Exploration of preventive treatment for high risk patients with metachronous multiple esophageal squamous cell carcinoma: A case report.

Background: Metachronous multiple esophageal squamous cell carcinomas (ESCCs) may occur in some patients after endoscopic resection. Multiple dysplastic lesions in the esophagus increase risk of multiple squamous cell carcinomas (SCCs). Endoscopic imaging technology such as narrow band imaging (NBI), can detect early SCC.

A mini-review of the relationship between intestinal microecology and acute respiratory distress syndrome.

Acute respiratory distress syndrome (ARDS), a critical condition with high mortality, arises from dysregulated inflammation and lung injury. While evidence-based supportive care remains foundational, the lack of effective targeted therapies underscores the need for novel approaches. This review focuses on the emerging role of intestinal microecology in ARDS pathogenesis the gut-lung axis.

Insights into structural deviations in attention deficit hyperactivity disorder (ADHD) and comorbidities using big data-derived brain charts: a cross-sectional study.

Background: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that often coexists with other neurodevelopmental disorders. The intricate comorbidity of ADHD with depression, Tourette syndrome (TS), and autism spectrum disorder (ASD) presents substantial challenges in the screening, diagnosis, and management of these conditions. The aim of this study was to utilize big data-derived brain charts as an objective standard to assess brain development, comparing regional brain development differences between children with pure ADHD and those with comorbidities, and to explore the presumed correlation between specific structural deviations and the severity of ADHD symptoms.

Identification of submergence tolerance QTLs/genes during seed germination in 432 rice varieties by GWAS.

Background: Submergence stress is a major obstacle limiting the application of direct seeding in rice cultivation. Therefore, understanding the genetic basis of submergence tolerance in rice is of great significance for identifying favorable genes and developing superior rice varieties. However, few studies have focused on submergence tolerance during seed germination; thus, the genetic basis of submergence tolerance at this stage deserves more attention.

The SIRT1 activator SRT2104 mitigates hypoxia-induced white matter injury in neonatal mice.

This study investigated the effects of the Sirtuin 1 (SIRT1) activator SRT2104 on hypoxia-induced white matter injury (WMI) in neonatal mice. A mouse model of neonatal WMI was established by exposing C57BL/6 mice to chronic hypoxia from postnatal Day 3 to Day 11. SRT2104 was administered intraperitoneally at doses of 2 mg/kg or 4 mg/kg from Day 11 for 5 days.

The Effects of Alkalinity and Hardness on Uranium Speciation and Toxicity to Daphnia pulex.

The Province of Saskatchewan in western Canada is a global player when it comes to uranium (U) production. There are several active and decommissioned uranium mines in the northern region of the province, and new deposits continue to be discovered. Increases in U in the aquatic ecosystems surrounding uranium mining operations can lead to toxic effects on aquatic organisms.

c-Myc inhibits macrophage antimycobacterial response in Mycobacterium tuberculosis infection.

Mycobacterium tuberculosis (MTB) remains a major cause of global mortality, yet natural immunity prevents disease in more than 90% of exposed individuals. Interferon gamma (IFN-γ) is a critical regulator of innate immunity and enhances macrophage antimicrobial responses. In this study, we investigated how IFN-γ timing influences macrophage control of MTB.

Preparation of Bismuth Vanadates with Rich Oxygen Vacancies Using Different Sol pH and Their Photocatalytic Behavior in Degradation of Methylene Blue.

Gel precursors were formed by reacting bismuth nitrate pentahydrate, acetic acid, sodium metavanadate, and NaOH. pH was adjusted using NaOH solution followed by calcination to obtain bismuth vanadate (BiVO) photocatalysts. During synthesis, pH directly influenced the formation and structure of the gel network.

Synergistic surface doping of organic crystals with source-gated architectures: ultra-stable, high-mobility and strain-insensitive stretchable transistors.

Despite remarkable advancements in organic flexible electronics, performance variability and operational instability, rooted in weak van der Waals interaction correlated defects, remain long-standing challenges. Herein, we address these issues through a synergistic strategy integrating organic single crystals, surface doping, and source-gated transistors (SGTs). FTS ((tridecafluoro-1,1,2,2-tetrahydrooctyl)trichlorosilane) monolayer decoration contributes to a trap-free and high-conductance (11.

The Pathogenesis and Medical Treatment of Depression: Opportunity and Challenge.

Depression is a common mental disorder with high economic burden, characterized by high disability and mortality rates. The etiology of depression remains unclear to date, and there are various hypotheses regarding the pathogenesis of depression in clinical practice, including the monoamine neurotransmitter hypothesis, the hypothalamic-pituitary-adrenal (HPA) axis dysregulation hypothesis, the inflammatory cytokine hypothesis, and the neurotrophic factor hypothesis. These theories offer specific directional aid in the clinical management of individuals suffering from depression.

Surgical outcomes in elderly patients with vestibular schwannoma: a retrospective cohort study.

This study aims to evaluate the surgical outcomes and clinical differences of elderly vestibular schwannoma (VS) patients (> 65 years), compared with non-elderly patients, focusing on baseline characteristics, preoperative symptoms, postoperative facial and auditory functions, and quality of life. A retrospective study was conducted on 59 elderly and 59 non-elderly patients, matched 1:1 by tumor size. All patients underwent retro-sigmoid microsurgery performed by the same neurosurgical team during the period from December 2018 to September 2023.

Ampelopsis grossedentata protects against ethanol-induced acute duodenal injury by inhibiting TNF-triggered caspases-dependent apoptosis in mice.

Ethnopharmacological Relevance: Ampelopsis grossedentata (AG) is a popular folk tea that has been used in China for more than 1000 years. It is noteworthy that AG is widely recognized for preventing alcohol hangover in folk, and its protective effects on alcohol-induced hepatic steatosis have been demonstrated.

Aim Of The Study: Alcohol overconsumption can induce acute duodenal injury (ADI) that lacks effective therapeutic strategies.

Elucidation of the biodegradation pathways of polyurethane and polyethylene terephthalate by a Fusarium strain enriched from soil-plant systems.

Fungi are emerging as a promising solution for bioremediation. Several fungi have been identified to degrade polyester, but the specific molecular mechanisms involved remain poorly understood. In this study, we screened for polyester-degrading fungus, characterised its ability to depolymerise both polyurethane (PU) and polyethylene terephthalate (PET), and employed a multi-omics approach to identify key proteins involved in PU and PET hydrolysis.

Mechanism of atrazine migration and diffusion control in soil by clay matrix composites.

The study investigates the mechanisms of atrazine (ATZ) migration control in cold-zone black soil subjected to freeze-thaw cycles (FC). Current remediation technologies face several challenges, including destabilization of soil structure due to freeze-thaw cycles, unknown environmental effects, insufficient long-term effectiveness, and a lack of multifunctional materials and methods to quantify the migration capacity of ATZ in cold climate zones. In this study, three major problems of soil structure optimization, competitive adsorption enhancement and quantification of migration patterns in FC environments were solved through the preparation of clay-based composites (Sep/BC) combined with soil column simulation tests and isothermal adsorption tests.

Association between C-reactive protein-albumin-lymphocyte (CALLY) index with intravenous immunoglobulin non-response in Kawasaki disease.

Background: The CRP-albumin-lymphocyte (CALLY) index has been demonstrated to be a predictive tool for tumors. However, studies on its role and clinical significance in predicting intravenous immunoglobulin (IVIG) non-response in patients with Kawasaki disease (KD) remains limited.

Methods: A cohort of 975 patients with KD was recruited from four medical centers to examine their clinical and laboratory characteristics.

The Prognostic Value of the XPC rs2228001 Single Nucleotide Polymorphism in Cholangiocarcinoma.

Background And Aims: Cholangiocarcinoma (CCA) is one of the most prevalent primary liver malignancies with increasing incidence and mortality rates, particularly in Southeast Asia. Surgical resection is a primary therapeutic option offered to patients with localised disease. Unfortunately, early disease recurrence is common and robust tools for tailored patient-centric post-operative management and follow-up schemes are highly desired but currently lacking.

Placement of ureteric stents to address postoperative urinary leakage in calyceal diverticulum with partially duplicated ureters resembling a renal cyst: A case report.

Rationale: Renal pelvic diverticulum accounts for fewer than 5% of renal cystic lesions. Its coexistence with a duplicated renal system is exceedingly rare, posing significant diagnostic and therapeutic challenges. These cases require differentiation from typical renal cysts and often necessitate a unique management approach.

Exploring ferroptosis-associated immune characteristics in Kawasaki disease through bioinformatics.

Kawasaki disease (KD), as a common pediatric inflammatory vasculitis, has an unclear pathogenesis. This study integrated bioinformatics and clinical data analysis to explore the characteristics of ferroptosis in KD. We used data from the Gene Expression Omnibus (GEO) database to identify ferroptosis-related genes, and variable selection was performed using Least Absolute Shrinkage and Selection Operator (LASSO) analysis.

Implication of Angio-based Microvascular Resistance, A Measure of Coronary Microvascular Dysfunction Severity, for Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy.

Coronary microvascular dysfunction (CMD) is a common feature in patients with hypertrophic cardiomyopathy (HCM). CMD is a risk factor for atrial fibrillation (AF) in the general population. However, the relationship between CMD and AF prevalence in HCM patients has not been fully explored.

Uniformly structured asymmetric coordination Ce single-atom catalysts for stable and efficient oxygen reduction reaction.

In oxygen reduction reactions, the symmetric M-N coordination restricts both performance and stability. NO-type catalysts show promise, but their irregular morphology limits practical use. We report a Ce-NO/C single-atom catalyst with uniform morphology synthesized an oxygen-ligand electrospinning-annealing route, delivering a 0.

Evaluation of the application effect of surface immobilization technology on fuel ethanol production at industrial scale.

This study evaluates the viability of surface immobilization method for ethanol production utilizing a 3400 m bioreactor. The reactor's agitation mechanism, featuring an integrated suspended carrier, was optimized by computational fluid dynamics (CFD) simulation, succeeded by a quantitative assessment of the fluid field distribution. A second intermittent fermentation experiment was performed in the optimized reactor, utilizing high-concentration maize hydrolysate as the substrate.

GALNT18-Mediated O-Glycosylation Promotes Development of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma Through Activation of EGR1/TGF-β1/Smad Signaling.

Nonalcoholic steatohepatitis-associated hepatocellular carcinoma (NASH-HCC) is an increasing global health issue. Research indicates that amyloid precursor protein (APP) might be a diagnostic marker and therapeutic target for HCC. However, the specific role of O-glycosylation of APP in NASH-HCC remains unclear.

FSKansformer: An ncRNA-Protein interaction prediction model based on feature salience and Kansformer.

The interaction between non-coding RNA (ncRNA) and protein (ncRPI) plays a crucial role in many physiological activities and disease progression. To identify ncRPIs on a large scale by computational methods based on deep learning is a common practice. However, existing computational methods face challenges such as low feature expression and redundant suppression capability when processing high dimensional feature data.

ResaPred: A Deep Residual Network With Self-Attention to Predict Protein Flexibility.

Grasping the intrinsic properties of protein structure is crucial for comprehending relevant biological mechanisms, with protein flexibility standing out as a critical aspect. Therefore, the prediction of protein flexibility is of great importance in understanding molecular mechanisms. We propose a deep learning method named ResaPred, which extracts diverse features from protein sequences, such as secondary structure, torsion angle, solvent accessibility, etc.

Highlights of Model Quality Assessment in CASP16.

Model quality assessment (MQA) remains a critical component of structural bioinformatics for both structure predictors and experimentalists seeking to use predictions for downstream applications. In CASP16, the Evaluation of Model Accuracy (EMA) category featured both global and local quality estimation for multimeric assemblies (QMODE1 and QMODE2), as well as a novel QMODE3 challenge-requiring predictors to identify the best five models from thousands generated by MassiveFold. This paper presents detailed results from several leading CASP16 EMA methods, highlighting the strengths and limitations of the approaches.