MXene-Based Peroxidase-Like Nanozymes: Interfacial Effects for Biomedical Applications.

MXene-based peroxidase (POD)-like nanozymes demonstrate significant potential in biomedical applications due to their 2D structure, tunable catalytic activity, and interfacial effects. This review summarizes recent advances in MXene-POD nanozyme design, focusing on interfacial effects modulation via external stimuli (e.g.

[Therapeutic mechanism of Compound Xuanju Capsule on erectile dysfunction].

Objective: To investigate the pharmacological mechanism of Compound Xuanju Capsule in the treatment of erectile dysfunction (ED) by using network pharmacology and molecular docking technology.

Methods: The active ingredients and targets of Compound Xuanju Capsule were screened using Traditional Chinese Medicine Systematic Pharmacology Database and Analysis Platform (TCMSP). TTD, OMIM, DrugBank and GeneCards databases were used to obtain genes related to ED, and the union of the results was taken as the disease genes of ED.

Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.

Background: Diabetic kidney disease (DKD) represents a common microvascular complication associated with diabetes. Research suggests that lipid accumulation contributes to lipotoxicity, exacerbating kidney injury in DKD. Quercetin (QCT), a flavonoid derived from specific fruits and vegetables, has shown potential in mitigating DKD progression; however, its precise protective mechanisms remain to be explored.

Osmotic Energy Directly Driving Flexible All-Solid-State 2D Nanofluidic Pressure Sensors.

Current utilization of osmotic energy often involves multiple complex processes, including collection, storage, and conversion, which limits its applicability in portable electronic devices. Inspired by the biosensing system of human skin, a novel iontronic pressure sensor is developed, directly driven by osmotic energy. By leveraging the tunable nanofluidic effects of 2D materials, ion selective migration driven by osmotic energy is controlled through mechanical modulating of interlayer spacing, thereby converting external pressure into encodable electrical signals.

GCDH Acetylation Orchestrates DNA Damage Response and Autophagy via Mitochondrial ROS to Suppress Hepatocellular Carcinoma Progression.

Metabolic enzyme dysregulation promotes hepatocellular carcinoma (HCC) progression through metabolic reprogramming and lysine acetylation. Glutaryl-CoA dehydrogenase (GCDH), a key enzyme in lysine metabolism, has been demonstrated to play an essential role in modulating lysine crotonylation, which impacts the progression of HCC. However, the specific mechanisms by which GCDH influences lysine acetylation in HCC have not been completely clarified.

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF State.

Unlabelled: The RAF kinases (ARAF, BRAF and CRAF) are essential components of the RAS-ERK signaling pathway, which controls vital cellular processes and is frequently dysregulated in human disease. Notably, mutations that alter BRAF function are prominent drivers of human cancer and certain RASopathy disorders, making BRAF an important target for therapeutic intervention. Despite extensive research, several aspects of BRAF regulation remain unclear.

MATCAP1 preferentially binds an expanded tubulin conformation to generate detyrosinated and ΔC2 α-tubulin.

Microtubules are cytoskeletal filaments with critical roles in cell division, cell motility, intracellular trafficking, and cilium function. In cells, subsets of microtubules are selectively marked by posttranslational modifications (PTMs), which control the ability of microtubule-associated proteins (MAPs) and molecular motors to engage microtubules. Detyrosination (ΔY) and ΔC2 are PTMs of α-tubulin, wherein one or two residues, respectively, are enzymatically removed from the C-terminus of the protein.

The impact of paternal body mass index on semen parameters and assisted reproductive outcomes in couples undergoing IVF/ICSI-ET treatment.

Purpose: To investigate the impact of paternal body mass index (BMI) on semen parameters and assisted reproductive outcomes in couples undergoing their first IVF/ICSI-ET cycle.

Materials And Methods: This retrospective study included 7618 couples undergoing IVF/ICSI-ET for maternal tubal/pelvic factors from 2017 to 2023. Paternal BMI was classified according to WHO criteria: normal weight (n = 3433), overweight (n = 3248), and obese (n = 937).

Research progress on NAT10-mediated acetylation in normal development and disease.

N4-acetylcytidine (ac4C) is an evolutionarily conserved RNA modification catalyzed by the acetyltransferase NAT10. It regulates RNA stability, translation, and post-transcriptional processes. Meanwhile, NAT10 functions as a dual-function enzyme exhibiting both protein acetyltransferase and RNA acetylase activities.

Nature-Inspired MXene Electrode with the Highly Interconnected Gradient Nanoconfined Architecture.

Achieving efficient ion transport in thick electrodes remains a fundamental challenge in electrochemical systems with high energy density, primarily due to prolonged diffusion pathways and poorly integrated architectures. Leveraging the nanoconfinement effect, (sub)nanoscale channels can significantly accelerate ion transport kinetics to maximize electrochemical performance. Inspired by the hierarchical network structure of bamboo membrane, a gradient nanoconfined MXene electrode (GNC-MX) is designed, where multiscale interlayer spacing is coupled with in-plane mesopores that bridge adjacent nanoconfined channels, enabling synergistic vertical and horizontal ion migration.

Impact of masticatory training on masticatory function: A systematic review and meta-analysis.

Statement Of Problem: Abnormal masticatory function has been reported to impact health, but evidence for the efficacy of training is inconsistent, and a systematic review is required.

Purpose: The purpose of this systematic review and meta-analysis was to assess the efficacy of training interventions to enhance masticatory function, including specific protocols and outcomes.

Material And Methods: Nine databases (PubMed, Embase, Web of Science, Cochrane Library, CINAHL, CNKI, Wanfang, China Science and Technology Database, and China Biomedical Literature Database) were searched from inception to February 2025.

Contrast-enhanced ultrasound for diagnosing subtypes of intrahepatic cholangiocarcinoma: a comparative study with poorly differentiated hepatocellular carcinoma.

Background: Pathologically, intrahepatic cholangiocarcinoma (ICC) is classified into small-duct (SD) type and large-duct (LD) type, each with distinct clinicopathological characteristics. The contrast-enhanced ultrasound (CEUS) features of the two ICC types remain insufficiently explored.

Purpose: To evaluate liver CEUS imaging for differentiating the SD and LD types of ICC and further compare them with poorly differentiated hepatocellular carcinoma (pHCC).

The relationship between cloud distribution characteristics and meteorological elements over China.

The meteorological elements in the cloud background field influence and change with the cloud macro and micro characteristics, so it is of great significance to study the relationship between them. Using CALIOP Level 2 VFM products and ERA5 reanalysis data, this paper studies and analyzes the relationship between the distribution characteristics of different types and phases clouds and meteorological elements over China through statistical methods. The results show that: In the two-dimensional probability density function distribution of cloud occurrence probability and relative humidity-temperature, there are two significant high value regions, which can be divided into tropical clouds and temperate clouds.

Photochemical reaction of 4-chlorobiphenyl with nitrous acid in atmospheric aqueous solution.

The photochemical reaction of 4-chlorobiphenyl (4-PCB) and HONO in atmospheric aqueous phase was studied by 355 nm laser flash photolysis combined with 365 nm UV steady-state irradiation technique. The steady-state study showed that the conversion rate of 4-PCB was affected by the initial concentration of 4-PCB, pH value and HONO concentration, while chloride ions had little effect on the conversion of 4-PCB. HONO produces an HO˙ attack on 4-PCB to form a 4-PCB-OH adduct with the second-order reaction rate constant of (9.

Social support and self-management activation among older adult chronic disease patients in China: the chain mediating role of acceptance of illness and fatigue.

Background: With the rapid aging of the global population and the continuous increase in the incidence of chronic diseases among the older adult, self-management activation has become a key factor in improving patients' quality of life. This study examines the relationship between social support and self-management activation in older adult patients with chronic diseases, with a focus on the mediating roles of illness acceptance and fatigue within this framework.

Methods: A convenience sampling method was employed to recruit 317 older adult patients with chronic diseases from three communities in Hefei, Anhui Province, China, between August and November 2023.

FTO inhibited miR-487a-3p biosynthesis via N6-methyladenosine-dependent pathway to promote WNT5A-mediated osteogenic differentiation of adipose-derived stem cells.

miR-487a-3p shows the potential of modulating adipose-derived stem cells (ADSCs) differentiation. This study aimed to investigate the mechanism of miR-487a-3p on the osteogenic differentiation of ADSCs. In this work, ADSCs were induced to differentiate into osteoblasts.

Meta-analysis on the safety and efficacy of Erdafitinib in treating FGFR1-4 mutated solid tumors.

Objective: This article aims to analyze the safety and efficacy of Erdafitinib in the treatment of patients with advanced solid tumors harboring FGFR1-4 mutations.

Methods: Search for relevant articles in databases such as PubMed, Embase, The Cochrane Library, Web of Science, and CNKI, covering the period from their establishment to October 25, 2024. Summarize the adverse drug reaction (AE) data, overall survival (OS), median progression-free survival (PFS), objective response rate (ORR), and other relevant data for patients with advanced solid tumors treated with Erdafitinib for FGFR1-4 mutations.

Towards expert-level autonomous carotid ultrasonography with large-scale learning-based robotic system.

Carotid ultrasound requires skilled operators due to small vessel dimensions and high anatomical variability, exacerbating sonographer shortages and diagnostic inconsistencies. Prior automation attempts, including rule-based approaches with manual heuristics and reinforcement learning trained in simulated environments, demonstrate limited generalizability and fail to complete real-world clinical workflows. Here, we present UltraBot, a fully learning-based autonomous carotid ultrasound robot, achieving human-expert-level performance through four innovations: (1) A unified imitation learning framework for acquiring anatomical knowledge and scanning operational skills; (2) A large-scale expert demonstration dataset (247,000 samples, 100 × scale-up), enabling embodied foundation models with strong generalization; (3) A comprehensive scanning protocol ensuring full anatomical coverage for biometric measurement and plaque screening; (4) The clinical-oriented validation showing over 90% success rates, expert-level accuracy, up to 5.

Impact of postoperative complications on patient-reported outcomes in deep inferior epigastric perforator flap breast reconstruction.

Objective: This study aims to investigate the factors that influence the occurrence of complications following deep inferior epigastric perforator (DIEP) flap breast reconstruction, and to determine whether these complications have an impact on the patient's quality of life in China.

Methods: We collected clinical data from patients who underwent DIEP flap breast reconstruction at the Department of Breast, Affiliated Cancer Hospital of Zhengzhou University between December 2019 and December 2023. We analyzed the incidence of postoperative complications and their relationship with patient clinical data and surgical parameters.

Global, regional, and national burden and trends of bladder cancer in individuals Aged 55 Years and older From 1990 to 2021: Findings from the Global Burden of Disease Study 2021.

Background: Bladder cancer (BC), a prevalent genitourinary malignancy, poses a substantial threat to public health, particularly among middle-aged and elderly populations. Given the increasing life expectancy, understanding the BC burden in these demographic groups is imperative.

Methods: Based on the GBD 2021 dataset encompassing 371 diseases and injuries with 88 risk factors globally, this study analyzed bladder cancer data from 204 countries and territories (1990-2021) for populations aged ≥55 years, with core metrics including incidence, deaths, and disability-adjusted life years (DALYs).

Dihydromyricetin protects hippocampal neurons in sepsis-associated encephalopathy by reducing ER stress-mediated apoptosis and inflammation.

Sepsis-associated encephalopathy (SAE) involves hippocampal dysfunction and cognitive deficits, but its underlying mechanisms remain unclear, and effective treatments are lacking. Dihydromyricetin (DHM), a key flavonoid in Japanese raisin trees and Chinese Rattan tea, exhibits broad therapeutic potential for neurological disorders. This study investigated whether DHM improves hippocampal dysfunction in SAE rats by targeting endoplasmic reticulum (ER) stress-mediated apoptosis and inflammation.

Multi-view Contrastive Learning for Drug-Drug Interaction Event Prediction.

Drug-drug interactions (DDIs) represent a critical challenge in pharmacology, often leading to adverse effects and compromised therapeutic efficacy. Accurate prediction of DDI events, which involve not only identifying interacting drug pairs but also characterizing the specific nature and context of their interactions, is essential for drug safety and personalized medicine. In this study, we propose a novel Multi-view Contrastive Learning framework, namely MCL-DDI, for DDI Event Prediction by leveraging multi-view representations of drugs to enhance predictive performance.

A latent profile analysis of post-traumatic growth in spouses of breast cancer patients.

Introduction: Post-traumatic growth is the positive psychological changes that an individual may undergo after coping with traumatic events. It can help individuals alleviate negative emotions, reduce physical and mental stress, and enhance self-efficacy. This study aims to characterize the latent profiles of spouses' post-traumatic growth and to explore the related factors for each subgroup based on the ABC-X model.

The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells and .

The anti-tumor actions of the Stearoyl-CoA desaturase (SCD1) inhibitor aramchol in tumor cells remains poorly understood. Aramchol interacted with the multi-kinase inhibitors sorafenib, regorafenib or lenvatinib, to kill GI tumor cells, with regorafenib exhibiting the greatest effect. In HCT116 cells homozygous for the autophagy-regulatory protein ATG16L1 T300, aramchol and regorafenib interacted to activate ATM and the AMPK and to inactivate mTORC1 and mTORC2.

Analysis of risk factors and early prediction model construction for gestational hypertension.

Gestational hypertension (GH), a prevalent pregnancy complication, requires early risk identification for timely intervention. This study assesses and compares traditional and placental function factors using multivariable logistic regression, random forest, and support vector machine (SVM) models to predict GH risk. We first compared the baseline information and pregnancy-related characteristics between normal pregnant women and those with GH.