MXene-Based Peroxidase-Like Nanozymes: Interfacial Effects for Biomedical Applications.

MXene-based peroxidase (POD)-like nanozymes demonstrate significant potential in biomedical applications due to their 2D structure, tunable catalytic activity, and interfacial effects. This review summarizes recent advances in MXene-POD nanozyme design, focusing on interfacial effects modulation via external stimuli (e.g.

The mechanisms of MTOCs maturation in human and mouse oocytes.

The microtubule organizing centers (MTOCs) of human and mouse oocytes are essential for meiotic spindle assembly and for ensuring precise chromosome segregations. Previous studies mainly focus on investigating MTOCs changes in metaphase I oocyte. However, the detailed dynamic changes and underlying mechanisms of the MTOCs in germinal vesicle (GV) oocytes-a stage that early events of MTOC maturation happened- remain unclear.

Effectiveness of sirolimus for early on-set autoimmune cytopenias of autoimmune lymphoproliferative immunodeficiencies.

Background: Pediatric patients with autoimmune lymphoproliferative immunodeficiencies (ALPIDs) who exhibit autoimmune cytopenias are frequently diagnosed with immune thrombocytopenia (ITP), autoimmune hemolytic anemia (AIHA), or Evans syndrome (ES). These conditions generally necessitate long-term immunosuppressive therapy using medications that are often ineffective and highly toxic before the diagnosis of ALPIDs. A less harmful treatment strategy is needed.

The protective role of ureteral stents in reducing fibrosis and preventing stricture in ureteral injuries of different severities.

Purpose: Ureteral injuries following endoscopic interventions often lead to fibrosis and subsequent stricture formation, yet the optimal use and duration of ureteral stents in preventing these outcomes remain unclear. This study aimed to determine whether ureteral stents have an inhibitory effect on fibrosis development and provide evidence to optimize stent use and duration.

Methods: This study was conducted between March and October 2023.

Efficacy of Chinese patent medicines combined with conventional western medicine in treatment of preeclampsia: A systematic review and Bayesian network meta-analysis.

Ethnopharmacological Relevance: Conventional Western treatments (CTs) for preeclampsia (PE) are often linked to serious side effects, such as higher rates of cesarean delivery and medically induced preterm birth. In contrast, recent clinical research has highlighted the potential of Chinese patent medicines (CPMs) as an effective alternative treatment. These studies show that CPMs may help lower blood pressure, reduce 24-h urinary protein levels, and improve pregnancy outcomes.

Analysis of clinical characteristics, diagnosis, treatment, and postoperative outcomes in deep infiltrating endometriosis: a retrospective study.

Objectives: To investigate the clinical characteristics of deep infiltrating endometriosis (DIE), summarize the experiences in its diagnosis and management, and identify potential peripheral blood indicators associated with the severity of pelvic adhesions.

Methods: Clinical data were collected from 185 patients with pathologically confirmed DIE admitted to Wuxi Maternal and Child Health Hospital between January 2015 and December 2024. A retrospective analysis was conducted on the general information, perioperative conditions, postoperative pregnancy outcomes, and recurrence status in patients with DIE.

Uncovering a new mechanism of ischemic stroke: a study of the association between γδ T cells and immunoinflammation.

Ischemic stroke, characterized by high clinical mortality and poor prognosis, has been prioritized by the World Health Organization (WHO) for reducing the burden of non-communicable diseases. However, the pathogenesis of ischemic stroke remains complex and poorly understood. Recent studies have revealed the infiltration of γδ T cells within ischemic stroke lesions, accompanied by the upregulation of IL-17, IL-23, and other inflammatory cytokines, suggesting their involvement in the stroke's pathological process.

Perovskite Tandems: the Next Big Leap in Photovoltaic Technology.

The global demand for clean energy is driving the need for next-generation solar technologies with higher power conversion efficiencies. Multijunction solar cells, which stack absorbers with cascaded bandgaps, offer a compelling path forward by more efficiently utilizing the solar spectrum. Among these, metal halide perovskites stand out for their bandgap tunability, enabling efficient tandem solar cells (TSCs) when paired with a range of semiconductors-including perovskite/perovskite, perovskite/silicon, perovskite/organic, and perovskite/CIGS.

Efficient Inverted Perovskite Solar Cells Utilizing Inorganic Composite Multiple Electron Transport Layers.

Electron transport layers (ETLs) featuring optimal film coverage and favorable electronic properties play a critical role in high-performance perovskite solar cells (PSCs). In contrast to organic ETLs, which have high material costs, inorganic metal oxide ETLs are considered promising alternatives for efficient inverted PSCs because of their low cost, high carrier mobility, and excellent stability. However, fabricating high-quality top inorganic ETLs that preserve the active perovskite layer remains a challenge.

Research progress of in vivo measurement methods of myopia sclera biomechanics.

Background: The study of the development mechanism of myopia involves many aspects, of which the remodeling and biomechanical changes of the sclera are currently recognized as some of the more important mechanisms. In recent years, new progress has been made in in vivo and ex vivo measurement methods to characterize scleral biomechanics. However, because ex vivo measurement methods cannot be used on the in vivo eyeball, there is still a lack of a reliable in vivo scleral biomechanical measurement method to assess the trend of myopia progression in clinical practice.

Trametinib treatment for early-stage extracranial arteriovenous malformations: A multicenter, prospective, single-arm pilot study.

Background: Extracranial arteriovenous malformations (eAVMs) are progressive vascular anomalies for which conventional therapies are rarely curative. Few standard therapies have been developed for early-stage eAVMs. In particular, the efficacy and safety of trametinib for treating early-stage childhood eAVM are unclear.

Acid-Enzyme Derived Agarotriose Facilitates Anti-Inflammatory Activity for Dextran Sulfate Sodium-Induced Colitis Alleviation as a Food Supplement.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with inadequate therapeutic options and has a significant impact on patient quality of life. We optimized the preparation of agarotriose (A3), a functional oligosaccharide, and assessed its health-promoting potential in a dextran sulfate sodium-induced UC mouse model. The beneficial effects of A3 were evaluated through histopathological, biochemical, immunological, and transcriptomic analyses.

Clinical efficacy and safety of transurethral prostate blue laser vaporization versus green laser vaporization in the treatment of benign prostatic hyperplasia with different prostate volumes: A retrospective comparative study.

This study analyzes and compares the clinical efficacy and safety of transurethral blue laser vaporization of the prostate (BL-PVP) and transurethral green laser vaporization of the prostate (GL-PVP) in the treatment of benign prostatic hyperplasia (BPH). A retrospective analysis was conducted on the clinical data of 97 patients with BPH who were treated at the Urology and Nephrology Department of Xi'an People's Hospital (Fourth Hospital of Xi'an) from June 2022 to June 2024. Patients were divided into 2 groups based on the surgical technique: the BL-PVP group (n = 46), which underwent transurethral BL-PVP, and the GL-PVP group (n = 51), which underwent transurethral GL-PVP.

Pathogenic variants in DLGAP5 cause female infertility characterized by oocyte maturation arrest and embryonic arrest.

Study Question: Can new genetic factors responsible for oocyte defects be identified in infertile women, especially for those with spindle assembly defects?

Summary Answer: We identified homozygous and compound heterozygous variants of DLGAP5 in three infertile individuals from two independent families.

What Is Known Already: Some genes have been found to be responsible for female infertility with oocyte maturation defects. During mitosis, DLGAP5 is involved in promoting microtubule polymerization and spindle formation.

Factors Associated With Perfluorohexyloctane Treatment Response in Dry Eye Disease Associated With Meibomian Gland Dysfunction.

Purpose: To explore critical factors associated with perfluorohexyloctane eye drop (SHR8058) treatment response in patients with dry eye disease associated with meibomian gland dysfunction.

Methods: The post hoc analysis was performed from a phase 3, randomized controlled trial (NCT05515471). Treatment response was defined as achieving 1) a ≥ 3-point reduction from baseline in total corneal fluorescein staining (tCFS response), 2) a ≥30% reduction from baseline in eye dryness score (EDS response), or 3) both tCFS and eye dryness score (EDS) responses (tCFS&EDS response) at day 57.

Cold-Adapted Nanozymes.

Cold-adapted nanozymes represent a distinct class of nanomaterials that exhibit robust catalytic activity and stability under low-temperature conditions (below 37 °C). By emulating the catalytic functions of natural enzymes, these nanozymes can overcome the inherent limitations of traditional enzymes, which typically suffer from the reduced activity and rapid deactivation in cold environments. Over the recent years, cold-adapted nanozymes have attracted considerable interdisciplinary interest, including chemistry, biomedicine, and materials science, which have demonstrated unique advantages in diverse applications, such as antiviral and antibacterial treatments, tumor therapy, environmental remediation, and food safety monitoring.

Recombinant production of isotope-labeled human α-defensin 5 via calmodulin fusion and insights into its expression enhancement.

Human α-defensin 5 (HD5), a cysteine-rich antimicrobial peptide critical for intestinal innate immunity, has been extensively studied for its structural and functional properties. Both the reduced form (HD5red) and the oxidized form (HD5oxi) exist in vivo and exhibit distinct antimicrobial activity spectra. In this study, we developed an efficient method to overexpress recombinant HD5 in Escherichia coli (E.

Early arteriovenous malformation mimicking pediatric capillary malformation: diagnostic value of infrared thermography.

Early-stage arteriovenous malformations (AVMs) and port-wine stains (PWS) exhibit overlapping clinical presentations, notably as flat, irregular erythema, posing significant diagnostic challenges. Conventional imaging techniques offer insufficient resolution for microvascular assessment during initial evaluation, and definitive diagnosis requires invasive tissue biopsy. We report a case of a 4-year-old boy initially misdiagnosed with facial PWS following ineffective photodynamic therapy.

Porcine SCD1 Regulates Lipid Droplet Number via CLSTN3B in PK15 Cells.

Fat deposition plays a key role in determining porcine meat quality traits, with lipid droplets serving as critical organelles for lipid storage in adipose tissue. Inhibiting lipid droplet biogenesis disrupts the lipid storage capacity of adipocytes. The Stearoyl-CoA Desaturase () family is crucial in regulating polyunsaturated fatty acid/monounsaturated fatty acid (PUFA/MUFA) composition, while its role in lipid droplet formation remains unclear.

LINC02562 Promotes Progression of Lung Cancer by Regulating NTHL1 Dependent DNA Damage Repair Mechanisms.

Lung cancer poses a serious threat to public health due to its high morbidity and mortality rates. The mechanisms of lung cancer formation and progression are complex and involve regulation of various biomolecules. Long noncoding RNAs (lncRNAs) have emerged to be critical in tumorigenesis of various malignancies.

Enhanced dry reforming of methane over nickel catalysts supported on zirconia coated mesoporous silica.

Dry reforming of methane (DRM) offers a sustainable route to convert CH and CO into syngas, addressing both greenhouse gas emissions and energy demand. However, catalyst deactivation due to sintering and coking limits practical applications. In this work, we developed a mesoporous Ni-based catalyst (Ni/ZrSBA-15-OH) featuring abundant Ni-ZrO interfaces and small Ni nanoparticles (5.

Nuclearporin subcomplex Nup98/Rae1 is vital for maternal-to-zygotic transition during early embryonic development.

The Nup98/Rae1 nuclear pore subcomplex, a critical mediator of nucleocytoplasmic transport, orchestrates fundamental cellular processes including transcriptional regulation, mRNA surveillance, and mitotic fidelity. However, its functional significance during early embryogenesis remains incompletely understood. In this study, we employed an in vitro embryo culture system combined with embryo electroporation-mediated interference to investigate the role of Nup98/Rae1 in early mouse embryos.

Syndromic capillary malformation with leg length discrepancy: Parkes-Weber syndrome treated by embolization, chemotherapy and Ilizarov technique.

Capillary malformations (CMs) are congenital low-flow vascular anomalies caused by dilated capillaries. Leg length discrepancy (LLD) is the condition characterized by unequal lower limb lengths, leading to functional and postural challenges. Capillary malformation with leg length discrepancy (CM-LLD) formally reveals syndrome such as Klippel-Trenaunay syndrome and Diffuse Capillary Malformation Overgrowth.

Mussel-Inspired Hemostatic Hydrogel Adhesive Formulated from a Gelatin-Oxidized Dextrin Double Network.

Hydrogels are recognized for their excellent biocompatibility and biodegradability, making them promising candidates for hemostatic materials, especially in cases of intra-abdominal bleeding or injury to vital organs. In this study, a mussel-inspired adhesive hemostatic hydrogel, GMOD, is developed, which features injectability, outstanding biocompatibility, and biodegradability. The hydrogel is synthesized through Schiff base crosslinking of oxidized dextran and gelatin, enhanced with dopamine to form a robust double network structure.