Prediction of favorable outcomes of acute basilar artery occlusion using machine learning.

Background: This study aims to develop an interpretable machine learning model using SHapley Additive exPlanations (SHAP) to predict favorable outcomes based on clinical, imaging, and angiographic data.

Methods: This study analyzed data from 184 patients with acute basilar artery occlusion (BAO) who underwent endovascular treatment (EVT) and completed a 90-day follow-up at Shanxi Provincial People's Hospital. A total of 68 medical variables were collected to develop predictive models using three machine learning algorithms: logistic regression (LR), support vector machine (SVM), and Light Gradient Boosting Machine (LightGBM).

Epidemiological investigation of venomous snakebites in Yunnan Province.

Background: Snakebite envenoming constitutes a substantial public health concern worldwide. Yunnan Province, The lack of comprehensive epidemiological data on snakebite in Yunnan affects research, diagnostic, and treatment advancements. This research evaluates patient demographics, seasonal patterns, snake species associated with the disease, and treatment approaches to guide preventative and therapeutic initiatives in the province.

Changes in source contribution to particle number concentrations during the 2022 COVID-19 Lockdown on southern edge of North China Plain.

The COVID-19 lockdown was a typical example of extreme emission reduction, providing an opportunity to study the impact of lockdown measures on air pollution. Particle number concentrations (PNC) originate from direct emissions or through new particle formation events. However, their variations during the lockdown period are under investigation.

Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep.

Background: Various regulators coregulate muscle development in animals. MicroRNAs (miRNAs) are crucial regulators that participate in multiple aspects of myofiber formation. Method: To identify key miRNAs and target genes associated with muscle development, embryos or longissimus dorsi of Chinese Merino sheep were collected for whole-transcriptome sequencing across 11 gestation periods: 26 days (D26), D29, D32, D35, D40, D45, D55, D75, D85, D105, and D135.

Efficacy and safety of heart rate control with esmolol on the incidence and duration of organ failure in predicted severe acute pancreatitis: protocol of a multicenter, open-label, randomized controlled trial.

Introduction: Overactivation of the sympathetic nerve system can lead to a sustained increase in heart rate, which may impair blood perfusion and organ function. Previous studies have demonstrated that the use of -blockers like esmolol can reduce heart rate, thereby improving clinical outcomes in patients with septic shock. For acute pancreatitis (AP), which shares a similar inflammatory pathophysiology with sepsis, previous experimental and observational studies showed significant sympathetic excitation during the acute phase, and the use of -blockers might be clinically beneficial.

Surface functionalized polystyrene nanoplastics impair nutrient assimilation from corn kernels (Zea mays L.) in a simulated human digestive tract.

Nanoplastics can be co-ingested with other food constituents by humans via food chain transfer, posing a potential risk to human health. Here, the impact of concentrations and surface chemistry (-COOH and -NH) of polystyrene nanoplastics (PS NPs) on nutrient bioaccessibility of corn kernels and the digestibility of corn starch was examined using a simulated gastrointestinal (INFOGEST) model. All types of PS NPs significantly reduced the bioaccessibility of phytochemicals in the corn, e.

Decoding JFT: a multifunctional fluorescence probe for sulfite and viscosity insights.

This study focuses on a multifunctional fluorescence probe JFT based on the FRET (Fluorescence Resonance Energy Transfer) and TICT (Twisted Intramolecular Charge Transfer) mechanism. JFT combines an electron donor and an acceptor, enabling it to detect sulfite and monitor intracellular viscosity. When reacting with sulfite, its electronic structure changes, turning off FRET and altering fluorescence wavelength and intensity.

The novel diagnostic markers for systemic lupus erythematosus and periodontal disease.

Background And Aims: Systemic lupus erythematosus (SLE) is one of the most prevalent systemic autoimmune diseases, characterized by aberrant activation of the immune system that leads to diverse clinical symptoms; periodontal disease (PD) is an inflammatory oral disorder caused by immune-mediated damage against subgingival microflora. Although clinical evidence suggests a potential association between SLE and PD, their shared pathogenic mechanisms remain unclear. This study aims to explore common genetic markers in SLE and PD that hold diagnostic and therapeutic implications.

Enhancing Photocatalytic Performance of Imine-Linked Covalent Organic Frameworks (COFs) through Grafting Methoxyl Groups.

Preparing imine-linked covalent organic frameworks (COFs) with good stability and excellent photocatalytic performance is highly desirable. Herein, methoxy groups were successfully grafted on the skeleton of highly stable TTA-DTM-COF through monomer modification strategy. The as-prepared TMTA-DTM-COF has a narrower bandgap and better photoelectric performance, which can be used as an efficient photocatalyst for the conversion of phenyl boronic acids into phenols.

Enclosed-terrain urbanized areas require vertically stratified air quality management: Insights from particulate matter vertical observations in China's Sichuan Basin.

Urbanized basins are widely recognized as hotspots‌ of particulate matter (PM) pollution. Characterizing the vertical stratification of PM in these regions is essential to elucidate the influence of regional air pollutant transport, dynamics of planetary boundary layer, and pollution-meteorology feedbacks. Using Mount Emei (500-3100 m a.

Enhanced Photothermal Conversion through 2D/0D Nano-Heterojunction Engineering for Highly Efficient Solar Desalination.

Two-dimensional (2D) materials are promising candidates for solar-driven desalination. However, conventional photothermal 2D materials like transition metal carbides and nitrides (MXenes) as well as transition metal dichalcogenides (TMDs) suffer from major limitations such as their complex synthesis and low photothermal conversion efficiency. In contrast, metal phosphorus trichalcogenides (MPCh) do not display the same drawbacks and possess widely tunable bandgaps (1.

LncRNA MCM3AP-AS1 protects against cerebral ischemia-reperfusion injury via targeting miR-27b-3p.

Objectives: Cerebral ischemia-reperfusion (CI/R) injury is a significant hurdle in ischemic stroke treatment. Substantial evidence indicates that long non-coding RNAs (lncRNAs) are implicated in CI/R injury. Here, we explore the function of lncRNA MCM3AP-AS1 in CI/R injury.

Untargeted Metabolomic Analysis Using UPLC-MS/MS Reveals Metabolic Changes Associated With Poisoning.

is known for its unique flavor; however, improper consumption can induce severe neuropsychiatric symptoms, including hallucinations and irritability. The underlying toxicity mechanism remains unclear, and the lack of specific antidotes poses a significant threat to patient safety. This study employed ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to analyze the plasma metabolic profiles of poisoning and healthy controls.

Recent Advances of Covalent Organic Frameworks-Based Materials for Photocatalytic U(VI) Separation: Structural Modulation and Mechanistic Exploration.

The development of efficient and selective U(VI) extraction from seawater and U(VI)-containing wastewater through photocatalytic technology holds significant importance for nuclear energy advancement and mitigation of radionuclide-related environmental and health risks. Covalent organic frameworks (COFs) have emerged as ideal photocatalytic materials for U(VI) separation due to their inherent porosity, robust frameworks, chemical stability, and exceptional structural regularity. This comprehensive review examines molecular-level structural optimization of COFs to enhance charge carrier separation and transfer, thereby improving photocatalytic U(VI) extraction efficiency.

Welding 2D Semiconducting Crystals by Covalent Stitching of Grain Boundaries in WS.

The advent of transition metal dichalcogenides (TMDCs) has revolutionized the field of optoelectronics. In this context, recent advances in the large-area synthesis of monolayer WS opened the door to potential optoelectronic applications because of its inherently high photoluminescence (PL) yield and superior electron mobility. However, randomly distributed point and line defects are key bottlenecks for efficient charge transport, hindering further development of system-on-chip (SoC) technologies.

Preliminary study on the time-correlation changes in brain neurotransmitters of mice exposed to mushroom toxin ibotenic acid.

Background: Mushroom poisoning represents a significant food safety issue globally, particularly neurotoxic mushroom poisoning, which raises considerable concern due to its potential to induce central nervous system symptoms. Ibotenic acid is identified as the primary neurotoxin associated with this form of poisoning; however, the underlying mechanisms of its neurotoxicity remain poorly understood.

Objective: This study aims to systematically evaluate the effects of ibotenic acid exposure across three consecutive key time points, from intoxication to recovery, on neurotransmitters related to the GABA/Glutamic-Acid, dopaminergic, serotonergic, and cholinergic systems in five brain regions: the cerebral cortex, hippocampus, striatum, brain stem, and cerebellum.

Cumulative handgrip strength and longitudinal changes in cognitive function and daily functioning among people aged 50 years and older: evidence from two longitudinal cohort studies.

Background And Purpose: Our study assesses the association between cumulative handgrip strength and longitudinal changes in cognitive function and daily functioning.

Methods: Two comparative cohort studies were used, including the English Longitudinal Study of Ageing (ELSA) and the Survey of Health, Ageing and Retirement in Europe (SHARE). Cumulative handgrip strength was calculated using three repeated measurements of handgrip strength.

Diagnosis of Tropheryma whipplei pneumonia in an immunocompromised lymphoma patient using metagenomic next generation sequencing: A case report.

Whipple's disease (WD) is a rare chronic infectious illness caused by Tropheryma whipplei (T.whipplei), primarily affecting the gastrointestinal tract and joints, with rare lung involvement. Diagnosis can be challenging due to nonspecific symptoms and the difficulty in isolating the bacterium.

Mass Spectrometry Imaging in Archaeobotany: An Illustration Through Analytical Characterisation of Sesame Lignans.

Rationale: Morphological analysis has been frequently applied in archaeobotany. Recently, increasing studies have been conducted on the identification of biomarkers in archaeobotanical materials, which are rarely attached to morphological analysis. To improve the interpretability of biomarker analysis, the localisation of characteristic biomarkers in ancient samples is needed.

Imaging-based lean mass distribution and diabetic nephropathy in the US population.

Aims: The present study aims to investigate the association between lean body mass (LBM) distribution and diabetic nephropathy (DN) in the US population with diabetes.

Methods: This cross-sectional study utilized the 2011 to 2018 data from the NHANES. Body composition was assessed using DXA.

Envenoming by King Cobra ( s str) with Cardiopulmonary Arrest in Yunnan, China.

The king cobra ( s str) is feared for its large size and highly toxic venom because its bite can result in severe envenoming and life-threatening injuries. We report a case involving a 50-y-old male from the mountainous town of Yunnan Province who experienced cardiopulmonary arrest after being bitten by a king cobra on his left index finger, followed by myocardial injury, pulmonary infection, and serologic reactions. During treatment, the patient received antivenom and cobra antivenom to neutralize the toxin, intubation, mechanical ventilation, antibiotics, anticholinergic drugs, and antiallergy therapy.

Plant growth-promoting rhizobacteria Halomonas alkaliantarcticae M23 promotes the salt tolerance of maize by increasing the K/Na ratio, antioxidant levels, and ABA levels and changing the rhizosphere bacterial community.

Background: Soil salinity is a global issue threatening crop growth and yield. Salt-tolerant plant growth-promoting rhizobacteria (PGPB) can survive in high-salinity environments and help plants adapt to stress, thus serving as an effective measure to mitigate salt stress.

Results: In this study, a salt-tolerant plant growth-promoting bacterium, Halomonas alkaliantarcticae M23 (M23), was isolated from the rhizosphere soil of the salt-tolerant plant Suaeda salsa.

Organic Dyes for Interfacial Regulation of Iodine in Metal Halide Perovskite Wide-Bandgap and Tandem Solar Cells.

In mixed-halide wide-bandgap (WBG, FACsPbIBr) perovskite solar cells (PSCs), halide ion migration triggered by light exposure results in phase separation. The migrating iodide anions (I) undergo oxidation to iodine (I) upon light exposure, whereas Pb is reduced to metallic Pb. This process induces irreversible degradation of PSCs, ultimately causing a marked decline in photovoltaic performance.

Fully Conjugated Sp Carbon-Linked Covalent Organic Frameworks Enables Accelerated Exciton Process for Superior Singlet Oxygen Photosynthesis for Water Remediation.

Photocatalytic oxygen (O) activation via energy transfer offers a sustainable approach for singlet oxygen (O) synthesis, while its performance suffers from the ultrafast exciton dissociation and sluggish intersystem crossing (ISC) process. Up to date, exciton regulation is still in its infancy. Here, via linkage engineering of covalent organic frameworks (COFs), we propose a fully conjugated sp carbon-linked COFs (spc-Py-Bpy COFs) with strong exciton interaction and fast ISC for boosted O photosynthesis.