Risk relationship between osteoporosis and plasma proteins.

Osteoporosis (OP) has gradually become a major public health problem. It is clinically important to elucidate further the pathophysiologic mechanisms that induce OP and to identify more effective therapeutic targets. In the present study, we used Mendelian randomization analysis to assess the causal effects of 4907 plasma proteins on bone mineral density (BMD) outcomes to identify their potential therapeutic targets.

Social support and risk perception of influenza among Chengdu residents: A cross-sectional study during post-pandemic recovery.

Influenza remains a global public health threat, yet limited evidence exists regarding public risk perception and social support dynamics in post-pandemic contexts. This study investigates the interplay between social support and influenza risk perception among residents in Chengdu, China, following the ease of COVID-19 restrictions. A cross-sectional survey was conducted from January to March 2024 using convenience sampling (n = 708).

Family protection motivation and economic vulnerability: a network analysis of public influenza risk perception, education and mitigation strategies in China.

Background: In the post-pandemic era, influenza and COVID-19 jointly exacerbate global public health burdens, yet persistent biases in risk perception drive declining vaccination rates and health disparities. Conventional linear models fail to capture the complex interactions between risk cognition, family protection motivation, and socioeconomic vulnerability-particularly within collectivist contexts like China. This gap impedes effective interventions targeting critical behavioral nodes in influenza mitigation.

The critical role of diet, exercise, and sleep in shaping the gut microbiota of children with idiopathic short stature: a Retrospective study.

Objectives: To investigate the gut microbiota in children with varying degrees of idiopathic short stature (ISS) and to examine the relationship between their intestinal microbiota and lifestyle factors, including diet, exercise, medication, sleep, and psychological state.

Methods: A retrospective study involving 58 ISS children was conducted from May to October 2022. Lifestyle data were collected using questionnaires.

Protocol for in situ transplantation of adipose stem cells into mouse epididymal white adipose tissue.

Adipose stem cells (ASCs) play a crucial role in maintaining adipose tissue homeostasis, but studying them in situ is technically challenging. Here, we present a protocol for the transplantation of ASCs into mouse epididymal white adipose tissue (eWAT). We describe steps for isolating and purifying ASCs, labeling them with a cell tracker, administering anesthesia, making an incision, and performing spot injections of ASCs into the eWAT of mice.

Volatile Organic Compounds in Teas: Identification, Extraction, Analysis, and Application of Tea Aroma.

Volatile organic compounds (VOCs) are important for teas' quality and act as a critical evaluative criterion in teas. The distinctive aromatic profile of tea not only facilitates tea classification but also has potential applications in aroma-driven product innovation. In this review, we summarized the tea aroma from tea classification, VOCs extraction methodologies, and VOCs detection techniques.

The predictive value of 3 risk assessment models for pulmonary embolism in acute exacerbation of chronic obstructive pulmonary disease.

This study evaluates the predictive value of the Caprini, Padua, and simplified Wells scoring systems for pulmonary embolism (PE) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and determine the optimal risk assessment tool. A retrospective cohort of 162 hospitalized AECOPD patients from January 2023 to December 2024 was included (51 in the PE+ group and 111 in the PE- group). Demographic data, clinical features, laboratory indices, and imaging data were collected.

Identification of Immune Hub Genes in Obese Postmenopausal Women Using Microarray and Single-Cell RNA Seq Data.

Obesity is characterized by a chronic state of low-grade inflammation. Investigating immune-critical genes and their biological functions in the adipose tissue of postmenopausal obese women is crucial for elucidating the underlying mechanisms of immune dysregulation associated with obesity. In this study, microarray (GSE151839) and single-cell RNA-seq (GSE176171) datasets were obtained from the Gene Expression Omnibus (GEO).

Mechanisms of nurses' AI use intention formation in Sichuan, Yunnan, and Beijing, China: mediating effects of AI literacy via self-efficacy-to-attitude pathways.

Aim: This study aimed to explore the formation mechanism of artificial intelligence (AI) usage intention among nurses in public hospitals in Beijing, Sichuan, and Yunnan, China, analyzing the influence of AI literacy on usage intention through AI self-efficacy and general attitudes.

Methods: A multi-center cross-sectional design was adopted, surveying 901 registered nurses via the Wenjuanxing platform from December 26, 2024, to February 25, 2025, with 878 valid questionnaires returned (effective rate 97.45%).

Research progress on evaluation methods for skeletal muscle mass assessment in sarcopenia (Review).

Sarcopenia, characterized by the age-related decline in muscle mass and function, especially in cancer patients, demands accurate diagnostic measures. Recent literature reflects a paradigm shift towards more accessible and diverse assessment tools. Traditional methods such as dual-energy X-ray absorptiometry and bioimpedance analysis offer precise measurements but are limited by equipment availability.

Eradicating fungal biofilm-based infections by ultrasound-assisted semiconductor sensitized upconversion photodynamic therapy.

Fungal biofilms, as self-produced extracellular polymeric substances that resist antifungal agents and immune defense, represent a major cause of treatment failure and recurrent infections. Therefore, it is of great importance to eradicate fungal biofilms to achieve efficient therapy. This study develops a synergistic reactive oxygen species (ROS)-enhanced strategy to eradicate Candida albicans biofilms by designing ultrasound-light dual-responsive nanohybrids (UCNP@CR).

Jianpi Qushi Heluo formula ameliorates podocytes injury related with ROS-mediated NLRP3 inflammasome activation in membranous nephropathy by promoting PINK1-dependent mitophagy.

Ethnopharmacological Relevance: Jianpi Qushi Heluo formula (JQHF) is an evidence-based herbal formula based on "Fangji Huangqi Decoction" in the classic of traditional Chinese medicine (TCM) synopsis of the Golden Chamber. Its effectiveness in reducing idiopathic membranous nephropathy (IMN) proteinuria, edema and other clinical symptoms and improving kidney injury has been confirmed by clinical trials and animal experiments. These results demonstrate the critical significance of reducing podocyte injury by regulating mitophagy through integrating ethnopharmacology.

The human gut microbiota is associated with host lifestyle: a comprehensive narrative review.

Background: The gut microbiota serves as a critical interface between lifestyle factors and host physiology. Despite extensive research on individual domains including diet, sleep, and exercise, an integrated understanding of their synergistic effects on microbial communities remains incomplete. This knowledge gap limits our ability to develop targeted microbiome-based interventions for metabolic and immune-related disorders.

Exploring the effectiveness of cytarabine in people living with HIV with progressive multifocal leukoencephalopathy: a retrospective cohort study in Chongqing, China.

Background: The incidence of progressive multifocal leukoencephalopathy (PML) in people living with HIV (PLWH) is approximately 2 %-4 % globally, and there is currently no effective therapeutic strategy. Cytarabine has been reported to increase the survival probability of PLWH with PML; however, its effectiveness remains controversial. The present study aimed to explore whether cytarabine improves the outcomes of PLWH with PML.

Evidence summary for the management of sleep disorders after malignant tumor surgery.

Introduction: This study aimed to extract, evaluate, and summarize the evidence related to the management of sleep disorders after malignant tumor surgery, providing a reference for evidence-based clinical practice.

Methods: A systematic and hierarchical search strategy was used to identify relevant evidence from authoritative databases and resources. Following the "6S" evidence pyramid model, we conducted a comprehensive review of the following databases: BMJ Best Practice, CINAHL, Cochrane Library, Clinical Trials, Embase, PubMed, UpToDate, Web of Science, Guidelines International Network, National Guideline Clearinghouse, and the National Guidelines Database.

Staphylococcus aureus Promotes Cutaneous Lesions in Patients With Epidermolysis Bullosa.

Epidermolysis bullosa (EB) is a group of rare, heterogeneous congenital conditions characterised by epidermal fragility, resulting in blister formation and lesions. Patients with EB are prone to developing cutaneous wounds. However, the composition of the EB skin microbiome in Chinese individuals remains poorly understood.

Fabrication of Printed Mesoscopic Perovskite Solar Cells Based on Nonannealing Strategy Perovskite Film to Achieve PCE > 18.

In printable mesoporous perovskite solar cells (p-MPSCs), the perovskite films deposited from room-temperature solvents can effectively optimize the interface between the perovskite films and the electrodes. However, the low crystallization rate of perovskite thin films at room temperature often leads to the formation of nonphotoactive phases and an increase in the density of defect states. To accelerate the crystallization of perovskite films at room temperature, acetonitrile (ACN) is introduced as a cosolvent in the binary solvent system of 2-methoxyethanol/-methyl-2-pyrrolidone (2 ME/NMP).

Charge microenvironment and bioactivity of -formed PEG-RGD dual hydrogel dressings promote wound healing.

Healing of large skin wounds involves a complex biological process with overlapping phases, facing challenges from fibroblast proliferation, immune response, and extracellular matrix (ECM) remolding. Hydrogel dressings serve as temporary barriers protecting injured tissue from exogenous infections while providing an advantageous microenvironment for cellular regeneration. However, traditionally molded hydrogels through catalyzed or triggered crosslinking into fixed size and strength prior to treatment struggle to integrate tightly with irregular wound surfaces, leading to dressing detachment and wound exposure in areas with high curvature and mobility.

Dysbiosis of gut microbiota with enriched pro-inflammatory species in children with idiopathic short stature: a case-control study.

Idiopathic short state (ISS) demotes a condition of diminished height in children lacking identifiable pathological etiologies, emering as a prominent elements, can precipitate ISS. We explored the prevalence, variability, organization, and contribution of gut microbiota in children affected by ISS. This study selected 58 ISS individuals aged 6-12, serving as the experimental group, 58 non-ISS children constituted the control group.

20.27% Efficient Carbon-Based Hole-Conductor-Free Printable Mesoscopic Perovskite Solar Cells Achieved by Halogen-free Room-Temperature Post-treatment.

Defects at grain boundaries and energy level mismatch at the perovskite film/carbon electrode interface in printable mesoscopic perovskite solar cells (p-MPSCs) lead to non-radiative carrier recombination and large open-circuit voltage (V) losses. Herein, a method for post-treating perovskite films in p-MPSCs at room-temperature using halogen-free aromatic amines, including Benzylamine (BA), 1-Naphthalenemethylamine (NMA), and 1-Naphthalenecarboximidamide (NFA), is reported. The halogen-free aromatic amines prevent the formation of iodine vacancy defects in perovskite films by interacting with under-coordinated Pb, significantly reducing the trap state density of the perovskite films.

Macrophage Vesicles-Loaded NIR-II AIEgens for Precise In Situ Fluorescence Imaging of Atherosclerosis.

Precise diagnosis of atherosclerosis (AS) is a crucial strategy for reducing acute cardiovascular events. Herein, a macrophage membrane (MM)-camouflaged biomimetic vesicle loaded with near-infrared-II (NIR-II) aggregation-induced emission luminogens (AIEgens) (P4TT@MM) is proposed to achieve localized in vivo imaging of atherosclerosis. The AIEgens characteristics of P4TT@MM effectively compensate for the fluorescence intensity decrease caused by the intramolecular torsional charge transfer (TICT) effect, even in foam cell-rich lesions.

The multifunctional role of hydroxyapatite nanoparticles as an emerging tool in tumor therapy.

Hydroxyapatite nanoparticles (HANPs) are well-known nanomaterials for bone regeneration or repair. In recent years, HANPs have emerged as a potential tool in tumor therapy because of the numerous advantages the nanoparticles offer, including the diverse physicochemical properties, the selective anti-tumor effect, intrinsic immunomodulatory activity, ability to reverse of drug or immune tolerance, allowance of ion substation, good drug-loading capabilities, etc. Notably, the physicochemical properties of the particles, such as size and shape, significantly influence their anti-tumor efficacy.