Correction: Leisure constraints and the negotiation of structural relationships: a case study of scuba diving enthusiasts.

[This corrects the article DOI: 10.3389/fspor.2025.

Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable Proteins.

Objectives: To construct multi-trait polygenic scores (PRS) predicting chronic obstructive pulmonary disease (COPD) and exacerbations, validate their performance in diverse cohorts, and identify PRS-related proteins for potential therapeutic targeting.

Design: Prospective cohort studies.

Setting: Genetic Epidemiology of COPD (COPDGene; 2007-present), Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE; 2005-2008), Mass General Brigham Biobank (MGBB; 2010-present), All of Us (2016-present), and UK Biobank (UKB; 2006-present).

InSe Dynamic Memristor-Based Reservoir Computing for Temporal and Spatial Signal Recognition.

Multimodal recognition techniques are pivotal for advancing contemporary artificial intelligence, particularly in enhancing visual perception. However, research on electronic devices capable of robust multimodal recognition remains limited. In this study, we employ an InSe/AlO/ Pb(Zr·Ti·)O (PZT) heterostructure as a dynamic memristor.

Effects of TCM aromatherapy on post-stroke depression: a meta-analysis of randomized controlled trials.

Background: Traditional Chinese Medicine(TCM) aromatherapy has been gradually applied to patients with post-stroke depression (PSD), but uncertainty remains. To systematically evaluate the effectiveness and safety of TCM aromatherapy in the treatment of post-stroke depression, we aim to conclude by synthesizing randomized controlled trials (RCTs).

Methods: We searched the following databases in English and Chinese: China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature (CBM), Wanfang Database, VIP Database, Chaoxing, PubMed, and The Cochrane Library for randomized controlled trials on the effects of TCM aromatherapy intervention in patients with post-stroke depression.

Polarization of Tumor Cells and Tumor-Associated Macrophages: Molecular Mechanisms and Therapeutic Targets.

Tumor-associated macrophages (TAMs) are prominent constituents of solid tumors, and their prevalence is often associated with poor clinical outcomes. These highly adaptable immune cells undergo dynamic functional changes within the immunosuppressive tumor microenvironment (TME), engaging in reciprocal interactions with malignant cells. This bidirectional communication facilitates concurrent phenotypic transformation: tumor cells shift toward invasive mesenchymal states, whereas TAMs develop immunosuppressive, pro-tumorigenic traits.

Exploration of the Mechanism of Action of in the Treatment of Liver Cancer Based on Network Pharmacology, Molecular Docking and in vitro Validation.

Purpose: The anti-tumor effects of , as a medicinal and dietary Chinese medicine, have long been documented. However, the mechanism of action for its therapeutic effect has not been fully elucidated.

Methods: The chemical constituents of were screened using PubMed, CNKI, and Wanfang databases.

Exposure to diethyl phthalates impairs ovarian reserve and oocyte maturation in female mice.

Diethyl phthalates (DEP) are commonly used as a plasticizer and have been found to cause male reproductive defects and metabolic disease in mammals as a potential environmental endocrine disruptor. However, the effects and underlying mechanisms of DEP exposure on female follicle development and oocyte maturation were still unclear. In this study, we found that mice exposed to DEP had significantly reduced primordial follicles.

Effects of immersive virtual reality training on the adaptive skills of children and adolescents with high functioning autism spectrum disorder: a mixed-methods pre-post study.

Background: Autism Spectrum Disorder (ASD) is characterized by social deficits and restricted, repetitive behaviors, with fewer than 10% achieving independent adulthood. Immersive virtual reality (IVR) provides a novel training approach through interactive and realistic environments. This study developed an IVR system to enhance adaptive skills in children and adolescents with high-functioning ASD.

Ischemic Stroke as a Rare Manifestation of Neurobrucellosis: A Case Report.

Background: This article presents a case report of a patient with neurobrucellosis (NB) complicated by ischemic stroke (IS).

Case Presentation: A male presented with new-onset left-sided limb weakness lasting three days, along with a 15-month history of intermittent fever and progressive right-sided limb weakness over eight months. A cranial MRI revealed an acute infarction in the left cerebellar vermis.

Progressive structural alterations in the cerebral small vessel disease with cognitive impairment and vascular dementia.

BackgroundThe progression of cerebral small vessel disease (CSVD) leads to cognitive decline, which can be categorized into subcortical vascular mild cognitive impairment (svMCI) and vascular dementia (VaD).ObjectiveThis research aimed to examine the structural changes in gray (GM) and white matter (WM) in the brain across the disease spectrum.MethodsA total of 30 healthy controls (HC), 26 individuals with svMCI, and 29 individuals with VaD were included in study.

Genome-wide association study of neuropathic pain phenotypes implicates loci involved in neural cell adhesion, channels, collagen matrix formation, and immune regulation.

Neuropathic pain is a common and debilitating symptom with limited treatment options. Genetic studies, which can provide vital evidence for drug development, have identified only 3 genome-wide significant signals for neuropathic pain traits. To address this, we performed the largest genome-wide association study (GWAS) to date of all-cause neuropathic pain and neuropathic pain subtypes.

Dietary Exposure to Imidacloprid at Environmental Doses Induces Renal Injury in Mice via P-AMPK Inhibition and Subsequent Purine Metabolism Dysregulation.

Imidacloprid (IMI), a neonicotinoid insecticide extensively applied in agriculture, is among the most frequently detected pesticides in food. However, the long-term impact of chronic dietary exposure to environmentally relevant IMI doses on kidney health has not been fully elucidated, particularly regarding its nephrotoxic mechanisms. To address this gap, chronic exposure to IMI was administered to mice through supplementation of their feed with environmentally relevant doses (approximately 100 and 1000 μg/kg/day) for 24 weeks to investigate its nephrotoxicity and underlying mechanisms.

Zeaxanthin augments CD8 effector T cell function and immunotherapy efficacy.

The detailed mechanisms underlying the regulatory significance of dietary components in modulating anti-tumor immunity remain largely unknown. Here, we apply a co-culture-based screening approach using a blood nutrient compound library and identify zeaxanthin (ZEA), a dietary carotenoid pigment found in many fruits and vegetables and known for its role in eye health, as an immunomodulator that enhances the cytotoxicity of CD8 T cells against tumor cells. Oral supplementation with ZEA, but not its structural isomer lutein (LUT), enhances anti-tumor immunity in vivo.

Latent profile analysis for benefit finding in ischemic stroke patients: A cross-sectional study.

This study aims to explore the benefit finding (BF) profile and to identify heterogeneous subgroups in patients with ischemic stroke. From November 2021 to July 2022, the cross-sectional study was carried out among patients with ischemic stroke using a convenient sampling. The general information questionnaire, modified Rankin Scale, revised Benefit Finding Scale, and Mutuality Scale were used for the investigation.

Hyperuricemia and the gut microbiota: current research hotspots and future trends.

Background: Hyperuricemia (HUA), found widely in humans and birds, is a key physiological factor responsible for the development of gout. In recent years, the relationship between the gut microbiota and HUA has garnered significant attention from researchers. This study aims to explore the current research hotspots, knowledge gaps, and future research trends regarding the gut microbiota and HUA.

Applications and prospects of spatial transcriptomics in prostate cancer research: A narrative review.

Spatial transcriptomics, an increasingly prominent technique, has been extensively utilized to examine tumors within the digestive tract (such as liver and colorectal cancers) and the nervous system. However, its application in prostate cancer research remains comparatively limited. This article provides a detailed overview of the principles and features of spatial transcriptomics, particularly highlighting its applications in studying the tumor microenvironment, heterogeneity, and clinical implications in prostate cancer.

Identification of proteomic markers of chronic prostatitis/chronic pelvic pain syndrome treated with melatonin using a tandem mass tag approach.

Background: Chronic prostatitis (CP)/chronic pelvic pain syndrome is the most common urological disorder in young and middle-aged men. A previous study showed that melatonin attenuates prostate inflammation through Sirt1-dependent suppression of the nonobese diabetic-like receptor thermal protein domain-associated protein 3 inflammasome in mouse models of experimental autoimmune prostatitis (EAP). However, the main differentially expressed proteins (DEPs) in melatonin-treated mice with EAP have not yet been fully identified.

Different Acupuncture Treatments for Myofascial Pain Syndrome in Neck or Shoulder: A Network Meta-Analysis Based on Randomized Controlled Trials.

Background: Myofascial Pain Syndrome (MPS) is a prevalent musculoskeletal condition. Acupuncture therapy demonstrates significant advantages due to its unique mechanism of action. However, there are notable discrepancies in the evidence levels among various acupuncture therapies, and direct comparative data between different treatments remain scarce.

A highly efficient ultra-broadband and wide-angle plasmon absorber based on nanocavity arrays for solar harvesting.

As the demand for renewable energy continues to rise, developing efficient solar energy harvesting technologies has become increasingly important. In this paper, we propose a plasmon absorber utilizing nanocavity arrays to achieve ultra-broadband absorption of solar energy. The results show that the absorber achieves an average absorption rate of 95.

Selective Toluene Separation via π-π Interactions in Cobalt sql Network Rubber Composites.

Selective removal of aromatic contaminants from water matrices poses substantial difficulties in environmental remediation processes, necessitating sophisticated materials with discriminatory molecular recognition properties. Herein, we report a framework-elastomer hybrid membrane containing [Co(4-pmntd)(NO)] (4-pmntd represents ,'-bis(4-pyridylmethyl)naphthalene diimide) designed for effective toluene recovery from trace aqueous environments. Systematic structural analysis employing crystallographic diffraction, gas adsorption measurements, surface electron spectroscopy, and proton nuclear magnetic resonance elucidates the material's architectural characteristics and surface phenomena.

Astaxanthin mitigates cardiac toxicity induced via doxorubicin by alleviating mitochondrial fission and autophagy in rats.

Unlabelled: Doxorubicin (DOX)-induced cardiotoxicity is the most prevalent adverse reaction of DOX during chemotherapy and significantly impacts its clinical application. At present, clinical interventions for mitigating DOX-induced cardiotoxicity remain sub-optimal. Mitochondria are the primary target organ of DOX-induced cardiotoxicity, which can result in cardiac mitochondrial dynamic imbalance and impaired mitochondrial autophagy.

Comprehensive analysis of MAGE-A10 in pan-cancer and its validation in gastric cancer.

Previous studies found that melanoma antigen genes (MAGE) were antigens expressed in various tumor cells but hardly expressed in normal tissues, and their unique expression pattern made them highly promising for cancer immunotherapy. MAGE-A10 was a member of the MAGE family, and although it was expressed in various tumors, its specific function remained unclear. In this study, we conducted a comprehensive pan-cancer analysis of MAGE-A10 expression, prognostic value, DNA methylation, genetic variation, function, immune infiltration, and drug sensitivity using multiple public databases.

Bioinformatic analyses and validated experiments reveal an aging hallmark gene set and protective miR of coronary artery disease.

To investigate how aging hallmarks exert roles in the age-related disease of coronary artery disease (CAD). R software and the GEO2R online tool identified differentially expressed genes (DEGs) and differentially expressed microRNAs (DEMis) in CAD microarray datasets from the Gene Expression Omnibus. Genes common to target genes of DEMis, DEGs, and an aging gene list from Human Aging Genomic Resources were then identified and analyzed for protein-protein interactions and functional and pathway enrichment.

Distribution characteristics and source analysis of heavy metals in surface sediments of the Yellow River estuary.

To investigate the spatial distribution, ecological risk, and potential sources of heavy metals in the surface sediments of the Yellow River estuary, we analyzed and evaluated the contents of 10 heavy metals (Cr, Cu, Zn, Cd, Pb, Ni, V, Co, Mn, and As). The results showed that heavy metals content in the surface sediments of the Yellow River estuary all met the marine sediment quality standard Class I, with the highest average content of Mn (676.60 mg·kg) and the lowest content of Cd (0.

LAPTM4B as a key regulator in the copper-induced endoplasmic reticulum-lysosome interplay disorder in duck liver and the protective role of baicalin.

Background: Copper (Cu) is a pervasive environmental pollutant with significant hepatotoxic effects in animals. The endoplasmic reticulum (ER) interacts closely with lysosomes to maintain intracellular homeostasis. However, the role and mechanism of ER-lysosome crosstalk in Cu-induced liver injury in ducks remains unclear.