Preoperative ultrasonography-guided core-needle biopsy-based factors for predicting the upgrade of axillary lymph nodes in breast cancer.

Background: The early detection of axillary lymph node metastasis (ALNM) is a critical prognostic factor in breast cancer (BC). The objective of this study was to establish and validate a nomogram to predict the upgrade in the diagnosis of axillary lymph nodes (ALNs) in BC via ultrasonography (US)-guided core-needle biopsy (CNB) in combination with related factors.

Methods: This study included a total of 304 patients who underwent preoperative US-guided CNB and were diagnostically negative for ALNM.

Preoperative magnetic resonance imaging identify feasibility of breast-conserving surgery for breast cancer patients.

Background: Breast-conserving surgery (BCS) stands as the favored modality for treating early-stage breast cancer. Accurately forecasting the feasibility of BCS preoperatively can aid in surgical planning and reduce the rate of switching of surgical methods and reoperation. The objective of this study is to identify the radiomics features and preoperative breast magnetic resonance imaging (MRI) characteristics that are linked with positive margins following BCS in patients with breast cancer, with the ultimate aim of creating a predictive model for the feasibility of BCS.

Exploring the degradation mechanism of nickel-copper-molybdenum hydrogen evolution catalysts during intermittent operation.

We investigate the dynamic degradation behaviors of a nickel-copper-molybdenum hydrogen evolution catalyst in a liquid and solid polymer electrolyte to figure out its endurance in a renewable energy-driven electrolyzer. A cathode current protection approach is proposed to achieve a durable electrolyzer during intermittent operation.

Continuous On-Site HO Electrosynthesis via Two-Electron Oxygen Reduction Enabled by an Oxygen-Doped Single-Cobalt Atom Catalyst with Nitrogen Coordination.

Single-Co atom catalysts are suggested as an efficient platinum metal group-free catalyst for promoting the oxygen reduction into water or hydrogen peroxide, while the relevance of the catalyst structure and selectivity is still ambiguous. Here, we propose a thermal evaporation method for modulating the chemical environment of single-Co atom catalysts and unveil the effect on the selectivity and activity. It discloses that nitrogen functional groups prefer to proceed the oxygen reduction via a 4e pathway and notably improve the intrinsic activity, especially when being coordinated with the Co center, while oxygen doping tempts the electron delocalization around cobalt sites and decreases the binding force toward HOO* intermediates, thereby increasing the 2e selectivity.

Effects of Glycogen Synthase Kinase-3 Beta Gene Polymorphisms on the Plasma Concentration of Aripiprazole in Chinese Patients with Schizophrenia: A Preliminary Study.

This study explored the differences in glycogen synthase kinase-3 beta (GSK3β) gene polymorphisms between patients with schizophrenia and healthy controls and investigated the association between gene polymorphisms and plasma concentration of aripiprazole. We enrolled 127 patients with schizophrenia and 125 healthy controls from southern Fujian. The genotypes of the rs6438552, rs12630592, and rs3732361 loci of GSK3β were evaluated by sequencing with amplified polymerase chain reaction, and the plasma concentration of aripiprazole was determined by high-performance liquid chromatography-tandem mass spectrometry.

PSMA1-mediated ultrasmall gold nanoparticles facilitate tumor targeting and MR/CT/NIRF multimodal detection of early-stage prostate cancer.

Prostate-specific membrane antigen (PSMA) is a prominent biomarker for prostate cancer (PCa) diagnosis. Safe contrast agents able to render the expression and distribution of PSMA would facilitate early accurate screening and prognostic prediction of PCa. However, current Gd-containing nanoparticles are often limited by nonspecific redistribution in mononuclear phagocyte system (MPS) and inadequate perfusion to target sites.

Magnetic resonance imaging semantic and quantitative features analyses: an additional diagnostic tool for breast phyllodes tumors.

Objective: This study aimed to differentiate benign and non-benign (borderline/malignant) phyllodes tumors of the breast by the semantic and quantitative features in magnetic resonance imaging (MRI).

Methods: The female patients, diagnosed with phyllodes tumors by MRI and pathological test, were retrospectively selected from December, 2006 to April, 2019. The MRI of benign, borderline and malignant phyllodes tumors was analyzed using 8 semantic features and 20 computed quantitative features from diffuse contrast-enhanced magnetic resonance imaging (DCE-MRI).

[Clinical study on depression differentiated as deficiency treated with the combined therapy of ginger-isolated moxibustion and western medicine].

Objective: To compare the differences in the clinical efficacy on depression differentiated as deficiency between the combined therapy of ginger-isolated moxibustion and escitalopram and the simple application escitalopram.

Methods: Eighty patients of depression differentiated as deficiency were randomized into an observation group and a control group, 40 cases in each one. In the control group, escitalopram was prescribed for oral administration, 10 mg a day, after each breakfast.