Beyond efficacy parity: a novel cost-equilibrium framework for value assessment of competing third-line therapies in metastatic colorectal cancer.

Background: Colorectal cancer remains a leading cause of global cancer mortality, with metastatic CRC (mCRC) requiring sequential therapies after first line treatment failure. While regorafenib and fruquintinib are guideline-endorsed third-line options, their comparative value remains unestablished due to absent head-to-head trials. This real-world study evaluates clinical outcomes, safety, and cost differentials to model value-equilibrium pricing.

Commercial amniotic membrane extract eye drops for canine SCCED: a retrospective clinical evaluation.

Objectives: This study aims to evaluate the efficacy of amniotic membrane extract eye drops (AMEED) in promoting the healing rate of SCCED after cotton-tip debridement (CTD) in dogs.

Methods: A retrospective review was conducted on the medical records of dogs with SCCED from October 2021 to December 2024. Cases treated with AMEED following CTD (AMEED group), as well as those treated with CTD alone (CTD group), were selected for further evaluation.

Structural, Mechanical, Electronic, and Optical Properties of Hydrogen-Storage Magnesium-Based MgXH (X = Cs, Rb).

Metal hydrides are emerging hydrogen-storage materials that have attracted much attention for their stability and practicality. The novel magnesium-based metal hydride MgCsH was investigated using the CALYPSO software (version 7.0).

Pressure-Induced Phase Transitions and Electronic Structure Evolution of BaAu.

Considering previous studies on the high-pressure phases and compressibility of Ba-Au alloys with stoichiometries AuBa, AuBa, and AuBa, the concentration of the alkaline-earth metal Ba increased, and a particle-swarm optimization algorithm was employed to conduct comprehensive structure searches for the BaAu compound at 0, 10, 20, and 50 GPa. First-principles calculations were subsequently carried out to investigate its structural evolution and electronic properties under compression. Enthalpy-difference calculations indicate that the 4 phase of BaAu transforms to the phase at approximately 0.

Oxidative stress and inflammation: roles in osteoporosis.

Osteoporosis (OP) is a prevalent bone disease characterized by reduced bone mineral density (BMD) and compromised microstructure, leading to an increased risk of fractures and disability. With an aging global population, OP has become a significant public health issue, affecting over 200 million people worldwide. OP can be classified into primary (type I and type II) and secondary forms, with estrogen deficiency playing a critical role in postmenopausal OP.

Structural Stability, Mechanical, and Electronic Properties of AlTM (TM = Mo, Nb, Os, Re, Ru, Ta, Tc, Ti) Intermetallics.

Al-based intermetallic compounds possess excellent mechanical and thermal properties, making them promising candidates for high-temperature structural applications. In this study, the structural stability, mechanical properties, and electronic characteristics of AlTM (TM = Mo, Nb, Os, Re, Ru, Ta, Tc, Ti) intermetallic compounds were systematically investigated using first-principles calculations based on density functional theory. All alloys exhibit negative formation energy, indicating favorable thermodynamic stability.

Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer.

Cancer is commonly caused by a gain of function in proto-oncogenes and a simultaneous loss of function in tumor suppressor genes. Advanced prostate cancer (PCa) is often linked with changes in the activity or expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a well-known tumor suppressor, and androgen receptor (AR), a pro-tumorigenic transcription factor. However, no therapies exist for the simultaneous correction of tumorigenic promotion and suppressor depletion.

HLA-DOB: A Key "Coordinator" Between Cutaneous Melanoma and Psoriasis.

Psoriasis is a chronic inflammatory skin disease associated with immune dysfunction, and its relationship to cutaneous melanoma is unclear. This study used Mendelian randomization (MR) to explore the causal link between the two and identify risk genes. SNPs from a psoriasis GWAS (5,072 cases, 478,102 controls) were used as instrumental variables, and melanoma GWAS data (3,751 cases, 372,016 controls) served as the outcome.

STAGE: A compact and versatile TnpB-based genome editing toolkit for .

are naturally endowed with the capacity to produce a wide array of natural products with biomedical and biotechnological value. They have garnered great interest in synthetic biology applications given the abundance of uncharacterized biosynthetic gene clusters (BGCs). However, progress has been hindered by the limited availability of genetic tools for manipulating these bacteria.

Fabricating a Curcumin-Loaded Chitin/Lignin Micelle Thermoresponsive Hydrogel with Dynamic Contractility and Tissue-Adhesive Properties for Enhanced Wound Regeneration.

Skin exhibits limited self-regenerative capacity following an injury; therefore, it is imperative to develop appropriate wound dressings capable of expediting postinjury closure to prevent microbial invasion and enhance the wound healing process. In this study, poly--isopropylacrylamide (PNI), sodium dodecyl sulfate/octadecyl methacrylate micellar (SA), and micellar (chitin/lignin)-loaded curcumin (Cur) were used for constructing a thermosensitive and tissue-adhesive hydrogel (PNI-SA@Cur), aiming to develop a wound dressing that enhanced wound healing. The results demonstrated that PNI-SA@Cur hydrogel exhibited superior thermal shrinkability, along with excellent adhesion and self-healing capabilities, and it also showed good hemocompatibility and cytocompatibility.

Ginsenoside Rg5 enhances Abemaciclib sensitivity in ER+ breast cancer by modulating cell cycle proteins via transcriptional and post-translational levels.

Background: The development of resistance to CDK4/6 inhibitors is a significant challenge in treating estrogen receptor-positive (ER+) breast cancer. This study aimed to explore the regulatory mechanisms of ginsenoside Rg5 in enhancing Abemaciclib sensitivity in ER+breast cancer.

Materials And Methods: Abemaciclib-resistant ER + breast cancer cell lines were established.

The Prophylactic Effect of Acupuncture for Migraine Without Aura: A Randomized, Sham-Controlled, Clinical Trial.

Objective: Acupuncture is recognized as an effective migraine treatment, but the comparative long-term efficacy of different acupuncture methods at identical acupoints remains unclear. This study investigates the prophylactic effects of manual acupuncture (manual penetrating acupuncture, MPA) versus sham acupuncture (non-penetrating acupuncture, NPA) at the same acupoints.

Methods: In this multicenter, single-blind randomized controlled trial conducted across four Chinese clinical centers (May 2020 to September 2022), 192 migraineurs without aura (International Classification of Headache Disorders 3rd edition criteria) were randomized 1:1 to 12 sessions of MPA or NPA.

Gut microbiota in rheumatoid arthritis: Mechanistic insights, clinical biomarkers, and translational perspectives.

Rheumatoid arthritis (RA) is a systemic autoimmune disease shaped by complex interactions between genetics and environmental factors, among which gut microbiota has emerged as a critical modulator. Recent advances have implicated gut microbiota dysbiosis in RA pathophysiology, with evidence spanning mechanistic, diagnostic, and therapeutic dimensions. This review summarizes current knowledge of the gut-joint axis and outlines microbiota-based strategies for RA management.

Near-Infrared Light-Responsive Lubricating Coating with Polyaniline Microspheres for Long-Term Anti-Icing and High-Efficiency De-Icing.

Despite significant advances in anti-icing/de-icing coating in recent years, key issues such as lubricant leakage and high de-icing energy consumption still substantially restrict their long-term performance in cold environments. To address this, a long-lasting lubricating coating based on silicone oil-loaded polyaniline (PANI) microspheres is developed. Through innovative structural design and regulation, PANI microspheres achieved "three birds with one stone" effect: photothermal conversion, electrothermal conversion, and lubricating properties.

Ultrathin DNA-copper nanosheets with antibacterial and anti-biofilm activity for treatment of infected wounds.

The development of innovative antibacterial materials is crucial for addressing wounds infected with bacterial biofilms. Advanced nanomaterials that enable non-antibiotic antibacterial strategies offer new possibilities for treating bacterial infections by eliminating pathogens without relying on antibiotics. Herein, we introduce non-toxic and biocompatible DNA-copper cluster nanosheets (DNS/CuNCs) as effective antibacterial agents.

Case report of non-gene editing CD7 CAR T cell therapy in CD7 Sézary syndrome: preclinical validation and first-in-human use.

Introduction: Sézary syndrome (SS) is a leukemic form of cutaneous T cell lymphoma (CTCL), distinguished from mycosis fungoides by the presence of cancerous lymphocytes in the blood and often bears very poor prognoses. SS treatment is palliative, and thus novel therapies are needed. The CD7 surface antigen is highly expressed and confined to the surface of T cells, therefore when present, serves as a promising target for immunotherapy.

Efficacy and safety of CT-guided microwave ablation for stage I non-small cell lung cancer in elderly patients.

Objective: To evaluate the efficacy of MWA for patients aged ≥ 75 years with stage I NSCLC, and to explore the impacts of age and comorbidities on the long-term outcomes.

Methods: Patients with stage I NSCLC underwent MWA between November 2016 and December 2020 were retrospectively enrolled. Patients were stratified into two cohorts: ≥ 75 years and < 75 years.

Current Status and Typing of Physical Activity in Lung Cancer Patients Post Surgery at Home Which Patients Need Support in Activities?

Background: Postsurgery physical activity is crucial for lung cancer rehabilitation. However, patients often lack sufficient activity at home, and the types of activities they engage in have not been well studied in China.

Objectives: This study aimed to identify physical activity profiles and assess their relationship with demographic and clinical characteristics, postoperative symptoms, and health capabilities in Chinese patients with lung cancer post surgery at home.

Optical systems design method based on glass material cost.

In the design of optical systems for consumer-grade optical products, achieving a balance between imaging performance and systems cost is crucial for enhancing product competitiveness. As a significant component of system cost, the selection and optimization of optical materials directly affect the system configuration, performance, and economic efficiency. This paper proposes a design method based on glass materials cost, which comprehensively considers the materials relative price, tolerance grade, and volume.

Transformer-based self-supervised learning of pixel- and frequency-domain features for DMI grading on OCTA images.

Diabetic macular ischemia (DMI) is a critical vision-threatening complication of diabetic retinopathy. While optical coherence tomography angiography (OCTA) enables non-invasive DMI progression diagnosis, acquiring labeled datasets remains challenging. This study proposes a self-supervised learning framework for DMI grading that leverages both pixel- and frequency-domain features.

Gut microbiota as a metabolic mediator to prevent or attenuate MASLD.

As a metabolic disorder, metabolic dysfunction-associated steatotic liver disease (MASLD) may be prevented through strategic adjustments of the gut microbiome, which could be reshaped by dietary intakes, and in turn, improve the host's health via various metabolic activities. The human gut harbors a diverse array of microorganisms that play a crucial role in host health. Through the gut-liver axis, bile acid metabolism, tryptophan metabolism, and short-chain fatty acid metabolism of gut microbiota significantly influence hepatic metabolic processes.

Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease.

The immunological synapse (IS) serves as the fundamental architectural framework for direct interactions and secretory crosstalk between immune cells, as well as between immune cells and other cells. Its dysregulation is thought to be a key underlying cause of immune evasion or inflammation observed in various diseases, including tumors and infections. Numerous recent studies have addressed key signaling mechanisms and reported novel targets related to IS, further broadening our understanding of its function and regulatory factors.

The dissociable effects of humorous reappraisal on free recall and recognition/implicit memory.

Humour is regarded as an adaptive coping strategy which could effectively reduce negative emotions. To fundamentally evaluate the function of humour reappraisal, our study aimed to explore the emotion-regulatory advantage effect of humour reappraisal from the perspective of memory mechanisms. Using a learning-testing paradigm, we examined the memory effects of humour reappraisal: first presented humour (or non-humour) reappraisal interpretations of the negative pictures during the learning phase and tested the memory performance from three aspects: free recall, recognition, and implicit memory in the test phase.

Identification of Causal Effects of Mitochondrial Dysfunction on the Risk of Multiple Autoimmune Disorders: Multi-Omics Mendelian Randomization and Colocalization Analyses.

Background: Mitochondrial dysfunction has been implicated in the pathogenesis of autoimmune disorders (AIDs), but its causal role in disease susceptibility and progression remains unclear. This study explores potential causal associations between mitochondrial-related genes and AIDs using integrated multi-omics evidence from Mendelian randomization (MR) and colocalization analyses.

Methods: Summary-level datasets from 10 common AIDs (303 590-456 348 participants) and quantitative trait loci (QTL) at the DNA methylation, gene expression, and protein abundance levels (mQTL, eQTL, and pQTL, respectively; 1 980-35 559 participants), as well as mitochondrial DNA copy number (465 809 participants), were analyzed.

Female-Biased Odorant Receptor LstiOR3 Mediates Oviposition Preference via Linalool Recognition in (Lepidoptera: Pyralidae).

The beet webworm, , whose oviposition behavior significantly affects population quantity and causes crop losses, has poorly understood olfactory mechanisms governing this behavior. Odorant receptors (ORs) play a critical role in the insect olfactory system. Here, three ORs (LstiOR1, LstiOR2, LstiOR3) were cloned, with all highly expressed in female antennae.