Association between maternal sexually transmitted diseases and birth defects in the United States: A nationwide population-based study.

Purpose: We estimated the association between maternal sexually transmitted diseases (STDs) and the risk of specific birth defects among live singleton births in the United States (US).

Methods: We conducted a population-based study using data from birth certificates for 14,602,822 live singleton births occurring from 2016 to 2019 in the US. We used logistic regression to estimate the associations between three maternal STDs (chlamydia, gonorrhea, and syphilis) and the risk of four specific birth defects (gastroschisis, cleft lip with or without cleft palate, spina bifida, and hypospadias), adjusting for socio-demographic and pregnancy-related factors.

Exploring the Causal Links Between 338 Cerebrospinal Fluid Metabolites and Parkinson's Disease.

Background: Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by motor impairments and intricate pathophysiological mechanisms. Although cerebrospinal fluid (CSF) metabolites are viewed as potential biomarkers, the primarily observational design of the majority of existing studies limits the ability to draw causal conclusions.

Objective: The purpose of this research was to explore the causal link between CSF metabolites and PD by employing two-sample Mendelian randomization (TSMR).

Combined effects of ambient temperature and ozone exposure before and during pregnancy on hypertensive disorders of pregnancy in 568 Chinese healthcare facilities.

Hypertensive disorders in pregnancy (HDP) are a major contributor of maternal and perinatal mortality and morbidity. Although ambient ozone (O) and temperature have been individually associated with increased HDP risk, their combined effects remain unclear. In this multicenter retrospective cohort study involving 173,644 women, we assessed the independent and interactive relationships of O and temperature on HDP risk using logistic regression and distributed lag non-linear models (DLNM).

Development of Potent and Selective RIPK1 Degraders Targeting Its Nonenzymatic Function for Cancer Treatment.

Receptor-interacting protein kinase 1 (RIPK1) is a threonine/serine kinase that serves as a critical regulator of immune responses and cell death pathways, functioning through both its kinase activity and nonenzymatic scaffolding function. The scaffolding function of RIPK1 contributes to both intrinsic and extrinsic resistance to immune checkpoint blockades (ICBs), making it a compelling therapeutic target for cancer treatment. Recent studies have highlighted RIPK1's potential as a key modulator for improving the efficacy of immune-stimulatory therapies, such as ICBs and X-ray radiotherapy (XRT).

Phthalide extract from stems and leaves of Ligusticum chuanxiong attenuates cerebral I/R injury via CaSR-mediated NLRP3 inflammasome suppression.

Ethnopharmacological Relevance: The stems and leaves of Ligusticum chuanxiong ("Miwu") have been historically documented in ancient texts such as "Shennong Bencao Jing Jizhu" for alleviating conditions like stroke and dizziness. However, the therapeutic potential of phthalide extract from the stems and leaves of Ligusticum chuanxiong (SLECX) needs further investigate.

Aim Of The Study: This study aimed to investigate the neuroprotective effects of SLECX against cerebral ischemia-reperfusion (I/R) injury and elucidate its mechanism of action.

Characterization of a dual degrader of MDM2 and GSPT1.

Murine double minute 2 (MDM2) has long been a therapeutic target to stabilize and upregulate wild-type tumor protein 53 (p53) in cancer. We initially reported WB156 as a degrader of MDM2 that can upregulate p53 levels in acute leukemia. To further evaluate the therapeutic potential of WB156, we tested it in a variety of cancers alongside another reported MDM2 degrader.

Effects of dental treatment under general anesthesia on the oral health quality of life and dental fear of preschool children: a systematic review and meta-analysis.

Objectives: In this review, we aimed to determine the effects of dental treatment under general anesthesia on the oral health-related quality of life and dental fear of preschool children.

Materials And Methods: A comprehensive electronic search of PubMed, Embase, Scopus, and the Cochrane Library was conducted up to July 20, 2023 (updated on April 10, 2024). A manual search and evaluation of the gray literature were also performed.

Relevance of selected pharmacogenetic polymorphisms to bleeding and thromboembolic risks in Chinese patients taking direct-acting oral anticoagulants.

Aims: Gene polymorphisms play a critical role in the variability of plasma concentrations of direct-acting oral anticoagulants (DOACs). In this study, we aimed to investigate the effects of genetic variants on the clinical outcomes of Chinese patients treated with DOACs.

Methods: The retrospective study recruited 720 patients with nonvalvular atrial fibrillation who were receiving dabigatran, rivaroxaban or edoxaban.

Maternal adverse childhood experiences were associated with early screen exposure and prolonged daily screen time in preschool children.

Background: Maternal adverse childhood experiences (ACEs) have been linked to negative outcomes in their children. However, limited research has explored their impacts on screen use habits in preschool children. This study aimed to examine the associations of maternal ACEs with early screen exposure and prolonged daily screen time in preschool children whose mothers were their primary caregivers.

Reducing the risk of perinatal depression using an app-based cognitive behavioral therapy program: protocol of a randomized controlled trial.

Introduction: Cognitive behavioral therapy (CBT) is recognized as one of the most effective methods for reducing the risk of perinatal depression. However, the traditional face-to-face delivery format limits its accessibility. With the advent of digital technology, app-based CBT offers new possibilities, yet its preventive role in perinatal depression remains insufficiently explored.

Potential association between allergic disease and risk of Alzheimer's disease: insight from genetic analysis.

Backgroud: Numerous evidence from observational studies indicated an association between allergic diseases and Alzheimer's Disease (AD). However, the causal association of this relationship remains unclear. To address this, we conducted a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the potential causal impact of allergic diseases on AD.

Assessment of Fetal Cardiac Geometry and Systolic Function in Fetuses With Ventricular Septal Defect During the Second Trimester Using Fetal Heart Quantification Technology.

Objective: This study aimed to assess the impact of ventricular septal defect (VSD) on fetal cardiac geometry and systolic function during the second trimester using Fetal Heart Quantification (Fetal HQ) technology.

Methods: In this prospective study, 91 fetuses with isolated VSD and 91 gestational age-matched healthy controls were evaluated. Using the GE Voluson E10 ultrasound system and Fetal HQ software, cardiac parameters such as global sphericity index (GSI), global longitudinal strain (GLS), ejection fraction (EF), and fractional area change (FAC) were measured.

Efficacy of probiotics in the treatment of allergic diseases: a meta-analysis.

Background Information: Allergic diseases are an increasingly serious health issue worldwide, affecting not only the physiological health of patients but also significantly reducing their quality of life, thereby imposing a substantial economic burden on families and society. According to data from the World Health Organization, the incidence of allergic diseases has risen markedly over the past few decades, particularly among children and adolescents, making it a significant public health challenge. Although several clinical studies have explored the effects of probiotics in the treatment of food-induced allergies and allergic diseases, the results have been inconsistent.

A DNA Tetrahedron Assembly-Based Nanoshell-Mediated Nanoflares for Intracellular MiRNA Imaging: Reducing False Positivity and Improving Reaction Kinetics and Efficiency.

Nanoflares (NFs) are extensively used for the analysis of biomarkers within living cells. However, the severe false positives and low reaction efficiency and kinetics have restricted the further application of NF. To address these issues, we have developed an aptamer-modified DNA tetrahedron-assembled 3D nucleic acid nanoshell-mediated nanoflares (Ap-TDN-NF) for highly sensitive and accurate analysis of miRNA in living cells.

Effector TalAE73-Targeted Mediates Bacterial Blight Resistance in Rice.

Transcription activator-like effectors (TALEs) secreted from pv () function as a pathogenicity factor to activate rice bacterial blight (BB) susceptibility, conforming to the gene-for-gene paradigm as well as resistance. pathotypes generally harbor one to three major TALEs targeting genes to determine pathogenicity; conversely, the immunity events mediated by minor TALEs have not been taken seriously. Here, we demonstrated that lipid transfer protein encoding gene positively regulates rice resistance to pathotype PXO61, and TalAE73, a representative member of the most widely distributed TALE family in 135 isolates, transcriptionally activates expression.

Association between family disharmony, maternal negative emotional states, and behavioral problems among Chinese children attending preschools.

Background: Although previous studies have shown that children from disharmonious families were more likely to exhibit behavioral problems, the underlying pathways remain unclear. This study aimed to assess the associations between family disharmony and behavioral problems among Chinese preschool children and to investigate the potential mediating role of maternal negative emotional states.

Methods: A cross-sectional study including 4243 preschool children and their mothers was conducted in Chengdu, China.

Application of and research on 5G mobile nursing stations in clinical settings.

Objective: This study investigated the application of and research on 5G mobile nursing stations in clinical settings.

Methods: A randomized sample of 300 nurses from one hospital was selected. The control group was established from December 2021 to September 2022 as the nurses used the computerized hospital information system (HIS) for nursing documentation and performed routine manual verification of the treatment and patient information.

Enhancing crop yields to ensure food security by optimizing photosynthesis.

The crop yields achieved through traditional plant breeding techniques appear to be nearing a plateau. Therefore, it is essential to accelerate advancements in photosynthesis, the fundamental process by which plants convert light energy into chemical energy, to further enhance crop yields. Research focused on improving photosynthesis holds significant promise for increasing sustainable agricultural productivity and addressing challenges related to global food security.

Macrophage accumulation in dorsal root ganglion is associated with neuropathic pain in experimental autoimmune neuritis.

Background: Neuropathic pain is a common symptom of Guillain-Barré syndrome (GBS). The infiltration of macrophages in the dorsal root ganglion (DRG) contributed to neuropathic pain in nerve injury. The underlying mechanisms of neuropathic pain in patients with GBS remain unknown.

A novel aptasensor based endogenous enzyme-powered DNA walker for ATP imaging in specific living cells.

Highly sensitive and specific imaging of ATP in living cells remains a challenge. Here, a novel aptasensor based endogenous enzyme-powered DNA walker for imaging ATP was proposed. The strategy leverages the highly expressed APE1 in tumor cells as the driving force of the DNA walker, achieving high sensitivity and superior imaging contrast.

Effects of nutritional interventions on cancer patients receiving neoadjuvant chemoradiotherapy: a meta-analysis of randomized controlled trials.

Background: Malnutrition commonly occurs in cancer patients, impacting their quality of life and survival duration. The objective of this meta-analysis and systematic review is to assess the effects of nutritional interventions on patients undergoing neoadjuvant chemoradiotherapy.

Methods: A comprehensive search was conducted in PubMed, Embase, and the Cochrane Library databases to obtain randomized controlled trials of nutritional interventions in patients with neoadjuvant chemoradiotherapy.

Overexpression of FERONIA receptor kinase MdMRLK2 regulates lignin accumulation and enhances water use efficiency in apple under long-term water deficit condition.

Water use efficiency (WUE) is crucial for apple tree fitness and survival, especially in response to climatic changes. The receptor-like kinase FERONIA is reportedly an essential regulator of plant stress responses, but its role in regulating WUE under water deficit conditions is unclear. Here, we found that overexpressing the apple FERONIA receptor kinase gene, MdMRLK2, enhanced apple WUE under long-term water deficit conditions.