Multi-frequency electromagnetic radiation promoted hepatic lipid metabolism via the adiponectin pathway in mice.

Radiofrequency electromagnetic radiation (RF-EMR) is ubiquitous in daily life, and the complexity of the electromagnetic environment continues to increase. Nevertheless, research on the biological effects of compound radiofrequency radiation-particularly its influence on lipid metabolism under realistic exposure scenarios-remains limited, and the underlying mechanisms are not yet fully elucidated. To investigate the impact of compound radiofrequency radiation on lipid metabolism, multi-frequency radiation exposure model both normal and obese mice were established.

Recent advances in oxygen reduction reaction catalysis under neutral conditions.

The oxygen reduction reaction (ORR) is central to energy devices and sustainable chemical production. While acidic and alkaline ORR systems are well studied, neutral media offer advantages such as biocompatibility, environmental safety, and material stability, yet remain less explored. This mini-review summarizes recent progress in ORR electrocatalysis under neutral conditions, covering both four-electron (4e) and two-electron (2e) pathways.

Peritoneal dialysis in neuropsychiatric systemic lupus erythematosus: A case report integrating proteomic insights into complement-mediated mechanisms.

Background: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe SLE complication with limited therapeutic options. While plasma exchange is used, it carries cardiovascular risks and logistical barriers.

Case Report: We report a 42-year-old East Asian female with SLE who developed progressive edema, dyspnea, and seizures.

The combined effects of polypropylene microplastics and sulfonamide antibiotics on the gut-liver axis of Gymnocypris przewalskii.

Microplastics (MPs) and antibiotics (ATs) accumulating in Qinghai Lake threaten aquatic health, yet their impact on Gymnocypris przewalskii (G.przewalskii) remains unclear.This multi-omics study investigated polypropylene MPs (PP-MPs) and sulfonamide antibiotics (SGD) on G.

Multiple biomarkers risk score for accurately predicting the long-term prognosis of patients with acute coronary syndrome.

Background: Biomarkers-based prediction of long-term risk of acute coronary syndrome (ACS) is scarce. We aim to develop a risk score integrating clinical routine information (C) and plasma biomarkers (B) for predicting long-term risk of ACS patients.

Methods: We included 2729 ACS patients from the OCEA (Observation of cardiovascular events in ACS patients).

Targeting macrophages and ion homeostasis in T2D: new genes and therapeutic pathways identified.

Introduction: Type 2 diabetes (T2D) is characterized by insulin resistance and chronic inflammation, with macrophages playing a crucial role in pancreatic islet dysfunction. This study explored the intersection of macrophage-specific gene expression and abnormal blood monovalent inorganic cation concentration-related genes (ABRGs) in T2D patients via single-cell RNA sequencing (scRNA-seq) and machine learning to identify key genes and potential therapeutic targets.

Methods: ScRNA-seq data from the pancreatic islet cells of 27 nondiabetic (ND) patients and 17 T2D patients were analyzed to identify differentially expressed genes (DEGs) in macrophages.

Engineering modification of human umbilical cord mesenchymal stem cell-derived small extracellular vesicles ameliorates polycystic ovary syndrome by enhancing the ovarian environment and regulating follicular development.

Background: Polycystic Ovary Syndrome (PCOS), is a complex endocrine disorder affecting 6-21% of reproductive-aged women, characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology. Current clinical management relies on lifestyle modifications and symptom-targeted therapies due to the absence of curative interventions. In recent years, Laparoscopic ovarian drilling (LOD), a surgical procedure that induces controlled ovarian damage to stimulate primordial follicle activation and regulate follicular growth, has emerged as an established therapeutic intervention for infertility in PCOS.

Household adoption of domestic water filtration for combating waterborne diseases in developing countries.

Drinking contaminated water is a leading cause of several waterborne diseases. Domestic water filtration plants are treated as one of the possible alternative tools to combat the disease caused by contaminated drinking water. Little is known about the usage behaviour of households to use water filtration plants at the domestic level in combating waterborne disease.

From mitochondria to immune networks: new mesenchymal stem cell strategies to treat periodontitis.

Periodontitis is a chronic inflammatory disease that damages periodontal tissues and is mainly caused by immune dysfunction. Current treatments, such as mechanical debridement and adjunctive antimicrobial, work poorly; periodontal surgery brings pain and complications.Mesenchymal stem cells (MSCs) have a powerful ability to regulate immune responses and great potential for tissue regeneration, thus attracting extensive attention in the field of periodontal treatment.

Uterine Microbiota Composition in Dairy Cows with Different Vaginal Discharge Scores: Suggesting Caviibacter as a Potential Pathogen in Mild Purulent Metritis.

The uterine microbiota plays a crucial role in maintaining postpartum reproductive health in dairy cows, and its dysregulation is closely associated with uterine diseases. Vaginal discharge characteristics serve as important clinical indicators for assessing uterine status and guiding clinical decision-making. This study employed 16S rRNA gene sequencing to analyze uterine microbial diversity in cows with different discharge types.

Pressure-Induced Phase Transitions and Electronic Structure Evolution of BaAu.

Considering previous studies on the high-pressure phases and compressibility of Ba-Au alloys with stoichiometries AuBa, AuBa, and AuBa, the concentration of the alkaline-earth metal Ba increased, and a particle-swarm optimization algorithm was employed to conduct comprehensive structure searches for the BaAu compound at 0, 10, 20, and 50 GPa. First-principles calculations were subsequently carried out to investigate its structural evolution and electronic properties under compression. Enthalpy-difference calculations indicate that the 4 phase of BaAu transforms to the phase at approximately 0.

Altered theta oscillations in basolateral amygdala and ventral hippocampus related to social defeat.

Background: Depression is a prevalent mental disorder, and prolonged exposure to social defeat is a major contributing factor in the onset of depression. Repeated social defeat stress (RSDS) is a commonly used animal model for depression, significantly impacting on the pathogenesis of depression-related to social disorders. The basolateral amygdala (BLA) and the ventral hippocampus (vHPC) are critical brain regions involved in RSDS-induced social behavioral disorders, but the specific neural oscillations occurring in these regions following social defeat remain unclear.

Anterior cingulate cortex mediates the comorbidity between colorectal cancer and depression-like behaviors.

Clinical studies demonstrate that comorbidity between colorectal cancer (CRC) and depression is common, leading to a higher mortality risk among CRC patients. However, the mechanisms remain largely unexplored. The role of core brain regions in comorbidity of CRC and depression and whether modulating these regions can improve both depression-like symptoms and CRC progression have yet to be clarified.

Accuracy of a wearable watch-type oscillometric blood pressure monitor in rest and ambulatory blood pressure measurements.

The aim of this study was to evaluate the accuracy of a watch-type oscillometric BP monitor HUAWEI WATCH D2 for rest and ambulatory BP measurements and compare with a conventional ambulatory BP monitor (A&D TM-2430, Tokyo, Japan). Subjects were recruited to fulfill the age, gender, BP and cuff distributions of the AAMI/ESH/ISO Universal Standard in the general population. Two cuffs of the test device were used for wrist circumference 13-16 (medium) and 16-21 cm (large), respectively.

PCK1 and ALDH1A1 are identified as biomarkers for inherent drug resistance in hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide, often diagnosed at advanced stages with limited treatment options. Despite advancements in systemic therapies, including the use of lenvatinib, the survival rate for advanced HCC remains low due to drug resistance and tumor heterogeneity.

Method: This study employed single-cell sequencing and spatial transcriptomics to investigate intra-tumor heterogeneity and identify subpopulations of malignant cells with inherent drug resistance.

A Novel Arene Trifluoromethyl-Based F-Labeling Strategy for Enhanced Biomolecular Tracer Development in PET Imaging.

Biologically active molecules, such as carbohydrates, peptides, and proteins, are attractive candidates for positron emission tomography (PET) imaging because of their strong target affinity and biocompatibility. Among available radionuclides, fluorine-18 (F) is widely used in clinical practice because of its moderate half-life and high-quality imaging properties. However, traditional F-labeling methods often require a laborious procedure and harsh conditions, which may compromise the structural integrity and biological functions.

Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement.

Background: The bone marrow microenvironment, comprising various cell types and molecular signals, finely orchestrates the self-renewal and lineage commitment of hematopoietic stem cells (HSCs). Although most investigations have centered on mesenchymal stem cells (MSCs) from long bones, the distinct properties and immunoregulatory functions of craniofacial bone marrow derived MSCs remain largely unexplored. Notably, jawbone MSCs not only exhibit a robust capacity for promoting hematopoietic regeneration but also offer therapeutic potential in infectious diseases.

Cucurbitacin B inhibits HIF-1α and attenuates non-small cell lung cancer ZFP91.

Non-small cell lung cancer (NSCLC) is among the most common types of cancer and contributes significantly to cancer-related mortality worldwide. Although some progress has been made in the treatment of NSCLC, drug resistance, high costs, and significant individual variability continue to be major obstacles to effective treatment. Cucurbitacin B (CuB) is a tetracyclic triterpenoid known for its anti-inflammatory and anticancer properties.

Deinococcus lichenicola sp. nov., A Bacterium Isolated from a Lichen Sample.

A Gram-stain-positive bacterium, designated as YIM 134068, was isolated from a lichen. Strain YIM 134068 was non-motile, non-spore forming, coccus shaped, oxidase, and catalase positive. Cells could grow at 10-40 °C (optimum 28 °C) and pH 7.

Single-Crystal Structure Determination of Superconducting LaNiO under High Pressure.

Ruddlesden-Popper nickelates have attracted enormous attention since the discovery of high-temperature superconductivity in bilayer LaNiO under high pressure. However, the crystal structure under high pressure remains elusive due to the lack of single crystal diffraction data. Here, high-pressure superconductivity with a superconducting onset temperature approaching 30K and a zero-resistance state at 7K at 53.

Preparation and mechanism of Lactobacillus plantarum and curcumin co-encapsulated in alginate-gelatin hydrogel beads.

Lactobacillus plantarum (LP) and curcumin (CUR) were co-encapsulated in sodium alginate-Lactobacillus plantarum-curcumin-gelatin (ALG-LP-CUR-GE) hydrogel beads to evaluate the synergistic function of probiotics and prebiotics. The encapsulation efficiency of LP and CUR peaked at 84.6 % and 94.

Inhibition of eEF2 kinase ameliorates hepatic injury induced by ACR through regulation of the MAPK pathway.

Background And Aims: Acrylamide (ACR) induces hepatotoxicity, yet its underlying mechanisms remain incompletely understood. Our prior proteomic analysis of serum from occupationally ACR-exposed individuals identified significantly elevated levels of eukaryotic elongation factor 2 (eEF2). Given that eEF2 activity is regulated by its phosphorylation status, which is solely mediated by eukaryotic elongation factor 2 kinase (eEF2K), we investigated the role of eEF2K in ACR-induced hepatic injury.

Brain plasticity induced by magnetic resonance-guided focused ultrasound correlates with tremor improvement in essential tremor: a prospective cohort study.

Background And Purpose: Magnetic resonance-guided focused ultrasound (MRgFUS) is a promising and noninvasive treatment for medication-refractory essential tremor (ET). However, the mechanism of long-term postoperative brain structural remodeling remains unclear. This study aimed to investigate the changes in gray matter volume (GMV) before and after MRgFUS, as well as to explore the relationship between GMV changes and tremor control.

Plasma ceramide mediates the association of peripheral T cells with Alzheimer's disease.

Introduction: Neuroinflammation involving peripheral immune cells, particularly T lymphocytes, has been implicated in Alzheimer's disease (AD) progression. Metabolic dysregulation in sphingolipid pathways may influence neuroinflammatory processes in AD pathogenesis. However, the specific roles of T cell subsets and their interactions with metabolic pathways in AD pathogenesis remain unclear.

Nanozyme-Crosslinked Poly(Thioctic Acid)-Based Hydrogel Adhesives with Coral-Like Structure for Promoting Wet Adhesion, Antibacterial Active, and Wound Healing.

Uncontrolled traumatic hemorrhage in emergency and surgical settings frequently leads to prolonged bleeding time, increased infection risks, and delayed wound healing. To overcome these issues, a novel multifunctional biomimetic PTALi-SCAA hydrogel adhesive is prepared by crosslinking caffeic acid-Ag (CAA) nanozyme with the double network of poly(thioctic acid)Li-sericin (PTALi-S). The introduction of CAA nanozyme significantly promoted wet tissue adhesion (48.