Collectin-11 promotes fibroblast proliferation and modulates their activation status and extracellular matrix synthesis.

Introduction: Collectin-11 (CL-11), a recently described soluble C-type lectin, has been shown to stimulate cell proliferation in fibroblasts and melanoma cells. However, its broader influence on fibroblast functions and the specific receptors mediating CL-11's effects remain to be elucidated.

Methods: The EDU proliferation assay and WB detection of PCNA protein levels were used to evaluate the fibroblast proliferative effect after CL-11 stimulated.

Explainable Reinforcement Learning for the Initial Design Optimization of Compressors Inspired by the Black-Winged Kite.

Although artificial intelligence methods such as reinforcement learning (RL) show potential in optimizing the design of compressors, there are still two major challenges remaining: limited design variables and insufficient model explainability. For the initial design of compressors, this paper proposes a technical approach that incorporates deep reinforcement learning and decision tree distillation to enhance both the optimization capability and explainability. First, a pre-selection platform for the initial design scheme of the compressors is constructed based on the Deep Deterministic Policy Gradient (DDPG) algorithm.

The association between triglyceride-glucose index and the recurrence of myocardial infarction in young patients with previous coronary heart disease.

The triglyceride-glucose (TyG) index is a reliable biomarker for assessing insulin resistance. While previous studies have demonstrated its strong predictive value for cardiovascular disease in the general population, its ability to predict adverse clinical outcomes in patients with coronary heart disease (CHD) remains uncertain. This study aims to explore the association between the TyG index and recurrent myocardial infarction (MI) in young patients with CHD.

Endovascular Therapy Versus Medical Management for Large Ischemic Infarct: 1-Year Outcomes of the ANGEL-ASPECT Trial.

Background: Several trials have shown the benefit and safety of endovascular therapy (EVT) compared with medical management (MM) of patients with a large ischemic core in the 90-day follow-up. However, the 1-year outcome comparison between EVT and MM in Asian patients with a large ischemic core has not been investigated. Our aim was to evaluate the 1-year outcomes of patients in the ANGEL-ASPECT trial (Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core).

PicoSleepNet: An Ultra Lightweight Sleep Stage Classification by Spike Neural Network using Single-channel EEG Signal.

This study introduces PicoSleepNet, an ultra-lightweight sleep stage classification method that utilizes a spiking neural network (SNN) with single-channel electroencephalogram (EEG) signals. Traditional methods use multi-bit Nyquist sampling and dense computing, which result in high complexity and power consumption, hindering their deployment on wearable devices. To address these limitations, we propose an innovative pipeline combining single-bit sub-Nyquist level-crossing sampling (LCS) and sparse computing based on SNN.

Combined effects of ambient temperature and ozone exposure before and during pregnancy on hypertensive disorders of pregnancy in 568 Chinese healthcare facilities.

Hypertensive disorders in pregnancy (HDP) are a major contributor of maternal and perinatal mortality and morbidity. Although ambient ozone (O) and temperature have been individually associated with increased HDP risk, their combined effects remain unclear. In this multicenter retrospective cohort study involving 173,644 women, we assessed the independent and interactive relationships of O and temperature on HDP risk using logistic regression and distributed lag non-linear models (DLNM).

Application of sodium alginate-pectin active intelligent film containing anthocyanins from Aronia melanocarpa and tea polyphenols in pork preservation and freshness monitoring.

To investigate the preservation effects of active intelligent packaging film (S/P/A/T film) incorporated with anthocyanins (AMA) and tea polyphenols (TP) on meat, pork was selected as a representative sample, and preservation and monitoring experiments were conducted at 4 °C. The antimicrobial properties of the S/P/A/T active intelligent packaging were confirmed by observing the effects of the film solution on the growth curves and bacterial morphology of S. aureus and E.

A student academic performance prediction model based on the interval belief rule base.

Student performance prediction (SPP) constitutes one of the pivotal tasks in educational data analysis. Outcomes from the prediction enables educators to implement targeted interventions for students. Therefore, developing an effective SPP model is of critical importance.

Cell-supporting cytoskeletons and phagocytic acquisition of compatible solutes emerge as common strategies for high-salt adaptation in different ciliates.

Understanding the adaptation of organisms to extreme environments is a fascinating topic in biology. Ciliated eukaryotes (ciliates) that inhabit high-salinity environments exhibit remarkable diversity. We revealed various structural and molecular adaptations through a comprehensive investigation of Schmidingerothrix, a ciliate tolerant to salinity levels of up to 25%.

Pembrolizumab-associated hepatobiliary disorders: a real-world pharmacovigilance study using the FDA Adverse Events Reporting System (FAERS).

The aim of this study was to evaluate hepatobiliary disorders adverse events associated with pembrolizumab by using the Food and Drug Administration Adverse Event Reporting System (FAERS).We collected FAERS data from the first quarter of 2009 to the third quarter of 2024 and used reporting odds ratio (ROR) to detect pembrolizumab-associated hepatobiliary adverse events (AEs). A signal was considered significant when the lower limit of the 95% confidence interval (CI) of the ROR exceeded 1, and≥5 AEs were reported.

Differential effects of central dopamine D receptor activation on the dynamic changes of maternal behavior throughout the postpartum period.

Maternal behavior during the postpartum period is mediated by various neural mechanisms. While dopamine D receptor activation is known to affect maternal behavior in early postpartum, its role in the late postpartum period remains unclear. This study explores the neural mechanisms governing maternal behavior across the early and late postpartum periods by activating D receptors in different maternal brain regions: the ventral tegmental area (VTA), nucleus accumbens (NAc), and medial prefrontal cortex (mPFC).

Psychosocial Support Needs of Small Cell Lung Cancer Patients in China: A Qualitative Study From a Cultural Adaptation Perspective.

ObjectiveThis qualitative study examined the psychosocial support needs of small cell lung cancer (SCLC) patients within China's family-oriented cultural context. Guided by cultural adaptation theory, the study explored how cultural values shape patients' psychological experiences and treatment decision-making.MethodsUsing a phenomenological purposive sampling strategy, 32 SCLC patients from a tertiary oncology hospital in Tianjin, China (May 2024-March 2025) participated in semi-structured, in-depth interviews.

Airway basal stem cell-derived extracellular vesicles drive ECM remodeling and suppress fibroblasts activation via the miR-30a-5p/FAP axis in benign tracheal stenosis.

Introduction: Benign tracheal stenosis (BTS) is characterized by granulation tissue hyperplasia, driven by abnormal fibroblast activation and excessive extracellular matrix deposition. Targeting these mechanisms with novel therapies may offer a promising approach to addressing or preventing re-stenosis. Our previous study demonstrated that airway basal stem cell (BSC) transplantation can inhibit granulation hyperplasia in BTS.

Experimental analysis of blast shock wave-induced injuries in rats: Neurobehavioral and tissue damage assessments.

To investigate the dynamic response characteristics of personnel injuries caused by blast shock waves under actual working conditions, experimental studies on blast-induced injuries in rats, behavioral experiments post-injury, and pathological examinations were conducted, followed by injury assessments. The results showed that all rats died when the peak overpressure was 0.427 MPa.

The role of intravenous tirofiban in patients undergoing endovascular treatment for acute intracranial atherosclerotic occlusion.

Background And Purpose: Previous reports regarding the impact of tirofiban on patients undergoing endovascular treatment for acute ischemic stroke have shown inconsistencies. In this study, we specifically focused on patients with intracranial atherosclerotic disease to evaluate the effectiveness and safety of intravenous tirofiban during endovascular treatment.

Methods: The participants were sourced from the ANGEL-ACT Registry (a prospective multicenter registry study focused on key endovascular treatment techniques and emergency workflow improvement for acute ischemic stroke) and categorized into two groups.

RNLS promotes ovarian cancer growth and inhibits ferroptosis via mediating STAT3.

Introduction: Ovarian cancer (OC) is a lethal malignancy for which there are limited therapeutic options. The role of renalase (RNLS) in cancer progression and ferroptosis regulation remains unclear. This study investigates how RNLS mediates STAT3 to promote OC growth and suppress ferroptosis.

Age as a non-contraindication for surgical intervention in patients with abdominal wall incisional hernia: an exploration and analysis.

Background: Surgery is the only potential curative option in patients presenting with abdominal wall incisional hernia (IH). The approach clearly enhances patients' quality of life and reduces complications, however, the management of patients over 60 years old presents significant challenges, primarily due to the comorbidities and the complexities associated with postoperative recovery. The objective of this study was to examine postoperative outcomes in the age group over 60 years and the age group under 60 years.

Effects of surface roughness of a waveplate on the development of diffractive polarization speckle.

A rough-surfaced retardation plate is a particular polarization-dependent phase modulation device, whose performance is affected by its surface roughness structures. In previous research [J. Opt.

Geometrical parameter measurement of optical fibers based on an autofocus zoom imaging system.

A zoom imaging system is designed, and an autofocus algorithm based on the three-neighborhood operator is proposed. Based on the autofocus zoom imaging system, the geometrical parameters of the optical fibers with different diameters are measured using the transmitted near-field method without the replacement of lenses and the adjustment of the object plane. A four-component positive group compensation method is employed to design and implement a lens that provides continuous magnification ranging from 10× to 40× with a resolution of 3.

Melatonin biosynthesis and regulation in reproduction.

Melatonin, a neuroendocrine hormone widely present in animals, is a derivative of tryptophan secreted by the pineal gland. This hormone regulates animal circadian rhythms and can affect reproductive performance in many ways; for example, melatonin levels change in response to sunshine duration changes, which can inhibit or promote reproductive performance. In juvenile animals, melatonin inhibits estrus, whereas in mature animals, it promotes estrus.

PPDPF promotes the progression of esophageal squamous cell carcinoma via c-Myc/CD24 axis.

Background: Despite a series of attempts during the last decades, the prognosis for esophageal squamous cell carcinoma (ESCC) remains poor. Although clinical immunotherapy trials have shown encouraging results, their benefits are limited. This study aims to identify novel targets for immunotherapy in ESCC.

MdPOB1L Positively Regulates Disease Resistance Against Botryosphaeria dothidea by Manipulating MdNPR1 Protein Stability in Malus domestica.

E3 ubiquitin ligase is a key component of the ubiquitin-proteasome system, which is deeply involved in multiple aspects of plant growth and development, including in plant defence responses. POZ/BTB containing-protein1 (POB1) is a type of BTB-BACK domain-containing E3 ligase, which was previously reported to be a negative regulator of defence responses in multiple plant species. In this report, we identified MdPOB1-like (MdPOB1L) as a positive regulator in defence responses against Botryosphaeria dothidea by manipulating protein stability of MdNPR1, a master regulator in salicylic acid (SA) signalling pathway, in apple (Malus domestica).

Reactive oxygen species in cancer: Mechanistic insights and therapeutic innovations.

Reactive oxygen species (ROS), once considered mere metabolic byproducts, are now recognized as crucial elements in the complex behavior of cancer, influencing both its progression and vulnerabilities. In healthy cells, ROS maintains a delicate balance: while small amounts are essential for signaling, excessive quantities can cause damage. Cancer disrupts this equilibrium, leveraging ROS to promote proliferation, metastasis, and survival, while employing antioxidant defenses to prevent self-destruction.