Baseline anxiety disorders are associated with progression of diabetic kidney disease in type 2 diabetes.

Background: Diabetic kidney disease (DKD) is a leading cause of kidney failure worldwide. Anxiety has been associated with disease progression in non-diabetes patients. We aimed to examine the prospective association between anxiety and progression of DKD in type 2 diabetes.

Papillary thyroid cancer organoids harboring BRAF mutation reveal potentially beneficial effects of BRAF inhibitor-based combination therapies.

Backgrounds: Papillary thyroid cancer (PTC), which is often driven by acquired somatic mutations in BRAF genes, is the most common pathologic type of thyroid cancer. PTC has an excellent prognosis after treatment with conventional therapies such as surgical resection, thyroid hormone therapy and adjuvant radioactive iodine therapy. Unfortunately, about 20% of patients develop regional recurrence or distant metastasis, making targeted therapeutics an important treatment option.

[Approach and evidence-based study of provincial-level eco-economic development planning].

The development of ecological economy is one of the core elements of the ecological civilization system and an essential means to optimize the social-ecological systems. The key to developing ecological economy lies in preparing the development plan to realize concrete implementation. Given the objective and realistic demand for the development of ecological economy, it is critically needed to propose the approach of eco-economic planning and conduct empirical research.

Rational Design of Ferroelectric 2D Perovskite for Improving the Efficiency of Flexible Perovskite Solar Cells Over 23 .

Despite the great progress of flexible perovskite solar cells (f-PSCs), it still faces several challenges during the homogeneous fabrication of high-quality perovskite thin films, and overcoming the insufficient exciton dissociation. To the ends, we rationally design the ferroelectric two-dimensional (2D) perovskite based on pyridine heterocyclic ring as the organic interlayer. We uncover that incorporation of the ferroelectric 2D material into 3D perovskite induces an increased built-in electric field (BEF), which enhances the exciton dissociation efficiency in the device.

Improving the sensitivity and selectivity of sulfonamides electrochemical detection with double-system imprinted polymers.

The extensive use of antibiotics leading to the rapid spread of antibiotic resistance poses high health risks to humans, but to date there is still lack of an on-site detection method of SA residues. In this study, we integrated radical polymerization using sodium p-styrenesulfonate as a functional monomer and the self-polymerization of dopamine to prepare double-system imprinted polymers (DIPs) using sulfonamide antibiotics as templates. We found that the DIPs were semi-interpenetrating polymer networks and introduction of poly(dopamine) improved the selectivity of the imprinted cavities as well as the conductivity.

Mixed-Dimensional van der Waals Heterostructure for High-Performance and Air-Stable Perovskite Nanowire Photodetectors.

An organic-inorganic hybrid perovskite nanowire (NW), CHNHPbI, shows great potential for high-performance photodetectors due to its excellent photoresponse. However, the inefficient carrier collection between the one-dimensional (1D) NWs and metallic electrodes, as well as degradation of the perovskite, limits the viability of the CHNHPbI NWs for commercial production. Here, we demonstrate a photodetector with a mixed-dimensional van der Waals heterostructure of hexagonal boron nitride (hBN)/graphene (Gr)/1D CHNHPbI, which exhibits excellent responsivity and specific detectivity of up to 558 A/W and 2.

Computer-Based Design of a Cell Factory for High-Yield Cytidine Production.

Pyrimidine ribonucleotide de novo biosynthesis pathway (PRdnBP) is an important pathway to produce pyrimidine nucleosides. We attempted to systematically investigate PRdnBP in with genome-scale metabolic models and utilized the models to guide strain design. The balance of central carbon metabolism and PRdnBP affected the production of cytidine from glucose.

Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis.

Non-small cell lung cancer (NSCLC) is associated with high morbidity and mortality. Propofol functions as a tumor-inhibitor drug by regulating microRNAs (miRNAs). The primary objective of this study is to explore the functional mechanism of propofol in cisplatin (Cis) resistance of NSCLC cells by regulating the miR-744-5p/miR-615-3p axis.

OsMADS58 Stabilizes Gene Regulatory Circuits during Rice Stamen Development.

Rice () OsMADS58 is a C-class MADS box protein, and characterization of a transposon insertion mutant suggested that OsMADS58 plays a role in stamen development. However, as no null mutation has been obtained, its role has remained unclear. Here, we report that the CRISPR knockout mutant exhibits complex altered phenotypes, including anomalous diploid germ cells, aberrant meiosis, and delayed tapetum degeneration.

Ambient fine particulate matter exposures and oxidative protein damage in early pregnant women.

The association between oxidative protein damage in early pregnant women and ambient fine particulate matter (PM) is unknown. We estimated the effect of PM exposures within seven days before blood collection on serum 3-nitrotyrosine (3-NT) and advanced oxidation protein products (AOPP) in 100 women with normal early pregnancy (NEP) and 100 women with clinically recognized early pregnancy loss (CREPL). Temporally-adjusted land use regression model was applied for estimation of maternal daily PM exposure.

The molecular basis of socially induced egg-size plasticity in honey bees.

Reproduction involves the investment of resources into offspring. Although variation in reproductive effort often affects the number of offspring, adjustments of propagule size are also found in numerous species, including the Western honey bee, . However, the proximate causes of these adjustments are insufficiently understood, especially in oviparous species with complex social organization in which adaptive evolution is shaped by kin selection.

Distribution characteristics, sources, and risk assessment of organochlorine pesticides in the Fildes Peninsula and Adelaide Island.

This work analyzed the distribution characteristics, sources, and corresponding environmental risks of 10 organochlorine pollutants (OCPs) in soil samples from 13 stations on the Fildes Peninsula and Adelaide Island in Antarctica in 2020. Results showed that the total amount of OCP residues in the study area ranged from N.D.

Image-mode performance characterisation of a positron emission tomography subsystem designed for Biology-guided radiotherapy (BgRT).

Objectives: In this study, we characterise the imaging-mode performance of the positron emission tomography (PET) subsystem of the RefleXion X1 machine using the NEMA NU-2 2018 standard.

Methods: The X1 machine consists of two symmetrically opposing 90 arcs of PET detectors incorporated into the architecture of a ring-gantry linear accelerator rotating up to 60 RPM. PET emissions from a tumour are detected by the PET detectors and used to guide the delivery of radiation beam.

Construction and Comprehensive Analysis of ceRNA Networks and Tumor-Infiltrating Immune Cells in Hepatocellular Carcinoma With Vascular Invasion.

Hepatocellular carcinoma (HCC) is a common malignant cancer. Metastasis plays a critical role in tumor progression, and vascular invasion is considered one of the most crucial factors for HCC metastasis. However, comprehensive analysis focusing on competitive endogenous RNA (ceRNA) and immune infiltration in the vascular invasion of HCC is lacking.

Genetic introgression between different groups reveals the differential process of Asian cultivated rice.

The Asian cultivated rice consists of two major subspecies: indica and japonica. There are already many reports about the existence of genetic introgression between the two subspecies. They propose some possible introgression-related genes from the comparison of population parameters.

Ambient fine particulate matter exposures and human early placental inflammation.

The effect of fine particulate matter (PM) on human early maternal-fetal interface is unknown. We explored the association between maternal exposure to ambient PM and inflammation in placental villus of 114 women with clinically recognized early pregnancy loss (CREPL) and 114 women with normal early pregnancy (NEP). Temporally-adjusted land use regression models were used to estimate maternal daily PM exposure during pregnancy.

Window filtering algorithm for a low repetition rate pulsed laser coherent combination system.

The multi-dithering method has been well verified in the phase-locking of polarization coherent combination experiments. However, it is difficult to apply to low repetition rate pulsed laser coherent combination, since there exists an overlap in the frequency domain between the pulse laser and the large amplitude-phase noise resulting in traditional filters being unable to effectively separate the phase noise. Aiming to solve the problem, we propose, to the best of our knowledge, a novel method of pulse noise detection, identification, and filtering based on the autocorrelation characteristics between noise signals.

One-step fabrication of lidocaine/CalliSpheres composites for painless transcatheter arterial embolization.

Background: Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer. The pain caused by TAE is a stark complication, which remains to be prevented by biomedical engineering methods.

Methods: Herein, a commercial embolic agent CalliSpheres bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.

Genome scale metabolic model combined with single molecule real-time sequencing to analyze Actinomycete chromosomal heterogeneity.

The rapid development of biotechnology has provided new perspectives to observe and helped to gradually understand the significance of genetic instability in Actinobacteria. High frequency deletions of extremities and abnormal methylation of chromosomes suggest there might be relevant between the two phenomena. With this suspicion, we used single molecule real-time (SMRT) sequencing to map the genome-level methylation of one branch of actinomycetes, Saccharopolyspora erythraea, which have ring-shaped chromosomes.

Chuanzhitongluo regulates microglia polarization and inflammatory response in acute ischemic stroke.

Background And Purpose: Chuanzhitongluo (CZTL), a traditional Chinese medicine mixture, is used in the recovery period of acute ischemic stroke (AIS), and effectively improves the prognosis of AIS patients. This study aims to evaluate whether CZTL regulates microglia polarization and inflammatory response to reduce brain damage in the acute phase of AIS.

Methods: A mouse model of AIS was prepared by the photochemical method.

Fertility costs of cryptic viral infections in a model social insect.

Declining insect populations emphasize the importance of understanding the drivers underlying reductions in insect fitness. Here, we investigated viruses as a threat to social insect reproduction, using honey bees as a model species. We report that in two independent surveys (N = 93 and N = 54, respectively) of honey bee (Apis mellifera) queens taken from a total of ten beekeeping operations across British Columbia, high levels of natural viral infection are associated with decreased ovary mass.

Functional mechanism of EGR3 in cerebral ischemia/reperfusion injury in rats by modulating transcription of pri-miR-146a/146b to miR-146 and suppressing SORT1 expression.

Objective: EGR3 is implicated in angiogenesis in rats with cerebral ischemia/reperfusion injury (CIRI). This research aimed to explore the effect and in vivo and ex vivo mechanisms of EGR3 in CIRI.

Methods: CIRI rat models were established via middle cerebral artery occlusion.

Conjugated polymer coating enabled light-resistant black phosphorus with enhanced stability.

As an advanced two-dimensional (2D) material with unique properties, black phosphorus (BP) has attracted great attention in a variety of fields. One of the main obstacles for the practical application of BP is the poor ambient stability of few-layer BP, especially under light irradiation. In this study, a light-absorbing conjugated polymer is functionalized on the surface of BP during the exfoliation process, yielding BP nanosheets with light-resistance.

[Size Distribution and Source Appointment of Road Particles During Winter in Tianjin].

The significant role of traffic emissions mixed from various sources in urban air pollution has been widely recognized. However, the corresponding contributions to the roadside particle distribution are poorly understood due to the mixed impacts of various sources. Particle number concentrations of different sizes at the roadside in Nankai District of Tianjin were continuously monitored using a portable aerosol particle spectrometer during the morning rush hour (07:30-09:20) from Nov.