The SIRT1 activator SRT2104 mitigates hypoxia-induced white matter injury in neonatal mice.

This study investigated the effects of the Sirtuin 1 (SIRT1) activator SRT2104 on hypoxia-induced white matter injury (WMI) in neonatal mice. A mouse model of neonatal WMI was established by exposing C57BL/6 mice to chronic hypoxia from postnatal Day 3 to Day 11. SRT2104 was administered intraperitoneally at doses of 2 mg/kg or 4 mg/kg from Day 11 for 5 days.

Enhancing 3D Printing Performance of Yellow-Flesh Peach Gels: The Role of Whey Protein Isolate in Printability, Rheological Properties, and Structural Characteristics.

The utilization of 3D printing technology in the food sector enables innovative product customization through the design of intricate shape, offering new potential for yellow peach product development. However, the 3D printing performance of pure yellow-flesh peach gel is suboptimal. This study aims to address this gap by exploring functional additives to optimize 3D printing performance for peach-based materials.

Study on the physicochemical properties and gelation characteristics of pea protein isolate modified by ultrasonic-assisted succinylation.

Ultrasound could facilitate the succinylation of protein and improve the function of succinylated protein. However, the effects of ultrasound-assisted succinylation on the physicochemical property and gelation characteristics of PPI were scarely reported. Therefore, this research studied the effect of succinylation with different ultrasonic power on the physicochemical properties and gelation characteristics of succinylated pea protein isolate (PPI).

Comprehensive mechanistic insights into the in vitro antibiofilm activity of graphene oxide (GO) nanopesticides against phytopathogen Ralstonia solanacearum.

Biofilms constitute the primary virulence factor in Ralstonia solanacearum (R. solanacearum), a soilborne bacterial plant pathogen, providing protection against antimicrobials and host defenses. Investigating biofilm inhibitors is both necessary and scientifically valuable.

Electric Field-Induced Underwater-Oil Diode on a Janus-Porous Ion-Doped Polypyrrole Membrane.

Directional liquid transport on the surface is of great significance in liquid collection, transfer, and separation. Despite extensive research on surface wetting control, achieving unidirectional liquid permeation on material surfaces under water remains a challenge. Here, we demonstrate that electric field-induced unidirectional oil permeation can be achieved on a Janus-porous ion-doped polypyrrole membrane (Janus-PIPM).

Relationship between sleep characteristics and aortic aneurysm/dissection: a two-sample Mendelian randomisation study.

Objective: The causal relationship between sleep characteristics and aortic aneurysm and dissection (AAD) is little known.

Methods: In this two-sample Mendelian randomisation (MR) study, we selected seven sleep-related traits (sleep duration, getting up in the morning, chronotype, nap during day, insomnia, snoring, and narcolepsy) from published genome-wide association study (GWAS)-related genetic variants as instrumental variables. Causality was assessed by two-sample MR analysis using inverse-variance weighting (IVW), MR-Egger regression, weighted median, weighted mode and simple model.

Effects of Sodium Hexametaphosphate on the Gel Properties and Structure of Glutaminase-Transaminase-Crosslinked Gelatin Gels.

Gelatin is a commonly used protein-based hydrogel. However, the thermo-reversible nature of gelatin makes it unstable at physiological and higher temperatures. Therefore, this study adopted phosphates and glutaminase transaminase (TG) to modify gelation and studied the effects of combining sodium hexametaphosphate (SHP) and TG on the structure and gel properties of TG-crosslinked gelatin.

Temperature and relative humidity prediction in South China greenhouse based on machine learning.

Prediction of the greenhouse temperature and relative humidity is very important, which can forecast the environment parameters for manual intervention in advance. However, temperature and relative humidity prediction systems face two critical limitations: inconsistent temporal resolution in data acquisition and the absence of standardized protocols for environmental data collection, which collectively lead to non-uniform control strategies that compromise system interoperability in agricultural applications. This research predicted the temperature and relative humidity with different time interval in South China greenhouse by the model of BPPSO, LSSVM and RBF, which has proved their superiority in temperature and relative humidity prediction.

Investigation on Cracking Mechanisms of Dehydrated Corn: Multiscale Changes Driven by Temperature Gradient.

This study systematically investigated the impact mechanism of hot-air drying temperature (40°C-80°C) on moisture migration, crack formation, and the microstructural evolution of corn kernels. Using multi-scale characterization techniques such as low-field nuclear magnetic resonance, scanning electron microscopy, and Fourier transform infrared spectroscopy, this study revealed temperature-gradient-driven changes in microscopic mechanical properties. The results showed that increasing the drying temperature accelerated moisture evaporation while exacerbating internal moisture gradients, which led to greater thermal stress and promoted crack formation.

Mechanical Performance Evaluation of Negative-Poisson's-Ratio Honeycomb Helmets in Craniocerebral Injury Protection.

Helmets are crucial for protecting motorcycle riders from head injuries in accidents. This study proposes a helmet pad design based on a negative-Poisson's-ratio (NPR) structure and comprehensively evaluates its protective effect on head injuries. A concave hexagonal honeycomb structure was embedded into the energy-absorbing lining of a motorcycle helmet, and finite element collision simulations were conducted according to the ECE R22.

Incorporation of multi-dynamic interactions into carboxyl graphene oxide-enhanced PVA/PAA/agarose hydrogels for multifunctional wearable sensors.

Recent advancements in conductive hydrogels have demonstrated significant progress in flexible sensing applications. However, integrating multifunctionality-including mechanical properties, environmental stability, high sensitivity, and great self-healing capability-into hydrogel sensors via a simple and eco-friendly synthesis approach remains a challenge. Herein, we reported multifunctional polyvinyl alcohol (PVA)/polyacrylic acid (PAA)/agarose (AG) hydrogels fabricated through a facile one-pot strategy.

Novel Strategy for Manufacturing Convenient Dehydrated Dumplings: Relying on Microwave Freeze-Drying and Its Underlying Mechanism.

Microwave freeze-drying (MFD) has emerged as an efficient alternative in the dehydration process; therefore, the current work attempts to introduce MFD into the production of instant dumplings. Pork-filled dumplings were treated with MFD at varying microwave power densities (0.10, 0.

Assessing Risk Factors and Posttransplant Outcomes of Nonadherence Among Kidney Transplant Recipients.

Background: Adherence of kidney transplant recipients (KTRs) to prescribed regimens is vital for long-term graft function. This study aimed to identify adherence rates using objective and composite measures, risk factors for nonadherence, and the latter's impact on posttransplant outcomes.

Methods: A retrospective single-center cohort study was conducted among KTR transplanted from January 1, 2003, to December 31, 2017.

Loss of NUMB promotes hepatomegaly and hepatocellular carcinoma through the AKT/glycogen/hippo signaling.

Excessive glycogen deposition is a common feature of liver enlargement, liver adenoma, and liver cancer, yet the underlying mechanisms remain poorly understood. In this study, we found that NUMB, a well-known cell fate determinant, is downregulated in glycogen-rich adenomas and hepatocellular carcinoma (HCC). NUMB-deficient livers developed excessive glycogen accumulation and adenoma formation particularly in aged mice.

From molecular design to clinical translation: dual-targeted CAR-T strategies in cancer immunotherapy.

The pathogenesis of tumors involves various abnormalities at both the cellular and genetic levels. Chimeric antigen receptor (CAR)-T cell immunotherapy has emerged as a transformative treatment strategy that effectively addresses these challenges. While CAR-T therapy has shown remarkable success in treating hematological malignancies, limitations have been identified, particularly in single antigen-targeting CAR-T therapies.

Ultrasonic and Deep Eutectic Solvent for Efficient Extraction of Phenolics from Leaves.

The purpose of this research was to establish an effective method for extracting phenolic compounds from leaves. Seven different deep eutectic solvents (DESs) were prepared, and ultrasonic-assisted technology was employed to optimize the extraction parameters. Factors such as the DES molar ratio, water content, liquid-to-solid ratio, ultrasonic duration, temperature, and power were systematically investigated.

Exploration of mechanism of Bufalin and Bufalin derivatives in hepatocellular carcinoma.

Background: Bufalin, a promising candidate for the treatment of hepatocellular carcinoma (HCC), has garnered interest from researchers in exploring its pharmacological mechanisms. The traditional single-target research method makes it difficult to elucidate the molecular mechanism systematically, and there are still limitations.

Purpose: To explore the synergistic mechanisms of Bufalin and its derivatives in the treatment of HCC through quantitative and integrated analysis of big data, this study provides a reference for clinical screening of anti-liver cancer drugs and accelerates the research and development of new drugs.

Effects of fatty acids with different degrees of saturation on the microwave freeze-drying characteristics and cross-linking behavior of wheat starch-fatty acid complexes.

This study aims to investigate the effect of fatty acids with different degrees of saturation on the microwave freeze-drying (MFD) characteristics and crosslinking behavior of wheat starch-fatty acid composite systems. In the composite system, with the increase in the unsaturation of fatty acids, the initial moisture content also increased. In terms of drying characteristics, both the MFD curve and the MFD rate curve indicate that composite systems of wheat starch with higher unsaturation levels respond more stably to changes in microwave power throughout the MFD process.

Interaction between the liver transcriptome and gut microbiota in mice during Toxoplasma gondii infection as identified by integrated transcriptomic and microbiome analysis.

Background: Toxoplasma gondii is a single-cell parasite capable of infecting both humans and a variety of animal species. Although T. gondii infection is known to adversely affect the liver and gut microbiota, the precise interplay between the gut microbiome and the liver transcriptome in infected mice remains largely unknown.

Dynamic changes in the phenolic profile, enzymatic, and antioxidant activity of grape skin during solid-state fermentation by Eurotium cristatum.

Grape skin, consisting of a significant portion of grape pomace, is a great source of dietary fibers and polyphenols. In this study, grape skins of Hutai No. 8 were subjected to solid-state fermentation (SSF) using the fungal strain Eurotium cristatum.

Characterization and genomic insights into the nitrogen metabolism of heterotrophic nitrifying and aerobic denitrifying bacterium Pseudomonas aeruginosa WS-03.

To achieve effective removal of various inorganic nitrogen in aquatic ecosystems, while expanding the applicability of existing heterotrophic nitrifying-aerobic denitrifying (HN-AD) strains and enhancing their stress tolerance, we isolated the Pseudomonas aeruginosa WS-03 from a sewage treatment plant. The results of parameter optimization indicated that the following were the most favorable conditions for nitrogen removal: using sodium citrate as the carbon source, a C/N ratio of 9, a pH of 7, a temperature of 30 °C and an NH-N concentrations below 300 mg/L. The maximum reduction rates of nitrogen are 8.

Strategy for enhancing Cistanche deserticola drying efficiency and quality based on novel freeze-infrared hybrid drying: moisture transition points control.

Background: Fresh Cistanche deserticola, a valuable medicinal and dietary ingredient with exceptional functional properties, exhibits a high moisture content and is susceptible to deterioration due to its high moisture content. Therefore, it is imperative to identify an appropriate dehydration method. This study primarily focuses on enhancing the efficiency and quality of dried C.

Quality deterioration mechanism of freeze-thawed sweet potato oat dough: In terms of ice crystals and protein changes.

Sweet potato-oat composite dough is a nutritious, functional dough with promising market potential. This study investigates its quality changes during freeze-thaw cycles from the perspectives of ice crystals and protein alterations to provide theoretical support for its processing and production. After freeze-thaw cycles, both the storage modulus and loss modulus of the dough decrease, resulting in increased hardness, reduced resilience and chewiness, lower sensory scores, decreased specific volume, and darker color.

Program temperature-controlled drying: An effective way to improve the quality of hot-air dried shiitake mushrooms.

This study applied program temperature-controlled drying (PTCD) to optimize the hot-air drying process for shiitake mushrooms, adjusting the drying temperature based on activity changes of γ-glutamyl transpeptidase (γ-GTase) and cysteine sulfoxide lyase (C-S lyase). Compared with constant temperature drying, PTCD (ST_75 and ST_150) significantly enhanced the umami and aroma profiles and sulfur compounds, increasing the levels of key flavor compounds such as glutamic acid and 5'-GMP. Moreover, PTCD improved rehydration capacity (515.