Regioselective construction of two isomeric BN-fused aromatic frameworks enabling the synthesis of ultralong room-temperature phosphorescence materials.

BN-fused aromatic compounds have garnered significant attention due to their unique electronic structures and exceptional photophysical properties, positioning them as highly promising candidates for applications in organic optoelectronics. However, the regioselective synthesis of BN isomers remains a formidable challenge, primarily stemming from the difficulty in precisely controlling reaction sites, limiting structural diversity and property tunability. Herein, we propose a regioselective synthetic strategy that employs 2,1-BN-naphthalene derivatives, wherein selective activation of N-H and C-H bonds is achieved in conjunction with -halogenated phenylboronic acids.

Exploring the role of long noncoding RNAs in immune regulation and pediatric asthma pathogenesis.

Pediatric asthma, a growing chronic condition, faces diagnostic and treatment challenges in the post-COVID era. This study uses bioinformatics to explore lncRNAs' roles in pediatric asthma, aiming to improve diagnosis and treatment. To identify differentially expressed lncRNAs, the study will utilize a 2-pronged approach: obtaining gene expression datasets from the gene expression omnibus and recruiting patients for gene sequencing.

Estrogen-mediated TRPV5 modulates proliferation and apoptosis of rat cochlear hair cells via the PI3K/Akt pathway.

Objective: Transient Receptor Potential Vanilloid 5 (TRPV5) is an essential Ca transporter mediated by estrogen in osteoclast differentiation and bone resorption. However, the mechanism of how estrogen mediates TRPV5 expression in Benign Paroxysmal Positional Vertigo (BPPV) remains unclear.

Methods: In this study, the Ovariectomized (OVX) rats were established to explore whether TRPV5 was regulated by estrogen.

Neoadjuvant chemoradiation with camrelizumab and nimotuzumab for initially inoperable esophageal squamous cell carcinoma: A single-arm phase 2 trial.

Background: Neoadjuvant regimen with a high surgical conversion rate was warranted for initially inoperable patients with locally advanced esophageal squamous cell carcinoma (LAESCC). To evaluate the efficacy and safety of neoadjuvant chemoradiotherapy combined with camrelizumab and nimotuzumab (NCRCN) followed by surgery in initially inoperable patients with LAESCC.

Methods: This cohort study was a prospective, one-arm, phase 2 study from December 2021 to December 2023.

Erratum: Random-walk shielding-potential viscosity model for warm dense metals [Phys. Rev. E 106, 014142 (2022)].

This corrects the article DOI: 10.1103/PhysRevE.106.

Theoretical Investigation of the Laser-Induced Ionization-Fragmentation Dynamics of H Associated with Ionization Timings.

The theoretical investigation on the laser-induced ionization-fragmentation dynamics is very challenging, all dynamics processes from neutrality to ionization and then to fragmentation of molecular ions must be considered. In this work, we develop a quantum time-dependent wave packet evolution method to simulate the entire process of laser-induced ionization-fragmentation of H. Our investigation specifically delves into the influence of laser ionization timing of neutral H on molecular kinetic energy release and orientation of H.

Splenectomy and risk of hepatocellular carcinoma.

Hypersplenism is a common complication of cirrhosis that is associated with significant impairment to patients' life quality. Splenectomy is often employed in clinical settings as a treatment for hypersplenism. While splenectomy is carried out for the purposes of alleviating hypersplenism-related adverse outcomes like thrombocytopenia or anaemia, studies have suggested alterations in the immune status, hemodynamics, and intestinal microbiota of patients following splenectomy, which may potentially influence the onset and progression of hepatocellular carcinoma (HCC).

Choline reduces inflammatory response and lipid accumulation in calf hepatocytes induced by NEFA via inhibiting ROS/ NF-κB/NLRP3 inflammasome axis.

Perinatal dairy cows are highly susceptible to fatty liver syndrome, a prevalent metabolic disorder characterized by excessive hepatic lipid accumulation. Although inflammatory progression drives the transition from physiological lipid storage to pathological steatosis, the underlying mechanisms remain incompletely understood. This study investigates the therapeutic potential of choline in non-esterified fatty acid (NEFA)-induced hepatic inflammation and lipid metabolism dysregulation using an in vitro calf hepatocytes model.

High-Entropy Metallene Arrays with a Turing Structure for Electrocatalytic Upcycling of Polyethylene Terephthalate Plastics Coupled with Electrosynthesis of Ammonia.

The electrocatalytic upgrading of polyethylene terephthalate (PET) plastics and nitrate-containing wastewater into value-added chemicals provides a promising sustainable strategy for dual-waste utilization. In this work, metallene arrays with a Turing structure were constructed through the self-assembly of high-entropy alloy (HEA) nanocrystals (PdPtCuNiAg MARs) and applied for the upcycling of PET plastics coupled with the electrosynthesis of ammonia. The electrocatalytic coupled system can achieve a current density of 400 mA cm at a low voltage of 1.

Optical Autocorrelator Based on InSe-Integrated Silicon Waveguide.

We demonstrate an on-chip single-shot autocorrelator by integrating few-layer InSe onto a silicon waveguide. With the strong second-order nonlinearity of InSe, a strong second harmonic generation (SHG) signal happens when counter-propagating pulses overlap within the InSe-integrated silicon waveguide. By mapping the spatial intensity distribution of the SHG signal into the time domain, the temporal profile of the pulse and group index of the waveguide modes were characterized successfully.

Prediction system for gallbladder cancer distant metastasis a retrospective cohort study based on machine learning.

Background: The prognosis for gallbladder cancer (GBC) patients is generally poor due to the early occurrence of distant metastasis (DM). However, research on predicting the risk of DM in GBC patients is still limited. Therefore, this study aimed to apply the Surveillance, Epidemiology, and End Results (SEER) database with machine learning (ML) methods to construct a novel model for predicting the risk of DM in GBC patients.

Application of Pulsed Laser Deposition (PLD) Technology in the Preparation of Two-Dimensional (2D) Film Materials.

Two-dimensional film materials with unique atomic structures and electronic operation modes have demonstrated amazing application potential and value in the field of high technology. Among the various methods for preparing 2D film materials, PLD technology has become the preferred technology for rapid and green preparation of high-quality, complex structured 2D film materials due to its features such as maintaining the excellent stoichiometric ratio of the target, strong process flexibility, and non-polluting environment. Therefore, this paper discusses the exciting topic of PLD technology in the preparation and application of 2D film materials.

Lag-Specific Transfer Entropy for Root Cause Diagnosis and Delay Estimation in Industrial Sensor Networks.

Industrial plants now stream thousands of temperature, pressure, flow rate, and composition measurements at minute-level intervals. These multi-sensor records often contain variable transport or residence time delays that hinder accurate disturbance analysis. This study applies lag-specific transfer entropy (LSTE) to historical sensor logs to identify the instrument that first deviates from normal operation and the time required for that deviation to appear at downstream points.

Unraveling the Causal Links Between Immune Traits and Hepatocellular Carcinoma: Insights From a Bi-Directional Mendelian Randomization Study.

Background/Aims: Hepatocellular carcinoma (HCC) is significantly influenced by the immune system, which plays a key role in its development, progression, treatment, and prognosis. While observational studies have revealed correlations between circulating immune traits and HCC, their genetic basis and causal links remain unclear. This study aims to investigate the genetic associations and bidirectional causal relationships between immune traits and HCC risk using Mendelian randomization (MR) approaches.

Doping Bulky Fluorinated Organic Anion to Construct Highly Efficient Anion-π Type Photosensitizers for Cancer Phototheranostics.

Anion-π type photosensitizers with aggregation-induced emission (AIE) feature have demonstrated promising potential in photodynamic therapy (PDT) against cancer. However, previous reports mainly focused on modifying the π core but often overlooked the crucial role of anions. Herein, we present a facile strategy to modulate the fluorescence intensity and cellular uptake of anion-π type AIE photosensitizers by doping bulky fluorinated organic anions into nanoparticles (NPs).

On-chip graphene photodetectors with a nonvolatile p-i-n homojunction.

Graphene's unique photothermoelectric (PTE) effect, combined with its compatibility for on-chip fabrication, promises its development in chip-integrated photodetectors with ultralow dark-current and ultrafast speed. Previous designs of on-chip graphene photodetectors required external electrical biases or gate voltages to separate photocarriers, leading to increased power consumption and complex circuitry. Here, we demonstrate a nonvolatile graphene p-i-n homojunction constructed on a silicon photonic crystal waveguide, which facilitates PTE-based photodetection without the need for electrical bias or gate voltages.

Diversity of symbiotic microbes and their potential functions associated with multiple development stages of Zeugodacus tau (Walker).

Zeugodacus tau is a major quarantine insect pest that causes considerable damage to vegetable industries in Jiangxi area. Symbiotic microbes play essential roles in the long-term coevolution of host insects. While symbiotic bacteria are increasingly recognized as pivotal mediators of insect physiology and ecology, characterization of bacteria dynamics across life cycles of Z.

The role of abnormal epigenetic regulation of small GTPases in glioma (Review).

Brain tumors are one of the most severe types of malignant tumors and glioma accounts for ~80% of malignant brain tumors. The current treatment methods for glioma are limited and patients with glioma often experience relapse following treatment, which leads to a poor prognosis for these patients. Therefore, novel therapeutic targets and methods urgently need to be explored.

Conceptual design of a decision knowledge service model integrating a multi-agent supply relationship diagram for electric power emergency equipment.

Introduction: The decision regarding the supply of emergency equipments for power emergencies requires timeliness, efficiency, and accuracy. The multi-agent supply relationship graph, based on complex data fusion, enables the comprehensive exploration of interconnections among key entities in power emergency supplies.

Methods: This approach enhances decision-making efficiency and quality by uncovering multiple relationships between main bodies involved.

Valence state engineering in multi-heteroatom-doped PAHs: a strategy for tunable photophysical properties and phototheranostic potentials.

Precise modulation of the electronic structures in heteroatom-doped polycyclic aromatic hydrocarbons (hetero-PAHs) is essential for advancing organic optoelectronic materials. Herein, we report a facile synthetic strategy for hetero-PAHs co-doped with N, O, and S/Se, achieved acid-catalyzed Pictet-Spengler reactions and thermally induced -substitution. Systematic π-extension results in a large redshift in optical absorption/emission and enhances fluorescence quantum yield ( ) from 4.

N─B─N Isomer Induced Room Temperature Phosphorescence: Expression, Mechanistic Insights, and Multi-Level Anti-Counterfeiting Applications.

Achieving pure organic room temperature phosphorescence (RTP) materials is of great interest due to their applications in optoelectronics. However, improving RTP in pure organic materials by controlling triplet excitons is challenging due to their complex relaxation processes. Therefore, exploring effective strategies to modulate triplet excitons is crucial.

Non-esterified fatty acids disrupt hepatic lipid metabolism and mitochondrial function via TLR4/MyD88/IRAK2 signaling in bovine hepatocytes.

Excessive non-esterified fatty acids (NEFA) in the blood often lead to ketosis and fatty liver in peripartal cows. The integrity of mitochondrial structure and function plays a key role in the development of lipid metabolism imbalance and inflammation. However, the precise molecular mechanisms of NEFA's impact on these processes remain unclear.

Mechanism of Isotropic Behavior in Titanium Alloy Plates Formed by Axial Closed Die Rolling.

The torsional behavior during the deformation process of the axial closed die rolling the axial closed rolling (ACDR) forming is studied in this paper using a numerical simulation technique on TC11 titanium alloy. The axial and radial pinch angles, as well as the degree of specimen torsion, increased with the amount of deformation. The orientation distribution function (ODF) maps of the α-phase and β-phase were obtained by Electron Back Scatter Diffraction (EBSD) treatment of the TC11 titanium alloy.

Association between the expression difference of cortisol in umbilical cord blood and discordant growth in dichorionic twins: a cross-sectional survey.

Background: This study aimed to assess whether the expression difference of cortisol in umbilical cord blood is associated with dichorionic twin inconsistent growth.

Methods: This research included 108 patients with dichorionic twin pregnancy delivered at Jiaxing Maternity and Child Health Care Hospital between January 2021 and December 2024. Depending on whether or not they had twin inconsistent growth, participants were classified into the discordant twins (DT) group (47 pairs of discordant twins) as the experimental group and the concordant twins (CT) group (61 pairs of concordant twins) as the control group.

Analytical Framework for Online Calibration of Sensor Systematic Errors Under the Generic Multisensor Integration Strategy.

This paper proposes an analytical framework for pre-analyzing the potential performance of online sensor calibration in Kalman filtering. Taking a multi-sensor integrated kinematic positioning and navigation system as an example, a pre-analysis of the system performance can be conducted: the observability of individual sensor systematic error states; minimum estimable values of sensor systematic error states; and minimum detectable systematic errors in sensor observations. These measures together allow for a rigorous characterization of the potential performance of a system as part of mission planning.