Techno-economic analysis of cost-competitive hard carbon production from biomass for sodium-ion batteries.

Sodium-ion batteries (SIBs) have gained increasing attention as a promising alternative to lithium-ion batteries due to sodium's abundance and cost-effectiveness. This growing interest in SIBs has spurred the development of hard carbon as a high-performance anode material. Although the electrochemical performance of biomass-derived hard carbon has been extensively investigated, the economic perspectives of its production have received limited attention, hindering its commercialization.

The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition.

HIV utilizes host proteins to manipulate cellular processes during replication. One key interaction involves the HIV regulatory protein Rev with the highly conserved nuclear exportin chromosome region maintenance 1(CRM1), which exports >1,000 proteins and ribonucleoprotein (RNP) complexes from the nucleus to the cytoplasm. Rev, with its associated viral RNA, is the first identified RNP cargo of CRM1.

HMGB1 deforms nucleosomal DNA to generate a dynamic chromatin environment counteracting the effects of linker histone.

The essential architectural protein HMGB1 increases accessibility of nucleosomal DNA and counteracts the effects of linker histone H1. However, HMGB1 is less abundant than H1 and binds nucleosomes more weakly, raising the question of how it competes with H1. Here, we find that HMGB1 increases nucleosomal DNA accessibility without displacing H1.

Long-term muscle-sparing benefits of proximal gastrectomy in elderly patients with upper-third early gastric cancer: A propensity score-matched analysis.

Background: As the global population ages, surgical strategies must shift from focusing solely on cancer control to prioritizing functional longevity. Laparoscopic proximal gastrectomy (LPG) has emerged as a potential organ-preserving alternative to laparoscopic total gastrectomy (LTG) for early upper-third gastric cancer (GC). However, the comparative efficacy of LPG versus LTG in elderly patients remains uncertain, as this population is more vulnerable to surgical stress due to age-related multimorbidity and frailty.

Hidden risk patterns among acute ischemic stroke patients identified by latent class analysis.

Background: Few studies focus on the comprehensive influence of multiple risk factors on the follow-up outcomes of acute ischemic stroke (AIS) patients. To fill this gap, this study aims to identify different subgroups with specific clinical characteristics and risk patterns among patients with AIS and to provide individualized treatment plans accordingly.

Methods: We obtained clinical follow-up data from 448 AIS patients within 72 h of admission.

Influence of computed tomography-based pelvimetric parameters and surgical approaches on surgical difficulty in mid‑low rectal cancer.

Introduction: Despite a lack of a well-defined concept of 'pelvic difficulties', pelvimetric parameters significantly influence surgical difficulty and outcomes in mid-low rectal cancer (MLRC).

Aim: The objective of this study was to explore the influence of pelvimetric parameters and surgical approaches on the difficulty of surgical procedures in MLRC.

Materials And Methods: A retrospective analysis was performed at the Northern Jiangsu People's Hospital, including patients with a diagnosis of MLRC who underwent total mesorectal excision between January 2016 and June 2023.

Warming Alaskan rivers affect first-year growth in critical northern food fishes.

Arctic and subarctic rivers are warming rapidly, with unknown consequences for migratory fishes and the human communities dependent on them. To date, few studies have provided a comprehensive assessment of possible climate change impacts on the hydrology and temperature of Arctic rivers at the regional scale, and even fewer have connected those changes to multiple fish species with input and guidance from Indigenous communities. We used climate, hydrologic, and fish-growth simulations of historical (1990-2021) and future (2034-2065) young-of-year (YOY) growth potential of Chinook salmon (Oncorhynchus tshawytscha) and Dolly Varden (Salvelinus malma) for seven river basins in the Arctic-Yukon-Kuskokwim (AYK) region of Alaska, USA and Yukon Territory, Canada.

Comparison of channel esophagogastrostomy and double tract reconstruction after laparoscopic-assisted proximal gastrectomy: a propensity score-matched analysis.

Background: Digestive tract reconstruction following proximal gastrectomy necessitates a synchronized approach to optimizing both anti-reflux efficacy and nutritional metabolism maintenance. However, academic debate over the optimal reconstruction technique remains ongoing. This study aims to compare the clinical outcomes of Channel Esophagogastrostomy (CE) and Double Tract Reconstruction (DTR) following laparoscopic-assisted Proximal Gastrectomy (LAPG).

Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.

Increasing the flanking DNA from 40 to 80 base pairs (bp) causes ~100-fold faster nucleosome sliding by INO80. A prevalent hypothesis posits that the Arp8 module within INO80 enables a ruler-like activity. Using cryogenic electron microscopy, we show that on nucleosomes with 40 bp of flanking DNA, the Arp8 module rotates 180° away from the DNA.

The structural basis of cold sensitivity.

Thermosensitive TRP ion channels enable somatosensory nerve fibers to detect changes in our thermal environment over a wide physiologic range . In mammals, the menthol receptor, TRPM8, is activated by temperatures below ~26°C and is essential for the perception of cold or chemical cooling agents . A fascinating, yet still unachieved goal is to elucidate structural mechanisms whereby TRPM8 or other thermosensitive channels are gated by changes in ambient temperature.

Development and validation of a prognostic nomogram for gastric GIST patients under 65 years of age.

Background: Gastric gastrointestinal stromal tumor (GIST) is the most common sarcoma of the digestive tract. Due to the fact that younger patients often present with more aggressive disease and exhibit different treatment responses compared to older patients, this study aimed to develop models to predict overall survival (OS) and cancer-specific survival (CSS) in postoperative gastric GIST patients under the age of 65, thereby aiding in the creation of optimal, individualized treatment strategies.

Methods: We first reviewed demographic and clinicopathological characteristics data from 1990 to 2021 of patients diagnosed with GIST in the Surveillance, Epidemiology, and End Results (SEER) database.

Epidemiological trends of gynecologic cancer burden in east Asian countries from 1990 to 2021 and projections to 2031.

Objective: This study aimed to estimate the incidence rates, deaths, and disability-adjusted life-years (DALYs) due to cervical, ovarian, and uterine cancers among females in East Asia (China, Democratic People's Republic of Korea, Mongolia, Japan, and Republic of Korea) between 1990 and 2021, and to predict the disease burden for the next decade.

Methods: The data were extracted from Global Burden of Disease (GBD) 2021 project. The joinpoint regression model was applied to reflect temporal trends.

Analysis of retinal markers and incident amyotrophic lateral sclerosis: An optical coherence tomography-based cohort study.

Background: Biomarkers are widely recognized as crucial breakthroughs in tackling amyotrophic lateral sclerosis (ALS). Among them, retina markers may hold promise due to the close retina-brain connection and non-invasive, portable detection methods. Thus, using optical coherence tomography (OCT), we investigated the link between baseline cell-level retinal features and future ALS risk.

MOL: Joint Estimation of Micro-Expression, Optical Flow, and Landmark via Transformer-Graph-Style Convolution.

Facial micro-expression recognition (MER) is a challenging problem, due to transient and subtle micro-expression (ME) actions. Most existing methods depend on hand-crafted features, key frames like onset, apex, and offset frames, or deep networks limited by small-scale and low-diversity datasets. In this paper, we propose an end-to-end micro-action-aware deep learning framework with advantages from transformer, graph convolution, and vanilla convolution.

Corrigendum to "Monocyte-to-lymphocyte ratio affects prognosis in LAA-type stroke patients" [Heliyon Volume 8, Issue 10, October 2022, Article e10948].

[This corrects the article DOI: 10.1016/j.heliyon.

Evaluation of combined tubular gastroesophageal anastomosis and C-shaped flap technique in proximal gastrectomy for gastric cancer: A retrospective propensity score matching analysis.

Background: Proximal gastrectomy (PG) is a functional-preserving surgical option for upper gastric and esophagogastric junction cancers. However, it is associated with a high risk of postoperative gastroesophageal reflux. This study evaluates the safety and effectiveness of combining tubular gastroesophageal (TG) anastomosis with a C-shaped single muscle flap technique to enhance anti-reflux function.

Describing dynamic electron correlation beyond a large active space.

The pursuit of quantitatively accurate electron correlation calculations for realistic large strongly correlated systems presents significant theoretical and computational challenges. These challenges stem primarily from two fundamental aspects: the inherent complexity of treating static correlations within extensive active spaces and the additional difficulty of incorporating dynamic correlation effects from the external space. In this comprehensive perspective, we systematically review and analyze state-of-the-art methodologies that address dynamic correlation beyond large active spaces, with particular emphasis on approaches that circumvent the computational burden associated with high-order reduced density matrices.

Global, regional, and national burden of mental disorders among women of reproductive age, 1990-2021: a systematic analysis of the global burden of disease study 2021.

Background: Women of reproductive age (WRA), a key reproductive group, face mental health issues that impact both their own well-being and that of the next generation. However, research on the burden and trends of mental disorders among WRA remains limited. This study aimed to assess these on a global scale.

Anti-polyphenol oxidase and antibacterial activities of 1-(2,5-dichlorophenyl)-2-thiourea as an anti-browning agent.

1-(2,5-Dichlorophenyl)-2-thiourea (DCPT) was selected from thiourea due to its extraordinary polyphenol oxidase (PPO) inhibitory activity (IC = 33.2 ± 0.2 nmol L).

Potential association between allergic disease and risk of Alzheimer's disease: insight from genetic analysis.

Backgroud: Numerous evidence from observational studies indicated an association between allergic diseases and Alzheimer's Disease (AD). However, the causal association of this relationship remains unclear. To address this, we conducted a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the potential causal impact of allergic diseases on AD.

Screening colorectal cancer associated autoantigens through multi-omics analysis and diagnostic performance evaluation of corresponding autoantibodies.

Background: This study aims to screen, validate novel biomarkers and develop a user-friendly online tool for the detection of colorectal cancer (CRC).

Methods: Multi-omics approach, comprising proteomic analysis and single-cell transcriptomic analysis, was utilized to discover candidate tumor-associated antigens (TAAs). The presence of tumor-associated autoantibodies (TAAbs) in serum was subsequently assessed using enzyme-linked immunosorbent assays (ELISA) in 300 CRC patients and 300 healthy controls.

The Contribution of Complement System in Multiple Sclerosis: Mechanisms and Therapeutic Potentials.

The complement system has been described as playing key roles in both innate and adaptive immune responses. Multiple sclerosis (MS) is an autoimmune disease characterised by the destruction of myelinated axons in the central nervous system (CNS). In this review, we will discuss the possible role of the complement system in MS.

An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains.

Conventional implantable electronic sensors for continuous monitoring of internal tissue strains are yet to match the biomechanics of tissues while maintaining biodegradability, biocompatibility and wireless monitoring capability. Here we present a two-dimensional phononic crystal composed of periodic air columns in soft hydrogel, which was named ultrasonic metagel, and we demonstrate its use as implantable sensor for continuous and wireless monitoring of internal tissue strains. The metagel's deformation shifts its ultrasonic bandgap, which can be wirelessly detected by an external ultrasonic probe.

Baicalin attenuates LPS-induced periodontal inflammation response by inhibiting autophagy.

Background: Periodontal disease causes gradual damage to the periodontal ligament and alveolar bone, ultimately resulting in tooth loss. This condition This condition results from the intricate interaction between bacterial infections and the host's inflammatory responses, driving disease progression. Autophagy, an essential process for cellular balance under stress, plays a vital role in the response to periodontal pathogens.

Condensed tannins from the pulp of Chinese hawthorn as an anti-browning agent: Structure, activity, and structure-activity relationship.

Condensed tannins (proanthocyanidins) were isolated from the pulp of Chinese hawthorn (Crataegus pinnatifida Bge. var. major N.