Predicting tumor response to TACE plus lenvatinib and PD-1 inhibitors for unresectable HCC: A multicenter observational study.

Objectives: Preoperatively identifying patients with unresectable hepatocellular carcinoma (uHCC) who are likely to achieve an objective response to the treatment regimen of transarterial chemoembolization (TACE) plus lenvatinib and programmed death-1 inhibitors (TLP) remains challenging. We aimed to develop and validate a predictive model for tumor response to TLP treatment in patients with uHCC.

Materials And Methods: Patients with uHCC who received TLP treatment were divided into training (n = 107), internal validation (n = 46), and external validation (n = 52) cohorts.

Advancing environmental safety and public health: a comprehensive review of luminescent probes for radioactive element detection.

Recently, radioactive pollutants have garnered significant attention within the realms of environmental science and public safety, such as nuclear energy (, uranium), radiation therapy (, I), and earthquake monitoring (, radon), exerting multifaceted impacts on human health and ecosystems. Therefore, the development of accurate detection technologies for key radioactive elements is of paramount importance and is also an important guarantee for ensuring public safety and comprehensively promoting harmonious coexistence between humans and nature. Luminescent probes represent a class of detection methods for radioactive elements, characterized by high sensitivity, simplicity, and visualization.

Hepatitis Virus Infection Predicts Heterogeneous Enhancement Patterns in Intrahepatic Cholangiocarcinoma on Contrast-Enhanced Ultrasound: A Retrospective Radiological Cohort Study.

Background: Chronic hepatitis is a significant risk factor for intrahepatic cholangiocarcinoma (ICC). Accurate identification of hepatitis-associated ICC is critical for optimizing clinical management. This study aimed to differentiate hepatitis-associated ICC from non-hepatitis cases by integrating clinical and contrast-enhanced ultrasound (CEUS) features.

Bruceine A ameliorates ulcerative colitis via macrophage polarization: Targeting HSP90-mediated IL-17 signaling and NF-κB activation.

Background: Bruceine A (BA), a natural quassinoid compound derived from the fruit of Brucea javanica, has demonstrated diverse pharmacological activities. However, the treatment effectiveness of BA against ulcerative colitis (UC) and its underlying mechanisms of action are yet to be fully elucidated.

Purpose: To explore the effects of BA against UC and uncover its underlying mechanisms, with a particular focus on its influence on inhibiting macrophage M1 polarization via the IL-17/NF-κB pathway.

Epigenetic Regulation of Aging and its Rejuvenation.

Aging increases the global burden of disease, yet its molecular basis remains incompletely understood. Recent studies indicate that reversible epigenetic drift-spanning DNA methylation clocks, histone codes, three-dimensional chromatin, and noncoding RNA networks-constitutes a central regulator of organismal decline and age-related diseases. How these epigenetic layers interact across different tissues-and how best to translate them into therapeutic strategies-are still open questions.

Dynamic Macropore Formation via Dual-Degrading Injectable Microgels Enhances Host-Mediated Angiogenesis and Regeneration.

Hydrogels are widely employed in tissue engineering for their biomimetic microenvironments. However, the dense crosslink network of hydrogels with matching mechanical properties of soft tissues often restricts cell infiltration and tissue integration. While granular hydrogels enhance host integration through the formation of porous channels between particles, they self-anneal in vivo, thereby limiting porosity and interconnectivity.

Effect of vibration loads acting on different body regions on lumbar spine: A finite element study based on a whole-body model.

The effects of vehicle-induced whole-body vibration on human body have received widespread attention, and investigations have found that vibrations would cause lumbar disorders of occupational drivers. Some investigations have revealed the harmful effects of vibrations on human body, but the studies about the effect of vibration applied to different body regions on lumbar spine are limited. In this study, a whole-body finite element model was used to predict the biomechanical response of lumbar spine under vibrations applied to the back of thoracic and lumbar regions, and the bottom of buttock regions, respectively.

Spontaneous or Stimulated? Investigating Raman's Detection Limits in Aqueous Environments.

Raman spectroscopy is a powerful method for analyzing chemical compositions across diverse samples. Spontaneous Raman scattering (spRS) provides complete Raman spectra but typically yields low signal levels, requiring long signal integration times. In contrast, stimulated Raman scattering (SRS) produces much stronger signals, allowing for rapid spectral acquisition, and has been widely used to accelerate chemical imaging.

GCDH Acetylation Orchestrates DNA Damage Response and Autophagy via Mitochondrial ROS to Suppress Hepatocellular Carcinoma Progression.

Metabolic enzyme dysregulation promotes hepatocellular carcinoma (HCC) progression through metabolic reprogramming and lysine acetylation. Glutaryl-CoA dehydrogenase (GCDH), a key enzyme in lysine metabolism, has been demonstrated to play an essential role in modulating lysine crotonylation, which impacts the progression of HCC. However, the specific mechanisms by which GCDH influences lysine acetylation in HCC have not been completely clarified.

Eicosapentaenoic acid restores inflammation-induced changes in chondrocyte mechanics by suppressing the NF-κB p65/CD44 signaling pathway and attenuates osteoarthritis.

Here we investigate the effects and mechanisms of eicosapentaenoic acid (EPA) in regulating chondrocyte mechanics during inflammation in the progression of osteoarthritis (OA). Primary porcine chondrocytes and human OA chondrocytes were isolated and cultured. Cell mechanical properties were measured using atomic force microscopy.

Global Circulation Dynamics and Its Determinants of Dengue Virus: A Network Evolution and Model Study from 1990 to 2019.

As dengue is an increasing global health threat, a better understanding of the global circulation dynamics and its determinants would be helpful for precise prevention and control of dengue. The dynamics of global circulation of the four dengue virus serotypes were explored utilizing genetic sequences through a network-based method. Four new circulation indicators, including local intensity, betweenness centrality, tip frequency, and persistence time, were defined.

Population Structure and Resource Dynamics of Three Schizothoracinae Species in the Duoxiong Zangbo River Tributary of the Yarlung Zangbo River, Tibet: Threat Assessment and Conservation Insights.

The Yarlung Zangbo River (With a total length of 2057 km, the river forms part of the Ganges-Brahmaputra River system), located in the core region of the Tibetan Plateau, hosts a unique yet fragile aquatic ecosystem. Fish populations inhabiting this ecosystem have been significantly impacted by external factors, leading to declining resources. This decline is particularly evident in local tributaries, including the DuoXiong Zangbo River-a main tributary where scientific research remains scarce due to its geographic remoteness.

Synchronous Double Primary Malignancy of Non-Small Cell Lung Cancer and Glioblastoma: A Case Report and Literature Review.

Introduction: Non-small cell lung cancer (NSCLC) is the most common form of lung cancer and has a propensity to metastasize to the brain. It is incredibly difficult to distinguish between a primary brain lesions and a solitary metastasis from distant occult disease using current imaging techniques. Further, complications arise from the shifting paradigm in how medicine views NSCLC brain metastasis due to contemporary nonsurgical curative treatments and the recent increase in the number of multiple primary malignancy (MPM) diagnoses associated with NSCLC.

Synergistic stabilization of high internal phase Pickering emulsions using zein nanoparticles and quillaja saponin: Advancing stability, functional properties, and fat replacement in food systems.

High internal phase Pickering emulsions (HIPPEs), stabilized by colloidal particles, have attracted interest owing to their exceptional stability, tunable viscoelasticity, and versatile encapsulation capabilities. With increasing health concerns over saturated fats and the demand for sustainable fat alternatives, novel emulsion-based substitutes are of significant interest. In this study, oil-in-water HIPPEs containing 80 % oil phase were formulated using food-grade zein nanoparticles (ZNPs) and quillaja saponin (QS) as co-stabilizers.

An intelligent method for detection of small target fungal wheat spores based on an improved YOLOv5 with microscopic images.

Wheat is significantly impacted by fungal diseases, which result in severe economic losses. These diseases result from pathogenic spores invading wheat. Rapid and accurate detection of these spores is essential for post-harvest contamination risk assessment and early warning.

Improving large language models for miRNA information extraction via prompt engineering.

Objective: Large language models (LLMs) demonstrate significant potential in biomedical knowledge discovery, yet their performance in extracting fine-grained biological information, such as miRNA, remains insufficiently explored. Accurate extraction of miRNA-related information is essential for understanding disease mechanisms and identifying biomarkers. This study aims to comprehensively evaluate the capabilities of LLMs in miRNA information extraction through diverse prompt learning strategies.

Clinical and Proteomic Profiling of Inflammatory Mediators in Henoch-Schönlein Purpura: Oncostatin M as a Key Cytokine Associated with Disease Severity.

Introduction: Henoch-Schönlein Purpura (HSP) is a systemic vessel vasculitis characterized by IgA- and complement-mediated vascular injuries. However, the precise mechanisms underlying disease progression and severity remain unclear. This study aimed to identify inflammation-related proteins and pathways associated with HSP and disease severity.

A Monolithically Integrated MXene-Printed Hybrid Energy System for Wireless Self-Powered Microelectronics.

Reliable and sustainable energy supply remains a critical challenge in wearable and implantable microelectronics. Although hybrid energy strategies show promise, most existing systems rely on stacked, multi-component designs, hindering integration and scalability. Here, a fully printed, monolithically integrated MXene-based system combining active wireless charging and passive energy harvesting is demonstrated.

Computer-Assisted Screening of Active Compounds in Traditional Chinese Medicine Targeting SNX10 as a Promising Treatment for Inflammatory Bowel Diseases.

Inflammatory bowel diseases (IBD) are chronic and recurrent gastrointestinal disorders affecting millions worldwide, imposing significant social and economic burdens. Safe and effective medications for IBD prevention and treatment are urgently needed. SNX10 has emerged as a potential therapeutic target, while traditional Chinese medicine (TCM) active compounds offer unique advantages in drug development due to their inherent safety and therapeutic properties.

Reactions of Surface-Confined Terminal Alkynes Mediated by Diverse Regulation Strategies.

Terminal alkynes, characterized by -hybridized carbon atoms at the molecular termini, possess high electron density and exceptional chemical reactivity. These properties make them ideal candidates for the synthesis of one-dimensional molecular wires and two-dimensional networks. Advances in nanoscale characterization techniques, such as scanning tunneling microscopy and atomic force microscopy, have enabled the real-space visualization of molecular assembly and chemical reactions of terminal alkynes and in situ atomic-level manipulations under surface-confined conditions.

Are Safety Net Hospitals Reimbursed Fairly Under Hospital Value-Based Purchasing-Prioritizing Satisfaction Over Outcomes?

Background: The Centers for Medicare and Medicaid Services (CMS) reimburse hospitals through the Hospital Value-Based Purchasing Program (HVBP) based on clinical outcomes, safety, efficiency, and patient satisfaction, currently weighted equally. The aim is to explore whether adjusting these weights could address reimbursement inequities for safety net hospitals (SNH).

Methods: We assessed 2,731 non-federal hospitals using CMS payment files.

The impact of cockroach control intervention on infectious diarrhea in Songjiang District, Shanghai, China - an interrupted time series analysis.

Introduction: Infectious diarrhea, as one of the oldest infectious diseases, has been fought against by people for hundreds of years. From changing lifestyle habits to developing new drugs, people have been tirelessly searching for ways to reduce the burden of diarrhea. This study evaluated the impact of cockroach control intervention on infectious diarrhea from the perspective of public health and explored influencing factors, providing practical suggestions for implementation in various regions.

A dual-mode LiDAR system enabled by mechanically tunable hybrid cascaded metasurfaces.

Light detection and ranging (LiDAR) is widely used for active three-dimensional (3D) perception. Beam scanning LiDAR provides high accuracy and long detection range with limited detection efficiency, while flash LiDAR can achieve high-efficiency detection through the snapshot approach at the expense of reduced accuracy and range. With the synergy of these distinct detection approaches, we develop a miniaturized dual-mode, reconfigurable beam forming device by cascading Pancharatnam-Berry phase and propagation phase metasurfaces, integrated with a micro-actuator.

Spinal Cord-Like Scaffold with Rapid Tissue Integration Enhanced Spinal Cord Nerve Repair.

Spinal cord injury (SCI) repair represents an immense challenge globally. Despite various beneficial strategies having been attempted for SCI repair, the ideal therapy has not yet been achieved. In this study, a multidimensional biomimetic spinal cord-like scaffold (MBSLS) is designed with a hierarchical structure and embryonic neurogenetic microenvironment and neural regeneration in SCI repair.