Modified Naples Prognostic Score for Postoperative Prognostic Stratification in Patients with Oral Squamous Cell Carcinoma.

Background: The Naples Prognostic Score (NPS) is a composite index that combines serum albumin (ALB), total cholesterol (TC), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR). It has proven prognostic value across various cancers. However, its use in oral squamous cell carcinoma (OSCC) has not been sufficiently recognized for disease-specific characteristics.

High-performance color-tunable organic light-emitting diodes based on an exciplex-forming co-host.

Color-tunable organic light-emitting diodes (OLEDs) have great potential for use in information security, smart lighting, and wearable healthcare. However, the performance of color-tunable OLEDs is currently far from meeting practical requirements. Here we present high-performance color-tunable OLEDs based on a novel, to the best of our knowledge, exciplex-forming co-host.

Comparison of Outcomes Between Ablation and Lobectomy in Stage IA Non-Small Cell Lung Cancer: A Retrospective Multicenter Study.

Background And Objective: Image-guided thermal ablation (IGTA) has been increasingly used in patients with stage IA non-small cell lung cancer (NSCLC) without surgical contraindications, but its long-term outcomes compared to lobectomy remain unknown. This study aims to evaluate the long-term outcomes of IGTA versus lobectomy and explore which patients may benefit most from ablation.

Methods: After propensity score matching, a total of 290 patients with stage IA NSCLC between 2015 and 2023 were included.

Non-planar A-D-A'-D-A type acceptors enabling EQEs over 5000% in near-infrared organic photomultiplying photodetectors.

We report two A-D-A'-D-A type non-fullerene acceptors, CS-3 and CS-4, with twisted backbones and low crystallinity. Despite these structural drawbacks, CS-3-based photomultiplying organic photodetectors exhibit an external quantum efficiency (EQE) of 5600% at 800 nm and detectivity exceeding 10 Jones. This work highlights the potential of non-planar molecular designs for achieving high-gain, broadband, near-infrared detection beyond conventional structure-performance expectations.

Topological structure synthesized by three-dimensional spin angular momentum of light.

Hopf links are important topological structures found in a range of disciplines. They represent the projection of higher-dimensional objects to three-dimensional (3D) physical space. Optical Hopf fibration texture has been demonstrated by synthesizing the transverse states of polarization and the phase.

From fish to fiber: 3D-nanoprinted optical neuromast for multi-integrated underwater detection.

Fish possess high sensitivity to acoustic, vibrational, and hydrodynamic stimuli through unique sensing cells, providing unparalleled paradigms for developing underwater detection methods. However, artificial perception devices face challenges in replicating comparable sensitivity and multi-dimensional integration of fish in function and scale. Here, we propose a biomimetic optical fiber neuromast (BOFN) by leveraging synergistic optical-mechanical interactions for multifunctional underwater detection and communication.

MdPOB1L Positively Regulates Disease Resistance Against Botryosphaeria dothidea by Manipulating MdNPR1 Protein Stability in Malus domestica.

E3 ubiquitin ligase is a key component of the ubiquitin-proteasome system, which is deeply involved in multiple aspects of plant growth and development, including in plant defence responses. POZ/BTB containing-protein1 (POB1) is a type of BTB-BACK domain-containing E3 ligase, which was previously reported to be a negative regulator of defence responses in multiple plant species. In this report, we identified MdPOB1-like (MdPOB1L) as a positive regulator in defence responses against Botryosphaeria dothidea by manipulating protein stability of MdNPR1, a master regulator in salicylic acid (SA) signalling pathway, in apple (Malus domestica).

Fine-control of electron trapping for photomultiplication in organic photodetectors by modulating the insulating properties of nonfullerene acceptors.

Enhancing photomultiplication (PM) in organic photodetectors (OPDs) requires effective control of photogenerated trapped electrons. Conventional approaches typically adjust the conduction band of the acceptor. In this study, we present a novel strategy for precisely controlling electron trapping and trapped carrier lifetime in PM-OPDs.

Broadband Photomultiplication-Type Organic Photodetectors by Employing an Interfacial Layer for Minimizing Dark Current.

Broadband photomultiplication-type organic photodetectors (PM-OPDs) were fabricated by employing a wide bandgap donor P3HT and narrow bandgap acceptor QxIC as the photoactive layers. The optimal weight ratio of P3HT to QxIC is adjusted as approximately 100:1 to achieve numerous isolated electron traps formed by P3HT/QxIC/P3HT and an efficient hole transport channel in the photoactive layers. The trapped photogenerated electrons in QxIC near the Al electrode will induce interfacial band bending for more efficient hole tunneling injection to obtain a large light current density (), resulting in the external quantum efficiency (EQE) over 100% of the PM-OPDs.

Improving the Efficiency of Layer-by-Layer Organic Photovoltaics to Exceed 19% by Establishing Effective Donor-Acceptor Interfacial Molecular Interactions.

The power conversion efficiency of layer-by-layer organic solar cells (LOSCs) has reached an impressive level by utilizing sequential processing (SqP) for the individual deposition and regulation of both donor and acceptor materials. However, the fundamental understanding of phase separation in LOSCs remains contentious, hindering the rational design of LOSCs due to the ambiguous contribution of stratification or the beneficial vertical segregation morphology. Here, we systematically investigate the utility of solvent effects on drying kinetics to understand how the interaction between the upper and bottom layers affects the formation of the donor/acceptor (D/A) interface and its impact on the performance of LOSCs.

Fingerprint Recognition Matrix Based on Photomultiplication-Type Organic Photodetectors with a Signal-to-Noise Ratio of 51,400.

Large-area and highly sensitive image sensors are vital for undercell fingerprint recognition technology. The photomultiplication-type organic photodetector (PM-OPD) is one of the alternative choices due to its special active layers with the ratio of donor to acceptor by weight of about 100:3 for achieving single charge carrier transport channels, resulting in relatively low dark current density and high external quantum efficiency under low bias. The optimal PM-OPDs exhibit a maximal 2.

Layered All-Polymer Solar Cells with Efficiency of 18.34% by Employing Alloyed Polymer Donors.

A series of layered all-polymer solar cells (LA-PSCs) with the normal or inverted structure are prepared by employing a sequential spin-coating method with PBQx-TCl, PM1 as polymer donor, and PY-DT as polymer acceptor. The power conversion efficiency (PCE) of normal LA-PSCs can be improved from 17.20% to 18.

Pharmacists' knowledge, attitudes, and perceived barriers to cancer pain management: a cross-sectional survey in Chongqing, China.

Background: The role of pharmacists in multidisciplinary cancer pain management teams is increasingly being recognized in Chinese medical practice. However, given the large number of patients, there is still a shortage of pharmacists with the necessary knowledge and skills. This study assessed pharmacists' attitudes and competencies in cancer pain management, identified major barriers in China, and provided evidence for the development of targeted interventions.

Implementing Cancer Pain Management Training for Pharmacists Using the Kirkpatrick Evaluation Model.

Purpose: To develop a training program on cancer pain management for pharmacists and to evaluate the effectiveness of the training.

Methods: The program developed a well-structured curriculum and subsequent evaluation of training effectiveness, guided by the Kirkpatrick four-tier evaluation model, including reaction, learning, behavior, and results. The training approach incorporated mentoring, study groups, and problem-based learning to create an immersive and impactful learning experience.

Hydrogen-Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine-125 Brachytherapy.

Radioactive iodine-125 (I) seed implantation, a brachytherapy technique, effectively kills tumor cells via X-rays and gamma rays, serving as an alternative therapeutic option following the failure of frontline treatments for various solid tumors. However, tumor radioresistance limits its efficacy. Hydrogen gas has anticancer properties and can enhance the efficacy of immunotherapy.

Triple-Phosphorescent Gold Nanoclusters Enabled by Isomerization of Terminal Thiouracils in the Surface Motifs.

Metal nanoclusters (NCs) hold great promise for expressing multipeak emission based on their well-defined total structure with diverse luminescent centers. Herein, we report the surface motif-dictated triple phosphorescence of Au NCs with dynamic color turning. The deprotonation-triggered isomerization of terminal thiouracils can evolve into a mutual transformation among their hierarchical motifs, thus serving a multipeak-emission expression with good tailoring.

Over 18.2% efficiency of layer-by-layer all-polymer solar cells enabled by homoleptic iridium(III) carbene complex as solid additive.

The vertical phase distribution of active layers plays a vital role in balancing exciton dissociation and charge transport for achieving efficient polymer solar cells (PSCs). The layer-by-layer (LbL) PSCs are commonly prepared by using sequential spin-coating method from donor and acceptor solutions with distinct solvents and solvent additives. The enhanced exciton dissociation is expected in the LbL PSCs with efficient charge transport in the relatively neat donor or acceptor layers.

A viroid-derived small interfering RNA targets bHLH transcription factor MdPIF1 to regulate anthocyanin biosynthesis in Malus domestica.

Fruit colour is a critical determinant for the appearance quality and commercial value of apple fruits. Viroid-induced dapple symptom severely affects the fruit coloration, however, the underlying mechanism remains unknown. In this study, we identified an apple dimple fruit viroid (ADFVd)-derived small interfering RNA, named vsiR693, which targeted the mRNA coding for a bHLH transcription factor MdPIF1 (PHYTOCHROME-INTERACTING FACTOR 1) to regulate anthocyanin biosynthesis in apple.

A review of robot-assisted ultrasound examination: Systems and technology.

Background: At present, the number and overall level of ultrasound (US) doctors cannot meet the medical needs, and the medical ultrasound robots will largely solve the shortage of medical resources.

Methods: According to the degree of automation, the handheld, semi-automatic and automatic ultrasound examination robot systems are summarised. Ultrasound scanning path planning and robot control are the keys to ensure that the robot systems can obtain high-quality images.

Highly Efficient Organic Solar Cells with the Highly Crystalline Third Component as a Morphology Regulator.

The morphology of the active layer is crucial for highly efficient organic solar cells (OSCs), which can be regulated by selecting a rational third component. In this work, the highly crystalline nonfullerene acceptor BTP-eC9 is selected as the morphology regulator in OSCs with PM6:BTP-BO-4Cl as the main system. The addition of BTP-eC9 can prolong the nucleation and crystallization progress of acceptor and donor molecules, thereby enhancing the order of molecular arrangement.

A method for calculating vector forces at human-mattress interface during sleeping positions utilizing image registration.

The vector forces at the human-mattress interface are not only crucial for understanding the distribution of vertical and shear forces exerted on the human body during sleep but also serves as a significant input for biomechanical models of sleeping positions, whose accuracy determines the credibility of predicting musculoskeletal system loads. In this study, we introduce a novel method for calculating the interface vector forces. By recording indentations after supine and lateral positions using a vacuum mattress and 3D scanner, we utilize image registration techniques to align body pressure distribution with the mattress deformation scanning images, thereby calculating the vector force values for each unit area (36.

Dual-Band Photomultiplication-Type Organic Photodetectors with Ultrahigh Signal-to-Noise Ratios.

A series of dual-band photomultiplication (PM)-type organic photodetectors (OPDs) were fabricated by employing a donor(s)/acceptor (100:1, wt/wt) mixed layer and an ultrathin Y6 layer as the active layers, as well as by using PNDIT-F3N as an interfacial layer near the indium tin oxide (ITO) electrode. The dual-band PM-type OPDs exhibit the response range of 330-650 nm under forward bias and the response range of 650-850 nm under reverse bias. The tunable spectral response range of dual-band PM-type OPDs under forward or reverse bias can be explained well from the trapped electron distribution near the electrodes.