Platycodin D targets ZNF70 to inhibit NLRP3 inflammasome and STAT3 signaling pathway to ameliorate colitis.

Background: UC is a chronic inflammatory bowel disease that can be severe enough lead to bowel perforation and even colorectal cancer. The current treatments for UC have several limitations, highlighting the urgent need for the development of novel therapeutic agents. Recent research has shown that ZNF70 plays a crucial role in colitis-associated colorectal cancer.

Occurrence, Distribution, Sources, and Risk Assessment of Heavy Metals in Brownfields From Wuhan, Central China.

Urban brownfields are abandoned industrial areas. They are generated as a result of land use transition in areas of rapid economic development within the urban context and are commonly contaminated with heavy metals and/or organics. Heavy metals lead to environmental degradation and functional degradation of the soil, thereby threatening the entire ecosystem.

Long-range deployment of tumor-antigen-specific cytotoxic T lymphocytes inhibits lung metastasis of breast cancer.

Tumor-antigen-specific CD8 T cells (CTLs) are the main effector immunocytes in anti-tumor immunity, but their systemic deployment against cancer metastasis remains uncharacterized. Here, we found that the abundance of tumor-specific CD103CD8 T cells in the tumor-draining lymph nodes (TDLNs) was associated with improved lung-metastasis-free survival in breast cancer patients. In mouse cancer models, CD103CD8 T cells were primed in TDLNs and recruited to the lungs via C-C motif chemokine ligand 5/receptor 9 (CCL25/CCR9) signaling to inhibit metastasis through antigen-specific immunity.

Cucurbitacin B inhibits HIF-1α and attenuates non-small cell lung cancer ZFP91.

Non-small cell lung cancer (NSCLC) is among the most common types of cancer and contributes significantly to cancer-related mortality worldwide. Although some progress has been made in the treatment of NSCLC, drug resistance, high costs, and significant individual variability continue to be major obstacles to effective treatment. Cucurbitacin B (CuB) is a tetracyclic triterpenoid known for its anti-inflammatory and anticancer properties.

Prognostic significance of DNA ploidy, stroma fraction, and nucleotyping in stage IIIb colon cancer and their implications for adjuvant chemotherapy.

Background: DNA ploidy (P), stroma fraction (S), and nucleotyping (N), collectively known as PSN, have demonstrated prognostic accuracy in various stages of colorectal cancer (CRC). However, the prognostic value of the PSN panel in stage IIIb colon cancer patients receiving CapOX adjuvant chemotherapy remains unclear.

Patients And Methods: Postoperative pathological samples from stage IIIb colon cancer patients who underwent radical surgery and postoperative adjuvant chemotherapy at Sun Yat-sen University Cancer Center were retrospectively collected.

Clinical evaluation of strengthening spleen and draining dampness in the treatment of idiopathic membranous nephropathy: a retrospective 10-year follow-up study.

Objective: To evaluate the 10-year therapeutic efficacy of Traditional Chinese Medicine (TCM) using the Strengthening Spleen and Draining Dampness therapy in the management of idiopathic membranous nephropathy (IMN).

Methods: A single-center, retrospective analysis was conducted on patients diagnosed with IMN who met predefined inclusion and exclusion criteria. Data were collected from the Department of Nephrology at Longhua Hospital, affiliated with Shanghai University of Traditional Chinese Medicine, between January 2007 and December 2011.

Cucurbitacin B alleviates DSS-induced experimental colitis by targeting ZNF70 to suppress the NLRP3/STAT3 signaling axis.

Ulcerative colitis (UC) is an inflammatory disease characterized by lifelong involvement and a complex pathogenesis. Due to the limitations of current treatment modalities, there remains a pressing need to discover new medications for the management of UC. Cucurbitacin B (CuB) is a tetracyclic triterpenoid derived from Lagenaria siceraria (Molina) Standl.

Bone reporting and data system on CT (Bone-RADS-CT): a validation study by four readers on 328 cases from three local and two public databases.

Objective: To evaluate the reproducibility and effectiveness of the bone reporting and data system on CT (Bone-RADS-CT) for incidental solitary bone lesions in adults.

Materials And Methods: We retrospectively included 328 CT cases from three local and two public databases, respectively. All the cases were histopathologically or clinically confirmed bone lesions, "do not touch" lesions with typical appearance, and remained stable for at least 2 years.

Bone Reporting and Data System on MRI (Bone-RADS-MRI): a validation study by four readers on 275 cases from three local and two public databases.

Objective: To evaluate the reproducibility and effectiveness of the Bone Reporting and Data System on MRI (Bone-RADS-MRI) for incidental solitary bone lesions in adults.

Materials And Methods: We retrospectively included 275 MRI cases from three local and two public databases, respectively. All the cases were histopathologically or clinically confirmed bone lesions, or "do not touch" lesions with typical appearance and remained stable for at least two years.

Influence of methylenetetrahydrofolate 677C > T variant in murine models following valproic acid exposure.

The teratogenic effects of valproic acid (VPA) can lead to abnormal fetal development, which may be related to abnormal maternal one-carbon metabolism. Methylene-tetrahydrofolate reductase (MTHFR) is a key enzyme involved in one-carbon metabolism. Variations in MTHFR, particularly 677 C>T, are associated with susceptibility to teratogenicity.

Diagnostic Value of Swallow Tail Sign at Brain MRI in Patients with Clinically Uncertain Parkinsonian Syndrome.

Background Striatal dopaminergic deficits, established with iodine 123-2β-carbomethoxy-3β-(4-iodophenyl)--(3-fluoropropyl)-nortropan (I-FP-CIT) SPECT, support the diagnosis of Parkinson disease (PD) or atypical parkinsonian syndrome in clinical uncertainty. The swallow tail sign (STS) at susceptibility-weighted (SW) MRI helps differentiate patients with PD from controls, but its utility in clinically uncertain parkinsonian syndromes remains unclear. Purpose To compare the diagnostic performance of STS absence at SW MRI in diagnosing PD with that of I-FP-CIT SPECT in participants with clinically uncertain parkinsonian syndrome.

Preoperative ultrasonography-guided core-needle biopsy-based factors for predicting the upgrade of axillary lymph nodes in breast cancer.

Background: The early detection of axillary lymph node metastasis (ALNM) is a critical prognostic factor in breast cancer (BC). The objective of this study was to establish and validate a nomogram to predict the upgrade in the diagnosis of axillary lymph nodes (ALNs) in BC via ultrasonography (US)-guided core-needle biopsy (CNB) in combination with related factors.

Methods: This study included a total of 304 patients who underwent preoperative US-guided CNB and were diagnostically negative for ALNM.

Photon-Counting Detector CT Allows Abdominal Virtual Monoenergetic Imaging at Lower Kiloelectron Volt Level with Lower Noise Using Lower Radiation Dose: A Prospective Matched Study Compared to Energy-Integrating Detector CT.

Our study aimed to assess the image quality of lower kiloelectron volt (keV) level abdominal virtual monoenergetic imaging (VMI) with lower radiation dose on photon-counting detector computed tomography (PCD-CT), in comparison to energy-integrating detector computed tomography (EID-CT). We prospectively included three matched groups, each with 59 participants, to undergo contrast-enhanced abdominal CT scans using EID-CT with full-dose (EID_FD), PCD-CT with full-dose (PCD_FD), and PCD-CT with low-dose (PCD_LD) protocols, respectively. The data of portal-venous phase were reconstructed into VMI at 40, 50, 60, and 70 keV, respectively.

Unraveling key transposable elements in pathogen-induced bovine mastitis through comparative in vivo and in vitro transcriptomic analysis.

Background: Bovine mastitis poses significant hazards to the yield and quality of dairy products, severely hindering the development of the dairy industry. Staphylococcus aureus (S. aureus) and Escherichia coli (E.

Single-Neuron Discharges Correlating High-Frequency Oscillations Dynamics in Epileptogenesis and Epilepsy Development.

The mechanism of epilepsy is still unclear. We aim to explore the relationship between high-frequency oscillations (HFOs) dynamics and epilepsy, with a focus on deciphering underlying mechanisms at the single-neuron level. Using a rat model of chronic focal cortical epilepsy induced by cobalt-wire implantation, we monitored the seizures and HFO dynamics, as well as the cross-frequency coupling trends between HFOs and theta activities.

Assessment of Robustness of MRI Radiomic Features in the Abdomen: Impact of Deep Learning Reconstruction and Accelerated Acquisition.

The objective of this study is to investigate the impact of deep learning reconstruction and accelerated acquisition on reproducibility and variability of radiomic features in abdominal MRI. Seventeen volunteers were prospectively included to undergo abdominal MRI on a 3-T scanner for axial T2-weighted, axial T2-weighted fat-suppressed, and coronal T2-weighted sequences. Each sequence was scanned for four times using clinical reference acquisition with standard reconstruction, clinical reference acquisition with deep learning reconstruction, accelerated acquisition with standard reconstruction, and accelerated acquisition with deep learning reconstruction, respectively.

Polysaccharides from Chrysanthemum morifolium: Optimization of ultrafiltration isolation and anti-oxidant and anti-inflammatory effects.

Chrysanthemum morifolium (Huangshan Gongju) crude polysaccharide (PCMC) has attracted considerable attention in the pharmaceutical and food industries due to its potential anti-oxidant and anti-inflammatory activities. This study aims to optimize its purification and concentration process using ultrafiltration technology, which was used to purify and concentrate the bio-macromolecular solutes. Employing PCM-C as the rough material, single-factor trials and response surface methodology (RSM) were used to estimate the effects of pressure, temperature and concentration for ultrafiltration on membrane fluxes.

YTHDF2-mediated mA modification regulates mRNA stability of to modulate cell death in induced bovine mastitis.

Background: ()-induced bovine mastitis is a major challenge for dairy production, causing significant economic losses. The regulatory mechanisms underlying host cell apoptosis and inflammation during infection remain unclear. Therefore, this study investigates the role of N6-methyladenosine (mA) modification and its reader protein YTHDF2 in regulating mRNA stability, apoptosis, and inflammation in bovine mammary epithelial cells (Mac-T cells) under challenge.

ZnO nanoparticles delivered by metal-organic framework ZIF-8 are highly effective in controlling tobacco brown spot disease.

Background: Fungal phytopathogens pose a significant threat to global crop yields. The overuse of pesticides leads to pesticide-resistant pathogens, environmental contamination and risks to human health. Consequently, there is an urgent need for effective and ecofriendly antifungal strategies to address these challenges.

Angiopep-2 modified naringin nanoparticles for Alzheimer's disease therapy overcoming BBB.

Naringin (4',5,7-trihydroxyflavanone-7-rhamnoglucoside, NG), a potential treatment for Alzheimer's disease (AD), has strong neuroprotective effects but is limited by poor solubility, low bioavailability, and limited brain accumulation. To address these issues, we developed ANG-NG-NPs, a novel NG-loaded poly (ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) nanoparticle modified with the brain-targeting peptide Angiopep-2 (TFFYGGSRGKRNNFKTEEY, ANG). ANG-NG-NPs exhibited an average size of 126.

Chemical Reaction Mechanism of Proton Irradiation to Polyimide Materials under Low Earth Orbit Using ReaxFF MD Methods.

Proton irradiation in the inner radiation belt significantly degrades the thermal stability and mechanical properties of aerospace polymer materials, but the involved reaction mechanism remains elusive. In this work, we systematically investigate the chemical reactions and performance degradation mechanisms of polyimide materials under proton irradiation using ReaxFF MD methods. The reactions between proton H and polyimide can be classified into substitution, hydrogenolysis, and hydrogenation reactions, while the latter two can create unsaturated reaction sites that trigger additional reactions with proton H.

Glutamatergic synaptic plasticity in medial vestibular nuclei during vestibular compensation.

Vestibular compensation, the spontaneous recovery from vestibular dysfunction following unilateral vestibular loss, serves as a valuable model for investigating post-lesion plasticity in the adult central nervous system. Elucidating the mechanisms underlying vestibular compensation also offers promising therapeutic avenues for treating vestibular disorders. While most studies have focused on the dynamics of GABAergic synaptic plasticity and intrinsic cellular adaptations in the ipsilesional medial vestibular nucleus (MVN) after unilateral labyrinthectomy (UL), the role of glutamatergic synaptic plasticity in this process remains largely unexplored.

A Subgroup Reanalysis of the Efficacy of Bufei Huoxue Capsules in Patients With "Long-Covid-19".

Bufei huoxue capsules (BFHX), manufactured products of traditional Chinese medicine, have demonstrated anti-inflammatory properties and efficacy against chronic pulmonary diseases and COVID-19. This study was designed to further determine the clinical efficacy of BFHX in diverse patient subgroups during the convalescent phase of COVID-19, extending upon previously reported findings from a multicenter randomized controlled trial. Patients who had clinically recovered from COVID-19 were blindly assigned to BFHX or placebo groups.

Microbiota-gut-brain axis: Novel Potential Pathways for Developing Antiepileptogenic Drugs.

The treatment of epilepsy remains imperfect due to a lack of understanding of its pathogenesis. Although antiseizure medications can control most seizures, up to 30% of patients experience uncontrolled seizures, leading to refractory epilepsy. Therefore, elucidating the pathogenesis of epilepsy and exploring new avenues to design antiepileptic drugs may improve epilepsy treatment.