Interpretable machine learning model predicts 1-year inguinal hernia risk after robot-assisted radical prostatectomy.

Inguinal hernia represents a clinically significant yet underreported complication of robot-assisted radical prostatectomy (RARP) for localized prostate cancer, with a notably high incidence within the first postoperative year. Despite its adverse impact on quality of life and potential for severe sequelae, predictive tools for this outcome remain limited. To develop and validate the first machine learning (ML)-based clinical prediction model for inguinal hernia within 1 year after RARP, leveraging explainable artificial intelligence (AI) techniques for clinical interpretability.

[Simultaneous identification and detection of four novel isoxazoline drugs in bovine-origin foods using ultra-high performance liquid chromatography coupled to quadrupole/linear ion trap mass spectrometry].

Isoxazoline drugs （ISOs） are a class of five-membered heterocyclic compounds containing N and O atoms. They can inhibit -aminobutyric acid gated chloride channels and are widely used in the treatment of parasitic diseases in poultry. The intake of animal-derived foods by humans is an important way to come into contact with ISOs.

Don't give up in adversity: A moderated mediation model of network centrality and performance in leadership identity construction.

Leadership identity construction emerges from complex interactions among individual, structural, and contextual factors. What mechanisms underlie the interaction of these multilevel factors in shaping the core claiming-granting process of leadership identity construction? This study investigates how leadership identity claiming, network centrality, individual performance, and team performance interact to influence managerial leadership identity granting. Employing hierarchical linear modeling with matched data from 134 teams (N = 658), we find that leadership identity claiming significantly enhances managerial granting, with network centrality serving as a mediator and performance functioning as a moderator.

Dynamic surgery video summarization with balancing informativeness and diversity.

Surgery video summarization can help medical professionals quickly gain the insight into the surgical process for the surgical education and skill evaluation. However, existing methods are unable to efficiently summarize information to satisfy medical professionals. Since it is challenging to summarize the video while balancing the information richness and diversity.

Glutathione S-transferase in the differentiation of adventitious buds from callus.

Introduction: holds cultural and horticultural significance in traditional Chinese gardens, as a regional endemic species in Yunnan Province. However, during the regeneration process of , there is often a phenomenon of low efficiency of adventitious bud differentiation or no adventitious bud differentiation at all.

Methods: In previous study, we observed significant morphological differences between the callus tissues of 'Zipao' and wild species.

Identification of proteomic markers of chronic prostatitis/chronic pelvic pain syndrome treated with melatonin using a tandem mass tag approach.

Background: Chronic prostatitis (CP)/chronic pelvic pain syndrome is the most common urological disorder in young and middle-aged men. A previous study showed that melatonin attenuates prostate inflammation through Sirt1-dependent suppression of the nonobese diabetic-like receptor thermal protein domain-associated protein 3 inflammasome in mouse models of experimental autoimmune prostatitis (EAP). However, the main differentially expressed proteins (DEPs) in melatonin-treated mice with EAP have not yet been fully identified.

Suppression of Spin-Orbit Torque Switching by the Magnetic Proximity Effect.

Functional magnetic multilayers are particularly interesting for enabling many emerging spintronic physics, including spin-orbit torque (SOT), magnetic proximity effect (MPE), and perpendicular magnetic anisotropy (PMA), among many others. A comprehension of these spintronic phenomena is vital for the development of advanced spintronic materials and devices. Here, we investigate the interplay between the MPE and the current-induced SOT switching in the perpendicularly magnetized Pt/[Co/Pd] multilayers (with being the number of repetitions).

Oxygen Vacancy-Abundant Molybdenum Dioxide Electrodes with Minimal Interfacial Charge-Transfer Resistance for Ultrafast Filter Electrochemical Capacitors.

Electrochemical Capacitors (ECs) are considered capable of replacing bulky and low-capacitance aluminum electrolytic capacitors (AECs) in alternative-current filtering, yet regrettably, they have been plagued by slow ion migration and sluggish electrical response. Non-carbon-based electrode materials, while exhibiting significantly higher electric double-layer capacitance (EDLC) compared to carbon-based electrodes, still face the challenge of relatively high interfacial charge transfer resistance (R) that needs to be overcome. Here, a charge-transfer kinetics enhancement strategy is demonstrated by utilizing the lattice oxygen deficiency in molybdenum dioxide (MoO ) to increase metallic electrical conductivity and the number of active sites.

Social support and risk perception of influenza among Chengdu residents: A cross-sectional study during post-pandemic recovery.

Influenza remains a global public health threat, yet limited evidence exists regarding public risk perception and social support dynamics in post-pandemic contexts. This study investigates the interplay between social support and influenza risk perception among residents in Chengdu, China, following the ease of COVID-19 restrictions. A cross-sectional survey was conducted from January to March 2024 using convenience sampling (n = 708).

An LCN2-Dependent Positive-Feedback Loop Between Gastric Cancer Cells and Tumor-Associated-Macrophages Mediates Lymphangiogenesis and Lymphatic Metastasis.

Lymph node (LN) metastasis is a major determinant of poor prognosis in patients with gastric cancer (GC). Tumor-associated macrophages (TAMs) play a crucial role in promoting tumor metastasis and progression; however, the underlying mechanisms through which TAMs induce LN metastasis in GC remain poorly understood. This study demonstrates that low lipocalin-2 (LCN2) expression is associated with increased LN metastasis and shorter survival in GC.

Urinary Metabolites Variation After High-Intensity Rowing Training and Potential Biomarker Screening for Exercise-Induced Muscle Damage.

Exercise-induced muscle damage (EIMD) is the most common health risk in physical exercise. However, instant and non-invasive methods for EIMD prediction have not been reported. Urine is a promising tool for EIMD prediction.

Photosynthetic Electron Transport in Winter Wheat: Responses to Low-Temperature and Weak-Light Condition.

Spring low temperatures are a serious natural threat to wheat production in the Huang-Huai wheat region, and they are often accompanied by weak light environments during the day. To elucidate the response patterns and adaptation mechanisms of winter wheat leaves to low-temperature and weak-light environments, we simultaneously measured prompt chlorophyll a fluorescence, delayed chlorophyll a fluorescence, and modulated 820 nm light reflection; moreover, we analyzed the effects of low temperature and weak light treatment for different duration (2 h and 4 h) on the donor-side activity of photosystem II (PSII), the degree of PSII unit dissociation, the efficiency of light energy absorption and capture by PSII, electron transfer to Q and PSI terminal, PSI activity and cyclic electron transport activity in isolated wheat leaves under controlled conditions. The results, which were corroborated using the three methods, revealed that in low-temperature and weak-light environments, the degree of PSII unit dissociation, and the efficiency of light energy absorption, capture, and electron transfer to Q decreased, while the donor-side activity remained unaffected.

Vasoactive intestinal peptide reduces ocular hypertension by regulating tight junction of trabecular meshwork through Rab13/PKA signalling complex.

Background: Schlemm's canal and trabecular meshwork (TM) are conventional outflow pathway of aqueous humour, which play an important role in maintaining intraocular pressure (IOP) homeostasis. Our previous research has implied that vasoactive intestinal peptide (VIP) reduces high IOP by regulating the distribution of F-actin in the endothelial cells of Schlemm's canal. In this study, we investigated the mechanism by which VIP affects tight junction (TJ) of TM.

Strontium-Loaded Chitosan/Wood Hydrogel with Anisotropic Cellular Architecture for Enhanced Critical Bone Regeneration.

The reconstruction of critical-sized bone defects remains a significant clinical challenge. Natural polymers used for bone defects exhibit excellent biocompatibility and degradability; however, their inadequate mechanical properties, absence of biomimetic topological structures, and limited osteogenic potential hinder their suitability for clinical applications. In this study, we developed an all-natural wood hydrogel by integrating natural lignocellulosic nanofibers into chitosan hydrogels through delignification and vacuum impregnation.

Prenatal linuron exposure disrupts adrenal steroidogenesis and induces adrenal insufficiency in male rat offspring.

Linuron, a commonly used agricultural herbicide in certain regions, has raised concerns due to its endocrine toxicity in humans and wildlife. While its gonadal toxicity is established, its direct impact on prenatal adrenal development remains unexplored. Pregnant Sprague-Dawley rats received linuron doses (0, 25, 50, 100 mg/kg/day) by oral gavage from gestational days 12-21.

Family protection motivation and economic vulnerability: a network analysis of public influenza risk perception, education and mitigation strategies in China.

Background: In the post-pandemic era, influenza and COVID-19 jointly exacerbate global public health burdens, yet persistent biases in risk perception drive declining vaccination rates and health disparities. Conventional linear models fail to capture the complex interactions between risk cognition, family protection motivation, and socioeconomic vulnerability-particularly within collectivist contexts like China. This gap impedes effective interventions targeting critical behavioral nodes in influenza mitigation.

Sub-2 nm Cu and Co Codoping SnO Ultrathin Nanosheet with Mesoporous Structure for Efficient Electrocatalytic Urea Synthesis.

The production of urea through C-N coupling via the electrochemical coreduction of CO and NO represents an environmentally friendly and promising approach. However, the C-N coupling reaction encompasses multiple reactants and complex pathways, necessitating a catalyst that exhibits a high efficiency in both CO and NO reduction. Herein, the sub-2 nm Cu and Co codoped SnO ultrathin nanosheet (SnOCuCo) with mesoporous structure is synthesized for the electrochemical coreduction of CO and NO for urea synthesis, and the thickness of SnOCuCo is only 1.

Multi-Metal Alloy Nanotubes with Sub-1 Nm Wall Thickness for Efficient Inorganic and Organic Nitrogen Reduction.

The multi-metal alloy (MMA) catalysts display exceptional multifunctional catalytic capabilities. However, it is still a great challenge to improve the catalytic performance by accurately synthesizing the morphology. Herein, we present a simple one-pot method for designing and synthesizing the ultrathin MMA nanotube-structured CuNiCoFeRu catalysts (CuNiCoFeRu UNT), which achieve unprecedented comprehensive performance in nitrate and nitrobenzene reduction.

Fibroblast growth factor receptor inhibitors ameliorate metabolic dysfunction-associated steatohepatitis by modulating the glycine-glutathione-gut microbiota axis.

Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic liver disease characterized by hepatic steatosis, inflammation, and fibrosis. Dysregulation of fibroblast growth factor receptor (FGFR) signaling is closely associated with various liver diseases, but its role in hepatic metabolism remains unclear. In this study, we developed a small-molecule FGFR inhibitor, CP0813, and evaluated its therapeutic potential in three diet-induced MASH mouse models.

Rapid detection of AAV8 binding antibodies in gene therapy candidates: development of a point-of-care approach.

Preexisting anti-AAV antibodies pose a significant challenge to the success of Adeno-associated Virus (AAV) mediated gene therapies, as they can diminish therapeutic effectiveness, restrict patient eligibility for treatment, and cause serious health issues during treatment. This study introduces the first point-of-care (POC) test for the rapid, quantitative detection of AAV8 binding antibodies in patients' plasma, serum, and blood, leveraging Chembio's Dual Path Platform (DPP) technology. The DPP AAV8 Total Antibody (TAb) assay delivers results within 20 min from sample addition, with a dynamic range of 0-32 µg/ml when evaluated with purified human polyclonal antibodies that bind to AAV8, with reasonable specificity and sensitivity relative to Chembio's AAV8 TAb ELISA (R² = 0.

Pauling's Rules Guided Design of High-Entropy Sulfide Solid-State Electrolyte with High Ionic Conductivity and Stability.

All-solid-state lithium batteries (ASSLBs) represent a promising next-generation energy storage technology. While sulfide-based solid-state electrolytes (SSEs) offer high ionic conductivity, their practical application is hindered by inherent instability issues. To further enhance the performance, Pauling's rules are considered.

New insights for microplastic degradation: Synergistic degradation mechanisms of microplastics and atrazine in sediments.

Microplastics (MPs) and pesticides are widely distributed in sediments and can interact with each other to form complex pollutants, thereby altering their environmental impacts. However, it remains unclear whether this process affects the microbial degradation of MPs and pesticides. In this study, 90-day microcosm incubation experiment was conducted using polystyrene (PS), polyethylene (PE), polyethylene terephthalate (PET), polylactic acid (PLA), and atrazine (ATZ).

Investigation of the Reinforcement Mechanism and Impact Resistance of Carbon Hollow Microsphere-Reinforced PDMS Composites.

For meeting the growing demand for lightweight impact-resistant materials, this study designed and fabricated a carbon hollow microsphere (CHM)-reinforced polydimethylsiloxane (PDMS) composite and systematically investigated the influence of CHM packing structure on its energy absorption performance. Through optimizing the controllable preparation processes of the CHMs, CHMs with low breaking rates and novel structural stability were successfully prepared. A vacuum-assisted mixing-casting method was employed to synthesize the CHM/PDMS composites with varying CHM contents (0~10 wt.

Physics-Informed Neural Networks for Depth-Dependent Constitutive Relationships of Gradient Nanostructured 316L Stainless Steel.

The structural units with different characteristic scales in gradient nanostructured (GS) 316L stainless steel act synergistically to achieve the matching of strength and plasticity, and the intrinsic plasticity of nanoscale and ultrafine grains is fully demonstrated. The macroscopic stress-strain responses of each material unit in the GS surface layer can be measured directly by tension or compression tests on microspecimens. However, the experimental results based on microspecimens do not reflect either the extraordinary strengthening effect caused by non-uniform deformation or the intrinsic plasticity of nanoscale and ultrafine grains.

Adaptive image selection method for focus stacking based on a low-level vision task-driven network and liquid lens.

An all-in-focus ( AIF) image has been employed broadly in various fields such as microscopy imaging, medical imaging, and high-level vision tasks. Focus stacking is a key technology for merging AIF images. Considerable efforts have been made to reconstruct AIF images accurately.