Exploring the Effect of Negative Mood on Working Memory Subprocesses: An Event-Related Potential Study.

Working memory (WM) regulates information flow through gate mechanisms, consisting of four subprocesses: gate opening, gate closing, updating, and substitution. However, their neural mechanisms remain underexplored. While emotion-cognition interactions are well studied, the effects of negative mood on these subprocesses are unclear.

Multicenter Practice of Non/Minimized Fluoroscopy Ablation for Paroxysmal AF in China: The PAF-ICE Trial.

Background: Intracardiac echocardiography (ICE)-guided non/minimized-fluoroscopy catheter ablation for atrial fibrillation (AF) has been reported, but its effectiveness and safety still lack multicenter evidence.

Objectives: The authors sought to evaluate the effectiveness and safety of ICE-guided non/minimized-fluoroscopy catheter ablation compared with the traditional fluoroscopy-guided approach in patients with paroxysmal AF.

Methods: A total of 448 patients with paroxysmal AF, from 15 centers in China, were randomly assigned in a 1:1 ratio to a non/minimized-fluoroscopy group (n = 223) and a traditional approach group (n = 225).

Using preprocessed datasets to construct and interpret multiclass identification models.

Introduction: Image and near-infrared (NIR) spectroscopic data are widely used for constructing analytical models in precision agriculture. While model interpretation can provide valuable insights for quality control and improvement, the inherent ambiguity of individual image pixels or spectral data points often hinders practical interpretability when using raw data directly. Furthermore, the presence of imbalanced datasets can lead to model overfitting and consequently, poor robustness.

Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarction.

Background And Aims: An overactive inflammatory response and immune cell infiltration following myocardial infarction (MI) impair cardiac tissue repair. This study investigates the mechanistic role of the arachidonic acid (AA) metabolic cascade in mediating post-MI inflammation.

Methods: Single-cell RNA-sequencing analysis was performed to characterize cardiac macrophage heterogeneity in post-MI mice.

Recent advances in copper sulfide nanoparticles for cancer diagnosis and therapy.

Cancer, a highly heterogeneous and complex disease characterized by multiple genetic and metabolic abnormalities, remains one of the leading causes of death worldwide. Although conventional treatments such as surgery, chemotherapy, and radiotherapy, can mitigate the disease to some extent, their efficacy remains constrained by various factors. In recent years, nanotechnology has emerged as a promising approach for cancer treatment, with copper-based nanomaterials garnering significant attention due to their unique physicochemical properties and favorable biocompatibility.

circSCAP-encoded SCAP-129aa mediates platinum resistance in triple-negative breast cancer via the PI3K/AKT pathway.

Triple-negative breast cancer (TNBC) often acquires resistance to platinum-based chemotherapy, presenting significant challenges to therapeutic management and adversely affecting patient survival. In such refractory cases, even advanced treatment modalities often exhibit diminished efficacy. This study aims to elucidate the molecular mechanisms underlying platinum resistance.

Visible-Light-Driven C-3 Selenocyanation of Indoles with Elemental Selenium and TMSCN.

We develop a photocatalyst-free, visible-light-driven three-component reaction of indole, elemental selenium, and TMSCN in air at room temperature to synthesize indole 3-selenocyanoates. This protocol features eco-friendly, photocatalyst-free, elemental selenium, and TMSCN serves as the source of "SeCN". Notably, the gram-scale reaction and product derivatizations demonstrated the practicality and effectiveness of this synergistic protocol.

Radiation-sensitive circRNA promotes intestinal regeneration.

Background: The intestine is one of the most sensitive organs to ionizing radiation (IR), and radiation-induced intestinal injury (RIII) impacts the quality of life of patients undergoing radiotherapy. There are limited early diagnostic biomarkers and specific medicines clinically approved for RIII. Therefore, we sought to identify new theranostic targets to prevent RIII and to facilitate the reestablishment of the intestinal epithelium.

Effects of Dietary Tannic Acid and Tea Polyphenol Supplementation on Rumen Fermentation, Methane Emissions, Milk Protein Synthesis and Microbiota in Cows.

To develop sustainable strategies for mitigating ruminal methanogenesis and improving nitrogen efficiency in dairy systems, this study investigated how low-dose tannic acid (T), tea polyphenols (TP), and their combination (T+TP; 50:50) modulate rumen microbiota and function. A sample of Holstein cows were given four dietary treatments: (1) control (basal diet); (2) T (basal diet + 0.4% DM tannic acid); (3) TP (basal diet + 0.

Effects of Rumen-Protected Chromium-Nicotinic Acid on Lactation Performance, Nutrient Digestion, Ruminal Fermentation, Serum Biochemical Parameters, and Antioxidant in Lactating Water Buffaloes.

This study evaluated the effects of rumen-protected chromium-nicotinic acid (RPCNA) supplementation on lactation performance, nutrient digestion, ruminal fermentation, serum biochemical parameters and antioxidant in lactating water buffaloes under conditions of a critical thermal comfort index (TCI). Healthy lactating water buffaloes (milk yield = 5.96 ± 0.

Amplified transmission in full- space empowered by photonic temporal quasicrystal.

Photonic time crystals can induce amplified radiation associated through momentum-gap modes, leading to various optical applications. However, the size of momentum is finite because of the finite relative change of the refraction index, while the amplification of the gaps is needed in the entire momentum space. Here, we introduce the concept of the photonic temporal Fibonacci quasicrystal.

Long-range deployment of tumor-antigen-specific cytotoxic T lymphocytes inhibits lung metastasis of breast cancer.

Tumor-antigen-specific CD8 T cells (CTLs) are the main effector immunocytes in anti-tumor immunity, but their systemic deployment against cancer metastasis remains uncharacterized. Here, we found that the abundance of tumor-specific CD103CD8 T cells in the tumor-draining lymph nodes (TDLNs) was associated with improved lung-metastasis-free survival in breast cancer patients. In mouse cancer models, CD103CD8 T cells were primed in TDLNs and recruited to the lungs via C-C motif chemokine ligand 5/receptor 9 (CCL25/CCR9) signaling to inhibit metastasis through antigen-specific immunity.

Safety and efficacy of sonography-guided PCNL under local versus general or spinal-epidural anesthesia: A meta-analysis.

Background: To conduct a comprehensive meta-analysis of existing evidence to compare the safety and efficacy of sonography-guided percutaneous nephrolithotomy (PCNL) under local infiltration anesthesia and both general anesthesia (GA) and combined spinal-epidural anesthesia for upper urinary calculi.

Methods: We conducted a systematic literature search in the EMBASE, MEDLINE, Cochrane databases, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Google Scholar to identify relevant studies published in English or Chinese up to March 2024. Literature reviewed included randomized and nonrandomized studies.

Diagonal paraspinal muscle degeneration and osteoporosis were associated with rotatory subluxation in degenerative lumbar scoliosis.

Purpose: This study aimed to investigate the potential association between paraspinal muscle (PSM) degeneration, osteoporosis, and vertebral rotatory subluxation (VRS) in patients with degenerative lumbar scoliosis (DLS).

Methods: This retrospective study analyzed standing anteroposterior radiographs to assess the coronal (Cobb angle, coronal balance distance, and lateral translation) and sagittal parameters (thoracic kyphosis, lumbar lordosis, and sagittal vertical axis). Patients were categorized into rotatory subluxation (RS, lateral translation ≥ 5 mm) and non-RS groups, with the RS group further subdivided into single- and double-level subgroups based on the frequency of RS occurrence.

Enhancing Alfalfa Hemicellulose Degradation by Anaerobic Bioprocessing with Engineered Xylanase-Secreting .

To enhance hemicellulose utilization in alfalfa silage, (NE) and (PE) expressing xylanase were engineered. The effects of recombinant LAB on hemicellulose utilization, fermentation characteristics, and microbiota diversity during alfalfa ensiling were investigated. The recombinant strains exhibited a 2.

Unraveling morphological brain network disparities Parkinsonian tremor from essential tremor: an artificial intelligence approach for clinical differentiation.

Tremor-dominant Parkinson's disease (TD) and Essential Tremor (ET) are the two most common types of tremors, posing huge challenges in diagnosis. This study was to investigate the pathogenesis of tremors using brain morphology and employ artificial intelligence techniques for distinguishing them. The cortical thickness differences in TD were primarily centered on the right precuneus, while in ET were mainly observed in the right medial orbitofrontal cortex.

An elite RNA-DEPENDENT RNA POLYMERASE3 allele enhances preharvest sprouting resistance in rice.

A new elite allele conferring enhanced preharvest sprouting resistance via hormonal pathways is a valuable target for molecular design breeding to improve seed quality and production stability.

Intracardiac thrombosis and its management during liver transplantation: international, multi-center, case-control study.

Background: Intracardiac thrombosis (ICT) during liver transplantation (LT) is a rare but life-threatening complication with limited data regarding its risk factors, management, and outcomes. This study aimed to identify factors associated with ICT development, define predictors of intraoperative outcomes and propose a novel classification and management algorithm for ICT.

Methods: A multicenter, international retrospective case-control study was conducted on liver transplant recipients from seven centers between January 2005 and December 2023.

LncRNA SNHG14 drives angiotensin-induced abdominal aortic aneurysm progression by regulating autophagy via the miR-27b-3p/Wnt/β-catenin/c-Myc axis.

Abdominal aortic aneurysm (AAA) is a global health concern associated with high mortality. It has been reported that long noncoding RNAs (lncRNAs) are involved in the development of AAA. In this study, our objective was to investigate the roles of lncRNA small nucleolar RNA host gene 14 (SNHG14) and the associated mechanisms in the development of AAA.

Natural killer cell granule protein 7 contributes to CD8 T cell-mediated platelet apoptosis in immune thrombocytopenia.

Background: CD8 T cells participate in the pathogenesis of primary immune thrombocytopenia (ITP). Natural killer cell granule protein 7 (NKG7) is essential for natural killer cell and CD8 T cell cytotoxicity. The function of NKG7 in CD8 T cells in ITP remains unclear.

mWAKE in the Central Amygdala Regulates Fear Learning and Memory.

The central amygdala (CeA) is an important neuronal hub that integrates external sensory inputs and information about internal states to regulate a range of innate and learned behaviors, including fear learning and memory. Prior studies, leveraging robust fear conditioning assays, have delineated detailed circuit mechanisms underlying the acquisition and recall of fear memories. However, the specific molecular mechanisms underlying these processes in the CeA remain poorly understood.

Evaluated dietary quality is associated with reduced probability of epilepsy.

Background: The occurrence of epilepsy is significantly associated with the intake of specific nutrients such as calcium. However, the potential association between overall dietary quality and epilepsy remains undetermined.

Methods: Analytical data were retrieved from three consecutive cycles (2013-2018) of the National Health and Nutrition Examination Survey.

Dynamic land-cover maps in the Guangdong-Hong Kong-Macao Greater Bay Area at 30 m spatial resolution, 2000-2022.

As a world-class urban agglomeration, the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) has experienced substantial land-cover restructuring driven by urbanization, necessitating high temporal resolution monitoring to capture dynamic surface processes. However, traditional land-cover products cannot capture intra-annual dynamics effectively due to their limited update cycles. Therefore, this study generates a publicly accessible dynamic land-cover dataset for the GBA spanning 2000-2022, with a 30-meter spatial resolution and a 15-day temporal resolution.

Digital outdoor exercise program for obese patients with type 2 diabetes mellitus: a non-inferiority randomized controlled trial.

Background: Obesity and physical inactivity exacerbate type 2 diabetes mellitus (T2DM), whereas regular exercise improves glycemic control, fitness, and quality of life. However, many patients face barriers to attending clinic-based exercise programs. Digital health interventions could increase access and adherence by enabling guided outdoor exercise via smartphone.

Unveiling ammonia-induced cell death: a new frontier in clear cell renal cell carcinoma prognosis.

Background: Clear cell renal cell carcinoma (KIRC) is the most aggressive renal carcinoma subtype of renal carcinoma, characterized by high mortality, early metastasis, and resistance to treatment. Ammonia-induced cell death (AICD) has recently been identified as a novel metabolic mechanism influencing tumor progression, yet its prognostic implication and regulatory networks in KIRC remain underexplored.

Methods: Transcriptomic and clinical information from the TCGA-KIRC cohort and the validation cohort (E-MTAB-1980) were analyzed.