The efficacy of early facial nerve decompression in treating severe Ramsay Hunt syndrome.

Background: The incidence of Ramsay Hunt syndrome (RHS) has significantly increased in recent years, highlighting the need to explore effective surgical treatment strategies.

Methods: A total of 12 patients with severe RHS who visited our hospital from January 2021 to March 2023 were retrospectively included. The results of neuroelectrophysiological examination of the affected and healthy sides of all patients at baseline, 1 month postoperatively, 3 months postoperatively, 6 months postoperatively, and 12 months postoperatively were counted.

High-performance color-tunable organic light-emitting diodes based on an exciplex-forming co-host.

Color-tunable organic light-emitting diodes (OLEDs) have great potential for use in information security, smart lighting, and wearable healthcare. However, the performance of color-tunable OLEDs is currently far from meeting practical requirements. Here we present high-performance color-tunable OLEDs based on a novel, to the best of our knowledge, exciplex-forming co-host.

Characterization of a novel invasive virulence of chymotrypsin-like elastase family member 2A from Trichinella spiralis.

A novel chymotrypsin-like elastase family member 2A (TsCELA2A) was identified in Trichinella spiralis intestinal infectious larvae (IIL) excretion/secretion protein (ESP), but its properties and function are unclear. The objective of this study was to identify TsCELA2A's biological characteristics and functions at the process of T. spiralis invasion of enteral epithelium.

Factors that influence technophobia in Chinese older patients with ischemic stroke: a cross-sectional survey.

Background: Older patients with ischemic stroke often have a large number of medical needs, technophobia refers to the irrational anxiety and fear of digital technologies such as mobile communication equipment, artificial intelligence and robots, resulting in emotional reactions such as fear and tension, which will lead individuals to avoid using technology. However, the research on these patients' technophobia and the factors that may lead to it is limited.  AIMS: This study aimed to investigate the status of technophobia and analyze its influencing factors in Chinese older patients with ischemic stroke.

Label-free prediction of vascular connectivity in perfused microvascular networks in vitro.

Background And Objective: Continuous monitoring and in-situ assessment of microvascular connectivity have significant implications for culturing vascularized organoids and optimizing the therapeutic strategies. However, commonly used methods for vascular connectivity assessment heavily rely on fluorescent labels that may either raise biocompatibility concerns or interrupt the normal cell growth process. This study provides a new avenue for label-free and continuous assessment of organoid or tumor vascularization in vitro.

Loss-induced enhancement of Kerr nonlinearity and optical-frequency-comb generation in a non-Hermitian cavity-QED system.

A scheme for realizing loss-induced enhancement of optical nonlinearity in a non-Hermitian cavity quantum electrodynamics system is proposed and investigated. It is shown that the system can experience an exceptional point (EP)-based phase transition process by varying the additional loss induced on the system, which leads to nontrivial phenomena with interesting counterintuitive features. We demonstrate that the Kerr nonlinearity in the system can be counterintuitively monotonically enhanced by increasing the additional loss, meanwhile, a high on-resonance linear transmission rate of the system can be maintained.

Integrated network pharmacology, molecular docking and pharmacodynamic studies reveal protective effects and mechanisms of tetrandrine against sepsis-induced acute lung injury.

Tetrandrine (Tet) is a bisbenzylisoquinoline alkaloid with anti-inflammatory properties. It may have the potential to protect against sepsis-induced acute lung injury (ALI). The present study aimed to investigate the protective effects and mechanism of Tet on sepsis-induced ALI.

The cotton gene family encoding translationally controlled tumor proteins and the role of GhTCTP5 in salt tolerance.

Translationally controlled tumor proteins (TCTPs) are highly conserved proteins found in virtually all eukaryotes, and their expression is intricately linked with numerous biochemical processes and cellular activities. However, intriguingly, within the realm of key cash crops, investigations of the TCTP gene in cotton are relatively limited. This study sought to elucidate the evolutionary relationships and structural functions of the TCTP gene in cotton with a whole-genome analysis approach.

A novel mouse model of acute vestibular dysfunction via semicircular canal injection of absolute ethanol.

Objective: Various vestibular pathology models have been developed to elucidate the underlying mechanisms of vestibular diseases; however, there is a notable absence of minimally invasive mouse model of vestibular dysfunction. In this study, we established a novel model and conducted a comprehensive evaluation of vestibular function alongside various behavioral assessments.

Methods: We developed a surgical procedure involving canalostomy followed by injection of absolute ethanol into the semicircular canal of mice.

Alleviative Effects of Ciprofol on Hepatic Ischemia/Reperfusion Injury Through Inhibiting Macrophage Polarization.

Background: Previous studies have demonstrated the protective role of ciprofol against ischemia/reperfusion (I/R) injury, with the present investigation focusing on elucidating its effects on hepatic I/R injury.

Methods: A hepatic I/R injury animal model was established, and macrophages were polarized using lipopolysaccharide (LPS) induction. Hepatic tissue damage and apoptosis were assessed through hematoxylin-eosin and TUNEL staining.

Distribution mapping and risk assessment of lead in topsoil across the Tibetan Plateau.

Lead exposure poses substantial long-term health risks, accounting for over 900,000 annual deaths worldwide and impairing cognitive development in more than 800 million children. Recent studies have indicated elevated soil lead contamination levels on the Tibetan Plateau (TP), yet critical knowledge gaps remain in understanding its spatial risk distribution patterns, environmental drivers, and the magnitude of vulnerable populations. To address these uncertainties, this study systematically analyzed 733 topsoil samples across the TP and developed a machine learning framework to generate a 250-meter resolution predictive map of lead concentrations exceeding the regional background value (28.

UGPase: A novel molecule that regulates LPS synthesis, virulence, and immunogenicity of Brucella melitensis.

UTP-glucose-1-phosphoryl transferase (UGPase) catalyzes the synthesis of UDP-glucose, a key precursor for glycogen production and an essential component in bacterial lipopolysaccharide (LPS) synthesis. In this study, we demonstrate that UGPase deletion significantly disrupted LPS synthesis in Brucella, leading to a phenotypic shift from a smooth to a rough type and a marked reduction in bacterial virulence. In vitro and in vivo experiments revealed that UGPase deletion impaired Brucella's ability to infect host cells and diminished its pathogenicity in mice.

Effects of WeChat-based telehealth on patients reported outcomes of hypertension: a randomized controlled trial.

Patient-reported outcomes (PROs) are assessments based on patients' self-perception. This study aimed to explore whether WeChat-based health education is more effective than traditional health education in terms of improving PROs for hypertensive patients during a 3-month period. This prospective, single-center, single-blind randomized controlled trial was conducted from April to August 2022 at the hypertension ward of Yunnan Province Fuwai Cardiovascular Hospital.

Astragaloside IV Improves Pulmonary Vascular Endothelial Dysfunction in Pulmonary Arterial Hypertension by Inhibiting Ferroptosis through Modulation of the Calpain-1/TGF-β/TFRC Pathway.

Pulmonary vascular endothelial dysfunction (PVED) is a significant contributor to pulmonary arterial hypertension (PAH). Research indicates that astragaloside IV (AS-IV) has a therapeutic effect on PAH, but the potential mechanism by which it improves the PVED in PAH remains unclear. This study primarily investigated the protective effect of AS-IV on PVED in PAH.

A brief exploration of the physical properties of single living cells under dynamic loading conditions.

Introduction: Single living cells exhibit both active biological functions and material-like mechanical behaviors. While extensive research has focused on static or quasi-static loading, the purely mechanical properties under high-rate impact remain underexplored. Investigating cell responses to dynamic loading can isolate rapid deformation characteristics, potentially clarifying how life activities modulate mechanical behavior.

The role of plasma glucose in association of food-specific serum immunoglobulin G reactivity with metabolic dysfunction-associated fatty liver disease: a real-world cross-sectional study.

Background: As the immune response product to food antigens, food-specific serum immunoglobulin G reactivity (FSsIgGR) has been reported the clinical relevance to metabolic disorders, but its connections to metabolic dysfunction-associated fatty liver disease (MAFLD) remain underexplored, particularly within Chinese populations. Understanding this association could facilitate personal diet modification for MAFLD treatment. We investigated the association between FSsIgGR and MAFLD and the mediating roles of plasma glucose markers, specifically fasting blood glucose (FPG) and hemoglobin A1c (HbA1c).

Integrative transcriptome and metabolome analyses provide insights into rice defence against Chilo suppressalis oviposition.

Rice (Oryza sativa) is a crucial staple for more than half of the global population, yet it faces significant pest pressures, notably from the striped stem borer, Chilo suppressalis. This insect deposits eggs on rice surfaces, and their hatched larvae bore into stems, causing substantial yield losses. Whereas the responses of rice to larval feeding are well-documented, less is known about its reaction to C.

Breadth of influenza A antibody cross-reactivity varies by virus isolation interval and subtype.

Influenza virus infections generate antibodies that cross-react with antigenically similar viruses. However, the breadth of cross-reactivity is unclear. Here we analysed 200,000 haemagglutination inhibition (HAI) titrations from ferrets singly infected with A(H3N2) or A(H1N1)pdm09.

Genomic assembly and resequencing of the mango seed weevil Sternochetus mangiferae (Fabricius) provide insights into host adaptation and invasion control.

Background: Sternochetus mangiferae (Fabricius) is a monophagous beetle that exclusively feeds on mango seeds and is recognized as one of the most destructive quarantine pests worldwide. Despite its considerable ecological and economic impacts, the genomic basis underpinning its host specialization and invasion potential remains poorly understood.

Results: A high-quality genomic assembly was generated, totaling 701.

Antibacterial, sensitive, conformable electronics device by engineered two-dimensional-material-based organic electrochemical transistor.

Wearable devices are transforming health diagnostics through continuous, non-invasive monitoring. To enhance detection effectiveness, three aspects are crucial: sufficient sensitivity, antibacterial functionality of the skin biointerface, and mechanical compatibility. This study introduced a conformable wearable device based on two-dimensional-material MBene@AgNWs-doped serpentine organic electronic transistor biosensors (MB-Ag-Ser-OECTs), specifically engineered for antibacterial, non-invasive, and ultrasensitive estradiol detection.

Prospective Association Between Sarcopenia and Long-Term Risk of Hospitalization for Infection: A Cohort Study.

Objectives: The relationship between sarcopenia and the long-term risk of hospitalization for infectious diseases is unclear. This study aimed to evaluate this relationship using a large prospective Caucasian cohort from the UK Biobank.

Design: This is a large prospective cohort study.

Direct synthesis of N-trifluoromethyl amides via photocatalytic trifluoromethylamidation.

N-CF amides are promising targets for pharmaceutical and agrochemistry. Unfortunately, there is a defluorination problem of N-CF amine starting materials when using common amide bond formation method. Recently, elegant alternative approaches emerged.

Dual Cohort Insights Into Accelerometer-Derived Weekend Warrior Physical Activity and Its Impact on Mortality.

Background: Although guidelines on physical activity recommend at least 150 minutes of moderate-to-vigorous exercise weekly for optimal health outcomes, the distinction between concentrated and evenly distributed activity patterns remains unclear. We explored the relationships between accelerometer-measured weekend warrior and evenly spread moderate-to-vigorous physical activity (MVPA) and the risks of all-cause, cardiovascular disease, and cancer mortality.

Methods: Accelerometer-based physical activity data from the UK Biobank (Cohort 1 [June 8, 2013-December 30, 2015]: 89 488 individuals) and the US National Health and Nutrition Examination Survey (Cohort 2 [2003-2006]: 6198 individuals) were included in this study.

Spatial distribution, phase partitioning, and ecological risk assessment of typical pesticides in Yangtze River Basin.

Yangtze River Basin (YRB) is the largest agricultural and economic corridor in Asia, accounting for 40 % of China's rice production and 49 % of its arable land. Additionally, the Huangpu River (HR), the largest river in Shanghai, features developed agriculture and an extensive shipping industry. Overall, extensive agricultural activities coupled with frequent pesticide applications have resulted in aquatic contamination.

Assessing the effectiveness of travel control measures in preventing imported COVID-19 cases reveals the critical role of travel volume.

Background: Although travel control measures have played a key role in mitigating COVID-19 spread in certain regions, few empirical observational studies have specifically quantified their effectiveness in preventing the importation of infectious cases into communities. In Hong Kong, layered policies (e.g.