The Role of EphrinB2-EphB4 Signalling Pathway in Regeneration of Inflammatory Bone Defect.

The important role of the EphrinB2-EphB4 signalling pathway in bone remodelling has been demonstrated, while its effect on inflammatory bone defect regeneration remains poorly understood. This study was to assess the effect of EphB4-EphrinB2 signalling on inflammation-mediated bone defect repair in murine models. The modelling method of inflammation-mediated bone defect in mice was established by intraperitoneally injecting different concentrations of TNF-α.

Targeting YES1 enhances the efficacy of chemotherapy, targeted therapy and Onco-immunotherapy.

YES1 (Yamaguchi sarcoma virus homolog 1), a non-receptor tyrosine kinase of the SRC family (SFK), has been abnormally amplified or mutated in several types of solid tumors. The alteration of YES1 impacted multiple biological processes, including promoting tumor progression and metastasis, especially, producing cancer therapy resistance via bypass pathways. Thus, YES1 can serve as a druggable target to overcome drug resistance and suppress tumor growth.

Graft Dimensions and Residual Tissue Thickness Impact on Donor Site Healing After FGG Procedure: A 3D Comparative Study.

Introduction And Aims: Free gingival grafting (FGG) is a common procedure in periodontal and implant therapy to augment keratinized tissue and improve esthetic outcomes. However, the effects of graft dimensions and residual tissue thickness (RTT) on palatal donor site healing remain poorly characterized, lacking standardized 3-dimensional analysis. This study aimed to quantify how these factors influence 3-dimensional tissue recovery over 6 months, with thickness recovery rate as the primary outcome.

Detecting Acute Ischemic Lesions Using Mobile, Low-Field MRI in TIA and minor stroke in the Emergency Room.

Background: Using mobile low-field MRI in the emergency department to detect cerebral infarction(s) in patients with minor ischemic stroke (MIS) and transient ischemic attack (TIA) has not yet been thoroughly reported.

Aim: We aimed to evaluate the performance of mobile low-field (0.23T) MRI in detecting acute ischemic infarction in MIS or TIA patients within 72 hours of symptom onset and compare it to CT in those scanned within 24 hours.

Transferrin receptor 1 is an entry factor for Japanese encephalitis virus.

Japanese encephalitis virus (JEV) is a zoonotic pathogen that can be transmitted to humans and animals via arthropods, causing viral encephalitis. In this study, we investigated the role of transferrin receptor 1 (TfR1) in JEV infection. We found that knocking down TfR1 expression in A549 and HeLa cells significantly inhibited JEV entry, while overexpression of TfR1 in 293 T cells enhanced viral entry.

Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer.

Background: Colorectal cancer (CRC) is the second deadliest cancer worldwide and new treatment options are urgently needed. Cyclin dependent kinase 9 (CDK9) promotes aberrant RNA transcription in cancer and is a promising target for cancer therapies.

Methods: Using CRC cell lines as well as newly established patient-derived organoid models of CRC, we studied the clinically promising CDK9 inhibitors (AZD4573, BAY1125152/VIP152/enitociclib, and NVP2) to determine their therapeutic potential.

Case Report: From IgA nephropathy to pneumonia, periappendiceal abscess, pulmonary arterial hypertension, and basal ganglia calcification: a case of chronic active Epstein-Barr infection in a child.

Chronic active Epstein-Barr virus infection (CAEBV) is a lymphoproliferative disorder characterized by persistent EBV infection, which can lead to multi-organ involvement. This case describes a child with CAEBV who initially presented with IgA nephropathy (IgAN) without characteristic infectious mononucleosis (IM) features. The patient initially presented with intermittent gross hematuria, Renal biopsy confirmed focal proliferative IgAN, and the child was treated with methylprednisolone pulse therapy followed by oral prednisone.

The role of ephaptic coupling and gap junctional coupling in modulating the initiation and dynamics of reentrant arrhythmias.

Cardiac myocytes synchronize through electrical signaling to contract heart muscles, facilitated by gap junctions (GJs) located in the intercalated disc (ID). GJs provide low-resistance pathways for electrical impulse propagation between myocytes, considered the primary mechanism for electrical communication in the heart. However, research indicates that conduction can persist without GJs.

Role of ionic electrodiffusion and ephaptic coupling in cardiac dynamics.

Cardiac myocytes coordinate the heart contractions through electrical signaling, facilitated by gap junctions (GJs) in the intercalated disk. GJs provide low-resistance pathways for electrical propagation between myocytes, acting as the main mechanism for electrical communication in the heart. However, studies show that conduction can persist in the absence of GJs.

An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting.

RNA post-transcriptional modifications act by stabilizing the functional conformations of RNA. While their role in messenger RNA (mRNA) decoding is well established, it is less clear how transfer RNA (tRNA) modifications outside the anticodon contribute to tRNA stability and accurate protein synthesis. Absence of such modifications causes translation errors, including mRNA frameshifting.

Timely Diagnosis of Kawasaki Disease Shock Syndrome Based on Positive Transthoracic Echocardiography.

In this article, we describe a Kawasaki disease shock syndrome (KDSS) in a 14-year-old girl, who presented with a fever for 8 days and annular erythema on her back for 2 days. Mycoplasma pneumoniae antibodies were positive. Chest computed tomography showed no abnormalities in the lungs and mediastinum.

Nanoparticle-Delivered siRNA Targeting NSUN4 Relieves Systemic Lupus Erythematosus through Declining Mitophagy-Mediated CD8+T Cell Exhaustion.

5-Methylcytosine modification (m5C) is an important posttranscriptional regulatory mechanism of gene expression. Exhausted CD8+T cells contribute to the development of many major diseases; however, their exact role and relationship to m5C in systemic lupus erythematosus (SLE) remain unknown. In this study, we identified a CD7CD74 CD8+T subgroup that were robustly expanded in SLE patients through single-cell transcriptome sequencing (scRNA-seq).

Development and validation of a remote NIH stroke scale (rNIHSS) for caregiver-assisted telestroke assessments.

Objectives: NIH stroke scale (NIHSS) assessment is crucial in Telestroke. However, certain NIHSS items demonstrated poor reliability when assessed remotely. We aimed to develop a modified remote version of the NIHSS (rNIHSS) for caregiver-assisted telestroke assessments.

Sleep Traits to the Risk of Breast Cancer Disease Incidence, Adverse Progression and Mortality: Evidence From a Global Systematic Review and Meta-Analysis.

Objectives: This study aimed to identify the effect of sleep traits on the risk of breast cancer incidence and adverse progression and mortality.

Methods: Cohort studies measuring the relationship between sleep traits (including sleep quality and sleep duration) and breast cancer risk were eligible for inclusion. We searched the Web of Science, PubMed, EMBASE and Cochrane library databases for studies published between 2014 and 2024.

Parallel Multi-Scale Semantic-Depth Interactive Fusion Network for Depth Estimation.

Self-supervised depth estimation from monocular image sequences provides depth information without costly sensors like LiDAR, offering significant value for autonomous driving. Although self-supervised algorithms can reduce the dependence on labeled data, the performance is still affected by scene occlusions, lighting differences, and sparse textures. Existing methods do not consider the enhancement and interaction fusion of features.

Genome-Wide Detection of Leukemia Biomarkers from lincRNA-Protein-Coding Gene Interaction Networks in the Three-Dimensional Chromatin Structure.

The human genome is widely transcribed, with part of these transcribed regions producing stably expressed protein-coding or non-coding RNAs. Long intergenic non-coding RNAs (lincRNAs) are significantly differentially expressed in various cell lines and tissues. However, the influence of their transcription events remains unclear.

CALR promotes corneal epithelial cell proliferation and migration through Wnt7a.

Objective: The repair of corneal epithelial injury is essential to maintain the cornea integrity and transparency, and the molecular regulation mechanism is still unclear. CALR promotes wound healing through a variety of biological effects. Therefore, this study explored effect and mechanism of CALR on corneal epithelial wound healing.

[Effectiveness analysis of Zhang's double reverse traction reducer in minimally invasive treatment of bilateral tibial plateau fractures].

Objective: To evaluate the effectiveness and safety of minimally invasive treatment for bilateral tibial plateau fractures using the double reverse traction reducer.

Methods: The clinical data of 4 patients with bilateral tibial plateau fractures who met the selection criteria and treated between January 2016 and April 2024 were retrospectively analyzed. The cohort included 3 males and 1 female, aged 30-65 years (mean, 52.

Acoustic-driven nanofluids for phase-change thermal management of electronic devices.

Thermal management in confined spaces presents a critical challenge for electronic device performance. Two-phase cooling demonstrates exceptional heat transfer capabilities in compact environments through latent heat utilization during phase change process. However, vapor film formation occurs prematurely due to bubble adhesion and accumulation in confined spaces.

Electroencephalography-based psychological and physiological effects of winter virtual forest trail landscapes on youth.

In the context of escalating urbanization and modernization, urban residents are facing a progressive rise in stress levels, particularly during winter when severe cold and limited daylight hours intensify psychological strain and physical fatigue. Despite the acknowledged health benefits of brief exposure to natural settings, research on the restorative effects of virtual winter forest settings remains limited. This study undertook the creation of immersive winter forest trail landscapes using virtual technology, generating six distinct audiovisual configurations by manipulating variables such as Evergreen Tree Density (ETD) and Event Ambient Sound (EAS).

High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS Mutated CRC.

Unlabelled: Colorectal cancer (CRC) remains a significant clinical challenge, with a 5-year survival rate of 10%. Over half of all CRCs harbor mutations in the KRAS gene, leading to poor response to standard therapy. This underscores the crucial need for novel therapeutics targeting KRAS and overcoming the growing barrier of resistance.

CHMP6 as a novel prognostic biomarker in bladder cancer: insights from a comprehensive cell death-related gene risk model.

Introduction: Bladder cancer (BLCA) is a prevalent and aggressive disease characterized by substantial molecular heterogeneity, complicating its diagnosis and treatment. Existing therapies, including surgery and chemotherapy, often lack specificity. Alterations in cell death mechanisms, such as ferroptosis, cuproptosis, and immunogenic cell death, significantly impact cancer progression and prognosis.

Dorsal hyperintensity and iron deposition patterns in the substantia nigra of Parkinson's disease, idiopathic REM sleep behavior disorder, and Parkinson-plus syndromes at 7T MRI: a prospective diagnostic study.

Background: Dorsal nigral hyperintensity (DNH) abnormality associated with excessive iron deposition in the substantia nigra, is recognized as an imaging characteristic of Parkinson's disease (PD) and can be effectively visualized using 7T MRI. This study was aimed to develop and validate the optimal DNH assessment method as a biomarker for PD, idiopathic rapid eye movement sleep behavior disorder (iRBD), and Parkinson-plus syndromes, and to explore the nigral iron deposition patterns in these diseases.

Methods: Three-dimensional gradient-echo T2*-weighted images were acquired by 7T MRI from a total of 402 patients and 100 healthy controls (HCs) in two independent cohorts (development and validation cohorts).