Chitosan-Based Photothermal Hydrogel with Rapid Bacterial Capture for Enhanced Disinfection.

Constructing a novel antibacterial platform is of great significance for inhibiting bacterial infections. In this work, we developed a composite hydrogel (CS/PPy/PDA hydrogel) by incorporating photothermal material polypyrrole (PPy), chitosan (CS) and polydopamine (PDA) into poly acrylamide (PAAM) hydrogel network. First, CS/PPy/PDA hydrogel could capture bacteria through strong electrostatic interactions, enhancing the contact between hydrogels and bacteria.

Effects of non-nutritive sweeteners on body weight: a systematic review and meta-analysis of randomized controlled trial (RCT) studies.

Purposes: Controversy has emerged regarding the impact of non-nutritive sweeteners (NNS) on body weight. This systematic review and meta-analysis of randomized controlled trials aims to assess the effect of NNS intake on body weight change.

Results: Of the 3327 studies retrieved, 19 met the eligibility criteria for inclusion in the meta-analysis.

The Role of EphrinB2-EphB4 Signalling Pathway in Regeneration of Inflammatory Bone Defect.

The important role of the EphrinB2-EphB4 signalling pathway in bone remodelling has been demonstrated, while its effect on inflammatory bone defect regeneration remains poorly understood. This study was to assess the effect of EphB4-EphrinB2 signalling on inflammation-mediated bone defect repair in murine models. The modelling method of inflammation-mediated bone defect in mice was established by intraperitoneally injecting different concentrations of TNF-α.

Innate lymphoid cells prevent graft-versus-host disease via IL-9-driven T-cell senescence.

ABSTRACTInnate lymphoid cells (ILCs) are tissue-resident lymphocytes that regulate tissue homeostasis and immune responses. How ILCs modulate T cells remains incompletely understood. To investigate the interaction between ILCs and T cells, we differentiated ILC2s and ILC3s from hematopoietic stem cells (HSCs).

Ultrabroadband Photosensitivity and Frequency-Mixing in Anisotropic Weyl Semimetal NbNiTe.

Broadband anisotropic photodetectors show great promise for polarization-sensitive imaging and multispectral optoelectronic systems yet face critical challenges in material anisotropy modulation and broadband sensitivity. Weyl semimetals exhibit giant optical anisotropy and tunable heterojunction band alignment, enabling high-performance anisotropic photodetection. Herein, ultrabroadband PDs based on the NbNiTe (niobium nickel telluride), enabled by antenna integration and heterostructure engineering, achieve high sensitivity from visible to Terahertz (THz).

Recent Advances and Prospects of Indole Derivatives in the Discovery of New Agricultural Chemicals.

Indole, as a unique natural scaffold structure, has attracted considerable attention in recent years in the discovery of agrochemicals. As a distinct molecular scaffold, indole offers multiple modifiable sites and is extensively used in the development of new pesticides, such as fungicides, insecticides, herbicides, and antibacterial agents. Additionally, some indole derivatives can interact with various biological targets, enabling effective control of pathogens, pests, and weeds.

Refined Signal Organic Photodetectors via Transfer Lamination of pH-Controlled PEDOT:PSS for Durable In Situ Stress Monitoring.

This paper presents a strategy for noise suppression and stability enhancement of organic photodetectors (OPDs) by introducing pH-neutralized and transfer-laminated poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) as the hole-transporting layer (HTL). Although PEDOT:PSS is widely used as an HTL material, its intrinsic acidity and structural instability hinder the performance of the OPD. Here, imidazole-induced neutralization promotes a linear entangled structure, while transfer lamination enables controlled PSS domain distribution.

Impact of individualized nursing on postoperative sleep quality after cardiovascular interventions: A retrospective analysis.

Sleep problems are a common postoperative complication among patients undergoing cardiovascular procedures, often triggered by emotional distress, surgical discomfort, and the clinical setting itself. These issues may hinder recovery and reduce life quality. A patient-oriented nursing model, known as precision or individualized nursing, delivers customized support tailored to each patient's needs.

Serum Galectin-9 and Decorin in relation to brain aging and the green-Mediterranean diet: A secondary analysis of the DIRECT PLUS randomized trial.

Background And Aims: We explored whether changes in serum proteomic profiles differed between participants with distinct brain aging trajectories, and whether these changes were influenced by dietary intervention.

Methods: In this secondary analysis of the 18-month DIRECT PLUS trial, 294 participants were randomized to one of three arms: 1) Healthy dietary guidelines (HDG); 2) Mediterranean (MED) diet (+440 mg/day polyphenols from walnuts); or 3) low red/processed meat green-MED diet (+1240 mg/day polyphenols from walnuts, Mankai plant, and green tea). We measured 87 serum proteins (Olink-CVDII).

Machine learning-guided construction of MoS/MoO heterostructures on hollow carbon shells for polysulfide mitigation in lithium-sulfur batteries.

The commercialization of lithium‑sulfur (LiS) batteries faces fundamental issues from polysulfide shuttling to inefficient redox kinetics, compounded by the absence of systematic methods for catalyst design. Herein, we present a machine learning (ML)-driven strategy to design MoS/MoO heterostructures anchored on nitrogen-doped hollow carbon shells (NCS) via gradient boosting decision trees modeling. The ML-guided optimization identifies critical synthesis parameters (e.

Crystalline Covalent Organic Framework Paper for Sweating Disorder Disease Analysis.

Abnormal sweating is closely associated with the occurrence and progression of various serious diseases, yet quantitatively and accurately assessing sweat pore function remains challenging. In this study, a crystalline covalent organic framework (COF) paper was developed for precise sweat pore analysis of sweating disorders. The delicately designed COF system achieved high-contrast sweat-responsive color change through the doping of sweat contents while showing no response to water, greatly enhancing resistance to environmental humidity interference.

Influence of thermo-oxidatively aged mulch debris on the seedling emergence of field pea (Pisum sativum var. arvense L.) seeds.

The implementation of appropriate flame-spraying treatment on used polyethylene (PE) mulch film is a potential method for the rapid abatement of PE contamination in dryland fields. This study utilized self-made flame-spraying equipment to prepare thermo-oxidatively aged PE microplastics (aPE-MPs), with their structural properties characterized through analytical techniques. The effects of varying concentrations of aPE-MP suspensions (corresponding to residual film levels equivalent to 5-300 years of continuous mulching) on seed germination and seedling growth of field pea (Pisum sativum var.

Zero-Shot Dynamic MRI Reconstruction With Global-to-Local Diffusion Model.

Diffusion models have emerged as promising tools for tackle the challenges of MRI reconstruction, demonstrating superior performance in sample generation compared to traditional methods. However, their application in dynamic MRI reconstruction remains relatively underexplored, primarily owing to the substantial demand for fully sampled training data, which is challenging to obtain because of the spatiotemporal complexity and high acquisition costs associated with dynamic MRI. To address this challenge, this paper proposes a zero-shot learning framework for accurate dynamic MR image reconstruction from undersampled k-space data directly.

Leaf anatomical structure of dominant shrubs and their influencing factors across habitats in hyper-arid region.

We analyzed the drought adaptation mechanism of shrub species in three typical habitats (oasis, transition zone, and desert) of the extremely arid area in the lower reaches of the Heihe River, with 15 species as the objects. Using paraffin sectioning technology combined with microscopic observation, we measured 14 anatomical traits, including leaf epidermal thickness, total leaf thickness, palisade tissue thickness, spongy tissue thickness, and main vein vascular bundle thickness, etc. The results showed that leaf thickness, palisade tissue thickness, and leaf structure compactness (palisade tissue thickness/total leaf thickness) significantly varied among different habitats, and increased with the aggravation of drought degree.

Van der Waals β-GaO thin films on polycrystalline diamond substrates.

The self-heating effect in wide bandgap semiconductor devices makes epitaxial GaO on diamond substrates crucial for thermal management. However, the lack of wafer-scale single-crystal diamond and severe lattice mismatch limit its industrial application. This study presents van der Waals β-GaO (VdW-β-GaO) grown on high-thermal-conductivity polycrystalline diamond.

Green Synthesis and Flexibilization Engineering of (ECMP)MnBr for Smart Textile-Integrated Luminescence.

0D hybrid manganese halides represent an emerging class of luminescent materials, yet their practical application has been hindered by the intrinsic trade-off between optical performance and mechanical flexibility. Here, a green synthesis of 0D (ECMP)MnBr crystal is reported, exhibiting unprecedented triple-mode emission (photoluminescence, X-ray scintillation, and mechanoluminescence) through rationally designed highly symmetric [MnBr] tetrahedra, achieving near-unity photoluminescence quantum yield (98.97%), record-low X-ray detection limit (15.

Exploring protein-mediated quality control mechanisms in Rice cooking behavior: from static protein content to dynamic architecture.

Rice proteins significantly influence cooking properties and eating quality, yet their dynamic roles during thermal processing remain unclear. This study systematically investigated protein-mediated mechanisms in rice cooking through in-situ structural analysis (SEM, CLSM) and enzymatic hydrolysis. Three rice cultivars with a common genetic background but differing in protein content were used (NJ > LSS-1 > LSS-2: 6.

Colistimethate sodium is efficacious and safe for the management of sepsis in hematological diseases patients: a retrospective study in China.

Purpose: Patients afflicted with hematological diseases are at an elevated risk of infection, with the potential for the development of sepsis. This study aims to analyze the effectiveness and safety of colistimethate sodium (CMS) in the management of sepsis in Chinese patients with hematological diseases.

Methods: A retrospective study was conducted on hematological diseases patients diagnosed as sepsis and treated with CMS at the First Affiliated Hospital of Soochow University between November 2021 and July 2023.

Comparative Analysis of Chitosan, Lipid Nanoparticles, and Alum Adjuvants in Recombinant SARS-CoV-2 Vaccine: An Evaluation of Their Immunogenicity and Serological Efficacy.

Chitosan, a family of polysaccharides composed of glucosamine and N-acetyl glucosamine, is a promising adjuvant candidate for eliciting potent immune response. This study compared the adjuvant effects of chitosan to those of empty lipid nanoparticles (eLNPs) and aluminum hydroxide (alum) following administration of recombinant SARS-CoV-2 spike immunogen in adult mice. Mice received the adjuvanted recombinant protein vaccine in a prime-boost regimen with four weeks interval.

A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration.

Abnormal accumulation of both intracellular and extracellular free nucleic acids drives chronic inflammation in intervertebral disc degeneration (IVDD). Despite the development of numerous minimally invasive treatments for IVDD, systematic approaches targeting the chronic inflammation mediated by both nucleic acid types are lacking. We propose a dual clearance strategy that inhibits mitochondrial DNA release inside nucleus pulposus cells while removing extracellular DNA from the disc microenvironment.

A urinary DNA methylation assay using two genes enables noninvasive detection and prognostic prediction in urothelial carcinoma.

The incidence of urothelial carcinoma (UC) ranks second among all urological cancers, accounting for over 90% of malignant tumors in bladder. Patients diagnosed with UC experience a lower quality of life due to rapid progression of the disease. Early and non-invasive detection is curial for diagnosing UC and improving patient outcomes.

Magnetic Field-Driven Interface Hydroxylation via the Vibrational Stark Effect Boosts Alkaline Hydrogen Evolution Reaction.

Tuning interfacial water structures is a fundamental yet underexplored strategy for advancing the hydrogen evolution reaction (HER) and broader electrocatalytic processes. Here, we demonstrate a universal and scalable catalytic optimization strategy via the magnetic field-driven reconfiguration of interfacial water at the molecular level. Unlike conventional magnetohydrodynamic (MHD) strategies focusing on mass transport, this work pioneers a molecular-level interfacial water structure modulation via the vibrational Stark effect (VSE), achieving intrinsic catalytic enhancement for HER.

Sensitive analysis of tyrosine kinase inhibitors in plasma using polypropylene fabric-solid phase extraction combined with liquid chromatography-tandem mass spectrometry.

Accurate quantification of tyrosine kinase inhibitors (TKIs) in plasma is essential for therapeutic drug monitoring (TDM). This study presents a novel solid phase extraction (SPE) method employing hydrophobic polypropylene fabric (PPF)-a fibrous material derived from oil-absorbent pads-as the sorbent. The PPF-SPE device was prepared by directly packing fluffed PPF into syringe barrels, eliminating the need for sieve plates and simplifying column assembly.

Salt-Adapted Microorganisms: A Promising Resource for Novel Anti-Cancer Drug Discovery.

Microorganisms serve as a vital source of natural anticancer agents, with many of their secondary metabolites already employed in clinical oncology. In recent years, salt-adapted microbes, including halophilic and halotolerant species from marine, salt lake, and other high-salinity environments, have gained significant attention. Their unique adaptation mechanisms and diverse secondary metabolites offer promising potential for novel anticancer drug discovery.

An Enhanced Slime Mould Algorithm Based on Best-Worst Management for Numerical Optimization Problems.

The Slime Mould Algorithm (SMA) is a widely used swarm intelligence algorithm. Encouraged by the theory of no free lunch and the inherent shortcomings of the SMA, this work proposes a new variant of the SMA, called the BWSMA, in which three improvement mechanisms are integrated. The adaptive greedy mechanism is used to accelerate the convergence of the algorithm and avoid ineffective updates.