framework to predict optimal functional-food combinations. Twelve key phytochemicals were evaluated at nine ratios using DPPH and ABTS assays, revealing ratio-dependent synergy or antagonism (e.

Meta-analysis of mortality factors after COVID-19 infection in pediatric oncology patients.

Objective: There are few clinical studies related to COVID-19 in pediatric cancer patients, and systematic reviews or meta-analyses on its mortality risk factors are particularly lacking. Therefore, we conducted this meta-analysis to systematically analyze the mortality risk factors of pediatric cancer patients after COVID-19 infection, providing effective evidence-based medical evidence for epidemic prevention and control and clinical treatment of pediatric COVID-19 patients.

Methods: Electronic databases of PubMed, Embase, Cochrane Library and Web of Science were searched using "cancer" "COVID-19" "children" "mortality" related subject headings and keywords.

Organic carbon facilitates the release of organic phosphorus by converting stable organic phosphorus into bioavailable forms in eutrophic sediments.

Organic phosphorus (OP) constitutes an important fraction of total phosphorus in lake sediments, with its mobility being influenced by mineralization and transformation of organic carbon (OC). OP and OC co-exist in various forms in the environment, thus a thorough investigation on the impact of OC fractions on the release of OP in sediments should be comprehensively carried out. This study determined the chemical forms of OP and OC in the sediments over four seasons in Lake Taihu and found temporal and spatial variations in their concentrations.

Translation and psychometric evaluation of the Chinese version of the mathematical resilience scale.

The translation of the Mathematics Resilience Scale (MRS) into Chinese provides an essential tool for educational research within Chinese cultural contexts, and this study supports educators in identifying emotional and cognitive barriers that students encounter in mathematics learning, thereby enabling targeted interventions. This study focuses on translating the MRS into Chinese and evaluating its reliability and validity within the Chinese context. The translation adhered to Beaton et al.

Influence of six teaching methods on critical thinking ability of nursing students: a protocol for systematic review and network meta-analysis.

Introduction: To enhance nursing students' critical thinking abilities, numerous educators have explored alternative teaching methods. While meta-analyses have confirmed that various approaches are effective in developing critical thinking, consensus regarding their comparative effectiveness remains elusive. Furthermore, few investigations have directly contrasted the outcomes across these methods, highlighting the necessity to undertake a comprehensive evaluation of their impact on nursing students' critical thinking skills.

The toggle switch model for gene expression change during duck skeletal muscle development.

Skeletal muscle development, a precisely orchestrated process, is vital for animal movement, energy metabolism, and meat production. Among Chinese poultry breeds, the Pekin duck and Liancheng duck are prominent, distinguished by their unique meat qualities and growth rates. In this study, we identified developmentally dynamic genes (DDG) by RNA sequencing of skeletal muscle tissues at different time points, from 1 to 42 days after birth, and found DDGs with opposite expression patterns in the early and late periods of skeletal muscle development.

Factors influencing healthcare workers' vaccine recommendations: A cross-sectional study in Zhejiang Province, China.

To investigate factors influencing vaccine recommendations by healthcare workers (HCWs) in Zhejiang Province, China. A cross-sectional survey was conducted among 569 HCWs to assess their beliefs and attitudes toward vaccines, vaccine recommendations and barriers to recommending vaccinations. Logistic regression was utilized to analyze influencing factors.

Increased peripheral CD4 lymphocytes promote ketamine-induced abnormal behaviors in mice.

Ketamine (Ket) is a globally widely used injectable anesthetic and recreational drug that can lead to persistent behavioral deficits and induce psychotic states. Immune pathogenesis is believed to play a pivotal role in psychological symptoms and abnormal behavior. However, the role of the immune system, particularly peripheral immune changes, in ketamine-induced behavioral deficits and even psychotic symptoms remains largely elusive.

Effects of various static calibration postures on knee mechanics during locomotor tasks using statistical parametric mapping analysis.

This study aims to examine the effects of various static standing postures on knee biomechanics during dynamic activities, including walking, running, and jumping. Twenty healthy participants (10 males and 10 females; age: 24.7 ± 1.