A Cascaded Segmentation-Classification Deep Learning Framework for Preoperative Prediction of Occult Peritoneal Metastasis and Early Recurrence in Advanced Gastric Cancer.

Purpose: To develop a cascaded deep learning (DL) framework integrating tumor segmentation with metastatic risk stratification for preoperative prediction of occult peritoneal metastasis (OPM) in advanced gastric cancer (GC), and validate its generalizability for early peritoneal recurrence (PR) prediction.

Methods: This multicenter study enrolled 765 patients with advanced GC from three institutions. We developed a two-stage framework as follows: (1) V-Net-based tumor segmentation on CT; (2) DL-based metastatic risk classification using segmented tumor regions.

Diagnostic value of thyroid-related serological indicators and pan-immune-inflammation value for differentiated thyroid carcinoma.

Background: Over the past decade, the remarkable rise in differentiated thyroid carcinoma (DTC) incidence, combined with the limitations of conventional diagnostic approaches, have prompted this study to explore the diagnostic value of thyroid-related serological indicators and pan-immune-inflammation value (PIV) for DTC, based on advancements in molecular biology and immunology.

Methods: Based on postoperative pathological diagnosis, the present retrospective research comprised 112 individuals afflicted with DTC (observation group) and 93 individuals having benign thyroid tumors (control group) from January 2023 to January 2025. Differences in clinical data between the two groups were analyzed via univariate statistical methods.

Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol.

Background: Direct measurement of low-density lipoprotein cholesterol (LDL-C) is widely used and recommended by professional society guidelines despite its potential limitations in patients with hypertriglyceridemia and low LDL-C. This study evaluated the performance of 3 direct LDL-C (LDL-CD) assays, 2 modern LDL-C calculation methods [LDL-C Martin (LDL-CM), LDL-C modified Sampson (LDL-CS)] and the conventional Friedewald (LDL-CF) method against the reference method, beta-quantification (LDL-CBQ).

Methods: A total of 181 remnant sera from patients with standard lipid panel orders or from patients with LDL-CBQ orders with triglycerides (TG) ≥ 400 mg/dL (4.

Differential lipid metabolism in beef cattle: A comparative study of high and low residual feed intake bulls.

This study investigated lipid metabolism differences between low and high residual feed intake (LRFI and HRFI) bulls. Fifty-five Simmental bulls (449.84 ± 8.

An arginine chiral sensor based on walnut-like molecularly imprinted polymers.

Enantioselective discrimination of chiral amino acids is critically important across biomedicine, pharmacology, and food science, given the distinct biological roles of D- and L-enantiomers. In this study, a novel chiral sensor based on walnut-shaped molecularly imprinted polymers (w-MIPs) was developed for the highly sensitive and selective recognition of D- and L-arginine (Arg). The unique core-shell w-MIPs architecture, containing targeted binding sites, was synthesized tailored precipitation polymerization and characterized using transmission electron microscopy (TEM), atomic force microscopy (AFM), and Fourier transform infrared spectroscopy (FT-IR).

Correction: Organoids in cancer therapies: a comprehensive review.

[This corrects the article DOI: 10.3389/fbioe.2025.

Biomechanical Implications of Mass Loading in a Swine Model of Acute Hypoxemic Respiratory Failure.

In obesity, excess weight of the chest and abdomen (mass loading) decreases lung volume and can worsen acute hypoxemic respiratory failure (AHRF). We investigated whether positive end-expiratory pressure (PEEP) fully reverses the effects of mass loading on lung volume and respiratory mechanics in an AHRF swine model. Eighteen Yorkshire pigs were studied: six healthy, eight pre- and post-injury, and four post-injury only.

The expression pattern and role of circulating CXCR5 T cells in children with newly diagnosed immune thrombocytopenia.

Introduction: Immune thrombocytopenia (ITP) is the most common bleeding disorder in children. Tfh cells play a crucial role in the pathogenesis of ITP by promoting the production of anti-platelet autoantibodies. Recent studies have shown that CXCR5 T cells not only possess "Tfh-like" cell functions but also can induce Tfh cell differentiation.

From an Antimicrobial Agent to a constituent of 3D Printed Heterogenous Scaffolds Stimulating Bone Characteristics: An In-vitro and Animal model evaluation.

Unlabelled: This paper describes a promising candidate molecule, investigates the pattern of scaffold composition which arises and assesses the effect of the agent on its mechanical properties.

Methods: Scaffold samples were fabricated using a commercial extrusion bioprinter equipped with a pneumatic printhead fitted with a 21G conical nozzle. The Pore Printability Index, and the area and perimeter of the pore within the grid patterns were quantified using ImageJ software (NIH, USA).

Nanostructured Dyed Wooden Materials for Interior Decoration of Automobiles.

Automotive interior materials are increasingly designed to be environmentally friendly, aesthetically pleasing, durable, and lightweight. Herein, we report on the production of nanostructured dyed wooden materials to meet these requirements for automotive interior materials. A natural veneer is created through dyeing processes at a mild temperature of 45 °C to produce various color materials with a maximum dyeing ratio of 83% and 5-fold liquid permeability due to the partial removal of lignin and hemicelluloses.

Multiparametric MRI-based radiomics for preoperative prediction of parametrial invasion in early-stage cervical cancer.

Objective: The aim of this study was to evaluate the performance of radiomics based on multiparametric magnetic resonance imaging (MRI) for the preoperative prediction of parametrial invasion (PMI) in cervical cancer (CC).

Materials And Methods: This retrospective study included 110 consecutive patients with International Federation of Obstetrics and Gynecology (FIGO) stage IB-IIA CC. Patients were randomly divided into a training and a testing cohort in an 8:2 ratio.

Development and validation of the time perspective scale of perceived benefits and harms of internet gaming among adolescents in China.

Background And Aims: Gaming-specific maladaptive cognitions were critical determinants of internet gaming disorder (IGD). This study was novel to develop and validate the Time Perspective Scale of Perceived Benefits and Harms of Internet Gaming (TPS-PBHIG) by integrating the concepts of present- and future-oriented time perspectives, perceived benefits, and perceived harms of internet gaming.

Methods: Item generation was conducted by using both inductive (focus group interviews among adolescents) and deductive (comprehensive literature review) approaches.

Real-time detection of singlet-oxygen signatures using a single-photon avalanche diode detector.

Singlet-oxygen, the first excited state of molecular oxygen (O), is a reactive oxygen species that plays a key role as a cytotoxic agent in photodynamic therapy (PDT). In this work, we report a highly light-sensitive detection system based on a single-photon avalanche diode (SPAD) detector and time-correlated single-photon counting (TCPSC) for real-time detection of luminescence signatures from photosensitized singlet-oxygen. Dynamics of singlet-oxygen produced by the excitation of small-scale organic nitrobenzoselenadiazole photosensitizers were extracted with acquisition times as short as 1 second.

Loss-induced enhancement of Kerr nonlinearity and optical-frequency-comb generation in a non-Hermitian cavity-QED system.

A scheme for realizing loss-induced enhancement of optical nonlinearity in a non-Hermitian cavity quantum electrodynamics system is proposed and investigated. It is shown that the system can experience an exceptional point (EP)-based phase transition process by varying the additional loss induced on the system, which leads to nontrivial phenomena with interesting counterintuitive features. We demonstrate that the Kerr nonlinearity in the system can be counterintuitively monotonically enhanced by increasing the additional loss, meanwhile, a high on-resonance linear transmission rate of the system can be maintained.

Research on parameter selection and optimization of C4.5 algorithm based on algorithm applicability knowledge base.

Given that the decision tree C4.5 algorithm has outstanding performance in prediction accuracy on medical datasets and is highly interpretable, this paper carries out an optimization study on the selection of hyperparameters of the algorithm in order to achieve fast and accurate optimization of the algorithm model. The decision tree models are first constructed by taking different values of hyperparameters, and then the performance of each model is evaluated, and then the evaluated data are associated and integrated with the character metadata of the dataset.

Psychosocial experiences of prostate cancer survivors after treatment: a systematic review of qualitative studies.

Background: Prostate cancer, the second most common male malignancy worldwide, treatment-related complications cause both physical dysfunction and psychosocial sequelae, significantly impairing quality of life. Now requires integrated biopsychosocial rehabilitation beyond disease-focused treatment, comprehensive assessment of psychosocial adaptation and illness perception is essential for developing evidence-based, patient-centered rehabilitation strategies to optimize post-therapy recovery.

Objective: This study aims to systematically review and synthesize qualitative evidence on post-treatment psychosocial experiences in prostate cancer patients, thoroughly analyze patients' lived experiences and coping strategies, and provide an evidence-based foundation for establishing a tiered psychosocial support system and developing clinical intervention protocols.

Multimodal Locomotion of Amphibious Soft Microrobots for Multi-Environment Exploration.

Amphibious robots have immense potential for exploration in complex environments, but rigid and intricate structures limit adaptability and may cause mechanical disruption or ecological damage. This study presents a novel amphibious soft microrobot capable of seamlessly transitioning between land and water locomotion. We leverage the high power density and reversible actuation of 4D-printed liquid crystal elastomers (LCEs) combined with flexible heating circuits to fabricate LCE amphibious actuators.

Organoids in cancer therapies: a comprehensive review.

Organoid technology has significantly advanced biomedical research, offering deep insights into tumor biology and therapeutic efficacy. While existing publications have covered organoid applications, this review uniquely stresses their transformative role in cancer research. We highlight their importance in studying intratumoral heterogeneity and microenvironment interactions.

Polysaccharides Ameliorate DSS-Induced Colitis by Restoring Intestinal Barrier Function and Reprogramming Immune Homeostasis via the Gut-Liver Axis.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease driven by immune dysregulation, microbiota imbalance, and intestinal barrier dysfunction. Despite its global burden, effective therapies remain limited. This study explores the therapeutic potential of polysaccharides (ACP) in a dextran sulfate sodium (DSS)-induced murine colitis model.

-derived polysaccharides alleviate DSS-induced colitis in mice by suppressing inflammation, enhancing intestinal barrier integrity, and restoring gut microbiota homeostasis.

Introduction: Inflammatory bowel disease (IBD), including ulcerative colitis (UC), is characterized by disturbances in the intestinal barrier, immune system dysfunction, and an altered gut microbiota composition. , a medicinal mushroom known for its bioactive polysaccharides, has shown potential anti-inflammatory properties. However, its therapeutic effects on ulcerative colitis have not been studied.

The Intrinsic Link between Optical Properties and Toxicity of Extractable Organic Matter in Combustion Particles: Mediated by Polycyclic Aromatic Compounds.

Organic compounds are important contributors to the optical properties and health effects of combustion-derived particles. However, the connection between optical properties and toxicity of combustion particles remains a matter of little concern. In this study, combustion particles were collected from 11 primary sources, including biomass burning, coal combustion, and vehicle exhaust.

Effect of Marine-Derived Scallop Peptide Hydrolysate on Immune Modulation and Gut Microbiota Restoration in Cyclophosphamide-Induced Immunosuppressed Mice.

Cyclophosphamide (CTX), a chemotherapy agent, can weaken immune responses and disrupt gut microbiota, resulting in dysbiosis and inflammation. The gut microbiota, a composite community of microorganisms, plays a central role in regulating metabolism, supporting biological functions, and maintaining immune balance. Dysbiosis may lead to various systemic diseases and metabolic issues.

Ultra-low noise nanoporous Ag/AgCl electric field sensor for telluric electric field detection.

This paper presents an ultra-low noise nanoporous Ag/AgCl electric field sensor fabricated using a sol in situ composite method, aiming to address the issues of high noise and significant drift encountered in traditional electric field sensors during low-frequency signal measurements. By utilizing polyvinylpyrrolidone (PVP) sol to regulate the nucleation process of AgCl and combining it with nano-silver powder, nanoscale Ag/AgCl particles were prepared. Through the use of NaCl as a pore-forming agent, an electrode with a porous structure was developed.

Dual mechanisms of olfactory plasticity: Transient modulation by phosphatidylcholine and D-chiro-inositol and sustained regulation via the sex peptide-juvenile hormone system.

Insects exhibit olfactory plasticity to optimize their survival and reproduction, which ensures that their sensory preferences flexibly meets their needs. However, a comprehensive understanding of the sequential regulatory mechanisms driving these sensory adjustments is lacking. Addressing this knowledge gap is crucial for clarifying how the olfactory system of insect flexibly meets their reproductive needs.

Preparation of Carbon Fiber Electrodes Modified with Silver Nanoparticles by Electroplating Method.

To solve the problems of carbon fiber (CF) electrodes, including poor frequency response and large potential drift, CFs were subjected to a roughening pretreatment process combining thermal oxidation and electrochemical anodic oxidation and then modified with Ag nanoparticles (AgNPs) using electroplating to prepare a CF electric field sensor. The surface morphology of the as-prepared AgNP-CF electric field sensor was characterized via optical microscopy, scanning electron microscopy, XPS, and energy-dispersive spectroscopy, and its impedance, polarization drift, self-noise, and temperature drift values were determined. Results show that the surface modification of the AgNP-CF electric field sensor is uniform, and its specific surface area is considerably increased.