Development of an evaluation index system for intelligent minimally invasive tumor ablation based on telemedicine.

Objective: This study aimed to establish an evaluation index system for intelligent minimally invasive tumor ablation based on telemedicine, thereby providing theoretical support for the assessment, application, and promotion of remote intelligent ablation therapies.

Methods: An expert consultation questionnaire was developed based on a review of the literature. Purposive sampling was performed to select 16 experts specializing in minimally invasive oncology, telemedicine management, and healthcare informatics.

Exposure to diethyl phthalates impairs ovarian reserve and oocyte maturation in female mice.

Diethyl phthalates (DEP) are commonly used as a plasticizer and have been found to cause male reproductive defects and metabolic disease in mammals as a potential environmental endocrine disruptor. However, the effects and underlying mechanisms of DEP exposure on female follicle development and oocyte maturation were still unclear. In this study, we found that mice exposed to DEP had significantly reduced primordial follicles.

Launching by cavitation.

Cavitation, characterized by formation of vapor bubbles in a low-pressure or high-temperature region of a liquid, is often destructive, but it can be harnessed for actuators and robots. We exploit cavitation to accumulate substantial energy in superheated liquids by suppressing its immediate release until reaching a stability limit. The energetic, unstable bubbles collapse violently, producing a burst of high power and force that initiates motion.

Digital Immunoassay for Rapid Detection of SARS-CoV-2 exposure in a Broad Spectrum of Animals.

The ability of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) to infect a wide-range of species raises significant concerns regarding both human-to-animal and animal-to-human transmission. There is an increasing demand for highly sensitive, rapid, and simple diagnostic assays capable of detecting viral infection across various species. In this study, we developed a biosensor assay based on a blocking ELISA (bELISA) immunoassay format.

Strain-Induced Distortion of MXene Nanosheets Enabling Freestanding Electrodes with Linearly Upscaling Areal Capacitance at Ultrahigh Mass Loadings.

The development of high-mass-loading electrodes offers a promising solution for enhancing energy density and reducing costs by minimizing inactive components. However, thick electrodes often face challenges, such as structural instability and poor electron and ion transport. Here, we present a strain-induced strategy for preparing distorted MXene nanosheets, enabling the fabrication of pressure-resistant crumpled freestanding electrodes with low tortuosity and a curvature-induced cation enrichment effect.

Bio-inspired multimodal soft actuator with environmental self-adaptation.

Autonomous soft robots with built-in feedback can achieve self-sustained motion under constant, untethered stimuli. However, these systems are constrained to single-mode actuation within a fixed structure under the same type of stimulus and require human intervention to switch modes, lacking the robust and efficient self-adaptation of living organisms in changing environments. Inspired by Gymnura micrura, we developed a light-responsive soft actuator with engineered asymmetry and a dynamic structure, integrating two distinct built-in feedback mechanisms governed by intrinsic bifurcation.

Air plastron-enabled heat management for enhanced photothermal actuation in underwater soft robots.

Photothermal self-excited actuators, offering untethered power and control, are promising for autonomous soft robots. While most efforts focus on enhancing heat absorption for greater actuation performance, managing heat dissipation remains underexplored, which becomes critical in underwater environments with rapid convective cooling. Inspired by amphibious mammals that use air plastrons for thermal insulation, we develop a strategy incorporating superhydrophobic candle soot coating to trap air on photothermal liquid crystal elastomer (LCE) actuators.

No Evidence of Metabolomic Disruptions From Real-World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study.

Background: Artificial sweeteners have become ubiquitous additives in the food supply, and yet the safety of their regular consumption remains controversial. The present study examined whether intakes of aspartame or saccharin are related to aberrations in the plasma metabolome indicating disruptions in metabolism.

Methods: A cohort of 2160 male and female participants, mean age 32.

Hybrid peptide DNA nanomaterials enable potent and broad-spectrum virus neutralization.

The continued emergence of antigenic drift and drug-resistant viral strains highlights the need for antiviral strategies that deliver robust efficacy, broad subtype coverage, and minimal off-target toxicity. We demonstrate a potent and broad-spectrum strategy that employs hybrid biomaterials of Urumin (a host defense peptide) and a honeycomb (HC) DNA origami through spatially organized multivalent presentation for enhanced antiviral efficacy. Molecular dynamics simulations reveal that Urumin penetrates and destabilizes the hemagglutinin (HA) trimer core, disrupting influenza A viral (IAV) entry.

Electrically-Driven 2D Semiconductor Microcavity Laser.

2D monolayered transition-metal dichalcogenides (TMDCs) are promising materials for realizing ultracompact, low-threshold semiconductor lasers. And the development of the electrical-driven TMDC devices is crucial for enhancing the integration potential of practical optoelectronic systems. However, at the current stage, the electrically-driven 2-D TMDC laser has never been realized.

Worldwide hotspots and trends in stem cell therapy for kidney disease in the last decade: a bibliometric and visualization analysis from 2015 to 2024.

Background: Kidney disease represents a significant global health concern. Stem cell therapy has gained attention as a potential solution for chronic kidney disease, acute kidney injury, and end-stage renal disease. This study aims to provide a comprehensive overview of the status of stem cell therapy for kidney disease through a systematic review of the literature.

Regulating Pores and Carbonyl Groups of Biomass-Derived Hard Carbon for Enhanced Sodium Storage.

This study investigates the impact of sulfuric acid-assisted hydrothermal pretreatment on the structural and electrochemical properties of biomass-derived hard carbon for sodium-ion batteries. Advanced characterization demonstrates that sulfuric acid-mediated hydrothermal strategy promotes the formation of crosslinked small molecules within the precursor. This process yields optimized hard carbon exhibiting pore-orifice nanoconfinement, enriched C═O functional groups at pore interface, and increased proportion of closed pores after carbonization.

Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice.

Cardiovascular homeostasis and locomotion are vital for animal survival and the maintenance of essential physiological functions. The parasubthalamic nucleus (PSTN) has recently emerged as a novel interoceptive center in the central nervous system, yet its role in coordinating cardiovascular homeostasis and locomotor behavior remains poorly understood. Here, we demonstrate that PSTN neurons serve as a novel baroreflex center, exhibiting heightened activity during acute hypertension.

Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein B.

Apolipoprotein B (apoB) can be measured directly and accurately, and better predicts atherogenic risk than conventional lipid profiles. We aimed to investigate whether total and regional (trunk or leg) fat deposits are associated with apoB levels in general US adults. 4585 participants were enrolled from the US National Health and Nutritional Surveys from 2011 to 2016.

Nickel-doped SbOClenables bifunctional electrochemical systems for efficient energy storage and saline water treatment.

Aqueous chloride-ion batteries have emerged as promising dual-functional electrochemical systems, offering simultaneous energy storage and desalination capabilities along with inherent environmental and economic benefits. Although SbOCl-based anodes operate at favorable low potentials that help mitigate electrode dissolution, their practical application is hindered by limited cycling stability and suboptimal charge efficiency. In this work, we propose a nickel doping strategy that simultaneously enhances the structural stability and chloride-ion storage capacity of SbOClin aqueous electrochemical systems.

Purely electronic insulator-metal transition in rutile VO.

Volatile resistive switching in neuromorphic computing can be tuned by external stimuli such as temperature or electric-field. However, this type of switching is generally coupled to structural changes, resulting in slower reaction speed and higher energy consumption when incorporated into an electronic device. The vanadium dioxide (VO), which has near room temperature metal-insulator transition (MIT), is an archetypical volatile resistive switching system.

Efficient GPT-4V level multimodal large language model for deployment on edge devices.

Multimodal large language models have revolutionized AI research and industry, paving the way toward the next milestone. However, their large sizes and high computational costs restrict deployment to cloud servers, limiting use in mobile, offline, energy-sensitive, or privacy-critical scenarios. We present MiniCPM-V, efficient models for edge devices that integrate advancements in architecture, training, and data.

HPV cancer burden by anatomical site, country, and region in 2022.

HPV vaccination can prevent more than 90% of HPV infection-related cancers. Understanding the epidemiological burden of HPV-related cancers can better promote HPV vaccination and HPV-based screening programs. We used three databases-Global Burden of Disease 2021 (GBD2021), Global Cancer Observatory 2022 (GLOBOCAN2022), and Cancer Incidence in Five Continents Plus (CI5Plus)-to evaluate the global disease burden of cervical cancer, penile cancer, vulvar cancer, vaginal cancer, laryngeal cancer, oropharyngeal cancer, oral cancer, anal cancer, and the relative contribution of HPV infection.

Evaluating the distribution and clustering of SARS-CoV-2 antibodies in dogs across the United States of America.

SARS-CoV-2 has been detected in various animal species, including dogs. While human-to-animal transmission has been documented, the extent and distribution of SARS-CoV-2 exposure in dogs across the United States of America (USA) remain unclear. To address this need, we investigated the seroprevalence of SARS-CoV-2 antibodies in dogs in the USA and scanned for spatial and temporal clusters of high seroprevalence.

L-Phenylalanine promotes liver steatosis by inhibiting BNIP3-mediated mitophagy.

Background: L-Phenylalanine (L-Phe) levels are elevated in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). However, whether L-Phe induces liver steatosis and the underlying mechanism remain unknown. This study aimed to investigate the mechanism through which L-Phe promotes liver steatosis.

Combined Oxaliplatin with 5-Fluorouracil for Effective Chemotherapy Against Gastric Cancer in Animal Model.

Introduction: Oxaliplatin (OXA) and 5-fluorouracil (5-Fu) are standard chemotherapy agents used to treat advanced gastric cancer (GC). However, their clinical efficacy is often limited by systemic toxicity, poor tumor selectivity, and suboptimal therapeutic outcomes when administered as monotherapy. These limitations underscore the need for innovative approaches to improve chemotherapy sensitivity and treatment efficacy.

Characterizing DNA Origami Nanostructures in TEM Images Using Convolutional Neural Networks.

Artificial intelligence (AI) models remain an emerging strategy to accelerate materials design and development. We demonstrate that CNN models can characterize DNA origami nanostructures employed in programmable self-assembly, which is important in many applications such as in biomedicine. Specifically, we benchmark the performance of 9 CNN models, namely, AlexNet, GoogLeNet, VGG16, VGG19, ResNet18, ResNet34, ResNet50, ResNet101, and ResNet152 to characterize the ligation number of DNA origami nanostructures in transmission electron microscopy (TEM) images.