Multimodal Integration in Health Care: Development With Applications in Disease Management.

Multimodal data integration has emerged as a transformative approach in the health care sector, systematically combining complementary biological and clinical data sources such as genomics, medical imaging, electronic health records, and wearable device outputs. This approach provides a multidimensional perspective of patient health that enhances the diagnosis, treatment, and management of various medical conditions. This viewpoint presents an overview of the current state of multimodal integration in health care, spanning clinical applications, current challenges, and future directions.

"Reciprocity": Moral Dilemmas Concerning Priority Rules in Organ Allocation.

A long-standing debate has persisted on whether reciprocity reasonably justifies the priority rules in organ allocation as some countries (e.g., Israel, Singapore, Chile, and China) have adopted this priority policy based on reciprocity.

Machine learning-enhanced SERS detection of melamine and its analogues in non-pretreated milk via filter-pressing assembled polytetrafluoroethylene-AgNPs substrate.

Melamine contamination from illegal additives, packaging contaminants, and pesticide residues threatens dairy product safety, demanding rapid detection. Traditional methods such as chromatography or mass spectrometry are precise but lack field applicability due to complexity, time consumption, and cost. Surface-enhanced Raman spectroscopy (SERS) is a promising alternative for sensitive, rapid, and label-free analysis.

Faecalibacterium prausnitzii promotes anti-PD-L1 efficacy in natural killer/T-cell lymphoma by enhancing antitumor immunity.

Background: Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive subtype of lymphoma characterized by a poor prognosis. While immune checkpoint blockade (ICB) therapy has emerged as an effective treatment modality for various cancers, its efficacy among individuals is inconsistent and remains suboptimal for the majority of NKTCL patients. Faecalibacterium prausnitzii, recognized as a next-generation probiotic with immunomodulatory capabilities, has not yet been fully explored for its potential to influence the outcomes of ICB therapy.

Development of a Novel Large-Animal Model for Craniofacial Microsomia: Proportional Skeletal Defects in Mandibular Ramus and Zygomatic Arch.

Craniofacial microsomia (CFM) involves complex skeletal asymmetries, including mandibular and zygomatic arch deficiencies, leading to facial deformities and occlusal cant. Current animal models inadequately replicate these features, hindering the development of customized temporomandibular joint prostheses for CFM. This study aimed to develop a miniature pig model that mimics the proportional craniofacial skeletal defects observed in severe CFM, serving as a platform for future TMJ reconstruction studies.

Bioinformatics analysis to identify key invasion related genes and construct a prognostic model for glioblastoma.

Glioblastoma (GBM) is the most common and lethal brain tumor with limited therapeutic strategies and incomplete studies on its progression and mechanisms. This study aims to reveal potential prognostic marker genes associated with GBM cell invasion, and establish an effective prognostic model for GBM patients. Differentially expressed genes (DEGs) were screened from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA), differentially invasive-related genes was obtained, qRT-PCR was used to verify gene expression.

Integrative transcriptomic and HS-SPME-GC-MS analysis reveals the influence mechanism of different altitude ecotypes on pulp aroma components and volatile metabolites in strawberry hybrid F and its parents.

Strawberry (Fragaria × ananassa) is an important horticultural crop and is highly nutritious and valuable. However, several molecular mechanisms on the biosynthesis and metabolism of aroma compounds and the regulatory network that governs aromas remain unknown. This study investigated the influence of different altitude ecotypes on the components of pulp aroma and volatile metabolites in strawberry hybrid F and its parents.

Efficient Conversion of Nicotinamide Mononucleotide Based on Elucidation of the Limitations in Multienzyme Cascade Reactions.

Nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD), provides a direct method for maintaining NAD levels, which may alleviate aging and metabolic disorders. However, the enzymatic conversion of NMN in cascade reactions is limited by intermediate product inhibition, and quantitative insights into these limitations remain scarce. Here, an efficient multienzyme cascade system was developed by quantifying intermediate inhibition, which synthesizes NMN from D-ribose in three tandem reactions with an Adenosine Triphosphate (ATP) regeneration system and pyrophosphatase (PPase).

Semaphorin 3A Confers Protection against Oxidative Stress-induced Damage in Periodontal Ligament Stem Cells through the Activation of the Wnt/β-catenin Signaling Pathway.

Objectives: The osteogenic potential of periodontal ligament stem cells (PDLSCs) is crucial for periodontal tissue regeneration. Prolonged and excessive oxidative stress (OS) impairs the osteogenic function of PDLSCs. Recently, Semaphorin 3A (Sema3A) has been reported to have multiple roles in bone protection.

Population sequencing of cherry accessions unravels the evolution of Cerasus species and the selection of genetic characteristics in edible cherries.

Cerasus is a subgenus of Prunus in the family Rosaceae that is popular owing to its ornamental, edible, and medicinal properties. Understanding the evolution of the Cerasus subgenus and identifying selective trait loci in edible cherries are crucial for the improvement of cherry cultivars to meet producer and consumer demands. In this study, we performed a de novo assembly of a chromosome-scale genome for the sweet cherry (Prunus avium L.

Portable astronomical observation system based on large-aperture concentric-ring metalens.

The core advantage of metalenses over traditional bulky lenses lies in their thin volume and lightweight. Nevertheless, as the application scenarios of metalenses extend to the macro-scale optical imaging field, a contradiction arises between the increasing demand for large-aperture metalenses and the synchronous rise in design and processing costs. In response to the application requirements of metalens with diameter reaching the order of 10λ or even 10λ, this paper proposes a novel design method for fixed-height concentric-ring metalenses, wherein, under the constraints of the processing technology, a subwavelength 2D building unit library is constructed based on different topological structures, and the overall cross-section of the metalens is assembled.

Endovascular Treatment of Mirror Aneurysms in Subarachnoid Hemorrhage Patients: Single Stage or Multiple Stage?

Objective: The study evaluated the effectiveness and safety of single-stage versus multistage endovascular treatment in subarachnoid hemorrhage patients with Mirror Aneurysms.

Materials And Methods: Our research team performed a prospective study, focusing on the radiographic and clinical data of patients diagnosed with subarachnoid hemorrhage, specifically those who presented with Mirror Aneurysms upon admission to our institutions. According to the different endovascular treatment stages, these patients were grouped into the multistage cohort and the single-stage cohort.

Technical note: Y-chromosome short tandem repeat inconsistent typing for loci Y_GATA_H4, DYS481, DYS444, DYS635, DYS437, DYS533 and DYS570.

Y-chromosome short tandem repeats (Y-STRs) loci have significant research and application value in individual identification, parentage testing, kinship determination and genealogical DNA analysis due to their unique genetic characteristics. Currently, various commercial STR typing kits have used in forensic detection, which greatly promoting the scientific application of STR in criminal investigation and judicial trials. However, due to the complexity and specificity of biological samples, the special STR typing in the sample poses certain difficulties for the construction of DNA databases.

Butyrate-producing suppresses natural killer/T-cell lymphoma by dampening the JAK-STAT pathway.

Background: Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive malignancy with a dismal prognosis, and gaps remain in understanding the determinants influencing disease outcomes.

Objective: To characterise the gut microbiota feature and identify potential probiotics that could ameliorate the development of NKTCL.

Design: This cross-sectional study employed shotgun metagenomic sequencing to profile the gut microbiota in two Chinese NKTCL cohorts, with validation conducted in an independent Korean cohort.

Synthesis of MoS/MoO nano-heterojunction towards enhanced photocatalytic activity under LED light irradiation oxidation sintering.

The MoS/MoO nano-heterojunction photocatalyst was synthesized the oxidation sintering method. The properties of the samples were characterized by XRD, SEM, EDX, TEM, UV-vis, PL, FT-IR, BET and electrochemical techniques. The MoS/MoO nano-heterojunction (MS-400) exhibited significantly better photocatalytic activity toward Rhodamine B degradation (0.

Haplotype-resolved genome assembly for tetraploid Chinese cherry () offers insights into fruit firmness.

Chinese cherry () holds considerable importance as one of the primary stone fruit crops in China. However, artificially improving its traits and genetic analysis are challenging due to lack of high-quality genomic resources, which mainly result from difficulties associated with resolving its tetraploid and highly heterozygous genome. Herein, we assembled a chromosome-level, haplotype-resolved genome of the cultivar 'Zhuji Duanbing', comprising 993.