Molecular Motor Matrix-Based Augment Heat Dissipation Strategy Affording Ultrahigh-PCE J-Aggregates for Potentiate Cancer Photothermal Immunotherapy.

The photothermal conversion efficiency (PCE) stands as a pivotal determinant in the therapeutic efficacy of photothermal nanoagents (PTNAs) within the context of photothermal therapy (PTT). The dearth of universal strategies to greatly enhance PCE has markedly curtailed the practical deployment of PTNAs. Now this problem is addressed by proposing a universal approach founded on molecular rotors and J-aggregates, "highly efficient molecular motor matrix", to greatly elevate the PCE of traditional PTNAs. Here, the donor-acceptor structural framework is endeavors to amalgamate with an expansive array of highly efficient molecular motors, culminating in the ingenuous synthesis of a validated small molecule denoted as BO-4, which boasts an exceptional PCE (>90%). Moreover, nanoparticles of BO-4, named BO-4 NPs, have demonstrated marked suppression of metastatic tumor growth in vitro by PTT induced immunization and achieves complete primary tumor ablation in tumor-bearing mice after just two laser exposures. The proposed "highly efficient molecular motor matrix" strategy will pioneering a comprehensive trajectory is believed for the future design of high performance PTNAs with potential for clinical application in cancer treatment.