Is the use of intraoperative vasopressors associated with flap failure in head and neck free tissue transfer surgery?

Background: Maintaining appropriate blood pressure during head and neck free tissue transfer surgery is important for both organ and flap perfusion. However, the use of vasopressors to treat intraoperative hypotension is controversial. The purpose of this prospective cohort study is to evaluate the impact of intraoperative vasopressors on the incidence of flap necrosis.

Molecular Motor Matrix-Based Augment Heat Dissipation Strategy Affording Ultrahigh-PCE J-Aggregates for Potentiate Cancer Photothermal Immunotherapy.

The photothermal conversion efficiency (PCE) stands as a pivotal determinant in the therapeutic efficacy of photothermal nanoagents (PTNAs) within the context of photothermal therapy (PTT). The dearth of universal strategies to greatly enhance PCE has markedly curtailed the practical deployment of PTNAs. Now this problem is addressed by proposing a universal approach founded on molecular rotors and J-aggregates, "highly efficient molecular motor matrix", to greatly elevate the PCE of traditional PTNAs.

Synergistic t-to-π* Electron Transfer and Nanotube Engineering in Spinal Catalysts for Ultra-Efficient Chloride Evolution.

Facing the massive energy consumption of over 200 TWh y of chlor-alkali industry, developing high-activity and durable non-precious CER (chlorine evolution reaction) catalysts is urgently needed to address the high overpotentials and suppress the dissolution high-valance metal species. Herein, a carbon quantum dots functionalized trimetallic Fe/Co/Ni spinel oxide nanotube architecture (FCNO@CQDs) is constructed, featuring t-to-π* π-backbonding for dramatically enhanced CER activity and stability. The reverse electron flow from Co d-obritals to the vacant CQDs' π* orbitals can upshift the d-band center for enhanced intermediate adsorption, while stabilizing high-valent Co centers via increased bond order.

Correction to "Functional role of long non-coding RNA CASC19/miR-140-5p/CEMIP axis in colorectal cancer progression ".

[This corrects the article on p. 1697 in vol. 25, PMID: 31011255.

Fractional flow reserve calculation optimized by myocardial computed tomography perfusion information.

Background: Current computed tomography angiography-derived fractional flow reserve (CT-FFR) diagnosis leaves room for improvement in diagnosing coronary heart disease. In this study, the computed fluid dynamics boundary condition optimization method was used to calculate CT-FFR aiming to improve the diagnostic accuracy of CT-FFR for coronary heart disease.

Methods: The two enhancement approaches are as follows: (A) inlet flow optimization, which involves determining the total coronary inlet flow rate by summing the myocardial blood flow (MBF) across the entire left ventricular myocardium; and (B) inlet & outlet flow optimization: building upon method A, where the outlet flow of coronary artery branches is calculated through blood supply area analysis.

Research progress of NLRP3 in immune cells of systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) represents a multifaceted autoimmune disorder characterised by widespread organ involvement and abnormal autoantibody production. Its underlying mechanisms are closely related to immune system dysfunction. Recent advancements in immunological research have highlighted the pivotal role of the NLRP3 inflammasome, which acts as a key regulator of both innate and adaptive immunity.

Efficacy of transcervical resection of polyp combined with levonorgestrel-releasing intrauterine system in the treatment of endometrial polyps: a randomized controlled trial.

Background: This study aimed to compare the clinical efficacy and prognosis of transcervical resection of polyp (TCRP) combined with levonorgestrel-releasing intrauterine system (LNG-IUS) or oral desogestrel and ethinyl estradiol tablets (DET) in patients with endometrial polyps (EMP).

Methods: A total of 100 EMP patients undergoing TCRP were divided into LNG-IUS ( = 50) and DET ( = 50) groups. Hemoglobin, endometrial thickness, FSH, E2, and LH levels were monitored pre-surgery and post-surgery.

Muscle Visualization and Evaluation Methods for Immune Checkpoint Inhibitor-Related Myositis.

Immune checkpoint inhibitors (ICIs) have fundamentally transformed the landscape of cancer therapy, yet their administration frequently correlates with immune-related adverse events (irAEs), amongst which myositis, an inflammatory disorder affecting the muscles, stands out. The prompt identification and thorough assessment of myositis associated with ICIs are imperative for effective therapeutic management and the enhancement of patient prognoses. In this report, we present a detailed evaluation of muscle function aimed at accurately diagnosing and appraising ICI-related myositis.

SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by dysregulated immune responses and macrophage-driven inflammation. In this study, we identify SAMHD1 (SAM domain and HD domain-containing protein 1) as a critical regulator of macrophage homeostasis in UC. Single-cell RNA sequencing (scRNA-seq) of colonic tissues revealed reduced SAMHD1 expression in UC-associated macrophages.

A small-size imidazole-derived ligand binds to the KRAS promoter G-quadruplex and inhibits cancer growth with enhanced immunomodulation.

KRAS overactivation is commonly present in a diversity of solid tumors. Recently, small-molecule inhibitors of KRAS G12C mutation are approved for clinical use, ending the long era of KRAS as an 'undruggable' target. However, new approaches to suppress a wide spectrum of KRAS abnormalities are still needed to be developed.

Microbial Assembly and Stress-Tolerance Mechanisms in Salt-Adapted Plants Along the Shore of a Salt Lake: Implications for Saline-Alkaline Soil Remediation.

Investigating the microbial community structure and stress-tolerance mechanisms in the rhizospheres of salt-adapted plants along saline lakes is critical for understanding plant-microbe interactions in extreme environments and developing effective strategies for saline-alkaline soil remediation. This study explored the rhizosphere microbiomes of four salt-adapted species (, , , and ) from the Yuncheng Salt Lake region in China using high-throughput sequencing. Cultivable salt-tolerant plant growth-promoting rhizobacteria (PGPR) were isolated and characterized to identify functional genes related to stress resistance.

The study of JAZF1-mediated apoptosis of decidual stromal cells by activating the NF-κB signaling pathway in spontaneous preterm birth.

Purpose: Juxtaposed with another zinc finger gene 1 (JAZF1) is known to be involved in various biological processes, including gluconeogenesis, insulin sensitivity, cell differentiation, lipid metabolism, and inflammation. However, its role in spontaneous preterm birth (SPTB) remains unclear.

Patients And Methods: We investigated the expression of JAZF1 mRNA using quantitative reverse transcription-PCR (qRT-PCR) in the decidual tissue of patients with SPTB compared to non-spontaneous preterm birth(non-SPTB).

Multiscale environmental drivers of human brucellosis transmission in Xinjiang: A spatiotemporal analysis integrating GAM and MaxEnt modeling (2015-2023).

This study investigated the epidemiological characteristics of human brucellosis and the associations with meteorological, environmental, and socio-economic factors in Xinjiang Uygur Autonomous Region (XUAR), China, between 2015 and 2023. Using a Generalized Additive Model (GAM), we analyzed nonlinear associations between meteorological variables and case counts, incorporating optimized lag periods for each climatic factor. The Maximum Entropy (MaxEnt) model was simultaneously applied to evaluate the synergistic effects of environmental and socio-economic determinants on disease distribution patterns throughout the region.

Reg3β promotes chondrocyte proliferation and ECM metabolism during acetabular roof remodeling in a rat model of DDH‑induced residual dysplasia.

Residual acetabular dysplasia (RAD) is a common complication after the successful management of developmental dysplasia of the hip (DDH). RAD remodeling is important for predicting the outcome of the affected hip, and optimal treatment can be chosen accordingly. Regenerating islet‑derived protein 3‑β (Reg3β), a multifaceted cytokine, is a prognostic marker for inflammation and cardiac disease.

METTL14 Enhances Anti-Tumor Immunity through m6A-dependent loss of PD-1.

N6-methyladenosine (m6A) modifications can impact immune responses by regulating different target genes. Here, we demonstrated that the programmed cell death-1 (PD-1) gene PDCD1 undergoes m6A modification, which subsequently impacts T cell function. METTL14 mediated PDCD1 downregulation in T cells by promoting m6A-dependent destabilization of PDCD1 mRNA, a process mediated by YTHDF1/2/3.

Global research trends in PARP inhibitors for ovarian cancer: a bibliometric analysis.

This bibliometric analysis maps global research trends on PARP inhibitors (PARPis) in ovarian cancer from January 2021 to May 2025, utilizing 1,434 publications retrieved from the Web of Science Core Collection. Employing Bibliometrix, VOSviewer, and CiteSpace, the study quantifies contributions across countries, institutions, authors, and research foci. Key findings reveal the United States (440 publications) and China (352) as leading producers, with UNICANCER (287 publications) and Memorial Sloan Kettering Cancer Center (61) as top institutions.

The Effect of Polysaccharide Combined with Cisplatin on LLC1 Lung Cancer.

Although cisplatin (DDP) is commonly used in the clinical treatment of lung cancer, the associated side effects remained serious. Chinese medicine can be used to increase the sensitivity of the body to antitumor drugs while reducing their adverse effects. polysaccharide (CSP), which is derived from , has already been demonstrated to regulate immune function, but the effects of CSP in combination with DDP have not yet been reported.

SARM1 activation promotes axonal degeneration via a two-step phase transition.

SARM1 is a key executioner of axonal degeneration, acting through NAD⁺ depletion by NADase activity of its TIR domain. Although normally autoinhibited, SARM1 becomes activated in response to axonal damage; however, the underlying mechanism remains unclear. Here, using a class of pyridine-containing compounds that trigger SARM1-dependent axon degeneration, we uncover a two-step activation process.

Integrated approach to predicting rock fracture intensity based on radon tracing and artificial neural network.

In geological and engineering practices, determining fracture intensity of rock masses is critical for the exploitation of resources such as oil, natural gas, uranium, and geothermal energy. Due to the lack of technological means to directly measure the distribution of rock fractures, it is very difficult to obtain the rock fracture intensity. This paper proposes an integrated approach to predicting rock fracture intensity based on artificial neural network (ANN) and radon tracing.

Adherence to outpatient cardiac rehabilitation and related factors in STEMI after PCI in China: a sequential explanatory mixed method study protocol.

Background: Acute myocardial infarction remains a major contributor to global morbidity and mortality. Cardiac rehabilitation is widely recognized as an essential component of the comprehensive medical management for patients with ST-elevation myocardial infarction, especially among those who have undergone percutaneous coronary intervention. Adherence to cardiac rehabilitation encompasses patient collaboration with a healthcare provider, active involvement in the treatment regimen, and persistence in practice, characterized by self-efficacy and relapse prevention.

Flexible AgSe-based thin-film thermoelectrics for sustainable energy harvesting and cooling.

The high cost and complexity of fabrication limit the large-scale application of flexible inorganic thermoelectric materials. Currently, BiTe-based materials are the only commercially viable option, but the inclusion of Te significantly increases production costs. This study presents a simple and cost-effective method for fabricating flexible AgSe films, employing a combination of solvothermal synthesis, screen printing, and spark plasma sintering.

Stress granule-mediated ZBP1 activation drives necroptotic cell death in non-obstructive azoospermia and testicular aging.

Male infertility remains a major unmet medical challenge, with poorly defined molecular mechanisms and no effective therapies. Here, we identify a stress granule-mediated necroptotic pathway as a key driver of non-obstructive azoospermia, a severe form of male infertility marked by the loss of spermatogenesis. Environmental or physiological stress activates eIF2α kinases, inducing stress granule formation and the recruitment of ZBP1 and RIPK3 into a cytoplasmic complex.

Influencing factors of rehabilitation participation among patients with pneumoconiosis in Chongqing, China.

Background: Pneumoconiosis is the most serious and common occupational disease in China. This study aimed to analyze the factors influencing participation in pulmonary rehabilitation among patients with pneumoconiosis and provide a basis for decision-making to promote their engagement in rehabilitation.

Methods: We collected data from patients with complete file information between January 2020 and December 2023.

A Sensor Data Prediction and Early-Warning Method for Coal Mining Faces Based on the MTGNN-Bayesian-IF-DBSCAN Algorithm.

In the context of intelligent coal mine safety monitoring, an integrated prediction and early-warning method named MTGNN-Bayesian-IF-DBSCAN (Multi-Task Graph Neural Network-Bayesian Optimization-Isolation Forest-Density-Based Spatial Clustering of Applications with Noise) is proposed to address the challenges of gas concentration prediction and anomaly detection in coal mining faces. The MTGNN (Multi-Task Graph Neural Network) is first employed to model the spatiotemporal coupling characteristics of gas concentration and wind speed data. By constructing a graph structure based on sensor spatial dependencies and utilizing temporal convolutional layers to capture long short-term time-series features, the high-precision dynamic prediction of gas concentrations is achieved via the MTGNN.