Senkyunolide I alleviates allergic rhinitis by inhibiting JAK1/3-STAT3/6 and JNK signalings.

Background: Allergic rhinitis (AR) is a common allergic disease with a high incidence rate. Senkyunolide I (SEI), a bioactive ingredient isolated from Ligusticum sinense 'Chuanxiong', exhibits known analgesic and anti-inflammatory effects, yet its anti-AR potential remains unexplored. Here, we aim to investigate the therapeutic efficacy and molecular mechanisms of SEI against AR.

Diagnostic value of thyroid-related serological indicators and pan-immune-inflammation value for differentiated thyroid carcinoma.

Background: Over the past decade, the remarkable rise in differentiated thyroid carcinoma (DTC) incidence, combined with the limitations of conventional diagnostic approaches, have prompted this study to explore the diagnostic value of thyroid-related serological indicators and pan-immune-inflammation value (PIV) for DTC, based on advancements in molecular biology and immunology.

Methods: Based on postoperative pathological diagnosis, the present retrospective research comprised 112 individuals afflicted with DTC (observation group) and 93 individuals having benign thyroid tumors (control group) from January 2023 to January 2025. Differences in clinical data between the two groups were analyzed via univariate statistical methods.

Diffusion Model-based Medical Image Generation as a Potential Data Augmentation Strategy for AI Applications.

Introduction: This study explored a generative image synthesis method based on diffusion models, potentially providing a low-cost and high-efficiency training data augmentation strategy for medical artificial intelligence (AI) applications.

Methods: The MedMNIST v2 dataset was utilized as a small-volume training dataset under low-performance computing conditions. Based on the characteristics of existing samples, new medical images were synthesized using the proposed annotated diffusion model.

Benefits of blue light-filtering intraocular lenses for subjective sleep quality: A systematic review and meta-analysis.

Background: The increasing use of digital devices has raised concerns about the effects of blue light exposure on overall well-being. Blue light-filtering intraocular lenses (BF-IOLs) have been developed to mitigate these effects, particularly in cataract surgery. This systematic review and meta-analysis aimed to evaluate and compare the benefits of BF-IOLs and standard intraocular lenses (IOLs) on the subjective sleep quality of cataract patients.

Strategies for enhancing yield and quality of forage-grain dual-purpose ratoon rice: role of first-season density and nitrogen management.

The "forage-grain dual-purpose" model helps ease land-use competition and supports high-yield, high-quality rice production. However, integrated strategies to simultaneously improve silage rice and ratoon rice yield and quality across both seasons require further systematic study. A two-year field study (2022-2023) was conducted using two widely cultivated indica hybrid rice cultivars, F You 498 (FY498) and Chuankangyou Simiao (CKYSM), in Southwest China.

Financial toxicity and psychological distress in cardiovascular non-cancer multimorbidity: a latent profile analysis and causal weighting.

Background: Cardiovascular disease with multimorbidity imposes substantial long-term financial burdens. Financial toxicity, the financial burden associated with healthcare, is increasingly recognized as a psychosocial stressor affecting health outcomes among chronically ill populations. However, its psychological heterogeneity in non-cancer patients is understudied.

The cation channel Trpa1 and chemokine Cxcl1 mediate axonal degeneration in spared nerve injury-induced neuropathic pain.

Demyelination of peripheral nerve injury is a vital cause of neuropathic pain. Schwann cells play an important role in supporting and maintaining the removal and regeneration of myelin debris from neuronal axons in the peripheral nervous system. Creating a good immune microenvironment would promote the Schwann cells to repair the injured nerve and reverse the allodynia of neuropathic pain.

Assessment and correction of the respiratory phase misalignment using different signals in 4-dimensional imaging and free-breathing gated radiotherapy.

Objective: To propose and validate a correction method for the respiratory phase shift of using different motion management systems in the 4-dimensional (4D) imaging and free-breathing gated radiotherapy.

Materials And Methods: Synchronized cone-beam CT (CBCT) and optical surface images (OSI) of 30 patients at two institutions were included. Reference diaphragm-signals were extracted from CBCT projections using Amsterdam-Shroud (AS) method.

CRISPR-SDA: an integrated isothermal amplification and CRISPR-Cas12a biosensing platform for sensitive detection of microRNA-21.

MicroRNA-21 (miRNA-21), a critical oncogenic biomarker, poses detection challenges due to low abundance and limitations of conventional methods. Herein, we developed a novel CRISPR-SDA biosensing platform by integrating strand displacement amplification (SDA) with CRISPR-Cas12a, leveraging SDA's efficient isothermal amplification of miRNA-21 and Cas12a's precise target recognition and -cleavage activity for signal amplification. Optimized conditions achieved high sensitivity with a detection limit of 10.

Mechanistic insights into aroma enhancement of Robusta coffee through ultrasound synergistic oil-solvent pretreatment: A combined lipidomics and volatilomics approach.

The relatively low lipid content of Robusta coffee is a major factor contributing to its monotonous aroma profile. In this study, Robusta green coffee beans were pretreated with ultrasound-assisted oil-solvent (coconut oil/palm oil/butter/camellia oil/walnut oil) to regulate the formation of aroma compounds during roasting by modifying their lipid composition, thereby enhancing the aroma profile of Robusta coffee. Lipidomic analysis showed that pretreatment significantly increased total lipid content and remodeled fatty acids and lipid molecules, with butter and coconut oil yielding the strongest effects.

Decoding the PTTG family's contribution to LUAD pathogenesis: a comprehensive study on expression, epigenetics, and therapeutic interventions.

Background: Lung adenocarcinoma (LUAD) stands as a prevalent malignancy, yet its pathology remains incompletely comprehended.

Methods: In this comprehensive study, we explored the roles of the pituitary tumor-transforming gene (PTTG) family, including PTTG1, PTTG2, and the pseudogene PTTG3P in lung adenocarcinoma (LUAD). Employing a multi-faceted approach, we conducted in-depth analyses using clinical samples and expression datasets.

Mycotoxin-Caused Intestinal Toxicity: Underlying Molecular Mechanisms and Further Directions.

Mycotoxins represent a group of highly toxic secondary metabolites produced by diverse fungal pathogens. Mycotoxin contaminations frequently occur in foods and feed and pose significant risks to human and animal health due to their carcinogenic, mutagenic, and immunosuppressive properties. Notably, deoxynivalenol, zearalenone, fumonisins (mainly including fumonisins B1, B2, and FB3), aflatoxin B1 (AFB1), and T-2/HT-2 toxins are the major mycotoxin contaminants in foods and feed.

Mendel randomization confirmed gastroesophageal reflux disease may increase the risk of mental disorders.

Background: The potential causal relationship between gastroesophageal reflux disease (GERD) and mental disorder was analyzed using the mendelian randomization (MR) method.

Methods: Data are derived from genome-wide association study (GWAS) summary data, using gastroesophageal reflux disease (GERD) as the exposure factor. Single nucleotide polymorphisms (SNPs) significantly associated with GERD were selected as instrumental variables (IVs), and mental disorders (bipolar disorder, major depression, Alzheimer's disease, anorexia nervosa, anxiety, and obsessive-compulsive disorder) were used as outcome variables.

Automated assessment of upper limb spasticity in stroke patients with fusion of multichannel surface electromyography features.

Objective: The objective of this study was to investigate a more accurate and efficient technique for assessing spasticity in stroke patients via surface electromyography (sEMG).

Methods: 45 hemiplegic individuals were recruited and spasticity was assessed via the modified Ashworth scale (MAS). Multichannel sEMG data were collected from 3 muscles: the long head of the biceps brachii (LB), the short head of the biceps brachii (SB), and the brachioradialis (BR).

An emerging PB2-627 polymorphism increases the zoonotic risk of avian influenza virus by overcoming ANP32 host restriction in mammalian and avian hosts.

Alterations in the PB2-627 domain of avian influenza virus (AIV) can potentially increase the risk of cross-host species infections in humans and mammals. Recently, there has been a rise in human cases of AIV infections without the presence of the known mammalian determinant PB2-E627K. Here, we identified a variant, PB2-627V, which has evolved in poultry and has contributed to the increase in human AIV infections.

Novel self-assembled metal-phenolic nanoplatforms for triple-negative breast cancer treatment: photothermal-chemotherapy/ferroptosis synergy inducing immunogenic cell death.

Triple-negative breast cancer (TNBC) poses a serious threat to women's health. Currently, chemotherapy remains the first-line treatment in the clinic, and more comprehensive treatments are urgently needed to improve the therapeutic efficacy of TNBC. Emerging studies have indicated that photothermal therapy, ferroptosis and immunotherapy also play crucial roles in TNBC treatment.

Burnout among intensive care physicians and nurses in the post-pandemic era in China: a national cross-sectional study.

Objectives: In the post-pandemic era, few studies have examined burnout among professionals in intensive care units (ICUs) in China. This study aimed to investigate the prevalence of burnout and associated mental health problems, including depression and stress, among ICU physicians and nurses following the pandemic, and to explore the factors contributing to burnout.

Design: A cross-sectional design was used in this study.

Toripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma: The DIAMOND Randomized Clinical Trial.

Importance: With the programmed cell death protein 1 (PD-1) blockade toripalimab, omitting highly toxic concurrent cisplatin may be feasible for nasopharyngeal carcinoma (NPC) without compromising survival.

Objective: To evaluate the efficacy and safety of toripalimab incorporated into induction chemotherapy and radiotherapy, without concurrent cisplatin, for locoregionally advanced NPC.

Design, Setting, And Participants: Open-label, multicenter, randomized phase 3 clinical trial conducted from August 2021 to July 2022 at 13 hospitals in China, enrolling 532 patients with T4N1M0 or T1-4N2-3M0 NPC; 400 (75.

Scalable metasurface-enhanced supercool cement.

Structural materials with the capability for passive daytime radiative cooling (PDRC) show promise for the sustainable cooling of buildings. However, developing durable PDRC structural materials with optical robustness, ease of deployment, and scalability remain a challenge for civil engineering applications. We synthesized a metasurface-enhanced cooling cement using a universal, scalable pressure-driven fabrication strategy during a low-carbon production process.

Mitigating voltage degradation in anion exchange membrane water electrolyzers by membrane-electrode interface engineering.

To shed light on the rapid voltage degradation of anion exchange membrane water electrolyzers, this study examines the degradation mechanism of a cathode electrode prepared spray coating. To circumvent this obstacle, a solution casting technique is suggested to enhance the stability of the membrane-electrode interface, thereby effectively mitigating the performance deterioration.

An oxidative stress related gene signature predicts prognosis in cholangiocarcinoma.

Background: Cholangiocarcinoma (CCA) is a malignancy with a poor prognosis and limited effective prognostic markers or therapeutic strategies. This study aims to construct and validate a prognostic risk model based on oxidative stress-related genes (OSRGs) to stratify patient risk and guide individualized treatment for CCA.

Methods: Using data from 66 tumors and 36 control samples obtained from the TCGA and GEO databases, we identified 3,632 differentially expressed genes (DEGs).

Mechanism of Defect-Impurity Synergy in Laser-Induced Conductive Layer on Single-Crystal Diamond Surfaces.

As a wide-band gap semiconductor, the formation of conductive layers on diamond surfaces is crucial for overcoming its insulating properties. Laser-induced doping has been demonstrated to be effective in generating low-resistance conductive layers on diamond. However, the underlying mechanism remains poorly understood.

Dextran-engineered Cu-MOF nanozyme with multi-enzyme mimetic cascade for cuproptosis-enhanced synergistic therapy in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is a highly aggressive subtype with limited therapeutic options. To address this challenge, we reported a novel multifunctional copper-based metal-organic framework (Cu-MOF) nanozyme, D@D@MOF, for targeted cascade catalytic therapy and synergistic induction of cuproptosis in TNBC. The Cu-MOF, synthesized via coordination of aminotriazole (3-AT) and copper, serves as a catalytic center, while disulfiram (DSF) is encapsulated for therapeutic synergy.

Nature Nano-Barrier: HPMC/MD-Based Pickering Emulsion to Extend Cherry Tomato Shelf Life.

To improve the postharvest preservation of cherry tomatoes and combat pathogenic, both bacterial and fungal contamination (particularly ), a novel biodegradable coating was developed based on a water-in-water (W/W) Pickering emulsion system. The emulsion was stabilized by (), with maltodextrin (MD) as the dispersed phase and hydroxypropyl methylcellulose (HPMC) as the continuous phase. Characterization of emulsions at varying concentrations revealed that the optimized W/W-PL^8 film exhibited superior stability, smooth morphology, and low water vapor permeability (WVP = 220.

Similar Genetic Routes Are Independently Targeted for Mimetic Color Convergence in Bumble Bees.

Bumble bees (Bombus) exhibit exceptional diversity in setal body color patterns, largely as a result of convergence onto multiple Mullerian mimicry patterns globally. When multiple species cross the same sets of mimicry complexes, they can acquire the same color polymorphisms, providing replicates of phenotypic evolution. This study examines the genetic basis of parallel color pattern acquisition in three bumble bee taxon pairs in western North America that shift between orange-red and black mid-abdominal segmental coloration in Rocky Mountain and Pacific Coastal mimicry regions: polymorphic Bombus vancouverensis and B.