Associations between triglyceride-glucose index and glaucoma risk in hypertensive adults: Evidence from a nationally representative cohort.

Background: The triglyceride-glucose (TyG) index and its obesity-related derivatives have emerged as surrogate markers for metabolic dysfunction. This study aimed to explore their associations with glaucoma in hypertensive adults in the U.S.

[Rapid screening of 111 pesticides and veterinary drugs in livestock and poultry meat by ultra performance liquid chromatography-quadrupole-time of flight mass spectrometry].

The consumption of agricultural products has increased in recent years owing to abundant production and improved living standards. Veterinary drugs are highly commercialized and widely used in animal husbandry to ensure animal health and production performance. Moreover， pesticides can become enriched during animal breeding， resulting in animal-derived food pollution through foraging， drinking， and environmental disinfection that can potentially damage human health.

Hypoxia-induced metastatic heterogeneity in pancreatic cancer.

In most solid tumors, hypoxia constitutes a defining microenvironmental feature that reprograms malignant cells into a highly metastatic state by driving cellular plasticity and exacerbating chromosomal instability (CIN). However, the mechanisms by which cancer cells concurrently co-opt these elements of hypoxic adaptation to promote metastasis remains poorly understood. Here, we report that hypoxia promotes metastasis by suppressing the JmjC-containing histone lysine demethylase Kdm8.

Construction and application of a mortality risk prediction model for patients with lung squamous cell carcinoma: A competing risk analysis.

Background: Lung squamous cell carcinoma (LUSC) is the dominant histological subtype of lung cancer, accounting for 30% of all cases. Most patients develop distant metastases by the time they are diagnosed with the disease, owing to a delay in the appearance of symptoms. Therefore, accurate prognostic prediction is essential for personalized treatment.

Podoplanin-TGF-β1 Autocrine Loop: Pivotal Regulator of Islet Stellate Cell Activation via Cell Deformation, Orchestrating Islet Fibrosis in Diabetes.

The activation of islet stellate cells (ISCs) plays an important role in islet fibrosis, which leads to impaired islet function. While our previous work showed that the expression of the Pdpn gene was significantly increased in activated ISCs, it remains unknown whether Pdpn is responsible for islet fibrosis. This study was aimed at elucidating its function on islet fibrosis, along with the exploration of the underlying mechanisms.

BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction.

Despite optimized guideline-directed medical therapy, patients with myocardial infarction (MI) often develop heart failure (HF) primarily because of excessive fibrosis. Bone morphogenetic protein 1 (BMP1) plays a critical role in the fibrotic process, yet its specific role in post-MI myocardial fibrosis remains unclear. In this study, we investigated the complex dynamics between BMP1 and fibrotic processes, offering critical insights for novel strategies to mitigate pathological fibrosis in cardiovascular diseases.

Differential transcriptome analysis and functional validation of genes associated with the biosynthesis of paeoniflorin in tree peony (Paeonia suffruticosa Andr.).

Tree peony (Paeonia suffruticosa Andr.), known as a woody plant of the genus paeonia in the peony family, is widely cultivated for ornamental and medicinal purposes. In tree peony, its roots have high medicinal values, and a number of active ingredients can be found in the root bark.

APOBEC1-Dependent RNA Eiting of TNF Signaling Orchestrates Ileal Villus Morphogenesis in Pigs: Integrative Transcriptomic and Editomic Insights.

The ileum serves as the primary site for nutrient digestion and absorption in the intestine, with villus height representing a critical indicator of intestinal absorptive capacity. To investigate the regulatory mechanisms underlying ileal villus development, we conducted a feeding trial using crossbred pigs (Duroc × Landrace × Yorkshire) with an initial body weight of 27.74 ± 0.

Structure regulation of O3-type layered cathode materials enables high-capacity and long-cycling sodium-ion batteries.

The O3-NaNiFeMnO, despite its cost-effectiveness and reliable specific capacity, suffers from rapid capacity decay and sluggish Na diffusion kinetics induced by undesirable phase transitions. To address these limitations, we proposed a Zn/Ti co-doping strategy to synthesize Na(NiFeMn)ZnTiO (NFMZT) via a straightforward solid-state reaction, which solves the structural instability while maintaining its inherent high-capacity characteristics. Comprehensive experimental investigations coupled with theoretical calculations demonstrate that Zn/Ti co-doping successfully delays the O3 → P3 phase transition, mitigates Jahn-Teller distortion, and boosts electrochemical activity through reduction of the Ni valence state.

Global research trends in PARP inhibitors for ovarian cancer: a bibliometric analysis.

This bibliometric analysis maps global research trends on PARP inhibitors (PARPis) in ovarian cancer from January 2021 to May 2025, utilizing 1,434 publications retrieved from the Web of Science Core Collection. Employing Bibliometrix, VOSviewer, and CiteSpace, the study quantifies contributions across countries, institutions, authors, and research foci. Key findings reveal the United States (440 publications) and China (352) as leading producers, with UNICANCER (287 publications) and Memorial Sloan Kettering Cancer Center (61) as top institutions.

Knitting Organic Cage into Hyper Cross-Linked Polymers for the Efficient Capture of Fluoroquinolones in Pork Samples.

Considering the ubiquitous presence and hazardous effects of fluoroquinolone antibiotics (FQs), developing efficient methods for their detection has become imperative to safeguard human health. In this work, we synthesized a porous organic cage-based novel hyper-cross-linked polymer bearing multiple amino moieties (denoted as Cage-HCP-NH) through knitting and reduction of nitro-functionalized organic cage. The Cage-HCP-NH exhibits high porosity (0.

Zhi-zi-chi decoction exerts hypnotic effect through gut-brain axis modulation in insomnia mice.

Background: Insomnia, a frequently encountered sleep disorder, boasts a high prevalence rate on a global scale. Currently, Western medications are widely used for its treatment; however, they may cause adverse effects such as dependence and daytime drowsiness. Traditional Chinese medicine (TCM) offers a safer alternative.

Multimodal Integration in Health Care: Development With Applications in Disease Management.

Multimodal data integration has emerged as a transformative approach in the health care sector, systematically combining complementary biological and clinical data sources such as genomics, medical imaging, electronic health records, and wearable device outputs. This approach provides a multidimensional perspective of patient health that enhances the diagnosis, treatment, and management of various medical conditions. This viewpoint presents an overview of the current state of multimodal integration in health care, spanning clinical applications, current challenges, and future directions.

Parameters indicating impaired frontal lobe development in the second trimester in fetuses with congenital heart disease.

Objective: This study investigates differences in frontal lobe development and fetal biometries in second-trimester fetuses with different phenotypes of congenital heart disease (CHD) and analyzes correlations between parameters.

Methods: A total of 137 fetuses of gestational age between 20 and 28 weeks diagnosed with CHD by ultrasound between 2017 and 2023 were retrospectively selected as the CHD group and divided into left-sided obstructive lesion (LSOL) and right-sided obstructive lesion (RSOL) groups according to the blood and/or oxygen supply to the brain. Normal fetuses matched for gestational age were selected as a control group.

Short-term effects of ambient air pollution on musculoskeletal diseases in Yangzhou during 2019-2022.

Background: Given the limited research on the association between air pollutants and musculoskeletal diseases (MDs), our study aimed to examine how exposure to air pollutants influenced the risk of developing musculoskeletal disorders.

Methods: We extracted daily air pollutants and musculoskeletal diseases data from 2019 to 2022 in Yangzhou. The combined effects of air pollutants particulate matte 2.

Prediction of Protein B-Factor Profiles Based on Bidirectional Long Short-Term Memory Network.

B-factor is a measure of ray attenuation or scattering caused by atomic thermal motion during X-ray diffraction of protein crystal structure. B-factor reflects the vibration of atoms; hence, it is the most common experimental descriptor of protein flexibility and has been extensively applied in the studies of protein dynamics, screening of bioactive small molecules, and protein engineering. The prediction of B-factor profiles has considerable significance for analyzing the dynamic properties of unknown proteins.

Mechanical Agitation-Assisted Transmembrane Drug Delivery by Magnetically Powered Spiky Nanorobots.

Breaking through cell membrane barriers is a crucial step for intracellular drug delivery in antitumor chemotherapy. Hereby, a magnetic nanorobot, capable of exerting mechanical agitation on cellular membrane to promote intracellular drug delivery, was developed. The main body of the nanorobots was composed of nano-scaled gold nanospikes that were deposited with Ni and Ti nanolayers for magnetic activation and biocompatibility, responsively.

Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation.

Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion's dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast formation of covalent albumin-gold adducts. Here we report that newly-added thiols can modulate the dynamic albumin-gold binding and recover the therapeutic efficacy.

Mitochondrial pyruvate dehydrogenase phosphatase metabolism disorder in malignant tumors.

This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase (PDP) in malignant tumors and its potential mechanisms. Recent research on tumor metabolic mechanisms has shown that PDP dysregulation is closely linked to metabolic reprogramming in tumor cells, and potentially promotes tumor. Research has comprehensively explored the structural-functional characteristics of PDP, its metabolic regulatory mechanisms, and its role in various types of malignant tumors.

Ecological dynamics and resilience of anabranching rivers: Ecohydraulic insights from fish habitats.

Anabranching river systems, characterized by multiple stable channels separated by vegetated islands, play a crucial role in maintaining aquatic biodiversity. Despite their ecological significance, anabranches' influence on ecohydraulic environments and fish habitats remains largely unexplored. This study seeks to address the gap by offering an in-depth investigation into the habitat dynamics and sensitivity of anabranching rivers, aiming to enhance the understanding of anabranches' ecological suitability, resilience, and stability.

Green fabrication of diazo-coupled porous polymer as solid-phase extraction adsorbent coupled with HPLC-MS for sensitive detection of phenolic endocrine disruptors in pork and carp.

The development of highly practical method for the monitoring of environmental endocrine disruptor (EDCs) is of vital importance. Herein, a nitrogen-rich porous organic polymer (DT-POP1) bearing phenolic -OH groups was synthesized by green coupling reaction between diosmetin and N,N,N',N'-tetra(p-aminophenyl)-p-phenylenediamine. The DT-POP1 was used as solid-phase extraction (SPE) adsorbent, exhibiting brilliant extraction performance for five phenolic EDCs (bisphenol S, bisphenol F, bisphenol A, bisphenol B, and 4-tert-butylphenol).

Dynamic Mechanisms of Neutral Amino Acid Exchanger ASCT2 Transporting Substrate Glutamine.

Tumor cells rely on the high expression of transporter proteins to meet their nutrient demands, with alanine-serine-cysteine transporter 2 (ASCT2) being a key player in glutamine (Gln) uptake. Glutamine, a conditionally essential amino acid abundant in protein-rich foods, such as meat, dairy, and legumes, serves as a critical nitrogen and carbon source for cellular biosynthesis. ASCT2-mediated Gln transport not only fuels cancer progression but also plays a role in nutrient absorption in healthy tissues, particularly the gut, where dietary amino acids are assimilated.

Integrated 16S rDNA-Seq and metabolomics reveal seasonal dynamics of gut microbial-SCFA-immune crosstalk in diarrheic calves.

Introduction: Neonatal calf diarrhea incidence varies seasonally, increasing during climatic fluctuations. This study investigated body weight and size, immune function, intestinal permeability, rectal microbiota, and short-chain fatty acid (SCFA) levels in diarrheal and healthy lactating calves across seasons.

Methods: Ten lactating healthy and ten diarrhea calves were selected in each season, blood and rectal contents samples were collected.

Sensory Afferent Neural Circuits Mediate Electroacupuncture to Improve Swallowing Function in a Post-Stroke Dysphagia Mouse Model.

Background: Electroacupuncture (EA) has been reported to improve post-stroke dysphagia (PSD) effectively. However, the underlying afferent neural circuit and neurological mechanism involved in improving PSD remain poorly understood.

Methods: A PSD mouse model was established via the photochemical embolization method.