A method based on B isotope tracer for seepage detection in salt lakes.

To address the technical challenges of monitoring brine seepage in salt lakes, this study pioneers the application of B isotope tracer to seepage detection, establishing a high-precision monitoring system that provides scientific foundations for precise seepage channel identification and flow field characterization. Systematic laboratory experiments validate the exceptional performance of the B tracer, including ultra-trace detection sensitivity of 10, a stable recovery rate of 92.8-106.

Antibacterial activity and mechanism of naphthoquine phosphate against ceftazidime-resistant via cell membrane disruption and ROS induction.

Introduction: Drug-resistant bacteria, particularly , present a significant threat to global public health, highlighting the urgent need for novel antibacterial therapies. Drug repurposing has emerged as a promising strategy to accelerate therapeutic development by identifying new applications for existing pharmaceuticals. This study investigates the potential of naphthoquine phosphate (NQP), an antimalarial agent, as a broad-spectrum antibacterial candidate against the multidrug-resistant strain LAC-4.

Survival Benefit of Adjuvant Treatment with Huaier Granules Plus Lenvatinib in Hepatocellular Carcinoma Patients with Tumors Greater Than 5 cm After Radical Hepatectomy.

Background: The postoperative recurrence of hepatocellular carcinoma (HCC), influenced by various factors, including microvascular invasion (MVI), plays a critical role in the long-term prognosis following radical liver resection. This study investigated potential adjuvant treatment strategies for HCC patients who exhibit multiple recurrence factors after radical resection.

Methods: A retrospective analysis was conducted on data from 243 patients who underwent radical resection for HCC and exhibited high recurrence factors at the First Affiliated Hospital of Harbin Medical University.

Efficient Diffusion Models: A Comprehensive Survey From Principles to Practices.

As one of the most popular and sought-after generative models in recent years, diffusion models have sparked the interests of many researchers and steadily shown excellent advantage in various generative tasks such as image synthesis, video generation, bioinformatics engineering, 3D scene rendering and multimodal generation, relying on their dense theoretical principles and reliable application practices. The remarkable success of these recent efforts on diffusion models comes largely from progressive design principles and efficient architecture, training, inference, and deployment methodologies. However, there has not been a comprehensive and in-depth review to summarize these principles and practices to help the rapid understanding and application of diffusion models.

A texture guided transmission line image enhancement method.

With the increasing demand of transmission line inspection, image detection technology plays a crucial role in foreign object detection on transmission lines. However, due to the influence of natural environment, the image quality is often interfered with by rain, fog, blur and other factors, which affects the accuracy of detection. In order to improve image quality and accuracy of foreign object detection, a texture guided transmission line image enhancement (TGTLIE) method is proposed.

Spray-Dried Inhalable Favipiravir Dry Powder Formulation for Influenza Therapy: Preparation and In vivo Evaluation.

Background: Influenza, a seasonal infectious disease, has consistently posed a formidable challenge to global health in recent years. Favipiravir, an RNA-dependent RNA polymerase inhibitor, serves as an anti-influenza medication, currently administered solely in oral form for clinical use. However, achieving an effective therapeutic outcome often necessitates high oral doses, which can be accompanied by adverse effects and suboptimal patient adherence.

Photobiomodulation inhibits retinal degeneration in diabetic mice through modulation of stem cell mobilization and gene expression.

The number of people suffering from type 2 diabetes (DM2) is increasing and over 30 percent of DM2 patients will develop diabetic retinopathy (DR). Available therapeutic approaches for DR have their limitations. It is of great significance to search for other effective alternate therapeutic approaches.

Suppressed oncogenic molecules involved in the treatment of colorectal cancer by fecal microbiota transplantation.

Dysbiosis of the intestinal microbiota is prevalent among patients with colorectal cancer (CRC). This study aims to explore the anticancer roles of the fecal microbiota in inhibiting the progression of colorectal cancer and possible mechanisms. The intestinal microbial dysbiosis in CRC mice was significantly ameliorated by fecal microbiota transplantation (FMT), as indicated by the restored ACE index and Shannon index.

Flexible Bridged Thermoelectric Device with an Optimized Heatsink for Personal Thermal Management.

A wearable thermoelectric cooler (TEC) for personal thermal management exhibits significant growth in numerous applications in personal thermal comfort and saving the energy consumed by space cooling. Most TECs provide a large cooling performance with the assistance of rigid heatsinks and electrodes, limiting wearability and practical implementation. Here, we design and propose a flexible bridged personal TEC with a high thermal management heatsink and spray-printed liquid metal electrodes.

In-cell bioluminescence resonance energy transfer (BRET)-based assay uncovers ceritinib and CA-074 as SARS-CoV-2 papain-like protease inhibitors.

Papain-like protease (PLpro) is an attractive anti-coronavirus target. The development of PLpro inhibitors, however, is hampered by the limitations of the existing PLpro assay and the scarcity of validated active compounds. We developed a novel in-cell PLpro assay based on BRET and used it to evaluate and discover SARS-CoV-2 PLpro inhibitors.

GMSA-Net: A Transmission Line Ice Thickness Identification Network Based on Global Micro Strip Awareness.

Ice-covered transmission lines seriously affect the normal operation of the power transmission system. Resonance deicing based on different ice thicknesses is an effective method to solve the issue of ice-covered transmission lines. In order to obtain accurate ice thickness of transmission lines, this paper designs an ice thickness of transmission line recognition model based on Global Micro Strip Awareness Net (GMSA-Net) and proposes a Mixed Strip Convolution Module (MSCM) and a global micro awareness module (GMAM).

Diverse functions and pathogenetic role of Crumbs in retinopathy.

The Crumbs protein (CRB) family plays a crucial role in maintaining the apical-basal polarity and integrity of embryonic epithelia. The family comprises different isoforms in different animals and possesses diverse structural, localization, and functional characteristics. Mutations in the human CRB1 or CRB2 gene may lead to a broad spectrum of retinal dystrophies.

interaction of naphthoquine with ivermectin, atovaquone, curcumin, and ketotifen in the asexual blood stage of 3D7.

Unlabelled: Naphthoquine is a promising candidate for antimalarial combination therapy. Its combination with artemisinin has demonstrated excellent efficacy in clinical trials conducted across various malaria-endemic areas. A co-formulated combination of naphthoquine and azithromycin has also shown high clinical efficacy for malaria prophylaxis in Southeast Asia.

Engrailed: Pathological and physiological effects of a multifunctional developmental gene.

Engrailed-1 (EN1) is a developmental gene that encodes En1, a highly conserved transcription factor involved in regionalization during early embryogenesis and in the later maintenance of normal neurons. After birth, EN1 still plays a role in the development and physiology of the body; for example, it exerts a protective effect on midbrain dopaminergic (mDA) neurons, and loss of EN1 causes mDA neurons in the ventral midbrain to gradually die approximately 6 weeks after birth, resulting in motor and nonmotor symptoms similar to those observed in Parkinson's disease. Notably, EN1 has been identified as a possible susceptibility gene for idiopathic Parkinson's disease in humans.

Evaluation of the Effect of Preharvest Melatonin Spraying on Fruit Quality of 'Yuluxiang' Pear Based on Principal Component Analysis.

Melatonin (MT), an indoleamine compound, has a pleiotropic effect on plant growth and development and can regulate the quality of tree fruit. Systematic research on the effect of preharvest MT spraying on pear fruit quality and technical solutions for MT application to regulate pear fruit quality are still lacking. Thus, here we aimed to evaluate the effects of different spraying times, concentrations, and exogenous MT application times on 'Yuluxiang' pear fruit quality.

Conducting quantitative mask fit tests: application details and affecting factors.

Introduction: Respirators chosen based on their assigned protection factor (APF) enable wearers to effectively reduce particulate matter concentrations to safe levels when used correctly. As a crucial factor in achieving the intended APF, the fit test has become a necessary procedure in respiratory disease protection.

Methods: This study involved 225 participants who underwent a fit test using two reusable types of half masks and two types of full masks.

The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy.

Background: In diabetic retinopathy, increasing evidence points to a link between the pathogenesis of retinal microangiopathy and the endothelial cell-specific factor roundabout4 (ROBO4). According to earlier research, specificity protein 1 (SP1) enhances the binding to the ROBO4 promoter, increasing Robo4 expression and hastening the progression of diabetic retinopathy. To determine if this is related to aberrant epigenetic modifications of ROBO4, we examined the methylation level of the ROBO4 promoter and the corresponding regulatory mechanism during the course of diabetic retinopathy and explored the effect of this mechanism on retinal vascular leakage and neovascularization.

Disulfide-incorporated lipid prodrugs of cidofovir: Synthesis, antiviral activity, and release mechanism.

The double-stranded DNA (dsDNA) viruses represented by adenovirus and monkeypox virus, have attracted widespread attention due to their high infectivity. In 2022, the global outbreak of mpox (or monkeypox) has led to the declaration of a Public Health Emergency of International Concern. However, to date therapeutics approved for dsDNA virus infections remain limited and there are still no available treatments for some of these diseases.

Cutting-Edge Research in Sports Biomechanics: From Basic Science to Applied Technology.

Sports biomechanics is the study of the mechanical principles of human movement and how they apply to sports performance [...

Orthogonal dual reporter-based gain-of-signal assay for probing SARS-CoV-2 3CL protease activity in living cells: inhibitor identification and mutation investigation.

The main protease (3-chymotrypsin-like protease, 3CLpro) of SARS-CoV-2 has become a focus of anti-coronavirus research. Despite efforts, drug development targeting 3CLpro has been hampered by limitations in the currently available activity assays. Additionally, the emergence of 3CLpro mutations in circulating SARS-CoV-2 variants has raised concerns about potential resistance.

Long-Term Outcomes of Posterior Capsular Opacification in Highly Myopic Eyes and Its Influencing Factors.

Introduction: The purpose of this study was to evaluate the long-term outcomes of posterior capsular opacification (PCO) in highly myopic eyes and its influencing factors.

Methods: Patients undergoing phacoemulsification with intraocular lens implantation and followed up for 1-5 years were included in this prospective cohort study. The severity of PCO was evaluated using EPCO2000 software system, with the area of central 3.

Mesoionic Carbene-Catalyzed Formyl Alkylation of Aldehydes.

Ketones are among the most useful functional groups in organic synthesis, and they are commonly encountered in a broad range of compounds with various applications. Herein, we describe the mesoionic carbene-catalyzed coupling reaction of aldehydes with non-activated secondary and even primary alkyl halides. This metal-free method utilizes deprotonated Breslow intermediates derived from mesoionic carbenes (MICs), which act as super electron donors and induce the single-electron reduction of alkyl halides.

Design, Synthesis, and Biological Evaluation of Benzimidazole Derivatives as Potential Lassa Virus Inhibitors.

The Lassa virus (LASV) causes Lassa fever, a highly infectious and lethal agent of acute viral hemorrhagic fever. At present, there are still no effective treatments available, creating an urgent need to develop novel therapeutics. Some benzimidazole compounds targeting the arenavirus envelope glycoprotein complex (GPC) are promising inhibitors of LASV.

The Bionic High-Cushioning Midsole of Shoes Inspired by Functional Characteristics of Ostrich Foot.

The sole is a key component of the interaction between foot and ground in daily activities, and its cushioning performance plays a crucial role in protecting the joints of lower limbs from impact injuries. Based on the excellent cushioning performance of the ostrich foot and inspired by the structure and material assembly features of the ostrich foot's metatarsophalangeal skeletal-tendon and the ostrich toe pad-fascia, a functional bionic cushioning unit for the midsole (including the forefoot and heel) area of athletic shoes was designed using engineering bionic technology. The bionic cushioning unit was then processed based on the bionic design model, and the shoe soles were tested with six impact energies ranging from 3.

Spray-Dried Inhalable Powder Formulations of Gentamicin Designed for Pneumonic Plague Therapy in a Mouse Model.

Infection with Yersinia pestis () may cause pneumonic plague, which is inevitably fatal without treatment. Gentamicin (GM), an aminoglycoside antibiotic, is a drug commonly used in the treatment of plague. However, it requires repeated intramuscular or intravenous administration.