Multidimensional Phenotypic and Microbiome Studies Uncover an Association Between Reduced Feed Efficiency in Sheep During Mycoplasmal Pneumonia and Microbial Crosstalk Within the Rumen-Lung Axis.

Mycoplasmal pneumonia of sheep (MPS), caused by , profoundly impacts ovine productivity and survival. Although gut-lung microbiota interactions are increasingly recognized in respiratory diseases, whether similar crosstalk occurs between the lung and rumen microbiota in MPS-affected sheep remains unknown. To investigate alterations in the lung and rumen microbiota of sheep with MPS, the crosstalk between these microbial communities, and their impacts on growth phenotypes.

A Functional Regulatory Variant of Gene Affected the Body Weight in Hu Sheep.

Body weight (BW) is a critical economic trait closely linked to livestock meat production performance and producer profitability. In the present study, we measured individual BW of 1070 male Hu sheep at six growth stages (80, 100, 120, 140, 160, and 180 days of age) and conducted descriptive statistical analyses. Results showed that the coefficient of variation (CV) for BW at each stage was higher than 13%.

Risk prediction model for overall survival in lung cancer based on inflammatory and nutritional markers.

This study aims to develop a multidimensional risk prediction model, identify characteristic inflammation-nutrition biomarkers, and optimize clinical decision-making. The study included 500 lung cancer patients diagnosed between October 2019 and October 2024 at a tertiary medical institution in Guiyang, China. The exposure variables included eight inflammation-nutrition biomarkers: neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), hemoglobin-albumin-lymphocyte-platelet score (HALP), prognostic nutritional index (PNI), hemoglobin-to-red cell distribution width ratio (HRR), and albumin-to-globulin ratio (ALB/GLB).

Revealing the characteristic honey-like aroma formation in honey-scented black tea via molecular sensory analysis.

Honey-scented black tea is highly favored by consumers for its unique flavor; however, the key components and mechanisms underlying its characteristic aroma remain unclear. The aroma characteristics and key components of honey-scented black tea (MXBT), sweet-scented black tea (TXBT), and honey (FM) were elucidated, and an aroma flavor wheel was constructed. β-Damascenone, phenylacetaldehyde, and linalool oxide I were identified as the primary aroma compounds responsible for the honey-like scent of MXBT.

Inflammation-nutrition biomarker model for survival prediction in lung cancer patients with concurrent tuberculosis.

Objectives: To explore the prognostic value of eight inflammation-nutrition biomarkers in patients with lung cancer and tuberculosis as no multidimensional prognostic models for this comorbid population are available currently.

Methodology: A retrospective study included 100 patients with lung cancer and tuberculosis admitted to a tertiary hospital from October 2019 to October 2024. Eight inflammation-nutrition markers (NLR, PLR, SII, LMR, PNI, HALP, HRR, ALB/GLB) were chosen as predictors while overall survival (OS) was the major event.

Oviduct-derived C-type natriuretic peptide improves bovine preimplantation embryo development in vitro by attenuating oxidative damage.

It is widely accepted that the poor quality of in vitro-produced (IVP) embryos becomes one of the most intractable issues currently limiting the outcomes of human assisted reproductive technology (ART). Although diverse molecules and pathways may be involved in this process, strategies to optimize culture conditions for the improvement of embryo development potential and the relevant mechanisms remain underexplored. Here, we demonstrate that the supplementation of C-type natriuretic peptide (CNP), a potential embryokine present in the oviduct, can improve the blastocyst formation rate and embryo quality, as evidenced by an increased total cell number and inner cell mass (ICM) cells, elevated embryonic cell proliferation, and reduced embryonic cell apoptosis.

Epigenetic modifications of gut microbiota and their potential role in atherosclerosis.

Emerging evidence positions the gut microbiota as a pivotal regulator of host metabolism and immunity, particularly in atherosclerosis pathogenesis, with epigenetic mechanisms serving as fundamental mediators of gene expression control. This review systematically summarizes gut microbiome-driven epigenetic pathways, encompassing DNA methylation, histone modifications, non-coding RNA networks and their interplay with atherosclerosis-related pathological processes. We synthesize current evidence on microbiota-epigenome crosstalk, highlighting its potential mechanistic contributions to atherosclerotic plaque development.

Successful Treatment of Mucormycosis and Azole-Resistant Coinfection in a Diabetic Patient: A Case Report.

Objective: To report a case of coinfection with mucormycosis and azole-resistant in a patient with poorly controlled type 2 diabetes, highlighting successfully treated with high-dose posaconazole combined with liposomal amphotericin B and lobectomy.

Methods: A 52-year-old man who presented to our hospital with a 1-month history of fever accompanied by productive cough and sputum. He had type 2 diabetes with poor control of glucose level.

The effects of moxibustion in chronic heart failure patients: a systematic review and meta-analysis.

Objective: Moxibustion has been utilized in China for 2,000 years as a safe and straightforward intervention for chronic heart failure (CHF). Numerous articles indicate that moxibustion enhances quality of life and certain heart failure indicators in CHF patients; however, there is a deficiency of high-quality, evidence-based studies with large sample sizes. Our objective was to systematically summarize and assess the clinical efficacy of moxibustion as an adjunctive treatment for CHF.

Integrative Analysis of Transcriptomics and Metabolomics Provides Insights into Meat Quality Differences in Hu Sheep with Different Carcass Performance.

Meat quality is a critical determinant of consumer preference and economic value in the livestock industry. However, the relationship between carcass performance and meat quality remains poorly understood. In our study, we conducted an integrative analysis of transcriptomics and metabolomics to investigate the molecular mechanisms underlying meat quality differences in Hu sheep with high (HHS, = 10) and low (LHS, = 10) carcass performance.

Ovine and Gene Polymorphisms and their Association with Tail Fat Weight in Sheep.

Tail fat weight is a key economic trait in fat-tailed sheep; reducing tail fat deposition is of significant importance for improving the economic efficiency of sheep farming. In this article, we measured the live weight before slaughter, tail fat weight, and carcass weight of Hu male sheep at 6 months of age and performed the descriptive statistical analysis. The results indicated the coefficient of variation of tail fat-related-traits ranged from 25% to 50%.

Parallel Multi-Scale Semantic-Depth Interactive Fusion Network for Depth Estimation.

Self-supervised depth estimation from monocular image sequences provides depth information without costly sensors like LiDAR, offering significant value for autonomous driving. Although self-supervised algorithms can reduce the dependence on labeled data, the performance is still affected by scene occlusions, lighting differences, and sparse textures. Existing methods do not consider the enhancement and interaction fusion of features.

Peptides with Soft-Aggregation Behavior Inhibit and Reverse Amyloid-β Fibrillization.

Amyloid-β fibrillization, characterized by ordered and compact peptide assembly, is a hallmark and a key therapeutic target of Alzheimer's disease. However, it is still challenging to completely inhibit or even reverse the fibrillization process. Here, it is reported an anti-fibrillization mechanism mediated by short peptides with a novel soft-aggregation behavior.

Magnetic signatures and origins of ferromagnetic minerals in Chang'e-6 lunar farside soils.

Ferromagnetic minerals in lunar materials record key information regarding the Moon's ancient dynamo, impact events, and space weathering. However, interpreting the magnetic signals is complicated by their diverse origins and properties. Here, we present comprehensive magnetic and mineralogical results of farside lunar soils returned by Chang'e-6 mission from the South Pole-Aitken Basin.

Differences of the respiratory microbiota between children suffering from community acquired pneumonia with presence or absence of asthma.

Recent advancements in respiratory microbiota research have progressively elucidated their pivotal role in pediatric respiratory pathologies. Alterations in airway microbial communities are intricately associated with diverse respiratory conditions and distinct disease states. This study conducted a comparative analysis of respiratory microecological profiles in pediatric cohorts diagnosed with community-acquired pneumonia (CAP), stratified by the presence or absence of comorbid bronchial asthma, from whom nasopharyngeal aspirates were obtained for metagenomic next-generation sequencing (mNGS).

Risk factors and predictive modeling of exclusive breastfeeding failure in mothers separated from their infants.

This study explored factors contributing to exclusive breastfeeding failure in mothers separated from their infants and developed a predictive nomogram model. Clinical data from 258 such mothers admitted to the First Affiliated Hospital of Soochow University between June 2023 and June 2024 were analyzed. Among them, 119 experienced breastfeeding failure.

Pulmonary fungal infection caused by Rhizopus microsporus in type II diabetic patient:A case report.

Pulmonary fungal infections are invasive fungal diseases with high mortality, particularly in immunocompromised patients. This case report describes a patient with type II diabetes mellitus who developed a pulmonary fungal infection. The patient presented with a one-week history of paroxysmal cough and expectoration of yellowish-white, purulent sputum following exposure to cold temperatures.

Identification of candidate genes for reproductive traits in Xinjiang sheep breeds based on genomic structural variation.

Reproductive traits are among the most important economic characteristics in sheep farming. Structural variations (SVs) are extensively distributed across sheep genomes and can directly or indirectly affect gene expression through a variety of mechanisms, leading to phenotypic variation among individuals or breeds. In this study, we characterized genomic SVs and identified candidate genes related to germplasm traits in seven sheep breeds.

Elucidating the effect of brewing temperature on the sensory quality of Longjing tea based on multi-scale molecular sensory science.

Longjing tea is popular due to its unique flavor characteristics, and the brewing process is of crucial importance in presenting its flavor. This study investigated how brewing temperature (BT) impacts Longjing tea's sensory and molecular profile. Sensory evaluations demonstrated that lower brewing temperatures (70-80 °C, with 70 °C optimal) enhanced umami taste while diminishing bitterness and astringency.

Mediating role of whole epigenome DNA methylation signatures in the association between copper and SGA.

Background: Trace element Cu is associated with the risk of small for gestational age infants, but its underlying mechanism is still unclear. This study aims to explore the possible mechanism of Cu induced SGA from the perspective of DNA methylation.

Methods: We performed epigenome-wide DNA methylation analysis of umbilical cord blood from small for gestational age infants (SGA, n = 35) and appropriate for gestational age infants (AGA, n = 61) at birth to explore SGA related epigenome-wide DNA methylation sites.

Efficacy and Safety of Hormone Replacement Combined With Escitalopram in the Treatment of Chronic Insomnia in Perimenopausal Women: A Randomized Controlled Trial.

Aims: To explore the efficacy of Femoston plus escitalopram for perimenopausal women with chronic insomnia and the relevant biomarkers.

Methods: A total of 166 patients randomly received: escitalopram plus placebo (Escitalopram Group), Femoston plus placebo (Hormone Group), and Femoston plus escitalopram (Combined Group) for 3 months and followed for 2, 4, 8, and 12 weeks. The primary efficacy endpoint was changes in Pittsburgh Sleep Quality Index Scale (PSQI), Insomnia Severity Index Scale (ISI), and Epworth Sleepiness Scale (ESS) scores at week 12 from baseline.

Diagnosis of Tropheryma whipplei pneumonia in an immunocompromised lymphoma patient using metagenomic next generation sequencing: A case report.

Whipple's disease (WD) is a rare chronic infectious illness caused by Tropheryma whipplei (T.whipplei), primarily affecting the gastrointestinal tract and joints, with rare lung involvement. Diagnosis can be challenging due to nonspecific symptoms and the difficulty in isolating the bacterium.

Differences in pulmonary microbiota of severe community-acquired pneumonia with different pathogenic microorganisms in children.

Background: Community-acquired pneumonia (CAP) is the leading cause of hospitalization and death in children under 5 years old. Recently, the number of children with severe CAP (SCAP) has increased significantly, and local or systemic complications may occur. However, changes in the pulmonary microbiota of SCAP with different pathogens and their relationship with the clinical features of SCAP remain unclear.

Autonomous All-in-One Patch for Closed-Loop Diagnosis-Therapy of Melanoma.

Early diagnosis, long-term monitoring, and precise therapy of melanoma are hampered by insufficient medical resources, significantly impacting the reduction of melanoma mortality rates and the mitigation of therapy-induced side effects. As an ideal autonomous all-in-one patch for long-term precision medicine on melanoma, several units, including sensing, drug delivery, power supply, and smart control, are required. Here, a microneedle-based sensing and drug release unit, a flexible printed-circuit board (FPCB)-based smart control platform, and a flexible Zn-air battery are integrated as an autonomous diagnosis-therapy system.