Prospective associations of dynapenic abdominal obesity status with distinct trajectories of depressive symptoms: A national cohort study.

Background And Aims: Dynapenic abdominal obesity has been shown as a risk factor for adverse outcomes. There is no evidence on the longitudinal association of this condition with different courses of depressive symptoms. This study aimed to investigate the association of dynapenic abdominal obesity status with the risk of distinct trajectories of depressive symptoms.

Revealing the heterogeneity of electrode surfaces using photoluminescence electrochemical microscopy.

Photoluminescence-based electrochemical microscopy enables micrometer-scale probing of electrode heterogeneity. Our results revealed a correlation between the potential-negative differential photoluminescence profile and the corresponding cyclic voltammogram. We further elucidated the structure-activity relationship linking interfacial heterogeneity to the electrocatalytic performance of electrodeposited CuO as a proof-of-concept experiment.

Fabrication of wide angle polarized 3He cells in China Spallation Neutron Source (CSNS).

As part of ongoing upgrade efforts in the China Spallation Neutron Source (CSNS), the neutron polarization team has been actively working on the fabrication procedure of 3He-based neutron spin filters having large angle coverage. We report substantial success in blowing and filling the first wide-angle 3He glass cells in China. The contained 3He gas is polarized on our off-situ spin-exchange optical pumping system.

Antibacterial activity and mechanism of naphthoquine phosphate against ceftazidime-resistant via cell membrane disruption and ROS induction.

Introduction: Drug-resistant bacteria, particularly , present a significant threat to global public health, highlighting the urgent need for novel antibacterial therapies. Drug repurposing has emerged as a promising strategy to accelerate therapeutic development by identifying new applications for existing pharmaceuticals. This study investigates the potential of naphthoquine phosphate (NQP), an antimalarial agent, as a broad-spectrum antibacterial candidate against the multidrug-resistant strain LAC-4.

Development and validation of a pediatric pharmacological readiness assessment scale for recurrent respiratory infections.

To develop and validate a Pediatric Pharmacological Readiness Assessment Scale for recurrent respiratory infections, focusing on medication adherence, caregiver pharmacological knowledge, and pharmacist-led interventions. An initial scale was constructed through literature review, expert consultation, and a pilot survey, guided by the Pharmaceutical Care Practice Model. A convenience sample of 156 primary caregivers of children hospitalized for recurrent respiratory infections was surveyed between April 2023 and April 2024.

Spatial morphoproteomic features predict disease states from tissue architectures.

Understanding how immune cells organize within tissue microenvironments is essential for interpreting disease responses in spatial proteomics data. We introduce SNOWFLAKE, a graph neural network pipeline that integrates single-cell protein expression and morphological features to predict disease status from lymphoid follicles. Using a pediatric COVID-19 dataset, SNOWFLAKE outperformed conventional machine learning and deep learning approaches in classifying infection status.

XFBLD-Platform: a crystallographic fragment-screening platform at Shanghai Synchrotron Radiation Facility.

Fragment-based lead discovery (FBLD) is an efficient and effective method for identifying novel chemical scaffolds that have advantages in drug development. X-ray crystallography has an inherent advantage in recognizing low-affinity fragments and integrates fragment identification with complex structure determination, making it an increasingly important tool for screening fragment compounds. Here, we introduce a crystallographic fragment-screening platform developed by the biological macromolecular crystallography group at Shanghai Synchrotron Radiation Facility, named the XFBLD-Platform.

Hypothetical Interventions on Frailty Heterogeneous Trajectories of Older Patients with Gastric Cancer Using Parametric G-Formula.

Background: Frailty is prevalent in older patients with gastric cancer, seriously affecting their prognosis. The time-varying nature of frailty increases the difficulty of intervention. This study aimed to estimate the effect of hypothetical interventions on the risk of frailty heterogeneous trajectory (FHT) at physical, psychological, familial, and social levels to provide a basis for the subsequent design of intervention programs of FHT.

Is it true that lower PTH control is associated with lower levels of inflammatory cytokines in patients with chronic kidney disease?

Background: The body of patients with chronic kidney disease (CKD)is in a state of microinflammation, which further aggravates the progression of CKD and the occurrence and development of its complications. The inflammatory state of the body is significantly increased in patients with secondary hyperparathyroidism of CKD.

Methods: Patients diagnosed with chronic kidney disease in the department of Nephrology of Henan Provincial People's Hospital were selected as the experimental group, and 58 normal subjects were selected as the control group.

Multidisciplinary, whole-process management of a patient with recurrent serous borderline ovarian tumor from embryo cryopreservation before re-fertility-sparing surgery to successful delivery: a case report.

Background: For patients with recurrent serous borderline ovarian tumors (BOT) who have undergone unilateral salpingo-oophorectomy, there is a risk of reduced or even lost ovarian reserve after the second surgery; therefore, fertility preservation (FP) prior to re-operation in patients of childbearing age is challenging, and has attracted increasing attention. Here, we discuss the multidisciplinary whole-process management of a patient with recurrent serous BOT, from embryo cryopreservation (EC) before re-fertility-sparing surgery (re-FSS) to successful delivery.

Case Presentation: We describe the treatment of a 28-year-old married, nulliparous female with recurrent serous BOT who requested FP.

Live birth following multimodal therapy in a patient with asherman's syndrome, recurrent pregnancy loss, and polycystic ovarian syndrome: a case report and literature review.

Background: Improving the endometrial thickness (EMT) and pregnancy outcomes in cases of thin endometrium (TE) induced by severe intrauterine adhesion (IUA) is a significant clinical challenge. This report provides insight into a potential protocol for improving EMT and pregnancy outcomes in challenging cases of TE induced by IUA, especially for patients with concurrent polycystic ovary syndrome (PCOS) and experiencing recurrent spontaneous abortion (RSA).

Case Presentation: We report the case of a 29-year-old woman with severe IUA, RSA, and PCOS, who experienced three spontaneous abortions.

GH16 Glycoside Hydrolases Divergently Contribute to Fungal Development, Stress Tolerance, and Virulence of an Insect Fungal Pathogen.

Fungal glycoside hydrolases (GHs) include β-glucanases and glycosyltransferases, which are involved in fungal cell wall metabolism and crucial for fungal development and adaptation to varied environments and host niches. However, many GHs in entomopathogenic fungi (EPF) have not been well characterized. Here, 13 detectably expressed members of the GH16 family were systemically and genetically characterized in the EPF .

Deep brain stimulation surgical timing, outcomes, and prognostic factors in patients with Parkinson's disease: A Chinese retrospective multicenter cohort study.

Background: Deep brain stimulation (DBS) has been increasingly introduced for patients with Parkinson's disease (PD). However, there has been extensive controversy regarding its surgical timing. This study aimed to evaluate surgical outcomes of DBS across different PD durations and identify key prognostic factors.

Revealing the Ion Channel Switch of the Cell Membrane via Electrochemiluminescence Pattern Transformation.

Ion channels as transmembrane proteins provide an important transport pathway for specific ions through cell membranes, which are crucial to studies involving the pathophysiology of the nervous system. However, the switch between different conformational states (i.e.

Comparative effectiveness and safety of atorvastatin versus rosuvastatin among patients with ischemic stroke or transient ischemic attack: a national registry-based observational study.

Background: Atorvastatin and rosuvastatin are the most widely used statins in patients with ischemic stroke or transient ischemic attack (TIA). However, evidence on their effectiveness and safety during actual use is scarce. This study aims to compare the effectiveness and safety of initiating atorvastatin versus rosuvastatin among patients with ischemic stroke or TIA.

Risk prediction model of frailty and its associated factors in older adults: a cross-sectional study in Anhui Province, China.

Background: In the context of aging in China, frailty has become a major public health challenge, placing an enormous economic burden on both society and families. Frailty can trigger serious adverse effects on the physical and mental health of older adults. It highlights the urgent requirement for addressing the issue of frailty among older adults.

Environmental stability characteristics of the immobilization effect of sulfhydryl grafted palygorskite on soil-available cadmium.

The stability of heavy metal immobilization amendments represents a critical factor in evaluating remediation effectiveness. To comprehensively investigate the environmental stability of a novel amendment, sulfhydryl grafted palygorskite (SGP), a series of experiments encompassing chemical exposure and sorption, incubation with simulated acid rain and thermal variations, and field validation were conducted. SGP demonstrated chemical stability across diverse media, including ambient atmosphere, aqueous solutions (HO, CuSO, and HO), and heterogeneous soil matrices, as evidenced by a maximum relative standard deviation of changes in the free sulfhydryl content and a sorption capacity below 5%.

Efficient Tonsillar T Follicular Helper Cell Processing and Functional Analysis through High-dimensional Flow Cytometry.

T follicular helper cells (Tfh) are a subset of CD4 T helper cells that aid in B cell isotype switching, germinal center (GC) formation, somatic hypermutation, and affinity maturation, thereby helping to orchestrate adaptive humoral immune responses in secondary lymphoid tissues during infection, autoimmunity, and vaccination. Understanding the development and function of Tfh cells is crucial for designing effective vaccines and developing targeted treatment strategies for diseases involving this population. Human tonsil cells are accessible mucosal lymphoid organs.

Au@Pt DNA Nanomachine Coupled with Photonic Crystal Microchip Enables High-Fidelity and Portable miRNA Detection.

Although great headway has been made in 3D DNA nanomachines, built from DNA-functionalized gold nanoparticles (Au NPs), for sensitive miRNA detection in complex media, their stability, accessibility, and portability still need to be improved. To surmount these hurdles, we are the first to develop a new way to integrate a Au@Pt (Pt-coated Au NPs) DNA nanomachine with a photonic crystal (PC) microchip for accurate and portable miRNA detection. Leveraging Au@Pt, characterized by ultraslow ligand exchange rate, as the core of 3D DNA nanomachines endows Au@Pt DNA nanomachine superior stability and signal fidelity.

The Association of Glycemic Gap with Cognitive Function After Ischemic Stroke or Transient Ischemic Attack.

Background: Glycemic gap (GG), as a measure of an acute derangement in glucose level in response to an active disease state, has been found to be associated with adverse outcomes in many diseases. This study aimed to determine the relationship of GG with cognitive function after ischemic stroke or transient ischemic attack (TIA).

Methods: Patients included were enrolled from a subgroup of China National Stroke Registry-III (CNSR-III).

Pain Status and Disability in Activities of Daily Living Among Older Adults in China: Evidence From CHARLS 2020.

Pain status is a common concern among older adults and has been linked to functional limitations. This study aimed to examine the association between pain status and disabilities risk in basic activities of daily living (BADL) and instrumental activities of daily living (IADL) in older adults in China, using data from the 2020 China Health and Retirement Longitudinal Study (CHARLS). A cross-sectional analysis was conducted using data from 8102 participants aged 60 and older from the 2020 CHARLS.

A fibrin gel-loaded Gouqi-derived nanovesicle (GqDNV) repairs the heart after myocardial infarction by inhibiting p38 MAPK/NF-κB p65 pathway.

The restoration of cardiac function post-myocardial infarction (MI) remains a significant clinical challenge. Emerging evidence indicates that Goji berries ("Gouqi" in Chinese) and their extracts exhibit substantial cardioprotective properties. Here, we introduce fibrin gel-loaded Gouqi-derived nanovesicles (GqDNVs-gel) as a delivery system targeted at the infarcted myocardium.

Dynamic Changes in Functional CTL and NK Lymphocyte Subsets in the Early Stage After Renal Transplantation.

Background: Functional lymphocytes play a pivotal role in renal injury and rejection following transplantation. Understanding their dynamic changes is essential for evaluating renal allograft function and predicting rejection. However, the early postoperative dynamics of these subsets and their relationship with renal function remain unclear.