Identification of proteomic markers of chronic prostatitis/chronic pelvic pain syndrome treated with melatonin using a tandem mass tag approach.

Background: Chronic prostatitis (CP)/chronic pelvic pain syndrome is the most common urological disorder in young and middle-aged men. A previous study showed that melatonin attenuates prostate inflammation through Sirt1-dependent suppression of the nonobese diabetic-like receptor thermal protein domain-associated protein 3 inflammasome in mouse models of experimental autoimmune prostatitis (EAP). However, the main differentially expressed proteins (DEPs) in melatonin-treated mice with EAP have not yet been fully identified.

Global burden of urinary tract infections in older women from 1990 to 2021 with projections to 2040: a trend analysis of the Global Burden of Disease Study 2021.

Background: Comprehensive estimations regarding the worldwide burden of urinary tract infections (UTIs) in older women aged ≥ 65 years are lacking. This study first explored the trends in the burden of UTIs among older women from 1990 to 2021 with projections to 2040.

Methods: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 analytical tool was adopted to calculate the age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life-years (DALYs) rate (ASDR).

Efficient UV-matchable light-converting agent based on a space-conjugated di-triarylboron structure.

Incomplete ultraviolet (UV) absorption and low fluorescence quantum yields (FLQY) of light-converting agents limit their applications. Here, the as-synthesized bis-triarylboron compounds, when doped into poly(methyl methacrylate) (PMMA) films, show highly matched UV absorption and a high FLQY (up to 0.65), attributed to the intramolecular space conjugation effect.

Clinical manifestations and risk factors of immune-related thyroid adverse events in patients treated with PD-1 inhibitors: a case-control study.

Background: Immune checkpoint inhibitors (ICPIs) have emerged as a powerful strategy to cancer treatment. However, while demonstrating antitumor efficacy, they can also induce a range of immune-related adverse events (irAEs). Immune-related thyroid dysfunction is one of the most common irAEs.

Juglone alleviates pelvic pain and prostatic inflammation via inhibiting the activation of NLRP3 inflammasome and alleviating oxidative stress in EAP mice.

Background: Juglone, a naphthoquinone compound that occurs naturally, is present predominantly in the fruits, leaves, and roots of walnut plants. Although its antioxidant and anti-inflammatory effects have been demonstrated in various diseases, its therapeutic potential remains unexplored in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Purpose: Our objective was to investigate the therapeutic effectiveness of juglone in treating CP/CPPS and elucidate the potential mechanism involved.

Involvement of the ovarian-specific Mro-IR in oogonia differentiation and oocyte development in freshwater giant prawn .

Introduction: Mro-IR is an insulin-like receptor and is uniquely expressed in the ovary of the freshwater giant prawn . However, the understanding of this conserved receptor involved in the molecular mechanism underpinning ovarian development and female reproduction of is still fragmentary.

Methods: In the present study, knockdown of Mro-IR in the proliferative stage and premature stage of ovarian development in female prawn induced abnormal oogonia differentiation and disordered oocyte development.

Clinical Manifestations and Risk Factors of Liver Injury Induced by PD-1 Inhibitors in Patients with Malignancies: A Case-Control Study.

Background: Hepatic injury induced by immune checkpoint inhibitors (ICPIs) is an inevitable challenge in the era of innovative anti-tumor therapies. However, studies on immune-related liver injury are relatively insufficient, and the associated risk factors are still lacking. The purpose of this study was to explore the incidence and clinical manifestations of immunotherapy-related liver injury.

Optimized microwave absorption and thermal properties for TiB@BN/PDMS composites via TiB@BN heterogeneous interface engineering.

The single electromagnetic (EM) wave loss mechanism leads to suboptimal microwave absorption in dielectric materials, whereas, introducing different materials and constructing distinctive microstructures can significantly improve microwave absorption. In this study, TiB and TiB@BN powders were synthesized using boron thermal reduction and chemical solution methods. Their microwave absorption and thermal properties were systematically analyzed.

User preference interaction fusion and swap attention graph neural network for recommender system.

Recommender systems are widely used in various applications. Knowledge graphs are increasingly used to improve recommendation performance by extracting valuable information from user-item interactions. However, current methods do not effectively use fine-grained information within the knowledge graph.

Spatio-temporal envolutional graph neural network for traffic flow prediction in UAV-based urban traffic monitoring system.

With the advancement of modern UAV technology, UAVs have become integral to creating traffic management monitoring systems. Additionally, UAV-based traffic monitoring systems can predict traffic flow by integrating machine learning methods. Specifically, traffic flow data contains both spatial and temporal information, which can be effectively processed by graph neural networks (GNNs).

CXCR4 regulates macrophage M1 polarization by altering glycolysis to promote prostate fibrosis.

Background: C-X-C receptor 4(CXCR4) is widely considered to be a highly conserved G protein-coupled receptor, widely involved in the pathophysiological processes in the human body, including fibrosis. However, its role in regulating macrophage-related inflammation in the fibrotic process of prostatitis has not been confirmed. Here, we aim to describe the role of CXCR4 in modulating macrophage M1 polarization through glycolysis in the development of prostatitis fibrosis.

CXCR4 influences PUFA desaturation and oxidative stress injury in experimental prostatitis mice by activating Fads2 via PPARγ.

Chronic prostatitis-induced excessive inflammation and oxidative stress (OS) damage substantially affect men's quality of life. However, its treatment remains a major clinical challenge. Therefore, the identification of drugs that can decrease chronic prostatitis and oxidative stress targets is urgent and essential.

Adaptive Decision Spatio-temporal neural ODE for traffic flow forecasting with Multi-Kernel Temporal Dynamic Dilation Convolution.

Traffic flow prediction is crucial for efficient traffic management. It involves predicting vehicle movement patterns to reduce congestion and enhance traffic flow. However, the highly non-linear and complex patterns commonly observed in traffic flow pose significant challenges for this task.

Nutrition-Related Knowledge Graph Neural Network for Food Recommendation.

Food recommendation systems are becoming increasingly vital in modern society, given the fast-paced lifestyle and diverse dietary habits. Existing research and implemented solutions often rely on user preferences and past behaviors for recommendations, which poses significant issues. Firstly, this approach inadequately considers the nutritional content of foods, potentially leading to recommendations that are overly homogeneous and lacking in diversity.

P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.

Chronic prostatitis is one of the most common urologic diseases that troubles young men, with unclear etiology and ineffective treatment approach. Pyroptosis is a novel model of cell death, and its roles in chronic prostatitis are unknown. In this study, P2X7R, NEK7, and GSDMD-NT expression levels were detected in prostate tissues from benign prostate hyperplasia (BPH) patients and experiment autoimmune prostatitis (EAP) mice.

Reoperation for ipsilateral local recurrence following prior nephron-sparing surgery: innovative surgical insights from a high-volume urological center with cross-sectional study.

Background: The main aim of this study was to examine the perioperative results of reoperations and suggest novel surgical approaches. Based on a substantial number of robotic and laparoscopic nephron-sparing surgery (NSS), the authors aim to propose novel surgical strategies that offer practical recommendations to surgeons.

Methods: Renal cell carcinoma patients with ipsilateral recurrent tumors, without evidence of metastasis, and who underwent primary NSS at our center between 2013 and 2023 were enrolled in this study, and all received the second time surgery.

Integrated analysis of histone modification features in clear cell renal cancer for risk stratification and therapeutic prediction.

Clear cell renal cell carcinoma (ccRCC) is a common urological malignancy that is involved in tumor genesis and development. However, few studies have focused on the predictive role of the global histone modification status in ccRCC. A total of 621 patients with complete transcript information and corresponding clinical profiles were obtained from TCGA-KIRC, GSE22541, and EMTAB3267 cohorts.

Smart Biosensor for Breast Cancer Survival Prediction Based on Multi-View Multi-Way Graph Learning.

Biosensors play a crucial role in detecting cancer signals by orchestrating a series of intricate biological and physical transduction processes. Among various cancers, breast cancer stands out due to its genetic underpinnings, which trigger uncontrolled cell proliferation, predominantly impacting women, and resulting in significant mortality rates. The utilization of biosensors in predicting survival time becomes paramount in formulating an optimal treatment strategy.

Modifying carbon dots with L-phenylalanine for rapid discrimination of tryptophan enantiomers.

New chiral carbon dots (CDs), L-PCDs, for discriminating tryptophan (Trp) enantiomers were prepared in this work. Firstly, original CDs were synthesized through a hydrothermal method using pyridine-2,6-dicarboxylic acid and -phenylenediamine as raw materials. Then, the surface of original CDs was modified with L-phenylalanine to create chiral fluorescent carbon L-PCDs.

Incidence, clinical features, and risk factors of hemocoagulase-induced hypofibrinogenemia: A retrospective real-world study.

The objective of this study was to explore the real-world incidence, severity, clinical features, and potential risk factors associated with hypofibrinogenemia induced by hemocoagulase. Based on Chinese Hospital Pharmacovigilance System, a retrospective case-control study was conducted, enrolling hospitalized patients who received hemocoagulase for the treatment or prevention of hemorrhage in Weifang People's Hospital in China from January 2021 to May 2022. Univariate and multivariate logistic regression was performed to analyze the potential risk factors.

Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice.

Purpose: Prostatitis is a highly prevalent condition that seriously affects men's physical and mental health. Although epidemiological investigations have provided evidence of a correlation between insufficient sleep and prostatitis, the pathogenesis of prostatitis remains unclear. We sought to identify the underlying mechanism involved and identify a promising therapeutic target.