Prenatal Ultrasound Findings of X-Linked Hypohidrotic Ectodermal Dysplasia: A Case Report.

X-linked hypohidrotic ectodermal dysplasia (HED) is a rare congenital hereditary disorder primarily affecting ectodermal-derived organs, including hair, sweat glands, and teeth. This case report presents a prenatal diagnosis of HED in a fetus without a familial history or parental phenotypic manifestations. The critical prenatal ultrasound finding was an abnormality in the alveolar bone.

The association between baseline and long-term status of metabolic score for insulin resistance index and the incidence of cardiometabolic multimorbidity.

Background: Cardiometabolic multimorbidity (CMM) is concurrently associated with a reduction in life expectancy and an increased propensity for all-cause mortality. Our objective was to evaluate the correlations between the baseline and longitudinal metabolic score for insulin resistance index (METS-IR) and the incidence of cardiometabolic multimorbidity (CMM) within a middle-aged and older Chinese population cohort..

Smoking is an independent risk factor for nosocomial sinusitis in neurocritical patients: evidence from a retrospective cohort study.

Objectives: To determine the risk factors associated with nosocomial sinusitis in general neurology ward patients with nasogastric tube (NGT) intubation and neurocritical care unit (NCU) patients.

Methods: A retrospective cohort study was conducted in a tertiary hospital, Guangzhou, China. We enrolled two groups of patients: (1) general neurology ward patients with NGT intubation between July 2018 and March 2021, and (2) those admitted to NCU between January 2021 and December 2022.

Vanadyl Complex-Mediated Molecular Engineering Enables Homogeneous Modulation of Lithium-Sulfur Chemistry.

The large-scale commercial application of lithium-sulfur batteries (LSBs) is hindered by several critical challenges, including severe lithium polysulfide shuttling, sluggish kinetics of sulfur redox reactions, and unstable lithium anode surface. These issues significantly restrict the discharge capacity, cycling life, and safety of LSBs. Herein, the vanadyl acetylacetonate (VO) complex, characterized by a high donor number, is used as an effective homogeneous catalyst to address these cross-cutting problems.

Synchronous Phase Transformation for Efficient Wide-Bandgap Perovskite Photovoltaics.

Mixed-halogen wide-bandgap (WBG) perovskite materials are employed in tandem solar cells (TSCs) due to their continuous tunability of bandgap. However, inhomogeneous halogen phases are often observed in bromine-rich perovskite films, which restricts the performance of WBG perovskite solar cells (PSCs) and TSCs. Here, homogeneous halogen-phase perovskite is proposed to form film by a synchronous halogen-phase transformation strategy.

[Quantitative Analysis of Wetland Evolution Characteristics and Driving Factors in Ruoergai Plateau Based on Landsat Time Series Remote Sensing Images].

The Ruoergai Wetland， China's largest high-altitude marsh， plays a crucial role in the carbon cycle and climate management. However， the Ruoergai Wetland has experienced significant damage as a result of human activity and global warming. Based on the Google Earth Engine （GEE） cloud platform and time-series Landsat images， a random forest algorithm was applied to produce a detailed classification map of the Ruoergai wetlands from 1990 to 2020.

Influence of methylenetetrahydrofolate 677C > T variant in murine models following valproic acid exposure.

The teratogenic effects of valproic acid (VPA) can lead to abnormal fetal development, which may be related to abnormal maternal one-carbon metabolism. Methylene-tetrahydrofolate reductase (MTHFR) is a key enzyme involved in one-carbon metabolism. Variations in MTHFR, particularly 677 C>T, are associated with susceptibility to teratogenicity.

Prevalence and risk factors of depressive and anxiety symptoms and functional constipation among university students in Eastern China.

Background: Depression and anxiety are prevalent among university students worldwide, often coexisting with functional constipation (FC). Family relationships have been identified as crucial factors affecting mental health, yet the gender-specific associations between these conditions remain underexplored.

Aim: To assess prevalence of depressive symptoms, anxiety symptoms, and FC among Chinese university students and explore their associations.

Improved surgical outcomes in adenomyosis: a novel insight into the superiority of secretory phase adenomyomectomy.

Objective: To evaluate whether the timing of adenomyomectomy within the menstrual cycle influences outcomes in patients with adenomyosis, and to assess whether surgery performed during the secretory phase offers clinical advantages over the proliferative phase.

Methods: We conducted a retrospective cohort study of patients with histologically confirmed adenomyosis who underwent uterus-sparing adenomyomectomy at our institution between January 2021 and April 2024. Patients were categorized according to the menstrual phase at the time of surgery: secretory phase and proliferative phase.

Comparative analysis of X-ray, CT, and MRI images in patients with chondroblastoma in tubular and non-tubular bones.

Objective: To compare and analyze the image features of X-ray, computerized tomography (CT), and magnetic resonance imaging (MRI) in patients with chondroblastoma (CB) in tubular and non-tubular bones, to improve the preoperative diagnostic accuracy and follow-up the postoperative recurrence rate.

Methods: Sixty-one CB patients confirmed by surgical pathology in our hospital and Huazhong University of Science and Technology Tongji Medical College Affiliated Union Hospital from August 2013 to March 2024 were included in this study. Their clinical, image, and pathological data were retrospectively collected and analyzed.

Immune Regulation in Atrial Cardiomyopathy.

Clinical observations have shown that cases of stroke or thromboembolism are not uncommon even in the absence of atrial fibrillation, suggesting that atrial fibrillation is a delayed marker of atrial thrombus formation. Atrial cardiomyopathy (ACM) is a pathophysiological concept characterized by atrial substrate and functional abnormalities closely associated with atrial myopathy, atrial enlargement, and impaired ventricular diastolic function. It is an independent factor for thromboembolic stroke, increasing the risk of serious complications such as atrial fibrillation, heart failure, and sudden cardiac death.

Microbial potential to mitigate neurotoxic methylmercury accumulation in farmlands and rice.

Toxic methylmercury (CHHg) is produced by microbial conversion of inorganic mercury in hypoxic environments such as rice paddy soils, and can accumulate in rice grains. Although microbial demethylation has been recognized as a crucial pathway for CHHg degradation, the identities of microbes and pathways accountable for CHHg degradation in soil remain elusive. Here, we combine CHHg-DNA stable-isotope probing experiments with shotgun metagenomics to explore microbial taxa and associated biochemical processes involved in CHHg degradation in paddy and upland soils.

Pharmacokinetics, bioequivalence, and food effect assessment of enteric-coated aspirin tablets: a randomized, single-dose, four-period crossover study in Chinese healthy subjects.

This study assessed the pharmacokinetics, bioequivalence, and food effect of two enteric-coated aspirin tablets (100 mg) in healthy Chinese subjects. Ninety subjects were enrolled and divided into fasted (n = 42) and fed cohorts (n = 48) in a single-center, randomized, open-label, single-dose, four-period, two-sequence and crossover study. The pharmacokinetic characteristics of acetylsalicylic acid (aspirin) and its metabolite salicylic acid, including C and AUC, were compared after subjects received single oral doses of enteric-coated aspirin tablet using a validated LC-MS/MS method.

Liver resection versus interventional treatments for hepatocellular carcinoma patients with hypohepatia: a multicenter study.

Background: Hypohepatia limits the feasibility of therapeutic options for hepatocellular carcinoma (HCC), negatively affecting patient prognosis. Established guidelines for the treatment strategies of HCC patients with hypohepatia are lacking. This study was performed to evaluate therapeutic benefits between liver resection (LR) and interventional treatments using ablation or transarterial chemoembolization (TACE) in such population.

Immunological enhancement of micro-nanoparticle formulated with risedronate and zinc as vaccine adjuvant in aged mice.

Background: Elderly individuals face heightened susceptibility to infectious diseases and diminished vaccine responses. Vaccine adjuvants offer a solution. Despite aluminum adjuvant's long history, its limitations in inducing strong cellular immunity and protecting immunocompromised individuals restrict its application.

Gecko-Inspired 2D Adhesives with Alternating Organogel/Hydrogel Strips Enable Robust and Durable Anisotropic Adhesion.

Gecko-inspired surface engineering, from microscale polymer pillars to nanoscale carbon nanotubes, has been scientifically guided by a thorough understanding of the adhesion mechanism of geckos. However, their adhesive performance inevitably deteriorates upon repetitive friction due to the collapse or destruction of 3D micro/nanostructures. Here, inspired by the arc lamellae structures of gecko toes, a 2D organohydrogel adhesive with alternating organogel and hydrogel strips of arc shape (TAS-arc) is demonstrated through a one-step wetting-enabled-transfer (WET) strategy.

[Clinical Effects of Pomalidomide-Based Regimen in the Treatment of Relapsed and Refractory Multiple Myeloma].

Objective: To study the clinical effects of pomalidomide-based regimen in the treatment of relapsed and refractory multiple myeloma (RRMM).

Methods: 60 patients with RRMM in hematology department of the First Affiliated Hospital of Xinxiang Medical University from November 2020 to January 2023 were selected. Among them, 15 cases were treated with PDD regimen (pomalidomide + daratumumab + dexamethasone), and 45 cases were treated with PCD regimen (pomalidomide + cyclophosphamide + dexamethasone).

Postoperative circulating tumor cells predict the benefits of tyrosine kinase inhibitor for hepatocellular carcinoma after transplantation.

Aim: Circulating tumor cells (CTC) have shown promise in predicting the outcomes of adjuvant treatments for several malignancies. The clinical significance of CTC in predicting the efficacy of tyrosine kinase inhibitor (TKI) administration in patients with hepatocellular carcinoma (HCC) was unclear.

Methods: A total of 429 patients who underwent liver transplantation for HCC had provided 335 preoperative and 373 postoperative blood samples that could be used for CTC detection (pre-CTC and post-CTC).

Bioequivalence and Food Effect Assessment of Two Fixed-Dose Combination Formulations of Telmisartan-Hydrochlorothiazide Tablets in Chinese Healthy Subjects.

This study assessed the bioequivalence and food effect of two fixed-dose combination (FDC) formulations of telmisartan-hydrochlorothiazide tablets (telmisartan 40 mg, hydrochlorothiazide 12.5 mg) in healthy Chinese subjects. Seventy-two subjects were enrolled and divided into fasted and fed cohorts in a single-center, randomized, open-label, single-dose, three-period, three-sequence, and crossover study.

Thinning of the temporal and insular cortex is associated with negative symptoms and impaired attention in Chinese chronic schizophrenia patients with deficit syndrome.

Background: The considerable clinical heterogeneity of schizophrenia poses significant challenges for elucidating its neurobiology. The concept of deficit schizophrenia (DS) is a valuable framework for addressing the heterogeneity of schizophrenia. Growing evidence suggests notable differences between deficit (DS) and nondeficit (NDS) schizophrenia, indicating that DS could represent a separate disease entity.

High-Frequency repetitive transcranial magnetic stimulation enhances white matter integrity in a rat model of ischemic stroke: A diffusion tensor imaging study using tract-based spatial statistics.

Ischemic stroke leads to white matter damage and neurological deficits. Previous studies have revealed that high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has beneficial effects on white matter reorganization and neurological recovery after stroke. However, the characteristics of poststroke white matter repair after treatment with HF-rTMS remain unclear.

Autophagy-related genes in mesial temporal lobe epilepsy: an integrated bioinformatics analysis.

Background: Autophagy plays essential roles in the development and pathogenesis of mesial temporal lobe epilepsy (mTLE). In this research, we aim to identify and validate the autophagy-related genes associated with mTLE through bioinformatics analysis and experimental validations.

Methods: We obtained the dataset GSE143272 and high-throughput sequencing results of mTLE from public databases.

The migrant-native difference in the relationship between anxiety and depression among the elderly in China: a comparative network analysis.

In the context of the ongoing COVID-19 pandemic, elderly individuals are confronted with an elevated vulnerability to psychological distress. However, disparities in the manifestation of anxiety and depression between migrant and native elderly populations have yet to be thoroughly examined. The purpose of this study was to identify the network characteristics of anxiety and depression among migrant and native elderly during the COVID-19 pandemic.

Evaluation of the causal relationship between 28 circulating biomarkers and osteoarthritis : a bidirectional Mendelian randomization study.

Aims: Circulating biochemistry markers are commonly used to monitor and detect disease-induced dysfunctions including osteoarthritis (OA). However, the causal nature of this relationship is nevertheless largely unknown, due to unmeasured confounding factors from observational studies. We aimed to reveal the causal relationship between 28 circulating biochemistry markers and OA pathogenesis.